Is Vitamin D Deficiency a Risk Factor for Respiratory Distress Syndrome?

2013 ◽  
Vol 83 (4) ◽  
pp. 232-237 ◽  
Author(s):  
Fevzi Ataseven ◽  
Canan Aygün ◽  
Ali Okuyucu ◽  
Abdulkerim Bedir ◽  
Yasemin Kücük ◽  
...  
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Vitamin D Deficiency ◽  
Preterm Infants ◽  
Gestational Age ◽  
Distress Syndrome ◽  
In Utero ◽  
Preterm Babies

Background: Previous studies have shown the relationship between in utero lung development and vitamin D [25(OH)D], but there have been no studies to investigate whether vitamin D deficiency is a risk factor for respiratory distress syndrome (RDS) in preterm babies. Objectives: In this study, we investigated if 25(OH)D deficiency is a risk factor for RDS. Methods: One hundred fifty-two preterm newborns, born at 29 - 35 weeks gestational age, were included in the study following informed consent from the parents. Peripheral blood samples were collected within the first 24 hours of life and 25(OH)D levels were measured by liquid chromatography-tandem mass spectrometry. Demographic characteristics of the babies and the diagnosis of RDS were recorded. Results: In 64 % of preterm infants, 25(OH)D levels were compatible with severe deficiency (≤ 10 ng/mL), 33 % with moderate deficiency (10 - 20 ng/mL), and 3 % with mild deficiency (20 - 30 ng/mL). In none of the babies was a normal 25(OH)D level observed. Serum 25(OH)D levels were not correlated with gestational age. Respiratory distress syndrome was more common in preterm babies with severe (28 %) compared to mild-moderate 25(OH)D deficiency (14 %) (p < 0.05). Conclusions: None of the preterm infants in this study had normal vitamin D level, which underlined the burden of vitamin D deficiency in pregnant women and their offspring. RDS was more common in severely vitamin D-deficient preterms. Determination of vitamin D status of the mothers and appropriate supplementation might be a valuable strategy to reduce RDS, in addition to antenatal steroids. Besides, since vitamin D is a regulatory factor in many organs during fetal development, long-term effects of in utero vitamin D deficiency warrant further studies.

scholarly journals Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)

Thorax ◽  
2015 ◽  
Vol 70 (7) ◽  
pp. 617-624 ◽  
Author(s):  
R. C. A. Dancer ◽  
D. Parekh ◽  
S. Lax ◽  
V. D'Souza ◽  
S. Zheng ◽  
...  
Keyword(s):  
Vitamin D ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Vitamin D Deficiency ◽  
Distress Syndrome

scholarly journals Effect of vitamin D deficiency in Korean patients with acute respiratory distress syndrome

2019 ◽  
Vol 34 (3) ◽  
pp. 685-685 ◽  
Author(s):  
Sojung Park ◽  
Min Gee Lee ◽  
Sang-Bum Hong ◽  
Chae-Man Lim ◽  
Younsuck Koh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Vitamin D Deficiency ◽  
Distress Syndrome ◽  
Korean Patients

scholarly journals Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor-α 308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Abolfazl Khoshdel ◽  
Soleiman Kheiri ◽  
Peyman Omidvari ◽  
Fahimeh Moradi ◽  
Majid Hamidi ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Preterm Infants ◽  
Gestational Age ◽  
Gene Polymorphisms ◽  
Tumor Necrosis ◽  
Distress Syndrome ◽  
Interleukin 10 ◽  
Necrosis Factor

Cytokine polymorphisms may contribute to the prevalence of respiratory distress syndrome. The present study was done to investigate the frequency of interleukin- (IL-) 10 and tumor necrosis factor- (TNF-) α gene polymorphisms and their association with the risk of RDS in preterm infants. One-hundred and nineteen patients with RDS and 119 healthy preterm infants were enrolled. PCR restriction fragment length polymorphism was used to determine the frequency of IL-10 and TNF-α genotypes at -1082 A and -308 A, respectively. One-hundred and nineteen out of 238 infants had RDS (50%). The age of the mothers and gestational age ranged 17–45 (mean: 28.6±5.3) years and 24–34 (mean: 34.3±2.38) weeks, respectively. Totally, 23 deaths were recorded in the RDS group. Incidence of TNF-α-308 A/A and TNF-α-308 G/A was 84% and 16%, respectively. TNF-a-308 G/G was not found in both groups. Prevalence of IL-10-1082 G/G and IL-10-1082 G/A variants was 65.5% and 34.5%, respectively. IL-10-1082 A/A was not found in both groups. The incidence of the allele G in the IL-10-1082 polymorphism was lower in RDS group (P<0.05). We found that the risk of RDS was correlated to sex, gestational age, and IL-10-1082.

