scholarly journals Cochrane Review Summary: Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes

2016 ◽  
Vol 17 (04) ◽  
pp. 317-318 ◽  
Author(s):  
Daksha Trivedi
Keyword(s):  
Cochrane Review ◽  
Neonatal Morbidity ◽  
Neonatal Outcomes ◽  
Morbidity And Mortality ◽  
Community Based

scholarly journals 17-Alpha-Hydroxyprogesterone vs. Placebo for Preventing of Recurrent Preterm Birth: A Systematic Review and Meta-Analysis of Randomized Trials

2021 ◽  
Vol 8 ◽  
Author(s):  
Abdulaali R. Almutairi ◽  
Hadir I. Aljohani ◽  
Nouf S. Al-fadel
Keyword(s):  
Systematic Review ◽  
Preterm Birth ◽  
Meta Analysis ◽  
Neonatal Morbidity ◽  
Neonatal Outcomes ◽  
Morbidity And Mortality ◽  
Cochrane Library ◽  
Relative Risk Ratio ◽  
Analysis Model ◽  
Clinical Trial Registries

Background: Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality.Objective: To estimate the effect of 17-alpha-hydroxyprogesterone caproate (17-OHPC) compared to placebo in singleton gestations for reducing the risk of recurrent PTB and neonatal morbidity and mortality.Work Design: Systematic review and meta-analysis.Search Strategy: Searching MEDLINE, Embase, Web of Science, SCOPUS, Cochrane Library, and clinical trial registries.Selection Criteria: Randomized controlled trials of singleton gestations with a history of PTB and treated with a weekly intramuscular injection of 17-OHPC or placebo.Data Collection and Analysis: A random meta-analysis model was performed for the PTB outcomes (<32, <35, and <37 weeks) and neonatal outcomes (neonatal death, grade 3 or 4 intraventricular hemorrhage, respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, and sepsis). Effect estimates were measured by relative risk ratio (RR) with a 95% confidence interval (CI).Main Results: Six works were included. There were no statistically significant reductions in the PTB risk following the use of 17-OHPC at <32 weeks (RR = 0.61, 95% CI: 0.13–2.77, and I2 = 39%), <35weeks (RR = 0.60, 95% CI: 0.10–3.67, and I2 = 51%), and <37 weeks (RR = 0.68, 95% CI: 0.46–1, and I2 = 75%). Furthermore, all the neonatal outcomes were statistically similar between the two groups.Conclusion: Treatment with 17-OHPC is not associated with reducing the risk of PTB or neonatal outcomes compared to placebo.

scholarly journals Neonatal Outcomes from Mothers with Hypertension Disorders of Pregnancy: A Retrospective Study at a Referral Hospital in Rwanda

2020 ◽  
Vol 3 (2) ◽  
pp. 193-203
Author(s):  
Phoibe Uwizeyimana ◽  
Emerthe Musabyemariya ◽  
Olive Tengera ◽  
Anita Collins
Keyword(s):  
Retrospective Study ◽  
Neonatal Morbidity ◽  
Neonatal Outcomes ◽  
Morbidity And Mortality ◽  
University Teaching ◽  
Delivery Mode ◽  
Hypertensive Disorders ◽  
Hypertensive Disorders In Pregnancy ◽  
Maternal Hypertension ◽  
In Pregnancy

Background Globally, maternal hypertensive disorders in pregnancy significantly increase both maternal and perinatal morbidity and mortality. Maternal hypertension affects 14 percent of pregnancies. Eearly detection and management are critical for improving the health outcomes of both mother and neonate. Objective To assess the association between maternal hypertension disorders in pregnancy and immediate neonatal outcomes at a University Teaching Hospital in Rwanda. Methods A retrospective study of maternal files with hypertension disorders was conducted from January 1, 2016, to March 31, 2019. A census sample of 114 records and pretested checklist was used to collect data. Descriptive statistics were used to analyze associations between maternal factors and immediate neonatal outcomes. Results Neonatal outcomes included low birth weight (75.4%), prematurity (59.6%), admission to neonatal intensive care unit (50.4%), intrauterine growth restriction (32.4%), and neonatal death (22.8%). Nearly two-thirds (62%) of mothers had preeclampsia. Significant associations with immediate neonatal outcomes included gestational age, medical history, delivery mode, maternal referral status, preterm birth, prematurity, and abortion. Conclusion Maternal hypertensive disorders were significantly associated with adverse neonatal outcomes in our study population in Rwanda. Improving early detection, health education, and management of hypertensive disorders in pregnancy is critical to reduce maternal and neonatal morbidity and mortality. Rwanda J Med Health Sci 2020;3(2):193-203

scholarly journals Unintended Pregnancy in Ethiopia: Community Based Cross-Sectional Study

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Kidest Getu Melese ◽  
Mignote Hailu Gebrie ◽  
Martha Berta Badi ◽  
Wubalem Fekadu Mersha
Keyword(s):  
Unintended Pregnancy ◽  
Unwanted Pregnancy ◽  
Significant Proportion ◽  
Public Health Problem ◽  
Neonatal Morbidity ◽  
Cross Sectional Study ◽  
Morbidity And Mortality ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional

