AXAFS as a Probe of Charge Redistribution within Organometallic Complexes

2004 ◽  
Vol 126 (13) ◽  
pp. 4090-4091 ◽  
Author(s):  
Moniek Tromp ◽  
Jeroen A. van Bokhoven ◽  
Martijn Q. Slagt ◽  
Robertus J. M. Klein Gebbink ◽  
Gerard van Koten ◽  
...  
Keyword(s):  
Organometallic Complexes ◽  
Charge Redistribution

Bio-organometallic Peptide Conjugates: Recent Advances in Their Synthesis and Prospects for Biomedical Application

2020 ◽  
Vol 24 (21) ◽  
pp. 2508-2523
Author(s):  
Johana Gómez ◽  
Diego Sierra ◽  
Constanza Cárdenas ◽  
Fanny Guzmán
Keyword(s):  
Amino Acids ◽  
Biomedical Application ◽  
Structural Diversity ◽  
Biological Properties ◽  
Therapeutic Agents ◽  
Organometallic Complexes ◽  
Chemical Behavior ◽  
Metal Compounds ◽  
Bioorganometallic Chemistry ◽  
Pharmacological Control

One area of organometallic chemistry that has attracted great interest in recent years is the syntheses, characterization and study of organometallic complexes conjugated to biomolecules with different steric and electronic properties as potential therapeutic agents against cancer and malaria, as antibiotics and as radiopharmaceuticals. This minireview focuses on the unique structural diversity that has recently been discovered in α- amino acids and the reactions of metallocene complexes with peptides having different chemical behavior and potential medical applications. Replacing α-amino acids with metallocene fragments is an effective way of selectively influencing the physicochemical, structural, electrochemical and biological properties of the peptides. Consequently, research in the field of bioorganometallic chemistry offers the opportunity to develop bioactive metal compounds as an innovative and promising approach in the search for pharmacological control of different diseases.

Induction of Apoptosis by Nano‐Synthesized Complexes of H2L and its Cu(II) Complex in Human Hepatocellular Carcinoma Cells

2020 ◽  
Vol 20 ◽  
Author(s):  
Thoria Diab ◽  
Tarek M. Mohamed ◽  
Alaa Hamed ◽  
Mohamed Gaber
Keyword(s):  
Cell Cycle ◽  
Metal Complexes ◽  
Hepg2 Cells ◽  
Therapeutic Potential ◽  
Free Ligand ◽  
Organometallic Complexes ◽  
Phase Cell ◽  
Sod Activity ◽  
Induced Apoptosis

Background: Chemotherapy is currently the most utilized treatment for cancer. Therapeutic potential of metal complexes in cancer therapy has attracted a lot of interest. The mechanisms of action of most organometallic complexes are poorly understood. Objective: This study was designed to explore the mechanisms governing the anti-proliferative effect of the free ligand N1,N6‐bis((2‐hydroxynaphthalin‐1‐yl)methinyl)) adipohydrazone (H2L) and its complexes of Mn(II), Co(II), Ni(II) and Cu(II). Methods: Cells were exposed to H2L or its metal complexes where cell viability determined by MTT assay. Cell cycle was analysed by flow cytometry. In addition, qRT-PCR was used to monitor the expression of Bax and Bcl-2. Moreover, molecular docking was carried out to find the potentiality of Cu(II) complex as an inhibitor of Adenosine Deaminase (ADA). ADA, Superoxide Dismutase (SOD) and reduced Glutathione (GSH) levels were measured in the most affected cancer cell line. Results: The obtained results demonstrated that H2L and its Cu(II) complex exhibited a strong cytotoxic activity compared to other complexes against HepG2 cells (IC50 = 4.14±0.036μM/ml and 3.2±0.02μM/ml), respectively. Both H2L and its Cu(II) complex induced G2/M phase cell cycle arrest in HepG2 cells. Additionally, they induced apoptosis in HepG2 cells via upregulation of Bax and downregulation of Bcl-2. Interestingly, the activity of ADA was decreased by 2.8 fold in HepG2 cells treated with Cu(II) complex compared to untreated cells. An increase of SOD activity and GSH level in HepG2 cells compared to control was observed. Conclusion: The results concluded that Cu(II) complex of H2L induced apoptosis in HepG2 cells. Further studies are needed to confirm its anti-cancer effect in vivo.

