scholarly journals Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria

2007 ◽  
Vol 20 (6) ◽  
pp. 701-709 ◽  
Author(s):  
Yoh Zen ◽  
N Volkan Adsay ◽  
Krystof Bardadin ◽  
Romano Colombari ◽  
Linda Ferrell ◽  
...  
Keyword(s):  
Diagnostic Criteria ◽  
Interobserver Agreement ◽  
Intraepithelial Neoplasia ◽  
Biliary Intraepithelial Neoplasia ◽  
Agreement Study

scholarly journals Gleason grade 4 prostate adenocarcinoma patterns: an interobserver agreement study among genitourinary pathologists

2016 ◽  
Vol 69 (3) ◽  
pp. 441-449 ◽  
Author(s):  
Charlotte F Kweldam ◽  
Daan Nieboer ◽  
Ferran Algaba ◽  
Mahul B Amin ◽  
Dan M Berney ◽  
...  
Keyword(s):  
Interobserver Agreement ◽  
Prostate Adenocarcinoma ◽  
Gleason Grade ◽  
Agreement Study

scholarly journals INCIDENCE AND CLINICAL SIGNIFICANCE OF HIGH GRADE PROSTATIC INTRAEPITHELIAL NEOPLASIA IN TURP SPECIFIMENS

2020 ◽  
pp. 1-5
Author(s):  
B. Pavan Kumar ◽  
Imran Ali ◽  
Anwar Miya ◽  
Kishan Kishan
Keyword(s):  
Diagnostic Criteria ◽  
Prostatic Carcinoma ◽  
Invasive Carcinoma ◽  
Clinical Presentation ◽  
Intraepithelial Neoplasia ◽  
Diagnostic Techniques ◽  
Transurethral Resection Of Prostate ◽  
Low Grade ◽  
High Grade ◽  
Precancerous Condition

BACKGROUND : PIN is a well known precancerous condition of prostatic carcinoma. Transurethral resection of prostate has become the most prominent and the easiest way, to morphologically evaluate lesions of PIN. But clinicians are sometimes confused by the grading that is given in the report. So there is a need to define the diagnostic criteria and differential diagnosis of PIN using newer diagnostic techniques to assist in the better diagnosis and grading. AIMS AND OBJECTIVES: To evaluate whether the diagnostic criteria can be defined PIN and using newer techniques for PIN grading to improve the clinical management of patients with prostatic lesions. MATERIALS AND METHODS: This study will be done in the Department of Pathology MGM Hospitals, Warangal for a period of 2 years and includes consecutive cases of TURP specimens from the patients who present with obstructive symptoms as a major clinical presentation and correlated with PSA levels. INCLULSION CRITERIA: Patients who present with obstructive symptoms as a major clinical presentation. RESULTS: 1.160 cases of TURP specimens were studied out of which 53 (33.12%) cases are PIN. BPH -78 (48/74%), PC-15 (9.37%), SM-14 (8.75%) 2. Majority cases are low grade PIN 34 out of 53 cases (21.25%) High Grade PIN 19 out of 53cases. (11.87%) 3. High Grade PIN and prostatic Carcinoma shared increased incidence and severity with advancing age in the study. Majority of HG PIN cases in our study noted in (70-79 years of age) 4. The risk of carcinoma is more in cases of High Grade PIN (68.42%) than in low grade PIN (17.64%) 5. This warrants are need for repeat prostatic biopsies to diagnose the invasive carcinoma in patient with High grade PIN.

Biliary neoplasia with extensive intraductal spread associated with liver cirrhosis: a hitherto unreported variant of biliary intraepithelial neoplasia

2008 ◽  
Vol 39 (6) ◽  
pp. 939-947 ◽  
Author(s):  
Shinichi Aishima ◽  
Yunosuke Nishihara ◽  
Eiji Tsujita ◽  
Kenichi Taguchi ◽  
Yuji Soejima ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Intraepithelial Neoplasia ◽  
Intraductal Spread ◽  
Biliary Intraepithelial Neoplasia

scholarly journals Smooth Muscle Distribution Patterns of Choledochal Cysts and Their Implications for Pathogenesis and Postoperative Complications

2020 ◽  
Vol 153 (6) ◽  
pp. 760-771
Author(s):  
Hee Sang Hwang ◽  
Mee-Jeong Kim ◽  
Seung-Soo Lee ◽  
Jae Hoon Lee ◽  
Ki Byung Song ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Biliary Stricture ◽  
Intraepithelial Neoplasia ◽  
Distribution Patterns ◽  
Postoperative Management ◽  
Clinical Implications ◽  
Type I ◽  
Choledochal Cysts ◽  
Biliary Intraepithelial Neoplasia ◽  
Chronic Irritation

Abstract Objectives Histopathologic characteristics of choledochal cysts and their clinical implications have not been previously comprehensively studied. Methods Smooth muscle distribution patterns and other histologic findings (inflammation, metaplasia, dysplasia, and heterotopia) in 233 surgically resected choledochal cysts were evaluated. Results Mean patient age was 23.3 ± 19.8 years, with male:female ratio of 0.3. Most cases were Todani type I (175 cases, 75.1%) or IVa (56 cases, 24.1%). Choledochal cysts with thin scattered/no muscle fiber (175 cases, 75.1%) were the predominant pattern and were associated with more frequent postoperative biliary stricture (P = .031), less frequent pyloric metaplasia (P = .016), and mucosal smooth muscle aggregates (P < .001) compared to cysts with thick muscle bundles. Severe chronic cholangitis (P = .049), pyloric metaplasia (P = .019), mucosal smooth muscle aggregates (P < .001), biliary intraepithelial neoplasia (P = .021), and associated bile duct (P = .021) and gallbladder carcinomas (P = .03) were more common in adults (age >20 years vs ≤20 years), suggesting that chronic irritation in association with developmental anomalies involves tumorigenesis from choledochal cysts. Conclusion Smooth muscle distribution pattern of choledochal cyst may predict postoperative complication, raising clinical implications of smooth muscle patterns in postoperative management of choledochal cysts.

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