Prevention of Ischemic and Postischemic Brain Edema by a Novel Calcium Antagonist (PN200-110)
1988 ◽
Vol 8
(3)
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pp. 436-439
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Keyword(s):
The effect of PN200-110, a novel calcium antagonist, on the formation of brain edema was examined with rats using a middle cerebral artery (MCA) occlusion model. PN200-110 was effective in preventing the formation of brain edema in 6-h ischemia and in 3-h reperfusion following 3-h ischemia, which were cases in which great accumulations of calcium were autoradiographically observed. Furthermore, PN200-110 diminished the excessive accumulation of calcium in the MCA area involved. These results indicate that an inhibition of the massive influx of calcium into brain cells by PN200-110 may partially ameliorate cell damage, resulting in prevention of brain edema.
1987 ◽
Vol 7
(5)
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pp. 557-562
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1996 ◽
Vol 16
(4)
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pp. 599-604
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1988 ◽
Vol 8
(3)
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pp. 357-366
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Keyword(s):
2006 ◽
Vol 23
(Supplement 37)
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pp. 155
Keyword(s):
1997 ◽
Vol 87
(4)
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pp. 595-601
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Keyword(s):
1990 ◽
Vol 53
(2)
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pp. 247-253
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2019 ◽
Vol 23
(4)
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pp. 2468-2474
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