Correlates of memory decline: A 4-year longitudinal study of older adults with memory complaints.

1992 ◽  
Vol 7 (2) ◽  
pp. 185-193 ◽  
Author(s):  
Joy L. Taylor ◽  
Terry P. Miller ◽  
Jared R. Tinklenberg
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Beatriz Olaya ◽  
Maria Victoria Moneta ◽  
Martin Bobak ◽  
Josep Maria Haro ◽  
Panayotes Demakakos

Abstract Background We investigated the association between trajectories of verbal episodic memory and burden of cardiovascular risk factors in middle-aged and older community-dwellers. Methods We analysed data from 4372 participants aged 50–64 and 3005 persons aged 65–79 years old from the English Longitudinal Study of Ageing who were repeatedly evaluated every 2 years and had six interviews of a 10-year follow-up. We measured the following baseline risk factors: diabetes, hypertension, smoking, physical inactivity and obesity to derive a cardiovascular risk factor score (CVRFs). Adjusted linear mixed effect regression models were estimated to determine the association between number of CVFRs and six repeated measurements of verbal memory scores, separately for middle-aged and older adults. Results CVRFs was not significantly associated with memory at baseline. CVFRs was significantly associated with memory decline in middle-aged (50-64y), but not in older (65-79y) participants. This association followed a dose-response pattern with increasing number of CVFRs being associated with greater cognitive decline. Comparisons between none versus some CVRFs yielded significant differences (p < 0.05). Conclusions Our findings confirm that the effect of cumulative CVRFs on subsequent cognitive deterioration is age-dependent. CVRFs are associated with cognitive decline in people aged 50–64 years, but not in those aged ≥65 years. Although modest, the memory decline associated with accumulation of cardiovascular risk factors in midlife may increase the risk of late-life dementia.


2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S220-S221
Author(s):  
Tyler Bell ◽  
Tyler Bell ◽  
Jacqueline Mogle ◽  
Nikki Hill

Abstract Memory complaints increase cognitive decline but show weak concurrent associations with objective memory. Instead, affect might underlie some memory complaints and their impact on future cognition. Perceived stress influences cognitive performance, but temporal associations with memory complaints is unknown. We therefore explored longitudinal relationships between perceived stress and memory complaints among cognitively normal older adults. From the Einstein Aging Study (n=507, Mage=77.88, 63.30% female; 73.21% White), multilevel models examined bi-directional concurrent and one-year-lagged associations between within-person changes in perceived stress and memory complaints (frequency of forgetting, perceived one-year memory decline, perceived ten-year memory decline). Perceived stress positively covaried with memory complaints. Looking at lagged effects, only frequency of forgetting predicted next-year perceived stress. Higher frequency of forgetting thus increases perceived stress while perceived decline associates with current perceived stress. Reframing perceptions of forgetfulness might reduce stress in cognitively intact older adults, which in turn may benefit cognition long term.


2005 ◽  
Vol 1 ◽  
pp. S82-S83 ◽  
Author(s):  
Andrew J. Saykin ◽  
Heather A. Wishart ◽  
Tara L. McHugh ◽  
Laura A. Rabin ◽  
John D. West ◽  
...  

2017 ◽  
Vol 75 (4) ◽  
pp. 228-233 ◽  
Author(s):  
Rodrigo de Rosso Krug ◽  
Anna Quialheiro Abreu da Silva ◽  
Ione Jayce Ceola Schneider ◽  
Luiz Roberto Ramos ◽  
Eleonora d’Orsi ◽  
...  

ABSTRACT Objective To estimate the effect of participating in cognitive cooperation groups, mediated by computers and the internet, on the Mini-Mental State Examination (MMSE) percent variation of outpatients with memory complaints attending two memory clinics. Methods A prospective controlled intervention study carried out from 2006 to 2013 with 293 elders. The intervention group (n = 160) attended a cognitive cooperation group (20 sessions of 1.5 hours each). The control group (n = 133) received routine medical care. Outcome was the percent variation in the MMSE. Control variables included gender, age, marital status, schooling, hypertension, diabetes, dyslipidaemia, hypothyroidism, depression, vascular diseases, polymedication, use of benzodiazepines, exposure to tobacco, sedentary lifestyle, obesity and functional capacity. The final model was obtained by multivariate linear regression. Results The intervention group obtained an independent positive variation of 24.39% (CI 95% = 14.86/33.91) in the MMSE compared to the control group. Conclusion The results suggested that cognitive cooperation groups, mediated by computers and the internet, are associated with cognitive status improvement of older adults in memory clinics.


2018 ◽  
Vol 61 (3) ◽  
pp. 1089-1096 ◽  
Author(s):  
Prabha Siddarth ◽  
Berna Rahi ◽  
Natacha D. Emerson ◽  
Alison C. Burggren ◽  
Karen J. Miller ◽  
...  

JAMA ◽  
2021 ◽  
Vol 325 (19) ◽  
pp. 1955
Author(s):  
Elizabeth L. Whitlock ◽  
L. Grisell Diaz-Ramirez ◽  
Alexander K. Smith ◽  
W. John Boscardin ◽  
Kenneth E. Covinsky ◽  
...  

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