scholarly journals Vimentin regulates lung cancer cell adhesion through a VAV2–Rac1 pathway to control focal adhesion kinase activity

Oncogene ◽  
2014 ◽  
Vol 34 (15) ◽  
pp. 1979-1990 ◽  
Author(s):  
L S Havel ◽  
E R Kline ◽  
A M Salgueiro ◽  
A I Marcus
Keyword(s):  
Lung Cancer ◽  
Cell Adhesion ◽  
Focal Adhesion Kinase ◽  
Cancer Cell ◽  
Focal Adhesion ◽  
Kinase Activity ◽  
Lung Cancer Cell ◽  
Cancer Cell Adhesion ◽  
Focal Adhesion Kinase Activity

Inhibitory role of focal adhesion kinase on anoikis in the lung cancer cell A549

2008 ◽  
Vol 32 (6) ◽  
pp. 663-670 ◽  
Author(s):  
G LIU ◽  
X MENG ◽  
Y JIN ◽  
J BAI ◽  
Y ZHAO ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cell ◽  
Focal Adhesion ◽  
Lung Cancer Cell ◽  
Inhibitory Role

Abstract 1963: Toll-like receptor activation in bacterial pneumonia increases lung cancer cell adhesion and metastasis formation

2014 ◽  
Author(s):  
Stephen D. Gowing ◽  
Simon C. Chow ◽  
Jonathan J. Cools-Lartigue ◽  
Crystal B. Chen ◽  
Betty Giannias ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Bacterial Pneumonia ◽  
Receptor Activation ◽  
Metastasis Formation ◽  
Toll Like Receptor ◽  
Lung Cancer Cell ◽  
Cancer Cell Adhesion

scholarly journals Abstract 98: Cell membrane cholesterol modulates lung cancer cell adhesion and rolling on E-selectin

2018 ◽  
Author(s):  
Amina Mohammadalipour ◽  
Christian Showalter ◽  
Harrison T. Muturi ◽  
Vishva Sharma ◽  
Amir M. Farnoud ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Adhesion ◽  
Cell Membrane ◽  
Cancer Cell ◽  
Membrane Cholesterol ◽  
Lung Cancer Cell ◽  
Cancer Cell Adhesion

scholarly journals Integrin-Linked Kinase: A Multi-functional Regulator Modulating Extracellular Pressure-Stimulated Cancer Cell Adhesion through Focal Adhesion Kinase and AKT

2009 ◽  
Vol 31 (4) ◽  
pp. 273-289
Author(s):  
Shouye Wang ◽  
Marc D. Basson
Keyword(s):  
Cell Adhesion ◽  
Focal Adhesion Kinase ◽  
Cancer Cell ◽  
Focal Adhesion ◽  
Cancer Metastasis ◽  
Metastatic Cancer ◽  
Loss Of Function ◽  
Akt Phosphorylation ◽  
Cancer Cell Adhesion ◽  
Integrin Linked Kinase

Cell adhesion is important in cancer metastasis. Malignant cells in cancer patients may be exposed to physical forces such as extracellular pressure and shear, that stimulate their adhesion to matrix proteins, endothelium and surgical wounds. Pressure induces phosphorylation of AKT and focal adhesion kinase (FAK), which are required for pressure-stimulated cancer cell adhesion, but what mediates this effect is unknown. ILK may influence cell adhesion and FAK and AKT phosphorylation in other settings. We therefore hypothesized that ILK might also regulate pressure-stimulated cancer cell adhesion through AKT and FAK phosphorylation. Silencing ILK by siRNA reduced basal cancer cell adhesion and prevented the stimulation of adhesion by pressure. ILK mediated pressure-stimulated adhesion through specifically regulating phosphorylation of AKT at Ser473 and FAK at Tyr397 and 576 as well as ILK association with FAK and AKT. The siRNA-mediated loss of function of ILK in regulating increase in adhesion by pressure was not rescued by overexpression of α-parvin, an important ILK binding partner, although pressure promoted ILK–α-parvin association and translocated both ILK and α-parvin from cytosol to membrane/cytoskeleton. ILK may be a key mediator of mechanotransduced signals in cancer cells and an important therapeutic target to inhibit metastatic cancer cell adhesion.

Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway

Toxicology ◽  
2013 ◽  
Vol 308 ◽  
pp. 104-112 ◽  
Author(s):  
Heyong Wang ◽  
Chunlian Wu ◽  
Shengbang Wan ◽  
Huijun Zhang ◽  
Songwen Zhou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Extracellular Matrix ◽  
Cell Adhesion ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Lung Cancer Cell ◽  
Integrin Β1 ◽  
Cancer Cell Adhesion
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