Competing Risk Analysis of the Health Status of Neonates with Respiratory Distress Syndrome

2020 ◽  
Author(s):  
Zenaw Ayele ◽  
Mekonnen Tadesse ◽  
Zelalem Tazu
Keyword(s):  
Prognostic Factors ◽  
Birth Weight ◽  
Health Status ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Neonatal Mortality ◽  
Preterm Infants ◽  
Gestational Age ◽  
Distress Syndrome ◽  
Competing Risk

Introduction: Respiratory distress syndrome (RDS) is not only the most common respiratory disorder in premature infants but also the main cause of neonatal mortality. Methods: Competing risk framework was used to examine and identify potential prognostic factors of the health status of preterm infants with respiratory distress syndrome. Preterm infants with RDS admitted to the neonatal intensive care units (NICUs) of selected hospitals in Ethiopia were followed for 28 days and only neonates with complete cases were included in the analysis. The Fine-Gray or sub-distribution hazard model was used to identify significant prognostic factors. Three outcome variables (death due to RDS, death due to other causes and discharged alive) were considered. Results: The Fine-Gray model fit results revealed that anemia, multiple pregnancies, birth-weight and gestational age were the prognostic factors significantly associated with the death of neonates due to Respiratory distress syndrome problem while Pneumonia, meningitis, anemia and gestational age of neonates were the significant prognostic factors for death of neonates due to other causes. Moreover, pneumonia, birth weight and gestational age were identified as the prognostic factors associated with neonates being discharged alive. Conclusion: Offering intensive and adequate treatments for neonates with lowest birth-weights and gestational age may be useful to reduce neonatal mortality and increase the incidence of being discharged alive.

scholarly journals OUTCOME OF PRETERM BABIES WITH RESPIRATORY DISTRESS SYNDROME

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Shaitan Singh Balai ◽  
Vivek Arora
Keyword(s):  
Birth Weight ◽  
Mortality Rate ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Prospective Study ◽  
Gestational Age ◽  
Distress Syndrome ◽  
Preterm Neonates ◽  
Medical College ◽  
Preterm Babies

Background: To study outcome of preterm babies with RDS in babies admitted in NICU. Methods: This study was hospital based prospective study of preterm neonates with respiratory distress syndrome admitted in NICU of MBGH RNT medical college Udaipur, from February 2017 to January 2018. Results: Among 200 preterm neonates included in the study 31 neonates expired. Mortality was 15.5%. The mortality was 10.17% among the preterm neonates with RDS and hospitalized within 6 hrs. It was 31.81% among neonates hospitalized between 6-12 hrs and 62.5% and 66.66% among neonates hospitalized between 12-24 hrs and after 24 hrs of birth respectively. Conclusion: Mortality rate is inversely related to birth weight and gestational age and directly related to age at admission and severity of respiratory distress (Silverman-Anderson score). Keywords: Preterm, Neonates, Birth weight.

scholarly journals A Prediction Model of Extubation Failure Risk in Preterm Infants

2021 ◽  
Vol 9 ◽  
Author(s):  
Zimei Cheng ◽  
Ziwei Dong ◽  
Qian Zhao ◽  
Jingling Zhang ◽  
Su Han ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Prediction Model ◽  
Preterm Infants ◽  
Gestational Age ◽  
Distress Syndrome ◽  
Extubation Failure ◽  
Concordance Index ◽  
Training Cohort

Objectives: This study aimed to identify variables and develop a prediction model that could estimate extubation failure (EF) in preterm infants.Study Design: We enrolled 128 neonates as a training cohort and 58 neonates as a validation cohort. They were born between 2015 and 2020, had a gestational age between 250/7 and 296/7 weeks, and had been treated with mechanical ventilation through endotracheal intubation (MVEI) because of acute respiratory distress syndrome. In the training cohort, we performed univariate logistic regression analysis along with stepwise discriminant analysis to identify EF predictors. A monogram based on five predictors was built. The concordance index and calibration plot were used to assess the efficiency of the nomogram in the training and validation cohorts.Results: The results of this study identified a 5-min Apgar score, early-onset sepsis, hemoglobin before extubation, pH before extubation, and caffeine administration as independent risk factors that could be combined for accurate prediction of EF. The EF nomogram was created using these five predictors. The area under the receiver operator characteristic curve was 0.824 (95% confidence interval 0.748–0.900). The concordance index in the training and validation cohorts was 0.824 and 0.797, respectively. The calibration plots showed high coherence between the predicted probability of EF and actual observation.Conclusions: This EF nomogram was a useful model for the precise prediction of EF risk in preterm infants who were between 250/7 and 296/7 weeks' gestational age and treated with MVEI because of acute respiratory distress syndrome.

