Surfactant free synthesis of monodisperse styrenic nanoparticle colloids via flow chemistry

2020 ◽  
Author(s):  
Marta Antoniv ◽  
Shitong Zhu ◽  
Sehoon Chang ◽  
Nouf AlJabri
Keyword(s):  
Flow Chemistry

Scalable Synthesis of Functionalized Ferrocenyl Azides and Amines Enabled by Flow Chemistry

2019 ◽  
Author(s):  
Merlin Kleoff ◽  
Johannes Schwan ◽  
Lisa Boeser ◽  
Bence Hartmayer ◽  
Mathias Christmann ◽  
...  
Keyword(s):  
Reaction Time ◽  
Heterogeneous Reaction ◽  
Reduction Process ◽  
Flow Chemistry ◽  
Subsequent Reaction ◽  
Scalable Synthesis ◽  
High Yields ◽  
Reactor Section

A scalable access to functionalized 1,1’- and 1,2-ferrocenyl azides has been realized in flow. By halogen‒lithium exchange of ferrocenyl halides and subsequent reaction with tosyl azide, a variety of functionalized ferrocenyl azides was obtained in high yields. To allow a scalable preparation of these potentially explosive compounds, an efficient flow protocol was developed accelerating the reaction time to minutes and circumventing accumulation of potentially hazardous intermediates. Switching from homogeneous to triphasic flow amidst process was key for handling a heterogeneous reaction mixture formed after a heated reactor section. The corresponding and synthetically versatile ferrocenyl amines were then prepared by a reliable reduction process.

Room Temperature Flow Electrochemistry as a Means of Retaining the “Memory of Chirality” via Hofer Moest Type Reaction

2020 ◽  
Author(s):  
Tomas Hardwick ◽  
Rossana Cicala ◽  
Nisar Ahmed
Keyword(s):  
Continuous Flow ◽  
Room Temperature ◽  
Biological Activities ◽  
Supporting Electrolyte ◽  
Enantiomeric Excess ◽  
Flow Chemistry ◽  
Batch Processes ◽  
Enabling Technology ◽  
Chiral Compounds ◽  
Memory Of Chirality

<p>Many chiral compounds have become of great interest to the pharmaceutical industry as they possess various biological activities. Concurrently, the concept of “memory of chirality” has been proven as a powerful tool in asymmetric synthesis, while flow chemistry has begun its rise as a new enabling technology to add to the ever increasing arsenal of techniques available to the modern day chemist. Here, we have employed a new simple electrochemical microreactor design to oxidise an L-proline derivative at room temperature in continuous flow. Flow performed in microreactors offers up a number of benefits allowing reactions to be performed in a more convenient and safer manner, and even allow electrochemical reactions to take place without a supporting electrolyte due to a very short interelectrode distance. By the comparison of electrochemical oxidations in batch and flow we have found that continuous flow is able to outperform its batch counterpart, producing a good yield (71%) and a better enantiomeric excess (64%) than batch with a 98% conversion. We have, therefore, provided evidence that continuous flow chemistry has the potential to act as a new enabling technology to replace some aspects of conventional batch processes. </p>

Flow Chemistry Controls Both Self-Assembly and the Entrapped Oscillatory Cargo in Belousov-Zhabotinsky Driven Polymerization-Induced Self-Assembly

2019 ◽  
Author(s):  
Liman Hou ◽  
Marta Dueñas-Diez ◽  
Rohit Srivastava ◽  
Juan Perez-Mercader
Keyword(s):  
Self Assembly ◽  
Flow Chemistry ◽  
Batch Reactors ◽  
Equilibrium Conditions ◽  
One Pot ◽  
Bz Reaction ◽  
Polymer Vesicles ◽  
Simultaneous Control ◽  
Novel Method ◽  
Continuously Stirred Tank Reactor

