Supplemental vitamin D: will do no harm and might do good

A case of idiopathic hypercalcemia present from early infancy and diagnosed at 5 years of age is reported in which the serum assay of vitamin D indicated elevated levels. After discontinuation of supplemental vitamin D and a diet low in calcium the concentrations of calcium and vitamin D in the serum gradually returned to normal over a period of 18 months. Roentgenograms of the bones showed evidence of demineralization rather than increased density as reported in other cases of "idiopathic" hypercalcemia. During a subsequent 2-year follow-up the patient has maintained a normal serum calcium. The etiology is discussed with particular reference to the role of vitamin D in this case

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Association Between Vitamin D and Hyperuricemia Among Adults in the United States

Frontiers in Nutrition ◽

10.3389/fnut.2020.592777 ◽

2020 ◽

Vol 7 ◽

Author(s):

Yi-Ying Zhang ◽

Hong-Bin Qiu ◽

Jin-Wei Tian

Keyword(s):

Vitamin D ◽

Uric Acid ◽

Serum Uric Acid ◽

The United States ◽

Dietary Vitamin ◽

Multivariable Logistic Regression Analysis ◽

Total Vitamin ◽

Vitamin D Intake ◽

Supplemental Vitamin ◽

Dietary Vitamin D

Background: Serum uric acid can act as a risk factor for cardiovascular disease (CVD) and as antioxidant defense. Vitamin D deficiency can activate the parathyroid to induce the release of parathyroid hormone, which was thought to increase serum uric acid level, and low vitamin D status may also be associated with risk of CVD. No known studies have explored the association between serum 25(OH) D, vitamin D intake, and HU for the American population.Methods: We extracted 15,723 US adults aged 20–85 years from the National Health and Nutrition Examination Survey (NHANES) in 2007–2014. All dietary intakes were evaluated through 24-h dietary recalls. Multivariable logistic regression analysis was performed to examine the associations after adjustment for confounders.Results: Compared to the lowest quintile (Q1), for males, adjusted odds ratios (ORs) of HU in Q2 to Q4 of serum 25(OH) D levels were 0.78 (95% CI, 0.65–0.93), 0.97 (0.81–1.16), and 0.72 (0.60–0.88); ORs in Q2–Q5 of total vitamin D intake were 0.83 (0.69–0.98), 0.69 (0.58–0.83), 0.66 (0.55–0.79), and 0.59 (0.48–0.71), respectively. In females, OR was 0.80 (0.66–0.97) of serum 25(OH) D for Q3, and ORs in Q5 of total vitamin D intake were 0.80 (0.65–0.98).Conclusions: Our findings indicated that the serum 25(OH) D intakes of dietary vitamin D, supplemental vitamin D, and total vitamin D were inversely associated with HU in males. In females, a lower risk of HU with higher serum 25(OH) D, dietary vitamin D, and total vitamin D intake was found, but with no association between supplemental vitamin D intake and the risk of HU.

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1162 LONG-TERM USE OF SUPPLEMENTAL VITAMIN C, VITAMIN D AND VITAMIN E DOES NOT REDUCE THE RISK OF UROTHELIAL CELL CARCINOMA OF THE BLADDER IN THE VITAMINS AND LIFESTYLE STUDY

The Journal of Urology ◽

10.1016/j.juro.2010.02.662 ◽

2010 ◽

Vol 183 (4S) ◽

Author(s):

James Hotaling ◽

Jonathan Wright ◽

Gaia Pocobelli ◽

Michael Porter ◽

Emily White

Keyword(s):

Vitamin D ◽

Vitamin E ◽

Vitamin C ◽

Cell Carcinoma ◽

Urothelial Cell ◽

Urothelial Cell Carcinoma ◽

Supplemental Vitamin ◽

Carcinoma Of The Bladder

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Bone mineral content and serum 25-hydroxyvitamin D concentration in breast-fed infants with and without supplemental vitamin D

The Journal of Pediatrics ◽

10.1016/s0022-3476(81)80827-x ◽

1981 ◽

Vol 98 (5) ◽

pp. 696-701 ◽

Cited By ~ 66

Author(s):

Frank R. Greer ◽

John E. Searcy ◽

Ronald S. Levin ◽

Jean J. Steichen ◽

Paule Steichen Asch ◽

...

Keyword(s):

Vitamin D ◽

Bone Mineral Content ◽

Bone Mineral ◽

Mineral Content ◽

Hydroxyvitamin D ◽

Supplemental Vitamin ◽

25 Hydroxyvitamin D ◽

Breast Fed

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Intake of vitamin D and calcium, sun exposure, and risk of breast cancer subtypes among black women

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqz302 ◽

2019 ◽

Vol 111 (2) ◽

pp. 396-405 ◽

Cited By ~ 3

Author(s):

Bo Qin ◽

Baichen Xu ◽

Nan Ji ◽

Song Yao ◽

Karen Pawlish ◽

...

Keyword(s):

Breast Cancer ◽

Vitamin D ◽

Black Women ◽

Sun Exposure ◽

Breast Cancer Subtypes ◽

Dietary Vitamin ◽

Cancer Subtypes ◽

Diet Supplements ◽

Supplemental Vitamin ◽

Logistic Regressions

ABSTRACT Background The randomized placebo-controlled Vitamin D and Omega-3 Trial suggested a possible benefit of vitamin D on cancer incidence among black individuals. However, data are limited regarding the impact of vitamin D on breast cancer subtypes among African-American/black women, who tend to develop more aggressive forms of breast cancer. Objectives We hypothesize that more vitamin D exposure (through diet, supplements, and sunlight) and higher intake of calcium are associated with decreased risk of estrogen receptor (ER)+ and ER− breast cancer, and of triple-negative breast cancer (TNBC) among black women. Methods This study was conducted among 1724 black cases and 1233 controls in the Women's Circle of Health Study (WCHS) and WCHS2. Polytomous logistic regressions were used to estimate ORs and 95% CIs of ER+ and ER− breast cancer; logistic regressions were used for TNBC. The ORs from each study were pooled using an inverse-variance-weighted random-effects model. Results Dietary vitamin D and calcium intake were not associated with risk of breast cancer subtypes in the pooled analysis. For supplemental vitamin D, we observed possible inverse associations between intake of ≤800 IU/d (compared with nonuse) and risk of several subtypes, with effects that appeared strongest for TNBC (OR: 0.58; 95% CI: 0.35, 0.94); no association was found for >800 IU/d. More daylight hours spent outdoors in a year was associated with lower risk of ER+, ER−, and TNBC (e.g., highest compared with lowest quartile: TNBC OR: 0.53; 95% CI: 0.31, 0.91; P-trend = 0.02). Conclusions Moderate supplemental vitamin D intake was associated with decreased risk of TNBC, and increased sun exposure was associated with reduced risk of ER+, ER−, and TNBC among black women.

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