Introduction. Unintended pregnancy is defined as a pregnancy which is a sum of mistimed pregnancy (pregnancy wanted at a later time) and unwanted pregnancy (pregnancy which is not wanted at all). Unintended pregnancy is a global public health problem and its sequels are major causes for maternal and neonatal morbidity and mortality with its effect to maternal metal illness as well.Objective. To determine the prevalence and associated factors of unintended pregnancy in Debre Birhan town, northeast of Ethiopia, in 2014.Method. Community based cross-sectional study and questionnaire developed from Ethiopian demographic health survey 2011. Participants were 690 currently pregnant mothers. Association of unintended pregnancy with factors was measured with bivariate and multivariate logistic regressions.Result. In this study unintended pregnancy is found to be 23.5%. Being formerly married and never married, distance to the nearest health facility>80 minutes, gravidity>5, 1-2 parity, and partner disagreement on desired number of children are the variables significantly associated with unintended pregnancy.Conclusion. Significant proportion of unintended pregnancy is found in the study area. To minimize unintended pregnancy concerned bodies should work on the identified factors, so we can minimize maternal and neonatal morbidity and mortality and keep the health of the family specifically and country in general.

Women’s Preferences for Maternal and Neonatal Morbidity and Mortality in Childbirth

2019 ◽  
Vol 39 (7) ◽  
pp. 755-764 ◽  
Author(s):  
Brownsyne Tucker Edmonds ◽  
Fatima McKenzie ◽  
Stephen M. Downs ◽  
Aaron E. Carroll
Keyword(s):  
Neonatal Morbidity ◽  
Recruitment Rate ◽  
Reproductive Age ◽  
Morbidity And Mortality ◽  
Community Based ◽  
Health States ◽  
Healthy Baby ◽  
English Speaking ◽  
Women’S Preferences ◽  
Reproductive Aged Women

Purpose. To measure utility values that describe women’s willingness to tradeoff maternal morbidity for fetal benefit among pregnant and nonpregnant women of reproductive age. Methods. We recruited English-speaking women aged 18 to 45 years in clinical and community-based settings. Eight health states were studied: 4 maternal (healthy, stroke, hysterectomy, death) and 4 neonatal (healthy, severe cerebral palsy [CP], severe mental retardation [MR], death). Utilities were assessed on a subset of 9 pairs of mom/baby delivery outcomes. Participants ranked the 9 pairs of outcomes in order of preference, then standard gamble methods were used to calculate utilities. Numeracy skills were assessed. Results. Utilities were obtained from 477 participants (recruitment rate = 94%). Twenty-one percent were pregnant, 63% were parents, and 54% were African American. Utilities did not differ significantly between pregnant and nonpregnant women or based on numeracy score. The highest (nonhealthy) values were assigned to baby healthy/mom hysterectomy (0.999), baby healthy/mom stroke (0.946), and baby CP/mom healthy (0.940). The lowest values were assigned to baby death/mom hysterectomy (0.203), baby MR/mom death (0.150), and baby death/mom stroke (0.087). Nonwhite participants assigned a significantly higher value to baby MR/mom death ( P = 0.01), baby MR/mom stroke ( P = 0.02), baby MR/mom healthy ( P < 0.01), and baby MR/mom hysterectomy ( P = 0.02) than white participants. Conclusion. When asked to value pairs of maternal/fetal outcomes that required a tradeoff of morbidity and mortality, women tended to assign the highest utility to combinations that resulted in a “healthy baby.” They assigned the lowest values to combinations that resulted in a baby’s death or MR. Our findings highlight the importance of 1) assessing individual preferences and goals of care for pregnancy outcomes and 2) measuring utilities among reproductive-aged women when modeling obstetric decision making.

scholarly journals Maternal Preeclampsia and Neonatal Outcomes

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Carl H. Backes ◽  
Kara Markham ◽  
Pamela Moorehead ◽  
Leandro Cordero ◽  
Craig A. Nankervis ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Clinical Decision Making ◽  
Significant Risk ◽  
Optimal Strategies ◽  
Neonatal Morbidity ◽  
Neonatal Outcomes ◽  
Late Preterm ◽  
Morbidity And Mortality ◽  
Premature Delivery ◽  
Late Preterm Infants

Preeclampsia is a multiorgan, heterogeneous disorder of pregnancy associated with significant maternal and neonatal morbidity and mortality. Optimal strategies in the care of the women with preeclampsia have not been fully elucidated, leaving physicians with incomplete data to guide their clinical decision making. Because preeclampsia is a progressive disorder, in some circumstances, delivery is needed to halt the progression to the benefit of the mother and fetus. However, the need for premature delivery has adverse effects on important neonatal outcomes not limited to the most premature infants. Late-preterm infants account for approximately two thirds of all preterm deliveries and are at significant risk for morbidity and mortality. Reviewed is the current literature in the diagnosis and obstetrical management of preeclampsia, the outcomes of late-preterm infants, and potential strategies to optimize fetal outcomes in pregnancies complicated by preeclampsia.

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