Photothermal Therapy Combined with Light-Induced Generation of Alkyl Radicals for Enhanced Efficacy of Tumor Treatment

2020 ◽  
Vol 2 (10) ◽  
pp. 4188-4194
Author(s):  
Qihang Wu ◽  
Jinfeng Han ◽  
Chaonan Li ◽  
Tingting Sun ◽  
Zhigang Xie
Keyword(s):  
Photothermal Therapy ◽  
Tumor Treatment ◽  
Alkyl Radicals

The nanomedicine system has successfully inhibited tumor neovascularization using gene silencing, chemotherapy, photothermal therapy, and other therapies

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Treatment Outcome ◽  
Gene Silencing ◽  
Large Volume ◽  
Photothermal Therapy ◽  
Tumor Model ◽  
Vascular Wall ◽  
Tumor Treatment ◽  
Physical Methods ◽  
Vascular Disruption ◽  
Tumor Neovascularization

Customized nanomedicines can be used in a variety of ways, including angiogenesis suppression, vascular disruption, and vascular infarction. In the angiogenesis suppression approach, VEGF, VEGFR, mTOR, EGFR, bFGF, ROS, and other components have become promising therapeutic targets. The nanomedicine system has successfully inhibited tumor neovascularization using gene silencing, chemotherapy, photothermal therapy, and other therapies. In the vascular disruption approach, VDAs supplied by nanomaterials were bonded with the bonding sites of CA4, COL, PTX, and other medications on microtubules to promote rapid disintegration of tumor vascular wall cells. Combining many medicines increased the tumor treatment outcome even more. For example, disruption of tumor blood arteries caused by nanoparticle-mediated physical methods combined with chemotherapy resulted in effective treatment in a large volume tumor model. The vascular infarction methodology uses a variety of carriers, including nanoparticles, DNA nanorobots, platelet membranes, and others, to carry thrombin, tTF, and other drugs to generate local thrombosis and provide safe and effective tumor treatment.

Leveraging BODIPY nanomaterials for enhanced tumor photothermal therapy

2021 ◽  
Author(s):  
Chong Ma ◽  
Tao Zhang ◽  
Zhigang Xie
Keyword(s):  
Side Effects ◽  
Photothermal Therapy ◽  
Tumor Treatment ◽  
The Past

In the past ten years, photothermal therapy (PTT) has attracted widespread attention in tumor treatment due to its non-invasiveness and little side effects. PTT utilize the heat produced by photothermal...

scholarly journals Research on Targeted Thermal Effect of Molybdenum Disulfide Nanosheets Modified by Nucleic Acid Aptamers

2020 ◽  
Vol 185 ◽  
pp. 04003
Author(s):  
Bo pang ◽  
Lihong Jin ◽  
Liying Wang
Keyword(s):  
Nucleic Acid ◽  
Molybdenum Disulfide ◽  
Therapeutic Effect ◽  
Photothermal Therapy ◽  
Effective Concentration ◽  
Tumor Treatment ◽  
Nucleic Acid Aptamers ◽  
Low Toxicity ◽  
Good Biocompatibility ◽  
Molybdenum Disulfide Nanosheets

In this paper, the surface of molybdenum disulfide nanosheets synthesized by hydrothermal method was modified with bovine serum albumin (BSA) and nucleic acid aptamers in order to construct a photothermal system with high target recognition, stable size, good biocompatibility and low toxicity Nano material molybdenum disulfide; Under 808 nm laser irradiation, suitable functionalized molybdenum disulfide nanosheets can produce singlet oxygen at an effective concentration for photodynamic therapy, and at the same time, photothermal therapy can also be used to achieve synergistic therapy and the therapeutic effect is more excellent. This shows that such functionalized molybdenum disulfide nanosheets have excellent therapeutic effect and great potential in tumor treatment.