Organometallic Complexes of Zirconium and Hafnium

ChemInform ◽  
2004 ◽  
Vol 35 (15) ◽  
Author(s):  
E.-I. Negishi ◽  
T. Takahashi
Keyword(s):  
Organometallic Complexes

scholarly journals Reconfigurable Distributed Power Electronics Technique for Solar PV Systems

Electronics ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1121
Author(s):  
Kamran Ali Khan Niazi ◽  
Yongheng Yang ◽  
Tamas Kerekes ◽  
Dezso Sera
Keyword(s):  
Energy Yield ◽  
Solar Pv ◽  
Charge Redistribution ◽  
Pv System ◽  
Partial Shading ◽  
Pv Systems ◽  
Simulation Based ◽  
In Series ◽  
A Cell ◽  
Power Balancing

A reconfiguration technique using a switched-capacitor (SC)-based voltage equalizer differential power processing (DPP) concept is proposed in this paper for photovoltaic (PV) systems at a cell/subpanel/panel-level. The proposed active diffusion charge redistribution (ADCR) architecture increases the energy yield during mismatch and adds a voltage boosting capability to the PV system under no mismatch by connected the available PV cells/panels in series. The technique performs a reconfiguration by measuring the PV cell/panel voltages and their irradiances. The power balancing is achieved by charge redistribution through SC under mismatch conditions, e.g., partial shading. Moreover, PV cells/panels remain in series under no mismatch. Overall, this paper analyzes, simulates, and evaluates the effectiveness of the proposed DPP architecture through a simulation-based model prepared in PSIM. Additionally, the effectiveness is also demonstrated by comparing it with existing conventional DPP and traditional bypass diode architecture.

scholarly journals Electric and magnetic properties of cobalt, copper and nickel organometallic complexes for molecular wires

2021 ◽  
Author(s):  
Rehab I. Yousef ◽  
Naglaa F.H. Mahmoud ◽  
Fouad I. El-Hosiny ◽  
Fritz E. Kühn ◽  
Ghada Bassioni
Keyword(s):  
Magnetic Properties ◽  
Molecular Wires ◽  
Organometallic Complexes ◽  
Cobalt Copper

Recent advances in synthesis of organometallic complexes of indium

2020 ◽  
Vol 40 (3) ◽  
pp. 107-151
Author(s):  
Hira Anwar ◽  
Rosenani A. Haque ◽  
Rahman Shah Zaib Saleem ◽  
Muhammad Adnan Iqbal
Keyword(s):  
Material Science ◽  
Thin Film Transistors ◽  
Heterocyclic Carbenes ◽  
Organometallic Complexes ◽  
Organic Ligands ◽  
Group 13 ◽  
Indium Complexes ◽  
Different Types ◽  
Stirring Time ◽  
Different Temperatures

AbstractThe indium complexes are being used in many applications like catalysis, optoelectronics, sensors, solar cells, biochemistry, medicine, infrared (IR) mirrors and thin-film transistors (TFTs). In organometallic complexes of indium, it forms different types of complexes with single, double, triple and tetra linkages by coordinating with numerous elements like C, N, O and S and also with some other elements like Se and Ru. So, the present study comprises all the possible ways to synthesize the indium complexes by reacting with different organic ligands; most of them are N-heterocyclic carbenes, amines, amides and phenols. The commonly used solvents for these syntheses are tetrahydrofuran, dichloromethane, toluene, benzene, dimethyl sulfoxide (DMSO) and water. According to the nature of the ligands, indium complexes were reported at different temperatures and stirring time. Because of their unique characteristics, the organometallic chemistry of group 13 metal indium complexes remains a subject of continuing interest in synthetic chemistry as well as material science.

Sign in / Sign up

Export Citation Format

Share Document