Interstitial Fluid Biomarkers’ Minimally Invasive Monitoring Using Microneedle Sensor Arrays

2021 ◽  
Author(s):  
Jinze Li ◽  
Huiting Lu ◽  
Yeyu Wang ◽  
Shuangshuang Yang ◽  
Yufan Zhang ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Interstitial Fluid ◽  
Sensor Arrays ◽  
Invasive Monitoring

scholarly journals Invasive, minimally invasive and non-invasive hemodynamic monitoring in perioperative medicine

2020 ◽  
Vol 12 (1) ◽  
pp. 7-19
Author(s):  
Guerrero Gutiérrez Manuel Alberto ◽  
Pérez Nieto Orlando Rubén ◽  
Eder Iván Zamarrón López ◽  
Jesús Salvador Sánchez Díaz ◽  
Escarramán Martínez Diego ◽  
...  
Keyword(s):  
Intensive Care ◽  
Pulmonary Artery ◽  
Minimally Invasive ◽  
Hemodynamic Monitoring ◽  
Perioperative Period ◽  
Invasive Monitoring ◽  
Less Invasive ◽  
Non Invasive ◽  
Fundamental Part ◽  
Invasive Hemodynamic Monitoring

The hemodynamic monitoring is a fundamental part of the patient in the perioperative period, during the last decade the monitoring at the patient's bedside has grown at giant steps, from the emergency area, operating room, to the Intensive Care area. One of its most important advances is the decrease in the use of pulmonary artery catheter, which is being replaced by ultrasound and less invasive monitoring techniques, in this article we will review from the beginning of the monitoring to the most used less invasive monitors currently.

scholarly journals Minimally Invasive Monitoring of Chronic Central Venous Catheter Patency in Mice Using Digital Subtraction Angiography (DSA)

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0130661 ◽  
Author(s):  
Giovanna Figueiredo ◽  
Teresa Fiebig ◽  
Stefanie Kirschner ◽  
Omid Nikoubashman ◽  
Lisa Kabelitz ◽  
...  
Keyword(s):  
Central Venous Catheter ◽  
Minimally Invasive ◽  
Digital Subtraction Angiography ◽  
Venous Catheter ◽  
Invasive Monitoring ◽  
Digital Subtraction ◽  
Central Venous ◽  
Catheter Patency

scholarly journals Correction: Minimally invasive monitoring of CD4 T cells at multiple mucosal tissues after intranasal vaccination in rhesus macaques

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0191378
Author(s):  
Stephanie Dorta-Estremera ◽  
Pramod N. Nehete ◽  
Guojun Yang ◽  
Hong He ◽  
Bharti P. Nehete ◽  
...  
Keyword(s):  
T Cells ◽  
Minimally Invasive ◽  
Cd4 T Cells ◽  
Rhesus Macaques ◽  
Invasive Monitoring ◽  
Mucosal Tissues

scholarly journals Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid

Small ◽  
2020 ◽  
Vol 16 (16) ◽  
pp. 1905910 ◽  
Author(s):  
Jixiang Zhu ◽  
Xingwu Zhou ◽  
Han‐Jun Kim ◽  
Moyuan Qu ◽  
Xing Jiang ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Interstitial Fluid

scholarly journals Minimally Invasive Glucose Monitoring Using a Highly Porous Gold Microneedles-Based Biosensor: Characterization and Application in Artificial Interstitial Fluid

Catalysts ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 580 ◽  
Author(s):  
Paolo Bollella ◽  
Sanjiv Sharma ◽  
Anthony E. G. Cass ◽  
Federico Tasca ◽  
Riccarda Antiochia
Keyword(s):  
Minimally Invasive ◽  
Interstitial Fluid ◽  
Second Generation ◽  
Glucose Dehydrogenase ◽  
Saturated Calomel Electrode ◽  
Glucose Monitoring ◽  
Signal Loss ◽  
Templating Method ◽  
Porous Gold ◽  
Highly Porous

In this paper, we present the first highly porous gold (h-PG) microneedles-based second-generation biosensor for minimally invasive monitoring of glucose in artificial interstitial fluid (ISF). A highly porous microneedles-based electrode was prepared by a simple electrochemical self-templating method that involves two steps, gold electrodeposition and hydrogen bubbling at the electrode, which were realized by applying a potential of −2 V versus a saturated calomel electrode (SCE). The highly porous gold surface of the microneedles was modified by immobilization of 6-(ferrocenyl)hexanethiol (FcSH) as a redox mediator and subsequently by immobilization of a flavin adenine dinucleotide glucose dehydrogenase (FAD-GDH) enzyme using a drop-casting method. The microneedles-based FcSH/FAD-GDH biosensor allows for the detection of glucose in artificial interstitial fluid with an extended linear range (0.1–10 mM), high sensitivity (50.86 µA cm−2 mM−1), stability (20% signal loss after 30 days), selectivity (only ascorbic acid showed a response about 10% of glucose signal), and a short response time (3 s). These properties were favourably compared to other microneedles-based glucose biosensors reported in the literature. Finally, the microneedle-arrays-based second-generation biosensor for glucose detection was tested in artificial interstitial fluid opportunely spiked with different concentrations of glucose (simulating healthy physiological conditions while fasting and after lunch) and by placing the electrode into a simulated chitosan/agarose hydrogel skin model embedded in the artificial ISF (continuous glucose monitoring). The obtained current signals had a lag-time of about 2 min compared to the experiments in solution, but they fit perfectly into the linearity range of the biosensor (0.1–10 mM). These promising results show that the proposed h-PG microneedles-based sensor could be used as a wearable, disposable, user-friendly, and automated diagnostic tool for diabetes patients.

scholarly journals 3D printed patient-specific aortic root models with internal sensors for minimally invasive applications

2020 ◽  
Vol 6 (35) ◽  
pp. eabb4641 ◽  
Author(s):  
Ghazaleh Haghiashtiani ◽  
Kaiyan Qiu ◽  
Jorge D. Zhingre Sanchez ◽  
Zachary J. Fuenning ◽  
Priya Nair ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Aortic Root ◽  
Three Dimensional ◽  
Sensor Arrays ◽  
Invasive Procedure ◽  
Patient Specific ◽  
Anatomical Site ◽  
Transcatheter Aortic Valve ◽  
Critical Regions

Minimally invasive surgeries have numerous advantages, yet complications may arise from limited knowledge about the anatomical site targeted for the delivery of therapy. Transcatheter aortic valve replacement (TAVR) is a minimally invasive procedure for treating aortic stenosis. Here, we demonstrate multimaterial three-dimensional printing of patient-specific soft aortic root models with internally integrated electronic sensor arrays that can augment testing for TAVR preprocedural planning. We evaluated the efficacies of the models by comparing their geometric fidelities with postoperative data from patients, as well as their in vitro hemodynamic performances in cases with and without leaflet calcifications. Furthermore, we demonstrated that internal sensor arrays can facilitate the optimization of bioprosthetic valve selections and in vitro placements via mapping of the pressures applied on the critical regions of the aortic anatomies. These models may pave exciting avenues for mitigating the risks of postoperative complications and facilitating the development of next-generation medical devices.

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