Recent advances in nanomaterials for enhanced photothermal therapy of tumors

Nanoscale ◽  
2018 ◽  
Vol 10 (48) ◽  
pp. 22657-22672 ◽  
Author(s):  
Jing-Jing Hu ◽  
Ying-Jia Cheng ◽  
Xian-Zheng Zhang
Keyword(s):  
Therapeutic Efficacy ◽  
Photothermal Therapy ◽  
Tumor Treatment ◽  
Recent Advances

Recent advances in nanomaterials for enhanced therapeutic efficacy of photothermal therapy in tumor treatment were highlighted.

Application of Gold-Based Nanomaterials in Tumor Photothermal Therapy and Chemotherapy

2020 ◽  
Vol 16 (6) ◽  
pp. 739-762
Author(s):  
Minyu Zhou ◽  
Yunfei Zhou ◽  
Yixin Cheng ◽  
Yanqi Wu ◽  
Jun Yang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Targeting ◽  
Tumor Tissue ◽  
Treatment Method ◽  
Tumor Treatment ◽  
Targeting Therapy ◽  
Photothermal Conversion ◽  
Gold Nanomaterials ◽  
Development Prospects ◽  
Therapy Treatment

Photothermal therapy (PTT) is a minimally invasive tumor treatment method in which photothermal conversion agents (PTAs) can be enriched in tumor tissue by external light stimulation to convert photon energy into thermal energy to induce the temperature of tumor tissue higher than normal physiological, and can effectively kill tumor cells and tissues while avoiding damage to healthy tissue. As a well-known biocompatible nanomaterial, gold-based nanomaterials have high photothermal conversion efficiency and cross section, which can be used in tumor targeting therapy treatment as a potential photothermal conversion agent. Combining PTT and chemotherapy can be achieved by loading a chemotherapeutic drug modified on the surface of a gold nanomaterials. Therefore, this paper first reviews the preparation and surface functionalization of Au-based nanomaterials, such as Au nanorods, Au nanostars, Au nanoshells, and so on. Second, we have also introduced the application of Au-based nanomaterials in PTT, chemotherapy, and combination therapy. Finally, the limitations and challenges of Au-based photothermal conversion agents are summarized and the development prospects in this field are prospected.

scholarly journals Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Xunzhi Wu ◽  
Yongkuan Suo ◽  
Hui Shi ◽  
Ruiqi Liu ◽  
Fengxia Wu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Laser Excitation ◽  
Tumor Treatment ◽  
Deep Tissue ◽  
Laser Illumination ◽  
Nir Light ◽  
Cell Ablation

Abstract Photothermal therapy (PTT) using near-infrared (NIR) light for tumor treatment has triggered extensive attentions because of its advantages of noninvasion and convenience. The current research on PTT usually uses lasers in the first NIR window (NIR-I; 700–900 nm) as irradiation source. However, the second NIR window (NIR-II; 1000–1700 nm) especially NIR-IIa window (1300–1400 nm) is considered much more promising in diagnosis and treatment as its superiority in penetration depth and maximum permissible exposure over NIR-I window. Hereby, we propose the use of laser excitation at 1275 nm, which is approved by Food and Drug Administration for physical therapy, as an attractive technique for PTT to balance of tissue absorption and scattering with water absorption. Specifically, CuS-PEG nanoparticles with similar absorption values at 1275 and 808 nm, a conventional NIR-I window for PTT, were synthesized as PTT agents and a comparison platform, to explore the potential of 1275 and 808 nm lasers for PTT, especially in deep-tissue settings. The results showed that 1275 nm laser was practicable in PTT. It exhibited much more desirable outcomes in cell ablation in vitro and deep-tissue antitumor capabilities in vivo compared to that of 808 nm laser. NIR-IIa laser illumination is superior to NIR-I laser for deep-tissue PTT, and shows high potential to improve the PTT outcome.

