Nanoparticles Yield Increased Drug Uptake and Therapeutic Efficacy upon Sequential Near-Infrared Irradiation

ACS Nano ◽  
2020 ◽  
Vol 14 (11) ◽  
pp. 15193-15203
Author(s):  
Dong Luo ◽  
Xinning Wang ◽  
Ethan Walker ◽  
Jing Wang ◽  
Sarah Springer ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Near Infrared ◽  
Drug Uptake ◽  
Infrared Irradiation

Effect of near-infrared irradiation on photoconversion of the water-soluble chlorophyll-binding protein ofChenopodium album

2014 ◽  
Vol 79 (3) ◽  
pp. 439-442 ◽  
Author(s):  
Shigekazu Takahashi ◽  
Akira Uchida ◽  
Katsumi Nakayama ◽  
Hiroyuki Satoh
Keyword(s):  
Near Infrared ◽  
Binding Protein ◽  
Water Soluble ◽  
Infrared Irradiation

scholarly journals Near-infrared Irradiation and Graphene Oxide Film Fabricated on Dentin Surface Exhibit Photothermal and Antibacterial Effects

2018 ◽  
Vol 06 (01) ◽  
Author(s):  
Keishi Nagao ◽  
Hirofumi Miyaji ◽  
Erika Nishida ◽  
Tsukasa Akasaka ◽  
Saori Miyata ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Oxide Film ◽  
Near Infrared ◽  
Infrared Irradiation ◽  
Antibacterial Effects ◽  
Dentin Surface

Dissecting extracellular and intracellular distribution of nanoparticles and their contribution to therapeutic response by monochromatic ratiometric imaging

2021 ◽  
Author(s):  
Yue Yan ◽  
Binlong Chen ◽  
Qingqing Yin ◽  
Zenghui Wang ◽  
Ye Yang ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Therapeutic Efficacy ◽  
Near Infrared ◽  
Therapeutic Response ◽  
Intracellular Distribution ◽  
Infrared Light ◽  
Dual Responsive ◽  
Efficient Delivery ◽  
Ratiometric Imaging ◽  
Intracellular Targets

Abstract Efficient delivery of payload to intracellular targets has been identified as the central principle for nanomedicine development, while the extracellular targets are equally important for cancer treatment. Notably, the contribution of extracellularly distributed nanoparticles to therapeutic outcome is far from being understood. Herein, we develop a pH/light dual-responsive monochromatic ratiometric imaging nanoparticle (MRIN), which functions through sequentially lighting up the intracellular and extracellular fluorescence signals by acidic endocytic pH and near-infrared light. Enabled by MRIN nanotechnology, we accurately quantify the extracellular and intracellular distribution of nanoparticles in several tumor models, which account for 65-80% and 20-35% of total tumor exposure, respectively. Given that the majority of nanoparticles are trapped in extracellular regions, we successfully dissect the contribution of extracellularly distributed nanophotosensitizer to therapeutic efficacy, thereby maximize the treatment outcome. Our study provides key strategies to precisely quantify nanocarrier microdistribtion and engineer multifunctional nanomedicines for efficient theranostics.

scholarly journals Co-Delivery of CPT-11 and Panobinostat with Anti-GD2 Antibody Conjugated Immunoliposomes for Targeted Combination Chemotherapy

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3211
Author(s):  
Gils Jose ◽  
Yu-Jen Lu ◽  
Jung-Tung Hung ◽  
Alice L. Yu ◽  
Jyh-Ping Chen
Keyword(s):  
Combination Chemotherapy ◽  
Therapeutic Efficacy ◽  
Imaging System ◽  
Accumulation Rate ◽  
Fold Increase ◽  
Drug Uptake ◽  
Mice Model ◽  
Resistant Variant

