scholarly journals Network analysis of the relationship between depressive symptoms, demographics, nutrition, quality of life and medical condition factors in the Osteoarthritis Initiative database cohort of elderly North-American adults with or at risk for osteoarthritis

Author(s):  
Marco Solmi ◽  
Ai Koyanagi ◽  
Trevor Thompson ◽  
Michele Fornaro ◽  
Christoph U Correll ◽  
...  

Abstract Aims A complex interaction exists between age, body mass index, medical conditions, polypharmacotherapy, smoking, alcohol use, education, nutrition, depressive symptoms, functioning and quality of life (QoL). We aimed to examine the inter-relationships among these variables, test whether depressive symptomology plays a central role in a large sample of adults, and determine the degree of association with life-style and health variables. Methods Regularised network analysis was applied to 3532 North-American adults aged ⩾45 years drawn from the Osteoarthritis Initiative. Network stability (autocorrelation after case-dropping), centrality of nodes (strength, M, the sum of weight of the connections for each node), and edges/regularised partial correlations connecting the nodes were assessed. Results Physical and mental health-related QoL (M = 1.681; M = 1.342), income (M = 1.891), age (M = 1.416), depressive symptoms (M = 1.214) and education (M = 1.173) were central nodes. Depressive symptoms’ stronger negative connections were found with mental health-related QoL (−0.702), income (−0.090), education (−0.068) and physical health-related QoL (−0.354). This latter was a ‘bridge node’ that connected depressive symptoms with Charlson comorbidity index, and number of medications. Physical activity and Mediterranean diet adherence were associated with income and physical health-related QoL. This latter was a ‘bridge node’ between the former two and depressive symptoms. The network was stable (stability coefficient = 0.75, i.e. highest possible value) for all centrality measures. Conclusions A stable network exists between life-style behaviors and social, environmental, medical and psychiatric variables. QoL, income, age and depressive symptoms were central in the multidimensional network. Physical health-related QoL seems to be a ‘bridge node’ connecting depressive symptoms with several life-style and health variables. Further studies should assess such interactions in the general population.

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Zeng-Rong Luo ◽  
Dong-Shan Liao ◽  
Liang-Wan Chen

Abstract Background To compare postoperative sexual dysfunction (SD) and quality of life (QOL) in Type A Aortic Dissection (AAD) Patients of Different Ages. Methods From January 2018 to December 2019, 204 AAD postoperative survivors in Union Hospital of Fujian Medical University were selected and were divided into young group (less than 50 years old) and elderly group (more than 50 years old). We evaluated SD according to the male International Erectile Dysfunction Index (IIEF-5) and female sexual function index (FSFI). The Short Form 12 Health Survey Questionnaire (SF-12) and Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) were used to investigate the QOL, Quick Inventory Depressive Symptomatology-Self Report (QIDS-SR) and the Beck Depression Inventory-II (BDI-II) to investigate depressive symptoms. Results One hundred seventy-five patients completed all the questionnaire (85.8%). The total SD prevalence rate was 38.9% (68 cases), with 27.4% of the young (20 cases) and 47.1% of the elderly (48 cases). The age of non-SD and SD patients was 49.0 ± 11.5 and 56.9 ± 10.8 years, respectively (P = 0.03). Compared with non-SD patients, the total physical health of SD patients was significantly worse (P = 0.04), however, the mental health was not significantly worse (P = 0.77); the depressive symptoms did not expressed a significant difference between the SD and non-SD groups (QIDS-SR P = 0.15, BDI-II P = 0.06). Total physical health scores in the young SD group did not show significant better than elderly SD group (P = 0.24), however, total mental health scores showed significantly worse (P = 0.04), depressive symptoms scores were significantly higher (QIDS-SR P = 0.03, BDI-II P = 0.04). Conclusion The postoperative AAD SD prevalence of elderly is higher than that of young, and the total physical health of SD patients is poorer than those without SD patients. The young SD patients did not show a significant higher physical health scores than the elderly SD patients, instead, the young SD patients were more psychologically affected than the elderly SD patients, whose mental health was worse, and depression symptoms were more obvious, suggesting that the factors affecting the QOL of postoperative SD patients are related to physical factors, but the young postoperative SD patients mainly affected by psychological factors.


