scholarly journals Compound Ion Salt, a Novel Low-Sodium Salt Substitute: From Animal Study to Community-Based Population Trial

2009 ◽  
Vol 22 (9) ◽  
pp. 934-942 ◽  
Author(s):  
X. Zhou ◽  
J.-X. Liu ◽  
R. Shi ◽  
N. Yang ◽  
D.-L. Song ◽  
...  
BMJ Open ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. e041346
Author(s):  
Leopold Ndemnge Aminde ◽  
Linda Cobiac ◽  
J. Lennert Veerman

BackgroundReducing dietary sodium (salt) intake has been proposed as a population-wide strategy to reduce blood pressure and cardiovascular disease (CVD). The cost-effectiveness of such strategies has hitherto not been investigated in Cameroon.MethodsA multicohort multistate life table Markov model was used to evaluate the cost-effectiveness of three population salt reduction strategies: mass media campaign, school-based salt education programme and low-sodium salt substitute. A healthcare system perspective was considered and adults alive in 2016 were simulated over the life course. Outcomes were changes in disease incidence, mortality, health-adjusted life years (HALYs), healthcare costs and incremental cost-effectiveness ratios (ICERs) over the lifetime. Probabilistic sensitivity analysis was used to quantify uncertainty.ResultsOver the life span of the cohort of adults alive in Cameroon in 2016, substantial numbers of new CVD events could be prevented, with over 10 000, 79 000 and 84 000 CVD deaths that could be averted from mass media, school education programme and salt substitute interventions, respectively. Population health gains over the lifetime were 46 700 HALYs, 348 800 HALYs and 368 400 HALYs for the mass media, school education programme and salt substitute interventions, respectively. ICERs showed that all interventions were dominant, with probabilities of being cost-saving of 84% for the school education programme, 89% for the mass media campaign and 99% for the low sodium salt substitute. Results were largely robust in sensitivity analysis.ConclusionAll the salt reduction strategies evaluated were highly cost-effective with very high probabilities of being cost-saving. Salt reduction in Cameroon has the potential to save many lives and offers good value for money.


2021 ◽  
Vol 8 ◽  
Author(s):  
Hao Sun ◽  
Bing Ma ◽  
Xiaomei Wu ◽  
Hailong Wang ◽  
Bo Zhou

Background: Salt substitute, a strategy for salt reduction, has been shown to decrease blood pressure and the incidence of hypertension. However, whether its hypotensive effect will reduce long-term mortality remains unclear. Our study reported an exploratory follow-up of mortality outcomes from previous randomized controlled trial to assess the long-term effect of low-sodium salt on total and cardiovascular disease (CVD) mortality.Methods: Participants who completed a previous 3-year double-blind randomized controlled trial were followed up from 2009 to 2019 to collect mortality data. Multivariable Cox regression models were used to evaluate the association between low-sodium salt intervention and all-cause and CVD mortality.Results: Four hundred and forty participants completed the intervention trial, of which 428 participants had death outcome data recorded after 10 years follow-up: 209 in a salt substitute group and 219 in a normal salt group. Fifty participants died during follow-up, 25 died due to CVD. No significant differences in relative risks were found for all-cause mortality [HR = 0.81, 95% confidence interval (CI): 0.46–1.42] and CVD mortality (HR = 0.58, 95% CI: 0.26–1.32) in unadjusted analyses. After adjusted with age and alcohol drinking status, there were significant reductions for stroke mortality among all participants (HR = 0.26, 95% CI: 0.08–0.84) and for CVD mortality (HR = 0.38, 95% CI: 0.16–0.92) and stroke mortality (HR = 0.25, 95% CI: 0.08–0.82) among hypertensive participants.Conclusions: Compared to normal salt, salt substitute might reduce the risk of CVD death, especially stroke among hypertensive patients. Our exploratory follow-up results provide potential evidence that low-sodium salt may be an accessible and effective strategy for prevention of CVD events, but definitive randomized controlled trials are warranted.


1984 ◽  
Vol 6 ◽  
pp. S236 ◽  
Author(s):  
Heikki Karppanen ◽  
Antti Tanskanen ◽  
Jaakko Tuomilehto ◽  
Pekka Puska ◽  
Juhani Vuori ◽  
...  
Keyword(s):  

2017 ◽  
Vol 95 (3) ◽  
pp. 1179-1191
Author(s):  
HAMDY S. EL-TAWEEL ◽  
AHMED S. EL-SISI ◽  
MAHMOUD A. MAILAM

2019 ◽  
Vol 15 (1) ◽  
pp. 63
Author(s):  
Yuliana Salman ◽  
Siti Herbiati ◽  
Firyal Yasmin

