Delicately Designed Cancer Cell Membrane-Camouflaged Nanoparticles for Targeted 19F MR/PA/FL Imaging-Guided Photothermal Therapy

2020 ◽  
Vol 12 (51) ◽  
pp. 57290-57301
Author(s):  
Sha Li ◽  
Weiping Jiang ◽  
Yaping Yuan ◽  
Meiju Sui ◽  
Yuqi Yang ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Photothermal Therapy

The “nano to micro” transition of hydrophobic curcumin crystals leading to in situ adjuvant depots for Au-liposome nanoparticle mediated enhanced photothermal therapy

2019 ◽  
Vol 7 (9) ◽  
pp. 3866-3875 ◽  
Author(s):  
Syed Baseeruddin Alvi ◽  
Tejaswini Appidi ◽  
B. Pemmaraju Deepak ◽  
P. S. Rajalakshmi ◽  
Gillipsie Minhas ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Photothermal Therapy ◽  
Therapeutic Outcome

The transition of curcumin from nano to micro depots adhering to the cancer cell membrane aids in their localized availability. Thereby enhancing the therapeutic outcome.

scholarly journals Facile preparation of cancer cell membrane vehicle loaded with indocyanine green for effective photothermal therapy of cancer

2020 ◽  
Vol 15 (11) ◽  
pp. 784-787
Author(s):  
Ying Sun ◽  
Jiang Ni ◽  
Yiqing Zhao ◽  
Qiufang Gao
Keyword(s):  
Cell Membrane ◽  
Indocyanine Green ◽  
Cancer Cell ◽  
Photothermal Therapy ◽  
Facile Preparation

Cancer cell membrane-coated gold nanorods for photothermal therapy and radiotherapy on oral squamous cancer

2020 ◽  
Vol 8 (32) ◽  
pp. 7253-7263
Author(s):  
Qiang Sun ◽  
Jinggen Wu ◽  
Lulu Jin ◽  
Liangjie Hong ◽  
Fang Wang ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Squamous Cancer

Cancer cell membrane-coated gold nanorods are prepared for combinational photothermal therapy and radiation therapy of oral squamous cancer.

scholarly journals Cancer cell membrane coated silica nanoparticles loaded with ICG for tumour specific photothermal therapy of osteosarcoma

2019 ◽  
Vol 47 (1) ◽  
pp. 2298-2305 ◽  
Author(s):  
Jingwei Zhang ◽  
Yu Miao ◽  
Weifeng Ni ◽  
Haijun Xiao ◽  
Jieyuan Zhang
Keyword(s):  
Cell Membrane ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Photothermal Therapy

Cancer Cell Membrane–Biomimetic Nanoparticles for Homologous-Targeting Dual-Modal Imaging and Photothermal Therapy

ACS Nano ◽  
2016 ◽  
Vol 10 (11) ◽  
pp. 10049-10057 ◽  
Author(s):  
Ze Chen ◽  
Pengfei Zhao ◽  
Zhenyu Luo ◽  
Mingbin Zheng ◽  
Hao Tian ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Photothermal Therapy ◽  
Biomimetic Nanoparticles

scholarly journals Biomimetic Upconversion Nanoparticles and Gold Nanoparticles for Novel Simultaneous Dual-Modal Imaging-Guided Photothermal Therapy of Cancer

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3136 ◽  
Author(s):  
Ruliang Wang ◽  
Han Yang ◽  
Rongxin Fu ◽  
Ya Su ◽  
Xue Lin ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Imaging System ◽  
Imaging Systems ◽  
Coated Nanoparticles ◽  
Cancer Theranostics

Multimodal imaging-guided near-infrared (NIR) photothermal therapy (PTT) is an interesting and promising cancer theranostic method. However, most of the multimodal imaging systems provide structural and functional information used for imaging guidance separately by directly combining independent imaging systems with different detectors, and many problems arise when trying to fuse different modal images that are serially taken by inviting extra markers or image fusion algorithms. Further, most imaging and therapeutic agents passively target tumors through the enhanced permeability and retention (EPR) effect, which leads to low utilization efficiency. To address these problems and systematically improve the performance of the imaging-guided PTT methodology, we report a novel simultaneous dual-modal imaging system combined with cancer cell membrane-coated nanoparticles as a platform for PTT-based cancer theranostics. A novel detector with the ability to detect both high-energy X-ray and low-energy visible light at the same time, as well as a dual-modal imaging system based on the detector, was developed for simultaneous dual-modal imaging. Cancer cell membrane-coated upconversion nanoparticles (CC-UCNPs) and gold nanoparticles (CC-AuNPs) with the capacity for immune evasion and active tumor targeting were engineered for highly specific imaging and high-efficiency PTT therapy. In vitro and in vivo evaluation of macrophage escape and active homologous tumor targeting were performed. Cancer cell membrane-coated nanoparticles (CC-NPs) displayed excellent immune evasion ability, longer blood circulation time, and higher tumor targeting specificity compared to normal PEGylated nanoparticles, which led to highly specific upconversion luminescence (UCL) imaging and PTT-based anti-tumor efficacy. The anti-cancer efficacy of the dual-modal imaging-guided PTT was also evaluated both in vitro and in vivo. Dual-modal imaging yielded precise anatomical and functional information for the PTT process, and complete tumor ablation was achieved with CC-AuNPs. Our biomimetic UCNP/AuNP and novel simultaneous dual-modal imaging combination could be a promising platform and methodology for cancer theranostics.

