A Biomimetic Drug Delivery System by Integrating Grapefruit Extracellular Vesicles and Doxorubicin-Loaded Heparin-Based Nanoparticles for Glioma Therapy

Nano Letters ◽  
2021 ◽  
Vol 21 (3) ◽  
pp. 1484-1492
Author(s):  
Wenbo Niu ◽  
Qian Xiao ◽  
Xuejiao Wang ◽  
Junqiao Zhu ◽  
Jinheng Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Extracellular Vesicles ◽  
Delivery System

Mesenchymal stem/stromal cell extracellular vesicles: From active principle to next generation drug delivery system

2017 ◽  
Vol 262 ◽  
pp. 104-117 ◽  
Author(s):  
Barbara Crivelli ◽  
Theodora Chlapanidas ◽  
Sara Perteghella ◽  
Enrico Lucarelli ◽  
Luisa Pascucci ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Extracellular Vesicles ◽  
Delivery System ◽  
Stromal Cell ◽  
Active Principle ◽  
Next Generation

scholarly journals Challenges in Biomaterial-Based Drug Delivery Approach for the Treatment of Neurodegenerative Diseases: Opportunities for Extracellular Vesicles

2020 ◽  
Vol 22 (1) ◽  
pp. 138
Author(s):  
Asit Kumar ◽  
Lina Zhou ◽  
Kaining Zhi ◽  
Babatunde Raji ◽  
Shelby Pernell ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Neurodegenerative Diseases ◽  
Drug Delivery System ◽  
Extracellular Vesicles ◽  
Delivery System ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Therapeutic Interventions ◽  
Invasive Approach

Biomaterials have been the subject of numerous studies to pursue potential therapeutic interventions for a wide variety of disorders and diseases. The physical and chemical properties of various materials have been explored to develop natural, synthetic, or semi-synthetic materials with distinct advantages for use as drug delivery systems for the central nervous system (CNS) and non-CNS diseases. In this review, an overview of popular biomaterials as drug delivery systems for neurogenerative diseases is provided, balancing the potential and challenges associated with the CNS drug delivery. As an effective drug delivery system, desired properties of biomaterials are discussed, addressing the persistent challenges such as targeted drug delivery, stimuli responsiveness, and controlled drug release in vivo. Finally, we discuss the prospects and limitations of incorporating extracellular vesicles (EVs) as a drug delivery system and their use for biocompatible, stable, and targeted delivery with limited immunogenicity, as well as their ability to be delivered via a non-invasive approach for the treatment of neurodegenerative diseases.

scholarly journals Microbe-derived extracellular vesicles as a smart drug delivery system

2018 ◽  
Vol 26 (3) ◽  
pp. 103 ◽  
Author(s):  
Jinho Yang ◽  
Eun Kyoung Kim ◽  
Andrea McDowell ◽  
Yoon-Keun Kim
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Extracellular Vesicles ◽  
Delivery System ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals Overview and Update on Methods for Cargo Loading into Extracellular Vesicles

Processes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 356
Author(s):  
Yohan Han ◽  
Timothy W. Jones ◽  
Saugata Dutta ◽  
Yin Zhu ◽  
Xiaoyun Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Extracellular Vesicles ◽  
Delivery System ◽  
Therapeutic Potential ◽  
Drug Carriers ◽  
Biological Information ◽  
Therapeutic Drugs ◽  
Loading Methods ◽  
Novel Drug

The enormous library of pharmaceutical compounds presents endless research avenues. However, several factors limit the therapeutic potential of these drugs, such as drug resistance, stability, off-target toxicity, and inadequate delivery to the site of action. Extracellular vesicles (EVs) are lipid bilayer-delimited particles and are naturally released from cells. Growing evidence shows that EVs have great potential to serve as effective drug carriers. Since EVs can not only transfer biological information, but also effectively deliver hydrophobic drugs into cells, the application of EVs as a novel drug delivery system has attracted considerable scientific interest. Recently, EVs loaded with siRNA, miRNA, mRNA, CRISPR/Cas9, proteins, or therapeutic drugs show improved delivery efficiency and drug effect. In this review, we summarize the methods used for the cargo loading into EVs, including siRNA, miRNA, mRNA, CRISPR/Cas9, proteins, and therapeutic drugs. Furthermore, we also include the recent advance in engineered EVs for drug delivery. Finally, both advantages and challenges of EVs as a new drug delivery system are discussed. Here, we encourage researchers to further develop convenient and reliable loading methods for the potential clinical applications of EVs as drug carriers in the future.

Applications of extracellular vesicles as a drug-delivery system for chronic respiratory diseases

Nanomedicine ◽  
2022 ◽  
Author(s):  
Bikash Manandhar ◽  
Keshav Raj Paudel ◽  
Nisha Panth ◽  
Philip Hansbro ◽  
Brian G Oliver ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Extracellular Vesicles ◽  
Delivery System ◽  
Respiratory Diseases ◽  
Chronic Respiratory Diseases

Targeted delivery of dexamethasone in acute pneumonia

2021 ◽  
Author(s):  
Qingle Ma ◽  
Chenlu Yao ◽  
Haoliang Shi ◽  
Jialu Xu ◽  
Huaxing Dai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Extracellular Vesicles ◽  
Delivery System ◽  
Targeted Delivery ◽  
Free Drug ◽  
Cytokine Storm ◽  
Acute Pneumonia

Platelet extracellular vesicles are engineered to deliver dexamethasone in acute pneumonia. This drug delivery system considerably reduces the anxiety-like behavior and calms down cytokine storm compared to the mice treated with free drug.

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