scholarly journals Visuospatial Functioning in the Primary Progressive Aphasias

2017 ◽  
Vol 24 (3) ◽  
pp. 259-268 ◽  
Author(s):  
Christa L. Watson ◽  
Katherine Possin ◽  
I. Elaine Allen ◽  
H. Isabel Hubbard ◽  
Marita Meyer ◽  
...  
Keyword(s):  
Visual Information ◽  
Visual Memory ◽  
Primary Progressive Aphasia ◽  
Cross Sectional ◽  
Delayed Recall ◽  
Primary Progressive ◽  
Visuospatial Cognition ◽  
Immediate Recall ◽  
Visuospatial Tasks ◽  
Over Time

AbstractObjectives: The aim of this study was to identify whether the three main primary progressive aphasia (PPA) variants would show differential profiles on measures of visuospatial cognition. We hypothesized that the logopenic variant would have the most difficulty across tasks requiring visuospatial and visual memory abilities. Methods: PPA patients (n=156), diagnosed using current criteria, and controls were tested on a battery of tests tapping different aspects of visuospatial cognition. We compared the groups on an overall visuospatial factor; construction, immediate recall, delayed recall, and executive functioning composites; and on individual tests. Cross-sectional and longitudinal comparisons were made, adjusted for disease severity, age, and education. Results: The logopenic variant had significantly lower scores on the visuospatial factor and the most impaired scores on all composites. The nonfluent variant had significant difficulty on all visuospatial composites except the delayed recall, which differentiated them from the logopenic variant. In contrast, the semantic variants performed poorly only on delayed recall of visual information. The logopenic and nonfluent variants showed decline in figure copying performance over time, whereas in the semantic variant, this skill was remarkably preserved. Conclusions: This extensive examination of performance on visuospatial tasks in the PPA variants solidifies some previous findings, for example, delayed recall of visual stimuli adds value in differential diagnosis between logopenic variant PPA and nonfluent variant PPA variants, and illuminates the possibility of common mechanisms that underlie both linguistic and non-linguistic deficits in the variants. Furthermore, this is the first study that has investigated visuospatial functioning over time in the PPA variants. (JINS, 2018, 24, 259–268)

Spanish Version of the Mini-Linguistic State Examination for the Diagnosis of Primary Progressive Aphasia

2021 ◽  
pp. 1-8
Author(s):  
Jordi A. Matias-Guiu ◽  
Vanesa Pytel ◽  
Laura Hernández-Lorenzo ◽  
Nikil Patel ◽  
Katie A. Peterson ◽  
...  
Keyword(s):  
Primary Progressive Aphasia ◽  
Spanish Version ◽  
Classification Model ◽  
Healthy Controls ◽  
Language Test ◽  
Cross Sectional ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Clinical Variants ◽  
State Examination

Background: Primary progressive aphasia (PPA) is a neurodegenerative syndrome with three main clinical variants: non-fluent, semantic, and logopenic. Clinical diagnosis and accurate classification are challenging and often time-consuming. The Mini-Linguistic State Examination (MLSE) has been recently developed as a short language test to specifically assess language in neurodegenerative disorders. Objective: Our aim was to adapt and validate the Spanish version of MLSE for PPA diagnosis. Methods: Cross-sectional study involving 70 patients with PPA and 42 healthy controls evaluated with the MLSE. Patients were independently diagnosed and classified according to comprehensive cognitive evaluation and advanced neuroimaging. Results: Internal consistency was 0.758. The influence of age and education was very low. The area under the curve for discriminating PPA patients and healthy controls was 0.99. Effect sizes were moderate-large for the discrimination between PPA and healthy controls. Motor speech, phonology, and semantic subscores discriminated between the three clinical variants. A random forest classification model obtained an F1-score of 81%for the three PPA variants. Conclusion: Our study provides a brief and useful language test for PPA diagnosis, with excellent properties for both clinical routine assessment and research purposes.

scholarly journals Neuropsychological Profiles Differ among the Three Variants of Primary Progressive Aphasia

2015 ◽  
Vol 21 (6) ◽  
pp. 429-435 ◽  
Author(s):  
Alissa M. Butts ◽  
Mary M. Machulda ◽  
Joseph R. Duffy ◽  
Edythe A. Strand ◽  
Jennifer L. Whitwell ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Visual Memory ◽  
Primary Progressive Aphasia ◽  
Neuropsychological Evaluation ◽  
Neurocognitive Dysfunction ◽  
Memory Processing ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Frontal Lobe Functions ◽  
Visuospatial Functions

