Ethical Procedures for Research Using Human Participants

2007 ◽  
Keyword(s):  
Human Participants

不定自然変換理論に基づく比喩理解モデルの計算論的実装の試み

2020 ◽  
Author(s):  
Shunsuke Ikeda ◽  
Miho Fuyama ◽  
Hayato Saigo ◽  
Tatsuji Takahashi
Keyword(s):  
Category Theory ◽  
Analogical Reasoning ◽  
Machine Learning Techniques ◽  
Huge Amount ◽  
Metaphor Comprehension ◽  
Weighted Directed Graph ◽  
Learning Techniques ◽  
Descriptive Validity ◽  
Association Data ◽  
Human Participants

Machine learning techniques have realized some principal cognitive functionalities such as nonlinear generalization and causal model construction, as far as huge amount of data are available. A next frontier for cognitive modelling would be the ability of humans to transfer past knowledge to novel, ongoing experience, making analogies from the known to the unknown. Novel metaphor comprehension may be considered as an example of such transfer learning and analogical reasoning that can be empirically tested in a relatively straightforward way. Based on some concepts inherent in category theory, we implement a model of metaphor comprehension called the theory of indeterminate natural transformation (TINT), and test its descriptive validity of humans' metaphor comprehension. We simulate metaphor comprehension with two models: one being structure-ignoring, and the other being structure-respecting. The former is a sub-TINT model, while the latter is the minimal-TINT model. As the required input to the TINT models, we gathered the association data from human participants to construct the ``latent category'' for TINT, which is a complete weighted directed graph. To test the validity of metaphor comprehension by the TINT models, we conducted an experiment that examines how humans comprehend a metaphor. While the sub-TINT does not show any significant correlation, the minimal-TINT shows significant correlations with the human data. It suggests that we can capture metaphor comprehension processes in a quite bottom-up manner realized by TINT.

Ethical Issues in Dissemination and Implementation Research

2017 ◽  
Author(s):  
James M. DuBois ◽  
Beth Prusaczyk
Keyword(s):  
Ethical Decision ◽  
Ethical Decision Making ◽  
Ethical Issues ◽  
Dissemination And Implementation ◽  
Ethical Challenges ◽  
Specific Complex ◽  
Dissemination And Implementation Research ◽  
Research Regulations ◽  
Human Participants ◽  
Context Specific

This chapter focuses primarily on the protection of human participants in D&I studies. It begins by reviewing the Belmont principles that undergird US research regulations and considering the ethical case for D&I research. It then proceeds to examine some ethical issues that might arise during the course of a public health, D&I research agenda in middle schools. It covers the ethical case for D&I research and common ethical challenges. The chapter also discusses strategies for ethical decision-making. While these strategies may be beneficial to all researchers, the authors believe they are of particular value to dissemination and implementation researchers because the nature of their work—context specific, complex, and unfamiliar to many peers, collaborators, and reviewers—means they will deal with uncertainty and conflict on a regular basis, and solutions to the problems they face will rarely be found through simple reference principles, rules, or regulations.

scholarly journals Behavioral Dynamics of Pedestrians Crossing between Two Moving Vehicles

2020 ◽  
Vol 10 (3) ◽  
pp. 859 ◽  
Author(s):  
Soon Ho Kim ◽  
Jong Won Kim ◽  
Hyun-Chae Chung ◽  
Gyoo-Jae Choi ◽  
MooYoung Choi
Keyword(s):  
Traffic Accidents ◽  
Vehicle Speed ◽  
Mathematical Tool ◽  
Vehicle Type ◽  
Behavioral Dynamics ◽  
Moving Vehicles ◽  
Bearing Angle ◽  
Human Participants ◽  
Crossing Point ◽  
Insight Into

This study examines the human behavioral dynamics of pedestrians crossing a street with vehicular traffic. To this end, an experiment was constructed in which human participants cross a road between two moving vehicles in a virtual reality setting. A mathematical model is developed in which the position is given by a simple function. The model is used to extract information on each crossing by performing root-mean-square deviation (RMSD) minimization of the function from the data. By isolating the parameter adjusted to gap features, we find that the subjects primarily changed the timing of the acceleration to adjust to changing gap conditions, rather than walking speed or duration of acceleration. Moreover, this parameter was also adjusted to the vehicle speed and vehicle type, even when the gap size and timing were not changed. The model is found to provide a description of gap affordance via a simple inequality of the fitting parameters. In addition, the model turns out to predict a constant bearing angle with the crossing point, which is also observed in the data. We thus conclude that our model provides a mathematical tool useful for modeling crossing behaviors and probing existing models. It may also provide insight into the source of traffic accidents.

