Daytime sleepiness, performance, mood, nocturnal sleep: The effect of benzodiazepine and caffeine on their relationship

Author(s):  
L. C. Johnson ◽  
C. L. Spinweber ◽  
S. A. Gomez ◽  
L. T. Matteson
JMS SKIMS ◽  
2016 ◽  
Vol 19 (2) ◽  
pp. 65-74
Author(s):  
Javid Ahmad Malik ◽  
Sheikh Shoib ◽  
Bashir Ahmad Naikoo ◽  
Shabir Ahmad Lone ◽  
Ramees Mohi Ud Din Mir ◽  
...  

Obstructive sleep apnea (OSA) and obesity are two interacting global epidemics both with high prevalence and morbidity. Both epidemiologic and clinical studies suggest that majority of patients with obesity also have OSA and untreated OSA in these patients results in significant cardiovascular and metabolic complications.Objectives: To evaluate the profile of OSAin obese patients of Kashmir.Methods: We performed polysomnography studies in obese patients that were referred from various sub-specialty clinics from July 2011 to August 2013.Results: Out of 182 patients who underwent polysomnography (PSG), 11O (60.4%) were obese (BMI > 30 kg/m2). In 110 obese patients, 104 (94.5%) had OSA. Hypertension, diabetes and dyslipidemia were more prevalent among obese (p<0.05). The mean neck circumference and mean BMI of obese patients was significantly more than that of non-obese (33.9 kg/m2 vs. 26.8 kg/m2) (p <0.000). Presenting symptoms of obese were snoring (97.3%), daytime sleepiness (87.3%) with a mean ESS of 15.3, disturbed nocturnal sleep (70.0%), nocturia (62.7%) and witnessed apneas (45.5%). OSA was significantly (p=0.002) more common among obese compared to non-obese (93% vs 76%). Most were clinically suspected to have OSAby internists (29%), cardiologists (20%), endocrinologists (15%) and psychiatrists (13%). Sleep efficiency was significantly less (p< 0.03) in obese patients but sleep latency and REM sleep latency did not significantly differ between obese and non-obese. Unlike awake oxygen saturation the average nocturnal oxygen saturation of obese patients was significantly less [p=0.001] than that of nonobese patients (84.7% vs. 88.1%). The mean AHI of obese patients was significantly more than non-obese i.e 24.3 vs. 18.0 (p = 0.001) and so was the mean ODI i.e 24.6 vs. 17.2 (p = 0.001). Variables that significantly correlated with presence of OSA include age, gender, BMI, hypertension, diabetes and cardiovascular disease (p< 0.05), however on logistic regression only BMI, hypertension, and nocturia correlated with OSA. CPAPtherapy improved snoring, nocturia, nocturnal sleep and daytime sleepiness more in obese than non-obese OSApatients.Conclusions: OSA which is highly prevalent among obese Kashmiri patients, is largely unrecognized in the primary care setting. It is associated with significant comorbidities and most of these improve with CPAPtherapy. JMS 2016; 19(2):65-74.


2011 ◽  
Vol 17 (4) ◽  
pp. 4 ◽  
Author(s):  
Celestine Okorome Mume ◽  
Kamildeen Oladimeji Olawale ◽  
Adeagbo Funminiyi Osundina

<p><strong>Background and objectives.</strong> Short nocturnal sleep duration resulting in sleep debt may be a cause of excessive daytime sleepiness (EDS). Severity of depression (psychopathology) has been found to be directly related to EDS. There is an association between sleep duration and mental health, so there may therefore be an interrelationship between sleep duration, EDS and psychopathology. The objectives of this study were to determine the prevalence rates of EDS and general psychopathology among university students in Nigeria; determine the range of and mean sleep duration in the students; and determine the extent to which sleep duration and EDS predict general psychopathology in the same group of subjects. Materials and methods. Eight hundred and forty-five students at Obafemi Awolowo University, Ile-Ife, Nigeria, were recruited for the study. The subjects were required to provide information on their age, gender and the total amount of sleep per night they usually had. General psychopathology was assessed using the English language version of the 30-item General Health Questionnaire (GHQ-30). They were also evaluated for EDS using the English language version of the Epworth Sleepiness Scale (ESS).</p><p><strong>Results.</strong> Six hundred and thirty-four subjects (75.03% of the participants) provided complete data. The prevalence of EDS was 11.2% and the rate of general psychopathology in the subjects 13.1%. The range of sleep duration was 2 - 9 hours with a mean of 5.1 hours (standard deviation 1.3). On a regression model with the GHQ score as the dependent variable and sleep duration and ESS as the independent variables, the correlation coefficient between EDS, sleep duration and psychopathology (R) was 0.47.</p><p><strong>Conclusion.</strong> EDS and psychopathology are common in the student population studied. Nocturnal sleep duration for an average student is far less than that for an average adult. Nocturnal sleep duration and EDS acted as moderate predictors of general psychopathology among Nigerian university students.</p>


2018 ◽  
Vol 18 (2) ◽  
pp. 143 ◽  
Author(s):  
Mohammed A. Al-Abri ◽  
Samir Al-Adawi ◽  
Ibrahim Al-Abri ◽  
Faisal Al-Abri ◽  
Atsu Dorvlo ◽  
...  