AbstractThe objective of this study was to describe the neuropsychological profiles of the three variants of primary progressive aphasia (PPA). Based on a comprehensive speech and language evaluation, 91 subjects were classified as logopenic (lvPPA=51), semantic (svPPA=13), or agrammatic (agPPA=27). All subjects completed a separate neuropsychological evaluation assessing verbal and visual memory, processing speed, executive function, and visuospatial function. The groups did not differ on demographic variables or on measures of disease duration or aphasia severity. There were group differences on aspects of learning and memory, as well as aspects of executive and visuospatial functions, primarily with the lvPPA group performing lower than the agPPA and svPPA groups. The agPPA group showed subtle deficits consistent with frontal lobe impairment, whereas neurocognitive weaknesses in the svPPA group were restricted to temporal lobe functions. The pattern of neurocognitive dysfunction in lvPPA suggests disease involvement of frontal lobe functions in addition to temporoparietal functions. These neurocognitive findings emphasize the value of a comprehensive neuropsychological evaluation of individuals who present with primary language disturbance, given the pattern of cognitive deficits may provide additive information for differentiating these clinical syndromes. (JINS, 2015, 21, 429–435)

Effects of Angle of Model-Demonstration on Learning of Motor Skill

1995 ◽  
Vol 80 (2) ◽  
pp. 651-658 ◽  
Author(s):  
Tadao Ishikura ◽  
Kimihiro Inomata
Keyword(s):  
Visual Information ◽  
Recall Test ◽  
Objective Condition ◽  
Delayed Recall ◽  
Immediate Recall ◽  
Subjective Condition ◽  
The Subject ◽  
The Right ◽  
The Relationship ◽  
Looking Glass

The purpose was to examine the effects of three different demonstrations by a model on acquisition and retention of a sequential gross movement task. The second purpose was to examine the relationship between reversal processing of visual information about skills and coding of skill information. Thirty undergraduates (15 men and 15 women) were assigned into one of three conditions, Objective condition which demonstrated the task with the model facing the subject, Looking-glass condition in which the skill was demonstrated with the model facing the subject who viewed the performance opposite the right and left directions in executing the task, and the Subjective condition in which the subject observed the model from the rear. Number of immediate recall tests required to accomplish the sequential movements completely and the sum of the performance points for reproduced movements at each delayed recall test (1 day, 7 days, and 5 mo. after the immediate recall test) were employed. Analysis indicated the Subjective condition produced a significantly greater modeling effect in immediate recall of the movements than the Looking-glass condition. Retention of the acquired skills was almost equal under the three conditions.

Correlates of anomia in non-semantic variants of primary progressive aphasia converge over time

Cortex ◽  
2019 ◽  
Vol 120 ◽  
pp. 201-211 ◽  
Author(s):  
Cristian E. Leyton ◽  
Ramon Landin-Romero ◽  
Cheng Tao Liang ◽  
James R. Burrell ◽  
Fiona Kumfor ◽  
...  
Keyword(s):  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Over Time

scholarly journals Memory Performance in Patient with Systemic Lupus Erythematosus Using MoCA-Ina in Hasan Sadikin Genneral Hospital Bandung

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Safira Anjalia ◽  
Paulus Anam Ong ◽  
Nur Atik ◽  
Laniyati Hamijoyo
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cognitive Impairment ◽  
Lupus Erythematosus ◽  
Cognitive Assessment ◽  
Memory Impairment ◽  
Montreal Cognitive Assessment ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Delayed Recall ◽  
Immediate Recall

Background: The involvement of neuropsychiatry is reported in 6% to 91% of Systemic Lupus Erythematosus (SLE) patients. It can cause fatal morbidity and mortality. Memory impairment is one of the most common symptoms of neuropsychiatry involvement. This study aims to find out the performance of memory test in SLE patients using Indonesian version of Montreal Cognitive Assessment (MoCA-Ina).Method: This cross sectional study recruited 30 SLE patients. Cognitive abilities and patient’s memory were examined using Indonesian version of Montreal Cognitive Assessment (MoCA-Ina). Cognitive impairment was determined when total MoCA-Ina score was below 26. For memory evaluation, immediate recall or delayed recall impairment was determined when the patient failed in each memory subtests.Results: The mean of total MoCA-Ina score was 24.97 (SD±3.14). Fifty percent of the SLE patients had cognitive impairment, with the domain involved being delayed recall (86.67%), attention (60%), language (56.67%), abstraction (53.33%), and visuo-spatial/ executive function (36.67%). Most patients (86.67%) could completely repeat immediate recall. Whileonly 4 (13.33%) subjects could repeat delayed recall completely without any clue. Of the 26 SLE patients who failed to recall completely, 24 (92.3%) of them succeeded to recall completely after getting clue(s).Conclusion: Memory impairment is the most frequent cognitive impairment in SLE patients, especially in delayed recall. By using the memory subtests of MoCAIna, more than four fifth of patients with SLE was detected having delayed recall memory impairment and almost all of them could recalled completely after getting clue(s). This findings indicated that the finalstep of memory process retrieval in SLE was interrupted while being encoded, but retention pathway were stillintact.Keywords: Systemic Lupus Erythematous, Memory, MoCA-Ina

