Synthesis of pH-Responsive Biodegradable Mesoporous Silica–Calcium Phosphate Hybrid Nanoparticles as a High Potential Drug Carrier

2017 ◽  
Vol 9 (51) ◽  
pp. 44402-44409 ◽  
Author(s):  
Yongju He ◽  
Bowen Zeng ◽  
Shuquan Liang ◽  
Mengqiu Long ◽  
Hui Xu
Keyword(s):  
Calcium Phosphate ◽  
Mesoporous Silica ◽  
Drug Carrier ◽  
High Potential ◽  
Hybrid Nanoparticles ◽  
Potential Drug ◽  
Ph Responsive

scholarly journals Synthesis of surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

MedChemComm ◽  
2017 ◽  
Vol 8 (9) ◽  
pp. 1797-1805 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Kang Dae Lee ◽  
Junghwan Oh
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Drug Delivery Applications

Herein, we propose a “host–guest” complexation-based mesoporous silica drug carrier, MSNs@Mela@TTM, for pH-responsive drug delivery applications in cancer therapy.

Co-templating Synthesis of Bimodal Mesoporous Silica for Potential Drug Carrier

2016 ◽  
Vol 1 (7) ◽  
pp. 1339-1346 ◽  
Author(s):  
Wei C. Chu ◽  
Dong R. Peng ◽  
Bishnu P. Bastakoti ◽  
Malay Pramanik ◽  
Victor Malgras ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Drug Carrier ◽  
Potential Drug ◽  
Templating Synthesis

scholarly journals Glucosamine Modified the Surface of pH-Responsive Poly(2-(diethylamino)ethyl Methacrylate) Brushes Grafted on Hollow Mesoporous Silica Nanoparticles as Smart Nanocarrier

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2749 ◽  
Author(s):  
Abeer Beagan ◽  
Shatha Lahmadi ◽  
Ahlam Alghamdi ◽  
Majed Halwani ◽  
Mohammed Almeataq ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Drug Concentrations ◽  
Cytotoxicity Studies ◽  
Hollow Mesoporous Silica ◽  
Mcf 7

This work presents the synthesis of pH-responsive poly(2-(diethylamino) ethyl methacrylate) (PDEAEMA) brushes anchored on hollow mesoporous silica nanoparticles (HMSN-PDEAEMA) via a surface-initiated ARGET ATRP technique. The average size of HMSNs was ca. 340 nm, with a 90 nm mesoporous silica shell. The dry thickness of grafted PDEAEMA brushes was estimated to be ca 30 nm, as estimated by SEM and TEM. The halogen group on the surface of PDEAMA brushes was successfully derivatized with glucosamine, as confirmed by XPS. The effect of pH on the size of the hybrid nanoparticles was investigated by DLS. The size of fabricated nanoparticle decreased from ca. 950 nm in acidic media to ca. 500 nm in basic media due to the deprotonation of tertiary amine in the PDEAEMA. The PDEAEMA modified HMSNs nanocarrier was efficiently loaded with doxorubicin (DOX) with a loading capacity of ca. 64%. DOX was released in a relatively controlled pH-triggered manner from hybrid nanoparticles. The cytotoxicity studies demonstrated that DOX@HMSN-PDEAEMA-Glucosamine showed a strong ability to kill breast cancer cells (MCF-7 and MCF-7/ADR) at low drug concentrations, in comparison to free DOX.

scholarly journals Costunolide Loaded in pH-Responsive Mesoporous Silica Nanoparticles for Increased Stability and an Enhanced Anti-Fibrotic Effect

2021 ◽  
Vol 14 (10) ◽  
pp. 951
Author(s):  
Xia Niu ◽  
Xiaomei Wang ◽  
Bingyu Niu ◽  
Yanan Meng ◽  
Hongwei He ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Dissolution Rate ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Public Health Problem ◽  
Great Promise ◽  
Ph Responsive ◽  
Bile Duct Proliferation

Liver fibrosis remains a significant public health problem. However, few drugs have yet been validated. Costunolide (COS), as a monomeric component of the traditional Chinese medicinal herb Saussurea Lappa, has shown excellent anti-fibrotic efficacy. However, COS displays very poor aqueous solubility and poor stability in gastric juice, which greatly limits its application via an oral administration. To increase the stability, improve the dissolution rate and enhance the anti-liver fibrosis of COS, pH-responsive mesoporous silica nanoparticles (MSNs) were selected as a drug carrier. Methacrylic acid copolymer (MAC) as a pH-sensitive material was used to coat the surface of MSNs. The drug release behavior and anti-liver fibrosis effects of MSNs-COS-MAC were evaluated. The results showed that MSNs-COS-MAC prevented a release in the gastric fluid and enhanced the dissolution rate of COS in the intestinal juice. At half the dose of COS, MSNs-COS-MAC still effectively ameliorated parenchymal necrosis, bile duct proliferation and excessive collagen. MSNs-COS-MAC significantly repressed hepatic fibrogenesis by decreasing the expression of hepatic fibrogenic markers in LX-2 cells and liver tissue. These results suggest that MSNs-COS-MAC shows great promise for anti-liver fibrosis treatment.

Tumor-Targeting Peptide Conjugated pH-Responsive Micelles as a Potential Drug Carrier for Cancer Therapy

2010 ◽  
Vol 21 (2) ◽  
pp. 208-213 ◽  
Author(s):  
Xiang Lan Wu ◽  
Jong Ho Kim ◽  
Heebeom Koo ◽  
Sang Mun Bae ◽  
Hyeri Shin ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Targeting ◽  
Drug Carrier ◽  
Potential Drug ◽  
Ph Responsive ◽  
Targeting Peptide ◽  
Tumor Targeting Peptide

scholarly journals Hydrophilic and Hydrophobic Mesoporous Silica Derived from Rice Husk Ash as a Potential Drug Carrier

Materials ◽  
2018 ◽  
Vol 11 (7) ◽  
pp. 1142 ◽  
Author(s):  
Supakij Suttiruengwong ◽  
Sommai Pivsa-Art ◽  
Metta Chareonpanich
Keyword(s):  
Mesoporous Silica ◽  
Rice Husk ◽  
Rice Husk Ash ◽  
Drug Carrier ◽  
Potential Drug

In Vitro Evaluation of pH Responsive Doxazosin Loaded Mesoporous Silica Nanoparticles: A Smart Approach in Drug Delivery

2016 ◽  
Vol 13 (4) ◽  
pp. 574-581 ◽  
Author(s):  
Arijit Guha ◽  
Nikhil Biswas ◽  
Kaustav Bhattacharjee ◽  
Piu Das ◽  
Ketousetuo Kuotsu
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Responsive ◽  
In Vitro Evaluation
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