Decreased serum vitamin D levels in early spontaneous pregnancy loss

Background: Pregnancy loss in the first trimester is one of the most disappointing matters for a mother. But spontaneous pregnancy loss in the first trimester is the most common negative outcome of pregnancy. It's estimated that about 10% of known pregnancies are lost in the first trimester whereas fewer than 4% of pregnancies miscarry in the second trimester. Aim of current study was to assess the effect of the maternal vitamin D level on the risk of spontaneous pregnancy loss in the first trimester.Methods: It was a case-control study conducted in the department of obstetrics and gynecology, Sir Salimullah medical college Mitford hospital, Dhaka, Bangladesh during the period of September 2018 to August 2019. A total of 100 patients were included in this study. Statistical analyses of the results were obtained by using window-based computer software devised with SPSS version 22.0.Results: In analyzing the association of serum vitamin D status with first-trimester pregnancy state it was observed that more than half (52.0%) patients had severe deficiency (<10 ng/ml) in the case group and 14 (28.0%) patients in the control group. In total 24 (48.0%) patients had deficiency (10-20 ng/ml) in case and 35 (70.0%) in control group. Only 1 (2.0%) patient had insufficiency (21-29 ng/ml) in control group. The difference was statistically significant (p<0.05) between the two groups.Conclusions: Maternal serum vitamin D deficiency was significantly associated with early spontaneous pregnancy loss in the first trimester.

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The Association of Serum Vitamin D and Calcium Levels with Early Recurrent Spontaneous Pregnancy Loss

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v6i11.48 ◽

2018 ◽

Vol 6 (11) ◽

Author(s):

Prof. Maysoon Sharief ◽

Keyword(s):

Vitamin D ◽

Pregnancy Loss ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Spontaneous Pregnancy

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Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000662 ◽

2020 ◽

Vol 90 (3-4) ◽

pp. 346-352

Author(s):

Vincenzo Pilone ◽

Salvatore Tramontano ◽

Carmen Cutolo ◽

Federica Marchese ◽

Antonio Maria Pagano ◽

...

Keyword(s):

Bariatric Surgery ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Inverse Correlation ◽

Model Assessment ◽

Cross Sectional ◽

Serum Vitamin D ◽

Female Sex ◽

Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

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Maternal Serum Vitamin D Levels During Pregnancy and Offspring Neurocognitive Development

PEDIATRICS ◽

10.1542/peds.2011-2644d ◽

2012 ◽

Vol 129 (3) ◽

pp. X11-X11

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Maternal Serum ◽

Neurocognitive Development ◽

Serum Vitamin D ◽

Vitamin D Levels

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Faculty Opinions recommendation of Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3437965.3141061 ◽

2010 ◽

Author(s):

Leonard Bacharier ◽

Avraham Beigelman

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Children With Asthma

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Association of Vitamin D Levels and Other Risk Factors with Asthma Exacerbations in Children

Pakistan Journal of Medicine and Dentistry ◽

10.36283/pjmd9-4/004 ◽

2020 ◽

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Serum Vitamin ◽

Persistent Asthma ◽

Food Allergies ◽

P Value ◽

Serum Vitamin D ◽

Asthma Exacerbations ◽

Vitamin D Levels ◽

Animal Dander

Background: The risk factors for asthma exacerbations are well understood. However, the effect of vitamin D levels on number of asthma exacerbations per year is not clearly studied. The objective of the study was to ﬁnd out the association of serum vitamin D levels and asthma risk factors on asthma exacerbations. Methods: In this study, ninety-nine subjects from 5 to 15 years of age were recruited at an episode of acute exacerbation. It was a cross sectional study and carried out from 2012 to 2015. Pulmonary function test was done by spirometry. Asthma exacerbation was labeled when forced expiratory volume/ forced vital capacity (FEV1/FVC) ratio was less than 80% (American Thoracic Society). Global Initiative for Asthma (GINA) guidelines were used to classify asthma into mild, moderate and severe persistent asthma. Serum vitamin D levels were measured by chemiluminescence method. Pearson Chi-square test was applied and p value (p<0.05) was considered as statistically signiﬁcant. Results: Children who had exposure to animal dander had signiﬁcantly lower asthma exacerbations per year (p-value <0.046). There was no signiﬁcant association between vitamin D levels and number of exacerbations per years (p-value <0.099). Asthma was prevalent in girls of low socioeconomic status (SES) compared to males. However, there was no signiﬁcant association between smoke, exercise, home environment, food allergies, weather, pollen and dust with asthma exacerbations. Conclusion: Low levels of vitamin D were not associated with increased number of asthma exacerbations per year. However, children exposed to animal dander had lesser number of exacerbations per year (p-value <0.046). Keywords: Asthma; Vitamin D; Children; Exacerbations, Risk factors.

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