scholarly journals Hematologic Profiles of Ethiopian Preterm Infants With Clinical Diagnoses of Early-Onset Sepsis, Perinatal Asphyxia, and Respiratory Distress Syndrome

2020 ◽  
Vol 7 ◽  
pp. 2333794X2096026
Author(s):  
Zemene Tigabu Kebede ◽  
Yohannes Hailu Matebe ◽  
Abayneh Girma Demisse ◽  
Mulugeta Ayalew Yimer ◽  
Amha Mekasha ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Preterm Infants ◽  
Early Onset ◽  
Distress Syndrome ◽  
Perinatal Asphyxia ◽  
Platelet Counts ◽  
Early Onset Sepsis ◽  
Preterm Babies ◽  
Hematologic Profile

Objective. To determine the hematologic profile of preterm infants with regard to different diseases. Methods. A prospective, cross-sectional, observational study, conducted in 5 hospitals in Ethiopia from July 2016 to May 2018. Preterm babies <7 days of age were included and investigated with complete blood counts (CBC) and other investigations, accordingly. Results. Out of 4919 preterms, 3852 (78.3%) were admitted to a newborn intensive care unit, and of these, 68.3% had a CBC performed. The mean values of hemoglobin, white blood cell (WBC) and platelet counts were 17.9 mg/dL; 12 685 cells/mm3, and 159 340 cells/mm3, respectively. Early onset neonatal sepsis (EONS) 1433 (37%), asphyxia 266 (6.9%), and respiratory distress syndrome (RDS) 1738 (45.3%) were common reasons for admission. The WBC count was <5000 cells/mm3 for 8.8%, 9.0%, and 11.1% of neonates with EONS, asphyxia and RDS, respectively. The hemoglobin value was <7 mg/dL for 0.6%, 1.7%, and 0.4% of preterm infants with EONS, asphyxia, and RDS, respectively. The platelet count was <50 000 cells/mm3 for 16.8%, 17.7%, and 19.8% of preterms admitted with a diagnosis of EONS, asphyxia, and RDS, respectively. Conclusion. WBC and platelet counts were the most common to be associated with EONS, asphyxia, and RDS. Further study is recommended to determine the effect of abnormal hematologic profile on the outcome of preterm babies.

scholarly journals Investigation Into the Current Situation and Analysis of the Factors Influencing Extrauterine Growth Retardation in Preterm Infants

2021 ◽  
Vol 9 ◽  
Author(s):  
Ting Zhao ◽  
Hui-Ming Feng ◽  
Bayier Caicike ◽  
Yan-Ping Zhu
Keyword(s):  
Birth Weight ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Preterm Infants ◽  
Gestational Age ◽  
Growth Retardation ◽  
Distress Syndrome ◽  
Factors Influencing ◽  
Extrauterine Growth Retardation ◽  
Growth Indicators

Objective: This study aims to explore the occurrence of extrauterine growth retardation (EUGR) in preterm infants with a gestational age of &lt;34 weeks, at discharge, and the factors influencing the occurrence of EUGR.Method: A retrospective analysis of 691 preterm infants with a gestational age of less than 34 weeks, born in our hospital over the past 3 years. At discharge, the growth indicators head circumference, weight, and length were used to divide the infants into an EUGR group (n = 255) and the non-EUGR group (n = 436). The occurrence of EUGR and its influencing factors were then analyzed.Results: Of the 691 preterm infants evaluated for inclusion in the study, 255 cases (36.9%) met the requirements of EUGR at discharge. The different growth indicators used, i.e., weight, length, and head circumference, classified the infants differently. The incidence of EUGR using these measures was 30.2% (209), 27.9% (193), and 23.2% (161), respectively. The results of a univariate analysis showed that gestational age, birth weight, intrauterine growth retardation (IUGR), maternal gestational hypertension, age at which the infant commenced feeding, duration of the application of an invasive ventilator, length of hospital stay, nosocomial infection, respiratory and gastrointestinal diseases, symptomatic patent ductus arteriosus, and the early onset of neonatal sepsis were correlated with the occurrence of EUGR. Further logistic multivariate regression analysis revealed that low gestational age, low birth weight, complicated IUGR, respiratory distress syndrome, and necrotizing enterocolitis were independent risk factors for EUGR in preterm infants with a gestational age &lt;34 weeks.Conclusion: In preterm infants with a gestational age &lt;34 weeks in our hospital, there is a high incidence of EUGR, which is affected by factors such as the gestational age, birth weight, IUGR, respiratory distress syndrome, necrotizing enterocolitis, and other factors.

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