scholarly journals The research registry - answering the call to register every research study involving human participants

Trials ◽  
2015 ◽  
Vol 16 (S2) ◽  
Author(s):  
Riaz Agha ◽  
Katharine Whitehurst ◽  
Harkiran K Sagoo
Keyword(s):  
Research Study ◽  
Human Participants

Methods used to attribute costs avoided from pharmacist interventions in acute care: A scoping review

2021 ◽  
Author(s):  
Sujita W Narayan ◽  
Ivo Abraham ◽  
Brian L Erstad ◽  
Curtis E Haas ◽  
Arthur Sanders ◽  
...  
Keyword(s):  
Acute Care ◽  
Scoping Review ◽  
Pharmacy Practice ◽  
Economic Implications ◽  
Medline Search ◽  
Cost Avoidance ◽  
Harmful Consequence ◽  
Pharmacist Interventions ◽  
Acute Care Settings ◽  
Human Participants

Abstract Purpose Cost-avoidance studies are common in pharmacy practice literature. This scoping review summarizes, critiques, and identifies current limitations of the methods that have been used to determine cost avoidance associated with pharmacists’ interventions in acute care settings. Methods An Embase and MEDLINE search was conducted to identify studies that estimated cost avoidance from pharmacist interventions in acute care settings. We included studies with human participants and articles published in English from July 2010 to January 2021, with the intent of summarizing the evidence most relevant to contemporary practice. Results The database search retrieved 129 articles, of which 39 were included. Among these publications, less than half (18 of 39) mentioned whether the researchers assigned a probability for the occurrence of a harmful consequence in the absence of an intervention; thus, a 100% probability of a harmful consequence was assumed. Eleven of the 39 articles identified the specific harm that would occur in the absence of intervention. No clear methods of estimating cost avoidance could be identified for 7 studies. Among all 39 included articles, only 1 attributed both a probability to the potential harm and identified the cost specific to that harm. Conclusion Cost-avoidance studies of pharmacists’ interventions in acute care settings over the last decade have common flaws and provide estimates that are likely to be inflated. There is a need for guidance on consistent methodology for such investigations for reporting of results and to confirm the validity of their economic implications.

scholarly journals An Analysis of the External Validity of EEG Spectral Power in an Uncontrolled Outdoor Environment during Default and Complex Neurocognitive States

2021 ◽  
Vol 11 (3) ◽  
pp. 330
Author(s):  
Dalton J. Edwards ◽  
Logan T. Trujillo
Keyword(s):  
External Validity ◽  
Spectral Power ◽  
Brain Activity ◽  
Outdoor Environment ◽  
Oscillatory Activity ◽  
Brain State ◽  
Beta Band ◽  
Eeg Spectral Power ◽  
Eeg Power ◽  
Human Participants

Traditionally, quantitative electroencephalography (QEEG) studies collect data within controlled laboratory environments that limit the external validity of scientific conclusions. To probe these validity limits, we used a mobile EEG system to record electrophysiological signals from human participants while they were located within a controlled laboratory environment and an uncontrolled outdoor environment exhibiting several moderate background influences. Participants performed two tasks during these recordings, one engaging brain activity related to several complex cognitive functions (number sense, attention, memory, executive function) and the other engaging two default brain states. We computed EEG spectral power over three frequency bands (theta: 4–7 Hz, alpha: 8–13 Hz, low beta: 14–20 Hz) where EEG oscillatory activity is known to correlate with the neurocognitive states engaged by these tasks. Null hypothesis significance testing yielded significant EEG power effects typical of the neurocognitive states engaged by each task, but only a beta-band power difference between the two background recording environments during the default brain state. Bayesian analysis showed that the remaining environment null effects were unlikely to reflect measurement insensitivities. This overall pattern of results supports the external validity of laboratory EEG power findings for complex and default neurocognitive states engaged within moderately uncontrolled environments.