Objectives: Sleepiness and fatigue play significant roles in exacerbating the occurrence of car crashes. However, there is a dearth of studies examining the prevalence of sleepiness while driving among Omanis. This study aimedto determine the proportion of young Omani adults who confess to daytime sleepiness while driving and to investigate associations between gender, daytime sleepiness and risk of obstructive sleep apnoea syndrome (OSAS). Methods: This cross-sectional study took place at the Sultan Qaboos University Hospital, Muscat, Oman, between May and July 2014 and included 600 young adult Omani non-commercial drivers. The Berlin Questionnaire and Epworth Sleepiness Scale (ESS) were distributed among the participants, along with additional questions about their sleeping habits. Associations between daytime sleepiness while driving and nocturnal sleep duration, risk of OSAS and gender were determined. Results: A total of 492 private vehicle drivers took part in the study (response rate: 82%), of which 50.4% were male. Overall, 124 Omanis (25.2%) reported experiencing daytime sleepiness while driving at least once per month. There was a significant association between nocturnal sleep duration of <6 hours and sleepiness while driving (P = 0.042). Female participants were significantly more likely to score >10 on the ESS, indicating a greater propensity for daytime sleepiness (P = 0.006). However, male drivers were significantly more likely to report sleepiness while driving (P = 0.001). Conclusion: Sleepiness while driving was common among young male drivers in Oman and might be due to nocturnal sleep deprivation. Further studies are needed so that preventative measures can be developed.Keywords: Motor Vehicles; Traffic Accidents; Sleep; Fatigue; Obstructive Sleep Apnea Syndrome; Oman.


2007 ◽  
Vol 16 (3) ◽  
pp. 262-268 ◽  
Author(s):  
LYNNE J. LAMARCHE ◽  
HELEN S. DRIVER ◽  
SABRINA WIEBE ◽  
LEAH CRAWFORD ◽  
JOSEPH M. DE KONINCK

2020 ◽  
Vol 12 (6) ◽  
pp. 49-53
Author(s):  
A. A. Filin ◽  
M. V. Tardov ◽  
N. L. Kunelskaya ◽  
P. N. Vlasov

Perampanel (PER) is an antiepileptic drug (AED), the effects of which on sleep have not been studied in Russia.Objective: to assess changes in the quality of sleep, the level of daytime sleepiness, and the polysomnographic (PSG) characteristics of nocturnal sleep in patients with drug-resistant focal epilepsy when PER is incorporated into the therapy regimen as an additional AED.Patients and methods. The investigation enrolled 12 patients (4 men and 8 women) aged 21 to 49 years with drug-resistant epilepsy treated with several AEDs, who had initiated therapy with PER as an additional AED. PSG study and questioning survey were done before and 1 month after initiation of PER therapy.Results and discussion. After one month of PER therapy, there was an increase in the quality of night sleep in 5 cases and a reduction in daytime sleepiness in 6 cases. The PSG pattern was stable in 3 patients, worsened in 1, and improved in 8.Conclusion. The preliminary results suggest that PER therapy improves night sleep quality and reduces daytime sleepiness in about half of the cases, as evidenced by the improved PSG pattern in 67% of patients.


1999 ◽  
Vol 45 (6) ◽  
pp. 764-770 ◽  
Author(s):  
Eric O Johnson ◽  
Naomi Breslau ◽  
Thomas Roth ◽  
Timothy Roehrs ◽  
Leon Rosenthal

2011 ◽  
Vol 23 (6) ◽  
pp. 994-1002 ◽  
Author(s):  
Mette M. Aanes ◽  
Jørn Hetland ◽  
Ståle Pallesen ◽  
Maurice B. Mittelmark

ABSTRACTBackground: Sleep problems are common in the general population. A strong association between stress due to inadequate social relationships or loneliness and sleep problems has been found. This paper aims to investigate stress in close social relationships in relation to disrupted sleep patterns in middle-aged and older adults. In addition, in exploring the underlying processes involved in poor social interactions, loneliness is assumed to be a mediator in the stress-sleep quality relation.Methods: Data from a community sample of 7074 Norwegian middle-aged and older adults in the Hordaland Health Study (HUSK) were used to examine the mediating role of loneliness.Results: A significant association between interpersonal stress and both nocturnal sleep problems and daytime sleepiness was found in both age groups. This relation was mediated by loneliness (indirect path) as well as effected by a direct path (RMSEA = 0.051; CFI = 0.93). The size of the indirect effect varied with age. Nocturnal sleep problems were fully mediated by loneliness in the older group, while 74% of the total effect was mediated through loneliness in the middle-aged group. For daytime sleepiness, a partial mediation of 36% and 40% was observed for the two groups respectively.Conclusions: The mediation effects found in this study indicate that the wider social aspects of an individual's life should be taken into account when planning interventions for improving sleep quality in the elderly.


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