<p></p><p>Belousov-Zhabotinsky (B-Z) reaction driven polymerization-induced self-assembly (PISA), or B-Z PISA, is a novel method for the autonomous one-pot synthesis of polymer vesicles from a macroCTA (macro chain transfer agent) and monomer solution (“soup”) containing the above and the BZ reaction components. In it, the polymerization is driven (and controlled) by periodically generated radicals generated in the oscillations of the B-Z reaction. These are inhibitor/activator radicals for the polymerization. Until now B-Z PISA has only been carried out in batch reactors. In this manuscript we present the results of running the system using a continuously stirred tank reactor (CSTR) configuration which offers some interesting advantages.Indeed, by controlling the CSTR parameters we achieve reproducible and simultaneous control of the PISA process and of the properties of the oscillatory cargo encapsulated in the resulting vesicles. Furthermore, the use of flow chemistry enables a more precise morphology control and chemical cargo tuning. Finally, in the context of biomimetic applications a CSTR operation mimics more closely the open non-equilibrium conditions of living systems and their surrounding environments.</p><p></p>

scholarly journals Continuous Synthesis of Nanocrystals via Flow Chemistry Technology

Small ◽  
2021 ◽  
Vol 17 (33) ◽  
pp. 2104166
Author(s):  
Jinsong Sui ◽  
Junyu Yan ◽  
Di Liu ◽  
Kai Wang ◽  
Guangsheng Luo
Keyword(s):  
Flow Chemistry ◽  
Continuous Synthesis

scholarly journals Application of Reactor Engineering Concepts in Continuous Flow Chemistry: A Review

2021 ◽  
Author(s):  
Nicole Candice Neyt ◽  
Darren Lyall Riley
Keyword(s):  
Rapid Growth ◽  
Continuous Flow ◽  
Flow Chemistry ◽  
The Past ◽  
Continuous Flow Chemistry

The adoption of flow technology for the manufacture of chemical entities, and in particular pharmaceuticals, has seen rapid growth over the past two decades with the technology now blurring the...

scholarly journals Concentric annular liquid–liquid phase separation for flow chemistry and continuous processing

2021 ◽  
Author(s):  
Matthew J. Harding ◽  
Bin Feng ◽  
Rafael Lopez-Rodriguez ◽  
Heather O'Connor ◽  
Denis Dowling ◽  
...  
Keyword(s):  
Phase Separation ◽  
Liquid Phase ◽  
Low Cost ◽  
Flow Chemistry ◽  
Continuous Processing ◽  
Surface Wetting ◽  
Tubular Membrane ◽  
Annular Channels ◽  
Phase Separator ◽  
Liquid Liquid Phase Separation

A low-cost, modular, robust, and easily customisable continuous liquid–liquid phase separator has been developed that uses a tubular membrane and annular channels to allow high fluidic throughputs while maintaining rapid, surface wetting dominated, phase separation.

Microwave-Assisted Grafting to MCM-41 Silica and its Application as Catalyst in Flow Chemistry

2011 ◽  
Vol 64 (11) ◽  
pp. 1522 ◽  
Author(s):  
Manuela Oliverio ◽  
Antonio Procopio ◽  
Toma N. Glasnov ◽  
Walter Goessler ◽  
C. Oliver Kappe
Keyword(s):  
Continuous Flow ◽  
Rate Increase ◽  
Flow Chemistry ◽  
Conventional Heating ◽  
Kinetic Effect ◽  
Microwave Technology ◽  
Microwave Assisted ◽  
Technology Control ◽  
First Time ◽  
Mcm 41

Finding environmentally gentle methods to graft Lewis acid on the surface of mesoporous materials is a topic of current interest. Herein we describe the optimization of a preparation procedure of a mesoporous silica-supported ErIII catalyst using the microwave-assisted post-calcination functionalization of Mobil Composition of Matter-41 silica as the key step. The required time for functionalization was reduced from several hours to 10 min using sealed-vessel microwave technology. Control experiments using conventional heating at the same temperature demonstrated that the rate increase is owing to a simple thermal/kinetic effect as a result of the higher reaction temperature. The resulting ErIII catalyst was tested for the first time as a catalyst in the continuous flow deprotection of benzaldehyde dimethylacetal and a complete leaching study was performed.

scholarly journals Continuous-flow chemistry in chemical education

2017 ◽  
Vol 7 (3–4) ◽  
pp. 157-158 ◽  
Author(s):  
Daniel Blanco-Ania ◽  
Floris P. J. T. Rutjes
Keyword(s):  
Continuous Flow ◽  
Chemical Education ◽  
Flow Chemistry ◽  
Continuous Flow Chemistry
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