Model studies of thiamin catalysis. Inductive effects of nitrogen-bonded substituents and influence of steric inhibition of resonance on kinetic carbon acidities of thiazolium ions

1978 ◽  
Vol 43 (19) ◽  
pp. 3785-3787 ◽  
Author(s):  
John A. Zoltewicz ◽  
S. Sridharan
Geophysics ◽  
1984 ◽  
Vol 49 (7) ◽  
pp. 902-912 ◽  
Author(s):  
Brian R. Spies ◽  
Patricia D. Parker

Conventional interpretation aids used in transient electromagnetic (TEM) exploration assume that the anomalous response is due to induction in a simple model such as a plate, sphere, or uniform layer. Estimates of conductivity, depth, and size are based on analyzing the profile shape and transient decay constant. In regions with conductive overburden or conductive bedrock, TEM responses obtained with the large‐loop configuration can often be very dependent upon the location of the transmitter loop, and the results can be easily misinterpreted. A series of scale‐model studies was carried out to investigate the influence of current channeling and gathering phenomena with the large fixed loop and moving single‐loop configurations of the TEM method. Models studied included resistive and step discontinuities in a horizontal conductive slab, and a vertical plate in electrical contact with conductive overburden. Large TEM anomalies can be observed at the edge of a conductive unit, when diffusing eddy currents migrating through surface conductors are channeled and become spatially localized. Current gathering occurs when the diffusing eddy currents are gathered into a locally more conductive zone. The most common geometric condition under which these effects are observed is when a conductor of long strike length is located outside a large transmitter loop. The TEM response is enhanced by channeling and gathering, and it is often stronger than simple inductive effects. Current channeling and current gathering phenomena are relatively unimportant when measurements are made within a large transmitter loop, or when a single‐ or in‐loop configuration is used. It is therefore recommended that multiple transmitter loop locations be used when surveying in conductive terrains with the largeloop configuration, or alternatively that the single‐ or in‐loop configuration be employed for additional geophysical control.


1995 ◽  
Vol 74 (03) ◽  
pp. 868-873 ◽  
Author(s):  
Silvana Arrighi ◽  
Roberta Rossi ◽  
Maria Giuseppina Borri ◽  
Vladimir Lesnikov ◽  
Marina Lesnikov ◽  
...  

SummaryTo improve the safety of plasma derived factor VIII (FVIII) concentrate, we introduced a final super heat treatment (100° C for 30 min) as additional virus inactivation step applied to a lyophilized, highly purified FVIII concentrate (100 IU/mg of proteins) already virus inactivated using the solvent/detergent (SID) method during the manufacturing process.The efficiency of the super heat treatment was demonstrated in inactivating two non-lipid enveloped viruses (Hepatitis A virus and Poliovirus 1). The loss of FVIII procoagulant activity during the super heat treatment was of about 15%, estimated both by clotting and chromogenic assays. No substantial changes were observed in physical, biochemical and immunological characteristics of the heat treated FVIII concentrate in comparison with those of the FVIII before heat treatment.


2014 ◽  
Vol 59 (4) ◽  
pp. 971-986 ◽  
Author(s):  
Krzysztof Tajduś

Abstract The paper presents the analysis of the phenomenon of horizontal displacement of surface induced by underground mining exploitation. In the initial part, the basic theories describing horizontal displacement are discussed, followed by three illustrative examples of underground exploitation in varied mining conditions. It is argued that center of gravity (COG) method presented in the paper, hypothesis of Awierszyn and model studies carried out in Strata Mechanics Research Institute of the Polish Academy of Sciences indicate the proportionality between vectors of horizontal displacement and the vector of surface slope. The differences practically relate to the value of proportionality coefficient B, whose estimated values in currently realized design projects for mining industry range between 0.23r to 0.42r for deep exploitations, whereas in the present article the values of 0.33r and 0.47r were obtained for two instances of shallow exploitation. Furthermore, observations on changes of horizontal displacement vectors with face advancement indicated the possibility of existence of COG zones above the mined-out field, which proved the conclusions of hitherto carried out research studies (Tajduś 2013).


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