Based on creating generalized and hybrid set and library with neutrosophy and quad-stage method, this paper presents the concept of “computer information library clusters” (CILC). There are various ways and means to form CILC. For example, CILC can be considered as the “total-library”, and consists of several “sub-libraries”. As another example, in CILC, a “total-library” can be set up, and a number of “sub-libraries” are side by side with the “total-library”. Specially, for CILC, the operation functions can be added; for example, according to “natural science computer information library clusters” (natural science CILC), and applying “variation principle of library (or sub-library)”, “partial and temporary unified theory of natural science so far” with different degrees can be established. Referring to the concept of “natural science CILC”, the concepts of “social science CILC”, “natural science and social science CILC”, and the like, can be presented. While, referreing to the concept of “computer information library clusters”, the concepts of “computer and non-computer information library clusters”, “earth information library clusters”, “solar system information library clusters”, “Milky Way galaxy information library clusters”, “universe information library clusters”, and the like, can be presented.