Composite-dissolving microneedle patches for chemotherapy and photothermal therapy in superficial tumor treatment

2018 ◽  
Vol 6 (6) ◽  
pp. 1414-1423 ◽  
Author(s):  
Peng Pei ◽  
Fan Yang ◽  
Jiaxing Liu ◽  
Haoran Hu ◽  
Xiaoyu Du ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Photothermal Therapy ◽  
Casting Process ◽  
Doxorubicin Hydrochloride ◽  
Tumor Treatment ◽  
Promising Strategy ◽  
Superficial Tumor

Doxorubicin hydrochloride (DOX)- and indocyanine green (ICG)-loaded microneedle (MN) patches (PVP@DOX/MSN@ICG) were successfully fabricated using a two-step casting process, which is a promising strategy for synergistic therapy of superficial tumors.

scholarly journals Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair

2020 ◽  
Vol 6 (32) ◽  
pp. eabb1311
Author(s):  
Lingling Ma ◽  
Yanling Zhou ◽  
Zhaowenbin Zhang ◽  
Yaqin Liu ◽  
Dong Zhai ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Treatment Temperature ◽  
Temperature Monitoring ◽  
Tumor Treatment ◽  
Treatment Technology ◽  
Excessive Heat ◽  
Normal Tissues ◽  
Normal Tissue Damage ◽  
Photothermal Property

Photothermal therapy (PTT), an emerging tumor treatment technology, has attracted tremendous interest, but excessive heat will cause damage to surrounding healthy tissues. Therefore, in situ temperature monitoring during PTT is of great importance to determine optimal treatment temperature and repair heat-damaged normal tissues. Here, we report the preparation of multifunctional Nd-Ca-Si silicate glasses and glass/alginate composite hydrogels that not only have photothermal property but also emit fluorescence under 808-nm laser irradiation, and its fluorescence intensity is linearly correlated with in situ temperature. With this feature, optimal PTT temperature for effective tumor treatment with minimal normal tissue damage can be obtained. In addition, because of the bioactive silicate components, the composite hydrogel has bioactivity to repair heat damage caused by PTT. This implantable multifunctional material with unique temperature monitoring, photothermal function, and wound healing bioactivity can be used for localized thermal therapy.

scholarly journals Fenton/Fenton-like metal-based nanomaterials combine with oxidase for synergistic tumor therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Wei Cao ◽  
Mengyao Jin ◽  
Kang Yang ◽  
Bo Chen ◽  
Maoming Xiong ◽  
...  
Keyword(s):  
Catalytic System ◽  
Photothermal Therapy ◽  
Tumor Therapy ◽  
Catalytic Efficiency ◽  
Intracellular Metabolite ◽  
Tumor Treatment ◽  
Antitumor Effects ◽  
Oxidase System ◽  
New Ideas ◽  
Starvation Effect

AbstractChemodynamic therapy (CDT) catalyzed by transition metal and starvation therapy catalyzed by intracellular metabolite oxidases are both classic tumor treatments based on nanocatalysts. CDT monotherapy has limitations including low catalytic efficiency of metal ions and insufficient endogenous hydrogen peroxide (H2O2). Also, single starvation therapy shows limited ability on resisting tumors. The “metal-oxidase” cascade catalytic system is to introduce intracellular metabolite oxidases into the metal-based nanoplatform, which perfectly solves the shortcomings of the above-mentioned monotherapiesIn this system, oxidases can not only consume tumor nutrients to produce a “starvation effect”, but also provide CDT with sufficient H2O2 and a suitable acidic environment, which further promote synergy between CDT and starvation therapy, leading to enhanced antitumor effects. More importantly, the “metal-oxidase” system can be combined with other antitumor therapies (such as photothermal therapy, hypoxia-activated drug therapy, chemotherapy, and immunotherapy) to maximize their antitumor effects. In addition, both metal-based nanoparticles and oxidases can activate tumor immunity through multiple pathways, so the combination of the “metal-oxidase” system with immunotherapy has a powerful synergistic effect. This article firstly introduced the metals which induce CDT and the oxidases which induce starvation therapy and then described the “metal-oxidase” cascade catalytic system in detail. Moreover, we highlight the application of the “metal-oxidase” system in combination with numerous antitumor therapies, especially in combination with immunotherapy, expecting to provide new ideas for tumor treatment.

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