Cerebral microbleeds and CSF Alzheimer biomarkers in primary progressive aphasias

Neurology ◽  
2018 ◽  
Vol 90 (12) ◽  
pp. e1057-e1065 ◽  
Author(s):  
Aline Mendes ◽  
Anne Bertrand ◽  
Foudil Lamari ◽  
Olivier Colliot ◽  
Alexandre Routier ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Alzheimer Disease ◽  
White Matter Hyperintensities ◽  
Primary Progressive Aphasia ◽  
Cerebral Microbleeds ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Primary Progressive ◽  
Alzheimer Pathology

ObjectiveTo reveal the prevalence and localization of cerebral microbleeds (CMBs) in the 3 main variants of primary progressive aphasia (PPA) (logopenic, semantic, and nonfluent/agrammatic), to identify the relationship with underlying Alzheimer pathology, and to explore whether CMBs contribute to language breakdown.MethodsWe used a cross-sectional design in a multicenter cohort of 82 patients with PPA and 19 similarly aged healthy controls. MRI allowed for rating CMBs (2-dimensional gradient recalled echo T2*, susceptibility weighted imaging sequences) and white matter hyperintensities. CSF Alzheimer disease biomarker analyses available in 63 of the 82 patients provided the stratification of PPA into subgroups with patients who had or did not have probable underlying Alzheimer pathology.ResultsThe prevalence of CMBs was higher in patients with PPA (28%) than in controls (16%). They were more prevalent in logopenic PPA (50%) than in semantic PPA (18%) and nonfluent/agrammatic PPA (17%). The localization of CMBs was mainly lobar (81%) with no difference between the PPA variants. CMBs were more frequent in PPA patients with positive than with negative CSF Alzheimer disease biomarkers (67% vs 20%). Patients with and without lobar CMBs had similar volumes of white matter hyperintensities. Language and general cognitive impairment in PPA was unrelated to CMB rates.ConclusionsCMB prevalence in PPA is higher than in healthy controls. CMBs were most prevalent in the logopenic variant, were related to underlying Alzheimer pathology, and did not affect the language/cognitive impairment. Our findings also suggest that CMB detection with MRI contributes to PPA variant diagnosis, especially of logopenic PPA, and provides an estimator of the underlying neuropathology.

scholarly journals Visuomotor figure construction and visual figure delayed recall and recognition in primary progressive aphasia

Aphasiology ◽  
2019 ◽  
Vol 34 (12) ◽  
pp. 1456-1470 ◽  
Author(s):  
Donna C. Tippett ◽  
Bonnie Breining ◽  
Emily Goldberg ◽  
Erin Meier ◽  
Shannon M. Sheppard ◽  
...  
Keyword(s):  
Primary Progressive Aphasia ◽  
Delayed Recall ◽  
Progressive Aphasia ◽  
Primary Progressive

scholarly journals Speech production differences in English and Italian speakers with nonfluent variant PPA

Neurology ◽  
2020 ◽  
Vol 94 (10) ◽  
pp. e1062-e1072 ◽  
Author(s):  
Elisa Canu ◽  
Federica Agosta ◽  
Giovanni Battistella ◽  
Edoardo G. Spinelli ◽  
Jessica DeLeon ◽  
...  
Keyword(s):  
Gray Matter Volume ◽  
Primary Progressive Aphasia ◽  
Cross Sectional Study ◽  
Speech Impairment ◽  
Neuropsychological Battery ◽  
Connected Speech ◽  
Cross Sectional ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Language Measures

