Japanese Database of Families with Twins and Higher-Order Multiples

2012 ◽  
Vol 16 (1) ◽  
pp. 221-225 ◽  
Author(s):  
Syuichi Ooki
Keyword(s):  
Response Rate ◽  
Scientific Evidence ◽  
Epidemiologic Study ◽  
Epidemiologic Studies ◽  
Term Effect ◽  
Evidence Based ◽  
Long Term Effect ◽  
Health And Disease ◽  
Genetic Epidemiologic Study

To gain widespread participation, epidemiologic studies of twins from pregnancy through the childhood period are expected to reflect the needs and concerns of families and provide participants with appropriate and useful feedback based on scientific evidence. Our most recent database on families with twins throughout Japan is based on a questionnaire survey conducted from January 2010 to August 2011. Mailed or hand-delivered questionnaires, consisting of over 550 items were used to collect the basic data. The response rate was 40% (956/2,401). This is part of a nation-wide study designed to assess the long-term effect of perinatal conditions on mothers of multiples. Its aim was to study the growth and development of multiples in childhood, and to conduct a genetic epidemiologic study to test the developmental origin of health and disease hypothesis. One of the ultimate aims of this research was to provide evidence-based information on parenting multiples from pregnancy through childhood to families with multiples.

Database of Families with Twins and Higher Order Multiples in Japanese Twins Mothers Clubs

2019 ◽  
Vol 22 (6) ◽  
pp. 588-590
Author(s):  
Syuichi Ooki
Keyword(s):  
Response Rate ◽  
Scientific Evidence ◽  
Epidemiologic Study ◽  
Long Term Effect ◽  
Mother And Child Health ◽  
Mother And Child ◽  
Health And Disease ◽  
And Child Health ◽  
Genetic Epidemiologic Study

AbstractIt is desirable for twin researchers to be aware of the needs and concerns of families of multiples and provide participants with appropriate and useful feedback and advice based on scientific evidence. Our most recent database on families with twins throughout Japan is based on a questionnaire survey conducted in 2016. Mailed questionnaires, consisting of over 500 items, were used to collect the basic data. The response rate was 38% (566/1478). This is part of a nationwide study designed to assess the long-term effect of perinatal conditions on mothers of multiples. Its aim was to study the growth and development of multiples in childhood, and for the creation of a multifetal mother and child health handbook, and to conduct a genetic epidemiologic study to test the developmental origin of health and disease hypothesis. One of the ultimate aims of this research was to provide evidence-based information on parenting of multiples for families with multiples.

Epidemiology 2: Study Design

2010 ◽  
pp. 47-58
Author(s):  
Muktar H. Aliyu
Keyword(s):  
Study Design ◽  
Scientific Evidence ◽  
Epidemiologic Study ◽  
Scientific Research ◽  
Time Frame ◽  
Epidemiologic Studies ◽  
Evidence Based ◽  
Study Designs ◽  
Based Medicine

The usefulness of evidence arising from scientific research is influenced by several factors, and foremost among these factors is the design of the epidemiologic study from which the findings are drawn. In evidence-based medicine, the quality of scientific evidence is often graded on the base of the type of study design and includes appraisal of methods by which studies of exposure and outcomes are planned and implemented. Several factors must be considered when designing a scientific study, including the hypothesis being tested, study cost, time frame, subject characteristics, choice of variables or measurements, and ethical concerns. In this chapter, the different types of study designs commonly encountered in clinical research, common measures of morbidity and mortality in epidemiology, and errors (random and systematic) that may threaten conclusions derived from inferences arising from epidemiologic studies are discussed.

scholarly journals Long-Term Effect of a Gluten-Free Diet on Diarrhoea- or Bloating-Predominant Functional Bowel Disease: Role of the ‘Low-Grade Coeliac Score’ and the ‘Coeliac Lymphogram’ in the Response Rate to the Diet

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1812
Author(s):  
Fernando Fernández-Bañares ◽  
Beatriz Arau ◽  
Agnès Raga ◽  
Montserrat Aceituno ◽  
Eva Tristán ◽  
...  
Keyword(s):  
Response Rate ◽  
Term Effect ◽  
Gluten Free Diet ◽  
Watery Diarrhoea ◽  
Low Grade ◽  
Gluten Free ◽  
Long Term Effect ◽  
Long Term Treatment

1. Background: The long-term effect of a gluten-free diet (GFD) on functional bowel disorders (FBDs) has been scarcely studied. The aim was to assess the effect of a GFD on FBD patients, and to assess the role of both the low-grade coeliac score and coeliac lymphogram in the probability of response to a GFD. 2. Methods: 116 adult patients with either predominant diarrhoea or abdominal bloating, fulfilling Rome IV criteria of FBD, were treated with a GFD. Duodenum biopsies were performed for both pathology studies and intraepithelial lymphocyte subpopulation patterns. Coeliac lymphogram was defined as an increase in TCRγδ+ cells plus a decrease in CD3− cells. A low-grade coeliac score >10 was considered positive. 3. Results: Sustained response to GFD was observed in 72 patients (62%) after a median of 21 months of follow-up, who presented more often with coeliac lymphogram (37.5 vs. 11.4%; p = 0.02) and a score >10 (32 vs. 11.4%; p = 0.027) compared to non-responders. The frequency of low-grade coeliac enteropathy was 19.8%. 4. Conclusion: A GFD is effective in the long-term treatment of patients with previously unexplained chronic watery diarrhoea- or bloating-predominant symptoms fulfilling the criteria of FBD. The response rate was much higher in the subgroup of patients defined by the presence of both a positive low-grade coeliac score and coeliac lymphogram.

A long-term effect of subliminally presented words

2010 ◽  
Author(s):  
Andreas T. Breuer ◽  
Michael E. J. Masson ◽  
Glen E. Bodner
Keyword(s):  
Term Effect ◽  
Long Term Effect
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