Targeted delivery of dexamethasone in acute pneumonia

2021 ◽  
Author(s):  
Qingle Ma ◽  
Chenlu Yao ◽  
Haoliang Shi ◽  
Jialu Xu ◽  
Huaxing Dai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Extracellular Vesicles ◽  
Delivery System ◽  
Targeted Delivery ◽  
Free Drug ◽  
Cytokine Storm ◽  
Acute Pneumonia

Platelet extracellular vesicles are engineered to deliver dexamethasone in acute pneumonia. This drug delivery system considerably reduces the anxiety-like behavior and calms down cytokine storm compared to the mice treated with free drug.

scholarly journals Challenges in Biomaterial-Based Drug Delivery Approach for the Treatment of Neurodegenerative Diseases: Opportunities for Extracellular Vesicles

2020 ◽  
Vol 22 (1) ◽  
pp. 138
Author(s):  
Asit Kumar ◽  
Lina Zhou ◽  
Kaining Zhi ◽  
Babatunde Raji ◽  
Shelby Pernell ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Neurodegenerative Diseases ◽  
Drug Delivery System ◽  
Extracellular Vesicles ◽  
Delivery System ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Therapeutic Interventions ◽  
Invasive Approach

Biomaterials have been the subject of numerous studies to pursue potential therapeutic interventions for a wide variety of disorders and diseases. The physical and chemical properties of various materials have been explored to develop natural, synthetic, or semi-synthetic materials with distinct advantages for use as drug delivery systems for the central nervous system (CNS) and non-CNS diseases. In this review, an overview of popular biomaterials as drug delivery systems for neurogenerative diseases is provided, balancing the potential and challenges associated with the CNS drug delivery. As an effective drug delivery system, desired properties of biomaterials are discussed, addressing the persistent challenges such as targeted drug delivery, stimuli responsiveness, and controlled drug release in vivo. Finally, we discuss the prospects and limitations of incorporating extracellular vesicles (EVs) as a drug delivery system and their use for biocompatible, stable, and targeted delivery with limited immunogenicity, as well as their ability to be delivered via a non-invasive approach for the treatment of neurodegenerative diseases.

Mesenchymal stem/stromal cell extracellular vesicles: From active principle to next generation drug delivery system

2017 ◽  
Vol 262 ◽  
pp. 104-117 ◽  
Author(s):  
Barbara Crivelli ◽  
Theodora Chlapanidas ◽  
Sara Perteghella ◽  
Enrico Lucarelli ◽  
Luisa Pascucci ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Extracellular Vesicles ◽  
Delivery System ◽  
Stromal Cell ◽  
Active Principle ◽  
Next Generation

Dry Drops: a new preservative-free drug delivery system

1999 ◽  
Vol 237 (5) ◽  
pp. 394-398 ◽  
Author(s):  
M. Diestelhorst ◽  
S. Grunthal ◽  
R. Süverkrüp
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Free Drug ◽  
Preservative Free

A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways

Nanoscale ◽  
2017 ◽  
Vol 9 (27) ◽  
pp. 9428-9439 ◽  
Author(s):  
Kai Jiang ◽  
Ting Chi ◽  
Tao Li ◽  
Guirong Zheng ◽  
Lulu Fan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Ursolic Acid ◽  
Delivery System ◽  
Targeted Delivery ◽  
Cancer Growth ◽  
Ph Responsive ◽  
Nanodrug Delivery ◽  
System P ◽  
Multiple Signaling

Anti-tumor and anti-metastatic effects of ursolic acid based on one novel nanodrug delivery system.

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