Peningkatan tekanan darah atau biasa disebut hipertensi sampai saat ini masih merupakan penyebab utama dan faktor risiko yang penting terhadap penyakit kardiovaskular, serebrovaskular, penyakit jantung, dan gagal ginjal. Tujuan umum dari penelitian ini menganalisis kandungan natrium dan daya terima mandai goreng rendah natrium sebagai makanan alternatif bagi penderita hipertensi. Metode yang digunakan dalam penelitian ini adalah metode eksperimen menggunakan Rancangan Acak Lengkap (RAL) yang terdiri dari atas 4 perlakuan dan 3 kali replikasi dengan perlakuan kontrol F0 (fermentasi menggunakan garam dapur 10%), F1 (fermentasi menggunakan garam rendah natrium 2%), F2 (fermentasi menggunakan garam rendah natrium 6%), F3 (fermentasi menggunakan garam rendah natrium 10%). Kadar natrium diuji dengan metode AAS (Atomic Absorption Spectroscopy), sedangkan uji daya terima dengan metode Hedonic Scale Scoring..  Analisis data kadar natrium menggunakan one way anova dan data daya terima menggunakan analisis friedman.  Hasil penelitian menunjukkan bahwa nilai rata-rata kadar natrium terendah adalah mandai pada perlakuan F1 dengan konsentrasi 2% yaitu sebesar 0,87% dengan hasil uji statistik (p=0,000<α=0,05), yang artinya ada pengaruh terhadap kadar natrium mandai goreng. Nilai tertinggi daya terima yang terdiri dari warna 3,32 (F1), aroma 3,20 (F1 dan F3), tekstur 3,12 (F1) dan rasa 3,28 (F1). Mandai rendah natrium berpengaruh terhadap daya terima rasa yang dihasilkan karena p=0,015<α(p<0,05). Rekomendasi produk mandai yang dapat dijadikan alternatif bagi penderita hipertensi adalah mandai rendah natrium dengan perlakuan F1 yaitu 0,87% yang setara dengan 870mg/100g dengan konsentrasi garam rendah natrium 2%.Kata kunci : Mandai, Kadar natrium, Daya terima mandai goreng 


Medicine ◽  
2020 ◽  
Vol 99 (8) ◽  
pp. e19263 ◽  
Author(s):  
Lihong Mu ◽  
Chenglong Li ◽  
Ting Liu ◽  
Wuxiang Xie ◽  
Ge Li ◽  
...  

2019 ◽  
Vol 11 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Peter Lloyd-Sherlock ◽  
Francesc X. Gómez-Olivé ◽  
Sizzy Ngobeni ◽  
Ryan G. Wagner ◽  
Stephen Tollman

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3410
Author(s):  
Marta Beltrá ◽  
Fernando Borrás ◽  
Ana B. Ropero

High sodium/salt intake is a risk factor for Non-Communicable Diseases (NCDs). Excess sodium intake has been associated with high coronary heart disease, stroke and high blood pressure. The sodium daily intake is above the recommendations in the world as well as in Spain. Reducing salt content in processed foods and ready meals is one of the main strategies for reducing sodium intake. The aim of the present work is to characterise the presence of sodium in foods sold in the Spanish market. We also study a possible shift in sodium content in products over the last few years. For this purpose, 3897 products included in the BADALI food database were analysed, classified into 16 groups (G). We found that 93.3% of all foods displayed the sodium/salt content in the nutrition declaration. Meat—processed and derivatives (G8) had the highest mean and median values for sodium content, followed by snacks (G15) and sauces (G14). Only 12.7% of foods were sodium-free (≤ 5 mg/100 g or 100 mL), 32.4% had very low sodium (≤ 40 mg/100 g or 100 mL) and 48.2% were low in sodium (≤ 120 mg/100 g or 100 mL). On the contrary, 47.2% were high in sodium according to the Pan American Health Organisation Nutrient Profile Model (PAHO-NPM), while there were 31.9% according to the Chile-NPM. The agreement between the two NPMs was considered ‘substantial’ (κ = 0.67). When sodium content was compared over the years, no decrease was observed. This analysis was performed in the entire food population, by food group and in matched products. Therefore, more effort should be made by all parties involved in order to decrease the sodium/salt intake in the population.


Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3203
Author(s):  
Adefunke Ajenikoko ◽  
Nicole Ide ◽  
Roopa Shivashankar ◽  
Zeng Ge ◽  
Matti Marklund ◽  
...  

Excess sodium consumption and insufficient potassium intake contribute to high blood pressure and thus increase the risk of heart disease and stroke. In low-sodium salt, a portion of the sodium in salt (the amount varies, typically ranging from 10 to 50%) is replaced with minerals such as potassium chloride. Low-sodium salt may be an effective, scalable, and sustainable approach to reduce sodium and therefore reduce blood pressure and cardiovascular disease at the population level. Low-sodium salt programs have not been widely scaled up, although they have the potential to both reduce dietary sodium intake and increase dietary potassium intake. This article proposes a framework for a successful scale-up of low-sodium salt use in the home through four core strategies: availability, awareness and promotion, affordability, and advocacy. This framework identifies challenges and potential solutions within the core strategies to begin to understand the pathway to successful program implementation and evaluation of low-sodium salt use.


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