2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e18232-e18232
Author(s):  
Ali Alobaidi ◽  
Nadia Azmi Nabulsi ◽  
Brian Talon ◽  
Alemseged Ayele Asfaw ◽  
Jifang Zhou ◽  
...  

e18232 Background: Few studies have evaluated the impacts of depressive symptoms and mental health on patients diagnosed with multiple myeloma (MM). The aim of this study was to examine associations between depressive symptoms and poor mental health-related quality of life in relation to survival in a cohort of older MM patients. Methods: We conducted an analysis using a prospective cohort from the Surveillance, Epidemiology, and End Results (SEER)-Medicare Health Outcomes Survey (MHOS) of patients aged 65 years and older diagnosed with first primary MM between 1998 and 2014. Subjects were required to have completed at least 1 pre-diagnosis survey and depressive symptoms were determined based on positive responses to at least 1 of 3 depression screening questions. Veterans-RAND-12 mental component scores (MCS) were also analyzed to evaluate mental health-related quality of life. We used multivariable Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between pre-diagnosis depressive symptoms and risks of all-cause and cancer-specific mortality. Secondary analyses examined mortality risks in relation to pre-diagnosis MCS. Results: Of 522 multiple myeloma patients, the mean (SD) age at diagnosis was 76.9 (6.1) years and 158 (30%) self-reported positive depressive symptoms. Patients with depressive symptoms had a higher number of comorbid conditions and nearly all (84%) scored below the median MCS. Pre-diagnosis depressive symptoms were not associated with all-cause (HR 1.01, 95% CI: 0.79-1.29) or cancer-specific mortality (HR 0.94, 95% CI: 0.69-1.28). Myeloma patients scoring in the second MCS tertile (versus the highest tertile) had a modestly increased risk of all-cause (HR 1.19, 95% CI 0.91-1.55) and cancer-specific mortality (HR 1.17, 95% CI 0.86-1.60), but these estimates were not statistically significant. Conclusions: Pre-diagnosis depressive symptoms and lower mental health-related quality of life are not associated with survival for MM. Nevertheless, the considerably high prevalence of depressive symptoms and poor mental health status among older patients with multiple myeloma deserves clinical attention.


2012 ◽  
Vol 10 (3) ◽  
pp. 189-196 ◽  
Author(s):  
Ellen Karine Grov ◽  
Berit Taraldsen Valeberg

AbstractObjective:Cancer affects both patients and their caregivers. Caregiver burden may change during different stages of the patients' cancer trajectory. Limited research has focused on the impact of being a caregiver, assessed by the caregiver's mental health and quality of life (QOL) during the curative and the palliative phases of the patient's disease. The aim of this study is to compare caregivers of cancer patients during the curative and a palliative phases with respect to their mental health and health-related QOL.Method:This descriptive, cross-sectional study combines data from two studies. The first group consists of caregivers of patients with cancer in the late palliative phase and the second group consists of caregivers of outpatients with cancer who suffer from pain and/or use analgesics. Data were collected by means of standardized measures and analyzed with descriptive statistics.Results:Based on this material, no significant differences in mental health and health- related QOL were revealed for caregivers of cancer patients in the palliative and the curative phases, respectively. Neither education level in the caregivers, nor the patients' functional status influenced caregivers' mental health or QOL. Younger caregivers seem to have better physical QOL.Significance of results:Being caregivers of cancer patients seems to have a similar pattern of impact on caregivers' mental health and quality of life regardless of the patient's disease stage. We share some reflections about the way in which the cancer stage is divided and the appropriateness of such selection for measuring caregivers' mental health and QOL. Additionally, we discuss the use of generic instruments for measuring specific contexts and particular samples.


2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Ilham Alia ◽  
M.A. Fauzi ◽  
S.S Ismail ◽  
Ezmas Mahno ◽  
A W Ahmad ◽  
...  

Introduction: Foot ulcer is one of the most serious complications associated with diabetes mellitus that mat resulted in a disability and impairment of health related quality of life. Materials and Methods: The main objective of this cross-sectional study was to determine the factors adversely associated with quality of life among diabetic foot ulcer patients. Diabetic patients with evidence of diabetic foot ulcer attending outpatient orthopaedics and general surgical clinic of Hospital Tengku Ampuan Afzan were recruited into this study. A set of validated SF-36 questionnaire was employed to evaluate the health-related quality of life for each patient. This study was registered with the National Medical Research Register (NMRR registration no. 17-1520-36332). Results: There is a slightly higher proportion of female among the 104 respondents. Its prevalence is most pronounces in the lower income group. Majority presented with Wagner stage 2 and 3. Amputation has been performed in 54% of these patients. Physical health score fair worse than mental health. Age, low socioeconomic status, presence of comorbidities, major amputation, ulcer at the forefoot and wheelchair usage associated with an adverse effect on the physical health aspect in these patients. Interestingly, smoker seems to score better on the mental health aspect of the quality of life. Conclusion: Diabetic foot ulcer affected physical health aspect much more than mental health aspect within the context of the quality of life.