The consistent expression of disialoganglioside GD2 in neuroblastoma tumor cells and its restricted expression in normal tissues open the possibility to use it for molecularly targeted neuroblastoma therapy. On the other hand, immunoliposomes combining antibody-mediated tumor recognition with liposomal delivery of chemotherapeutics have been proved to enhance therapeutic efficacy in brain tumors. Therefore, we develop immunoliposomes (ImmuLipCP) conjugated with anti-GD2 antibody, for targeted co-delivery of CPT-11 and panobinostat in this study. U87MG human glioma cell line and its drug resistant variant (U87DR), which were confirmed to be associated with low and high expression of cell surface GD2, were employed to compare the targeting efficacy. From in vitro cytotoxicity assay, CPT-11 showed synergism drug interaction with panobinostat to support co-delivery of both drugs with ImmuLipCP for targeted synergistic combination chemotherapy. The molecular targeting mechanism was elucidated from intracellular uptake efficacy by confocal microscopy and flow cytometry analysis, where 6-fold increase in liposome and 1.8-fold increase in drug uptake efficiency was found using targeted liposomes. This enhanced intracellular trafficking for drug delivery endows ImmuLipCP with pronounced cytotoxicity toward U87DR cells in vitro, with 1.6-fold increase of apoptosis rate. Using xenograft nude mice model with subcutaneously implanted U87DR cells, we observe similar biodistribution profile but 5.1 times higher accumulation rate of ImmuLip from in vivo imaging system (IVIS) observation of Cy5.5-labelled liposomes. Taking advantage of this highly efficient GD-2 targeting, ImmuLipCP was demonstrated to be an effective cancer treatment modality to significantly enhance the anti-cancer therapeutic efficacy in U87DR tumors, shown from the significant reduced tumor size in and prolonged survival time of experiment animals as well as diminished expression of cell proliferation and enhanced expression of apoptosis marker proteins in tumor section.

Polydopamine Nanocoating for Effective Photothermal Killing of Bacteria and Fungus upon Near-Infrared Irradiation

2016 ◽  
Vol 3 (22) ◽  
pp. 1600767 ◽  
Author(s):  
Wenxi Lei ◽  
Kefeng Ren ◽  
Tingting Chen ◽  
Xiachao Chen ◽  
Bochao Li ◽  
...  
Keyword(s):  
Near Infrared ◽  
Infrared Irradiation

Transferrin-coated magnetic upconversion nanoparticles for efficient photodynamic therapy with near-infrared irradiation and luminescence bioimaging

Nanoscale ◽  
2017 ◽  
Vol 9 (31) ◽  
pp. 11214-11221 ◽  
Author(s):  
Dan Wang ◽  
Lin Zhu ◽  
Yuan Pu ◽  
Jie-Xin Wang ◽  
Jian-Feng Chen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Magnetic Force ◽  
Near Infrared ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Infrared Irradiation ◽  
Near Infrared Light

A novel platform based on transferrin coated magnetic upconversion nanoparticles was developed for near-infrared light induced imaging and photodynamic therapy with enhanced efficiency by magnetic force.

scholarly journals Artificial Synapses: Near‐Infrared‐Irradiation‐Mediated Synaptic Behavior from Tunable Charge‐Trapping Dynamics (Adv. Electron. Mater. 2/2020)

2020 ◽  
Vol 6 (2) ◽  
pp. 2070007
Author(s):  
Yan Wang ◽  
Jing Yang ◽  
Wenbin Ye ◽  
Donghong She ◽  
Jinrui Chen ◽  
...  
Keyword(s):  
Near Infrared ◽  
Charge Trapping ◽  
Infrared Irradiation

A Bi2WO6-Based Hybrid Photocatalyst with Broad Spectrum Photocatalytic Properties under UV, Visible, and Near-Infrared Irradiation

2013 ◽  
Vol 25 (36) ◽  
pp. 5075-5080 ◽  
Author(s):  
Jian Tian ◽  
Yuanhua Sang ◽  
Guangwei Yu ◽  
Huaidong Jiang ◽  
Xiaoning Mu ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Near Infrared ◽  
Photocatalytic Properties ◽  
Infrared Irradiation ◽  
Uv Visible ◽  
Hybrid Photocatalyst
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