Bragg peak characteristics of proton beams within therapeutic energy range and the comparison of stopping power using the GATE Monte Carlo simulation and the NIST data

2019 ◽  
Vol 19 (2) ◽  
pp. 173-181 ◽  
Author(s):  
Shiva Zarifi ◽  
Hadi Taleshi Ahangari ◽  
Sayyed Bijan Jia ◽  
Mohammad Ali Tajik-Mansoury ◽  
Milad Najafzadeh ◽  
...  

AbstractPurpose:To examine detail depth dose characteristics of ideal proton beams using the GATE Monte Carlo technique.Methods:In this study, in order to improve simulation efficiency, we used pencil beam geometry instead of parallel broad-field geometry. Depth dose distributions for beam energies from 5 to 250 MeV in a water phantom were obtained. This study used parameters named Rpeak, R90, R80, R73, R50, full width at half maximum (FWHM), width of 80–20% distal fall-off (W(80–20)) and peak-to-entrance ratio to represent Bragg peak characteristics. The obtained energy–range relationships were fitted into third-order polynomial formulae. The present study also used the GATE Monte Carlo code to calculate the stopping power of proton pencil beams in a water cubic phantom and compared results with the National Institute of Standards and Technology (NIST) standard reference database.Results:The study results revealed deeper penetration, broader FWHM and distal fall-off and decreased peak-to-entrance dose ratio with increasing beam energy. Study results for monoenergetic proton beams showed that R73 can be a good indicator to characterise a range of incident beams. These also suggest FWHM is more sensitive than W(80–20) distal fall-off in finding initial energy spread. Furthermore, the difference between the obtained stopping power from simulation and NIST data almost in all energies was lower than 1%.Conclusion:Detail depth dose characteristics for monoenergetic proton beams within therapeutic energy ranges were reported. These results can serve as a good reference for clinical practitioners in their daily practice.

2021 ◽  
Vol 27 (4) ◽  
pp. 279-289
Author(s):  
Elahe Sayyadi ◽  
Asghar Mesbahi ◽  
Reza Eghdam Zamiri ◽  
Farshad Seyyed Nejad

Abstract Introduction: The present study aimed to investigate the radiation protection properties of silicon-based composites doped with nano-sized Bi2O3, PbO, Sm2O3, Gd2O3, WO3, and IrO2 particles. Radiation shielding properties of Sm2O3 and IrO2 nanoparticles were investigated for the first time in the current study. Material and methods: The MCNPX (2.7.0) Monte Carlo code was utilized to calculate the linear attenuation coefficients of single and multi-nano structured composites over the X-ray energy range of 10–140 keV. Homogenous distribution of spherical nanoparticles with a diameter of 100 nm in a silicon rubber matrix was simulated. The narrow beam geometry was used to calculate the photon flux after attenuation by designed nanocomposites. Results: Based on results obtained for single nanoparticle composites, three combinations of different nano-sized fillers Sm2O3+WO3+Bi2O3, Gd2O3+WO3+Bi2O3, and Sm2O3+WO3+PbO were selected, and their shielding properties were estimated. In the energy range of 20-60 keV Sm2O3 and Gd2O3 nanoparticles, in 70-100 keV energy range WO3 and for photons energy higher than 90 keV, PbO and Bi2O3 nanoparticles showed higher attenuation. Despite its higher density, IrO2 had lower attenuation compared to other nanocomposites. The results showed that the nanocomposite containing Sm2O3, WO3, and Bi2O3 nanoparticles provided better shielding among the studied samples. Conclusions: All studied multi-nanoparticle nanocomposites provided optimum shielding properties and almost 8% higher attenuation relative to single nano-based composites over a wide range of photon energy used in diagnostic radiology. Application of these new composites is recommended in radiation protection. Further experimental studies are suggested to validate our findings.


2020 ◽  
Vol 21 (16) ◽  
pp. 5650 ◽  
Author(s):  
Anna Michaelidesová ◽  
Jana Vachelová ◽  
Jana Klementová ◽  
Tomáš Urban ◽  
Kateřina Pachnerová Brabcová ◽  
...  

Nowadays, the irradiation methodology in proton therapy is switching from the use of passively scattered beams to active pencil beams due to the possibility of more conformal dose distributions. The dose rates of active pencil beams are much higher than those of passive beams. The purpose of this study was to investigate whether there is any difference in the biological effectiveness of these passive and active irradiation modes. The beam qualities of double scattering and pencil beam scanning were measured dosimetrically and simulated using the Monte Carlo code. Using the medulloblastoma cell line DAOY, we performed an in vitro comparison of the two modes in two positions along the dose–deposition curve plateau and inside the Bragg peak. We followed the clonogenic cell survival, apoptosis, micronuclei, and γH2AX assays as biological endpoints. The Monte Carlo simulations did not reveal any difference between the beam qualities of the two modes. Furthermore, we did not observe any statistically significant difference between the two modes in the in vitro comparison of any of the examined biological endpoints. Our results do not show any biologically relevant differences related to the different dose rates of passive and active proton beams.


2007 ◽  
Vol 34 (2) ◽  
pp. 680-688 ◽  
Author(s):  
J. Hérault ◽  
N. Iborra ◽  
B. Serrano ◽  
P. Chauvel

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