2022 ◽  
Vol 21 (1) ◽  
pp. 90-95
Author(s):  
Md Abdul Qader ◽  
AKM Abu Mottaleb ◽  
Naznin Akter Shetu ◽  
Raonokosh Salehin Khan ◽  
Tanjima Ahad Nisha ◽  
...  

Objectives: Assessment of health related quality of life (HRQOL) is an essential part of evaluation of end stage renal disease (ESRD) as we have conducted this study on haemodialysis patients to see the HRQOL and to asses and compare the parameters which influence physical and mental health. Materials and Methods: This was a single centre study on haemodialysis patients using Short Form 36 (SF-36) of Kidney Disease Quality of Life (KDQOL). All the eight domains of HRQOL were assessed individually as well as summary scores for mental health (MCS Mental composite summary) and physical health (PCS Physical composite summary) were also evaluated. The questionnaire was completed by patient themselves and the clinical data was extracted from the medical records with prior consent from the patient. Results and discussion: The study participants showed a female predominance of 66% with a lower PCS and MCS scores among female participants in comparison to their male counterparts. Overall summary scores showed a lower PCS (38.71±8.15) than MCS (42.79±11.6) which reflects better mental health than physical health in the study population. A multiple regression analysis showed, the presence of residual renal function (β= -0.421, p= 0.02), duration of dialysis (β= 0.405, p= 0.03) and haemoglobin less than 12g/dL (β= 0.379, p= 0.02) were significant predictors of MCS. Conclusion: HRQOL in haemodialysis patients are influenced by socio-demographic as well as clinical parameters. In our population, kidney disease affects physical health more than mental health and the reasons are multifactorial. Bangladesh Journal of Medical Science Vol. 21(1) 2022 Page : 90-95


2020 ◽  
Author(s):  
Zeng-Rong Luo ◽  
Dong-Shan Liao ◽  
Liang-Wan Chen

Abstract Background: To compare postoperative sexual dysfunction (SD) and quality of life (QOL) in Type A Aortic Dissection (AAD) Patients of Different Ages. Methods: From January 2018 to December 2019, 204 AAD postoperative survivors in Union Hospital of Fujian Medical University were selected and were divided into youth group (less than 50 years old) and elderly group (more than 50 years old). We evaluated SD according to the male International Erectile Dysfunction Index (IIEF-5) and female sexual function index (FSFI) . The Short Form 12 Health Survey Questionnaire (SF-12) and Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) were used to investigate the QOL, Quick Inventory Depressive Symptomatology-Self Report (QIDS-SR) and the Beck Depression Inventory-II (BDI-II) to investigate depressive symptoms. Results: 175 patients completed all the questionnaire (85.8%). The total SD prevalence rate was 38.9% (68 cases), with 27.4% of the youth (20 cases) and 47.1% of the elderly (48 cases). The age of non-SD and SD patients was 49.0±11.5 and 56.9±10.8 years, respectively (P=0.03). Compared with non-SD patients, the total physical health of SD patients was significantly worse (P=0.04), however, the mental health was not significantly worse (P=0.77); the depressive symptoms did not expressed a significant difference between the SD and non-SD groups (QIDS-SR P=0.15, BDI-Ⅱ P=0.06) . Total physical health in the youth SD group did not show significant better (P = 0.24), however, total mental health showed significantly worse (P=0.04), depressive symptoms scores were significantly higher (QIDS-SR P=0.03, BDI-Ⅱ P=0.04). Conclusion: The postoperative AAD SD prevalence of elderly is higher than that of youth, and the total physical health of SD patients is poorer than those without SD patients. The youth SD patients did not show a significant higher scores than the elderly SD patients, instead, the youth SD patients were more psychologically affected than the elderly SD patients, whose mental health was worse, and depression symptoms were more obvious, suggesting that the factors affecting the QOL of postoperative SD patients are related to physical factors, but the youth postoperative SD patients mainly affected by psychological factors.