Sorafenib delivered by cancer cell membrane remodels tumor microenvironment to enhances the immunotherapy of mitoxantrone in breast cancer

2020 ◽  
Vol 35 (23-24) ◽  
pp. 3296-3303
Author(s):  
Jing Chen ◽  
Jian Huang
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cell Membrane ◽  
Cancer Cell

Abstract

Theoretical Study of the Process of Passage of Glycoside Amides through the Cell Membrane of Cancer Cell

2020 ◽  
Vol 20 ◽  
Author(s):  
Vasil Tsanov ◽  
Hristo Tsanov
Keyword(s):  
Cell Membrane ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Quantum Chemical ◽  
Density Functional ◽  
Enzyme Regulation ◽  
Amide Derivatives ◽  
Pass Through ◽  
Hydrolysis Of ◽  
Derivatives Of

Background:: This article concentrates on the processes occurring in the medium around the cancer cell and the transfer of glycoside amides through their cell membrane. They are obtained by modification of natural glycoside-nitriles (cyano-glycosides). Hydrolysis of starting materials in the blood medium and associated volume around physiologically active healthy and cancer cells, based on quantum-chemical semi-empirical methods, is considered. Objective:: Based on the fact that the cancer cell feeds primarily on carbohydrates, it is likely that organisms have adapted to take food containing nitrile glycosides and / or modified forms to counteract "external" bioactive activity. Cancers, for their part, have evolved to create conditions around their cells that eliminate their active apoptotic forms. This is far more appropriate for them than changing their entire enzyme regulation to counteract it. In this way, it protects itself and the gene sets and develops according to its instructions. Methods:: Derived pedestal that closely defines the processes of hydrolysis in the blood, the transfer of a specific molecular hydrolytic form to the cancer cell membrane and with the help of time-dependent density-functional quantum- chemical methods, its passage and the processes of re-hydrolysis within the cell itself, to forms causing chemical apoptosis of the cell - independent of its non-genetic set, which seeks to counteract the process. Results:: Used in oncology it could turn a cancer from a lethal to a chronic disease (such as diabetes). The causative agent and conditions for the development of the disease are not eliminated, but the amount of cancer cells could be kept low for a long time (even a lifetime). Conclusion:: The amide derivatives of nitrile glycosides exhibit anti-cancer activity, the cancer cell probably seeks to displace hydrolysis of these derivatives in a direction that would not pass through its cell membrane and the amide- carboxyl derivatives of nitrile glycosides could deliver extremely toxic compounds within the cancer cell itself and thus block and / or permanently damage its normal physiology.

scholarly journals Carrier-free highly drug-loaded biomimetic nanosuspensions encapsulated by cancer cell membrane based on homology and active targeting for the treatment of glioma

2021 ◽  
Vol 6 (12) ◽  
pp. 4402-4414
Author(s):  
Yueyue Fan ◽  
Yuexin Cui ◽  
Wenyan Hao ◽  
Mengyu Chen ◽  
Qianqian Liu ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cell ◽  
Active Targeting ◽  
Carrier Free

scholarly journals Investigation of an Optical Imaging Platform Integrated with an Ultrasound Application System for In Vitro Verification of Ultrasound-Mediated Drug Delivery

2021 ◽  
Vol 11 (6) ◽  
pp. 2846
Author(s):  
Jong-ryul Choi ◽  
Juyoung Park
Keyword(s):  
Drug Delivery ◽  
Cervical Cancer ◽  
Cell Membrane ◽  
Optical Imaging ◽  
Cancer Cell ◽  
Fluorescent Imaging ◽  
Calcium Flux ◽  
Cervical Cancer Cell ◽  
Application System ◽  
Ultrasound Application

Techniques that increase the permeability of the cell membrane and transfer drugs or genes to cells have been actively developed as effective therapeutic modalities. Also, in line with the development of these drug delivery techniques, the establishment of tools to verify the techniques at the cellular level is strongly required. In this study, we demonstrated an optical imaging platform integrated with an ultrasound application system to verify the feasibility of safe and efficient drug delivery through the cell membrane using ultrasound-microbubble cavitation. To examine the potential of the platform, fluorescence images of both Fura-2 AM and propidium iodide (PI) to measure calcium flux changes and intracellular PI delivery, respectively, during and after the ultrasound-microbubble cavitation in the cervical cancer cell were acquired. Using the optical imaging platform, we determined that calcium flux increased immediately after the ultrasound-microbubble cavitation and were restored to normal levels, and fluorescence signals from intracellular PI increased gradually after the cavitation. The results acquired by the platform indicated that ultrasound-microbubble cavitation can deliver PI into the cervical cancer cell without irreversible damage of the cell membrane. The application of an additional fluorescent imaging module and high-speed imaging modalities can provide further improvement of the performance of this platform. Also, as additional studies in ultrasound instrumentations to measure real-time cavitation signals progress, we believe that the ultrasound-microbubble cavitation-based sonoporation can be employed for safe and efficient drug and gene delivery to various cancer cells.

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