scholarly journals A consensus approach toward the standardization of spinal stiffness measurement using a loaded rolling wheel device: results of a Delphi study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Maliheh Hadizadeh ◽  
Greg Kawchuk ◽  
Simon French
Keyword(s):  
Delphi Study ◽  
Best Practice ◽  
Standard Protocol ◽  
Research Experience ◽  
Multicenter Studies ◽  
Stiffness Measurement ◽  
Delphi Approach ◽  
Spinal Stiffness ◽  
Human Participants ◽  
Rolling Wheel

Abstract Background Spinal stiffness assessment has the potential to become an important clinical measure. Various spinal stiffness-testing devices are available to help researchers objectively evaluate the spine and patient complaints. One of these is VerteTrack, a device capable of measuring posteroanterior displacement values over an entire spinal region. This study aimed to develop a best-practice protocol for evaluating spinal stiffness in human participants using VerteTrack. Methods Twenty-five individuals with research experience in measuring spinal stiffness, or who were trained in spinal stiffness measurement using the VerteTrack device, were invited to participate in this 3-Round Delphi study. Answers to open-ended questions in Round 1 were thematically analyzed and translated into statements about VerteTrack operation for spinal stiffness measurements. Participants then rated their level of agreement with these statements using a 5-point Likert scale in Rounds 2 and 3. A descriptive statistical analysis was performed. Consensus was achieved when at least 70% of the participants either strongly agreed, agreed, (or strongly disagreed, disagreed) to include a statement in the final protocol. Results Twenty participants completed Round 1 (80%). All these participants completed Rounds 2 and 3. In total, the pre-defined consensus threshold was reached for 67.2% (123/183) of statements after three rounds of surveys. From this, a best-practice protocol was created. Conclusions Using a Delphi approach, a consensus-based protocol for measuring spinal stiffness using the VerteTrack was developed. This standard protocol will help to improve the accuracy, efficiency, and safety of spinal stiffness measurements, facilitate the training of new operators, increase consistency of these measurements in multicenter studies, and provide the synergy and potential for data comparison between spine studies internationally. Although specific to VerteTrack, the resulting standard protocol could be modified for use with other devices designed to collect spinal stiffness measures.

scholarly journals Sex-related differences in response to masseteric injections of glutamate and nerve growth factor in healthy human participants

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Abdelrahman M. Alhilou ◽  
Akiko Shimada ◽  
Camilla I. Svensson ◽  
Peter Svensson ◽  
Malin Ernberg ◽  
...  
Keyword(s):  
Nmda Receptors ◽  
Nerve Fiber ◽  
Masseter Muscle ◽  
Pain Sensitivity ◽  
Nerve Fibers ◽  
Receptor Expression ◽  
Healthy Human ◽  
Neurophysiological Mechanisms ◽  
Human Participants ◽  
Positive Correlations

AbstractThe neurophysiological mechanisms underlying NGF-induced masseter muscle sensitization and sex-related differences in its effect are not well understood in humans. Therefore, this longitudinal cohort study aimed to investigate the effect of NGF injection on the density and expression of substance P, NMDA-receptors and NGF by the nerve fibers in the human masseter muscle, to correlate expression with pain characteristics, and to determine any possible sex-related differences in these effects of NGF. The magnitude of NGF-induced mechanical sensitization and pain during oral function was significantly greater in women than in men (P < 0.050). Significant positive correlations were found between nerve fiber expression of NMDA-receptors and peak pain intensity (rs = 0.620, P = 0.048), and expression of NMDA-receptors by putative nociceptors and change in temporal summation pain after glutamate injection (rs = 0.561, P = 0.003). In women, there was a significant inverse relationship between the degree of NGF-induced mechanical sensitization and the change in nerve fiber expression of NMDA-receptors alone (rs = − 0.659, P = 0.013), and in combination with NGF (rs = − 0.764, P = 0.001). In conclusion, women displayed a greater magnitude of NGF-induced mechanical sensitization that also was associated with nerve fibers expression of NMDA-receptors, when compared to men. The present findings suggest that, in women, increased peripheral NMDA-receptor expression could be associated with masseter muscle pain sensitivity.

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