Author(s):  
Mehdi Rezaei Far ◽  
Farzad Faraji-Khiavi

Background: Nurses face a lot of stress in their jobs, and the quality of life has a significant impact on the quality of their services. Therefore, the purpose of this study was to determine the relationship between general health and the quality of life conditions in nurses working in hospitals affiliated with Jundishapur University of Medical Sciences in Ahvaz. Methods: This cross-sectional descriptive-analytic study was conducted in 2017 on nurses working in educational hospitals in Ahvaz. The sample size was 265. A categorized random sampling was used for the research The collected data were analyzed using mean, standard deviation, independent t-test, ANOVA, regresson and Pearson correlation tests. Data collection tools included the general health questionnaire (GHQ) and the questionnaire on health-related quality of life (HRQOL). Results: Nurses had fairly good general health (23.9 ± 12.4) and their health-related quality of life was moderate (60.29 ± 16.07). Their physical health (63.4 ± 22.5) was found better than their mental health (61.7 ± 20.3) as a factor in the health-related quality of life states. General health had a strong and negative correlation with the quality of life associated with physical health (P-value < 0.001 and r = - 0.61) and the quality of life associated with mental health (P-value < 0.001 and r = - 0.68). Conclusion: Many aspects of health-related quality of life are influenced by general health factors. Therefore, it is recommended that prevention, identification, and treatment of physical and psychological problems and factors affecting the quality of life be considered as a priority, leading to an improvement in nurses’ quality of life.


2020 ◽  
pp. 073346482096651
Author(s):  
Hye-Min Park ◽  
Jinsei Jung ◽  
Jong-Koo Kim ◽  
Yong-Jae Lee

This study investigated the relationship of tinnitus with mental health and health-related quality of life (QoL) in older people. Data source included 5,129 community-dwelling men and women ≥60 years old from the Korean National Health and Nutrition Examination Survey. Tinnitus was categorized into three groups: normal, tolerable tinnitus, and annoying tinnitus. Mental health and health-related QoL were assessed according to three dimensions (depressive mood, psychological distress, and suicidal ideation) and five domains (impaired mobility, impaired self-care, impaired usual activities, pain/discomfort, and anxiety/depression). The odds ratios (ORs) and 95% confidence intervals (CIs) of mental health and health-related QoL were calculated using multiple logistic regression analyses. Annoying tinnitus was positively and independently associated with deteriorated mental health and health-related QoL, suggesting comprehensive care is needed in older people with annoying tinnitus.


2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S877-S877
Author(s):  
Anjana Muralidharan ◽  
Clayton H Brown ◽  
Richard W Goldberg

Abstract Older adults with serious mental illness (i.e., schizophrenia spectrum disorders and affective psychoses) exhibit marked impairments across medical, cognitive, and psychiatric domains. The present study examined predictors of health-related quality-of-life and mental health recovery in this population. Participants (N=211) were ages 50 and older with a chart diagnosis of serious mental illness and a co-occurring medical condition, engaged in outpatient mental health services at a study site. Participants completed a battery of assessments including subtests from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), the 24-Item Behavior and Symptom Identification Scale (BASIS-24), the 12-Item Short-Form Health Survey (SF-12), and the Maryland Assessment of Recovery Scale (MARS). Multiple linear regression analyses, with age, race, gender, and BMI as covariates, examined number of current medical conditions, RBANS, and BASIS as predictors of quality-of-life and recovery. Significant predictors of physical health-related quality-of-life (R-squared=.298, F(9,182)=8.57, p&lt;.0001) were number of medical conditions (β=-1.70, p&lt;.0001), BASIS-Depression/Functioning (β=-4.84, p&lt;.0001), and BASIS-Psychosis (β=2.39, p&lt;.0008). Significant predictors of mental health-related quality-of-life (R-squared=.575, F(9,182)=27.37, p&lt;.0001) were RBANS (β=0.03, p=.05), BASIS-Depression/Functioning (β=-6.49, p&lt;.0001), BASIS-Relationships (β=-3.17, p&lt;.0001), and BASIS-Psychosis (β=-1.30, p=.03). Significant predictors of MARS (R-squared=.434, F(9,183)=15.56, p&lt;.0001) were BASIS-Depression/Functioning (β=-4.68, p=.002) and BASIS-Relationships (β=-9.44, p&lt;.0001). To promote holistic recovery among older adults with serious mental illness, integrated interventions are required. For example, to improve physical health-related quality-of-life, one should target depression and psychotic symptoms as well as medical illness burden. To improve mental health-related quality-of-life, depression symptoms and interpersonal functioning may be key targets, as well as neurocognitive function.


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