ObjectiveTo understand whether the clinical phenotype of nonfluent/agrammatic primary progressive aphasia (nfvPPA) could present differences depending on the patient’s native language.MethodsIn this cross-sectional study, we analyzed connected speech samples in monolingual English (nfvPPA-E) and Italian speakers (nfvPPA-I) who were diagnosed with nfvPPA and matched for age, sex, and Mini-Mental State Examination scores. Patients also received a comprehensive neuropsychological battery. All patients and 2 groups of age-matched healthy controls underwent an MRI scan with 3D T1-weighted sequences. Connected speech measures and the other cognitive features were compared between patient groups. MRI variables, in terms of gray matter volume, were compared between each patient group and the corresponding controls.ResultsCompared to nfvPPA-E, nfvPPA-I had fewer years of education and shorter reported disease duration. The 2 groups showed similar regional atrophy compatible with clinical diagnosis. Patients did not differ in nonlanguage domains, comprising executive scores. Connected speech sample analysis showed that nfvPPA-E had significantly more distortions than nfvPPA-I, while nfvPPA-I showed reduced scores in some measures of syntactic complexity. On language measures, Italian speakers performed more poorly on syntactic comprehension.ConclusionsnfvPPA-E showed greater motor speech impairment than nfvPPA-I despite higher level of education and comparable disease severity and atrophy changes. The data also suggest greater grammatical impairment in nfvPPA-I. This study illustrates the need to take into account the possible effect of the individual's spoken language on the phenotype and clinical presentation of primary progressive aphasia variants.

scholarly journals Feature-specific reaction times reveal a semanticisation of memories over time and with repeated remembering

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Julia Lifanov ◽  
Juan Linde-Domingo ◽  
Maria Wimber
Keyword(s):  
Reaction Times ◽  
Control Group ◽  
Delayed Recall ◽  
Specific Reaction ◽  
Immediate Recall ◽  
Recall Data ◽  
Perceptual Detail ◽  
Semantic Transformation ◽  
Over Time ◽  
Qualitative Changes

AbstractMemories are thought to undergo an episodic-to-semantic transformation in the course of their consolidation. We here test if repeated recall induces a similar semanticisation, and if the resulting qualitative changes in memories can be measured using simple feature-specific reaction time probes. Participants studied associations between verbs and object images, and then repeatedly recalled the objects when cued with the verb, immediately and after a two-day delay. Reaction times during immediate recall demonstrate that conceptual features are accessed faster than perceptual features. Consistent with a semanticisation process, this perceptual-conceptual gap significantly increases across the delay. A significantly smaller perceptual-conceptual gap is found in the delayed recall data of a control group who repeatedly studied the verb-object pairings on the first day, instead of actively recalling them. Our findings suggest that wake recall and offline consolidation interact to transform memories over time, strengthening meaningful semantic information over perceptual detail.

scholarly journals The Course of Primary Progressive Aphasia Diagnosis : A Cross-Sectional Study.

2021 ◽  
Author(s):  
Aurélie Mouton ◽  
Alexandra PLONKA ◽  
Roxane FABRE ◽  
Maï Tran ◽  
Philippe ROBERT ◽  
...  
Keyword(s):  
Primary Progressive Aphasia ◽  
Data Bank ◽  
Cross Sectional Study ◽  
Diagnosis Delay ◽  
Sectional Study ◽  
Pharmacological Treatments ◽  
Cross Sectional ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
First Diagnosis

Abstract BackgroundThe Primary Progressive Aphasia (PPA) diagnosis trajectory is debated, as several changes in diagnosis occur during PPA course, due to phenotype evolution from isolated language alterations to global cognitive impairment.The goal of the present study, based on a French cohort was to describe the demographics and the evolution of subjects with (PPA) in comparison with Alzheimer Disease (AD) on a period of seven years. MethodsWe conducted a repeated cross-sectional study. The study population comprised individuals with PPA and AD diagnosis (N=167191) from 2010 to 2016 in the French National data Bank (BNA). Demographic variables, MMSE scores, diagnosis status at each visit and prescribed treatments were considered.ResultsFrom 2010 to 2016, 5186 patients were initially diagnosed with PPA, 162005 with AD. Compared to AD subjects, significant differences were found concerning: age (younger at first diagnosis for PPA), gender (more balanced in PPA), education level (higher in PPA) and MMSE score (higher in PPA). Percentage of pending diagnosis, delay between first consultation and first diagnosis and the number of different diagnoses before the diagnosis of interest were significantly higher in PPA group compared to AD group. Pharmacological and non-pharmacological treatments were significatively more recommended following PPA than AD diagnosis.ConclusionThis study improves the knowledge of PPA epidemiology and has the potential to help adopting appropriate public health service policies. It supports the hypothesis that PPA is diagnosed later than AD. The PPA diagnosis increases the prescription of non-pharmacological treatments, especially speech and language therapy (SLT) that is the main treatment available and most effective when at the initial stage.Trial registrationClinicalTrials.gov identifier NCT03687112

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