Inhibitory role of focal adhesion kinase on anoikis in the lung cancer cell A549

2008 ◽  
Vol 32 (6) ◽  
pp. 663-670 ◽  
Author(s):  
G LIU ◽  
X MENG ◽  
Y JIN ◽  
J BAI ◽  
Y ZHAO ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cell ◽  
Focal Adhesion ◽  
Lung Cancer Cell ◽  
Inhibitory Role

scholarly journals Inhibition of the Focal Adhesion Kinase Has Anti-Tumoral Effect in Small-Cell Lung Cancer Cell Lines

2015 ◽  
Vol 26 ◽  
pp. i17
Author(s):  
F. Aboubakar ◽  
M. Lecocq ◽  
B. Detry ◽  
L. Maha ◽  
P.P. Massion ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Focal Adhesion Kinase ◽  
Cell Lines ◽  
Cancer Cell ◽  
Focal Adhesion ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cell ◽  
Small Cell Lung

scholarly journals miR-196b-5p-mediated downregulation of FAS promotes NSCLC progression by activating IL6-STAT3 signaling

2020 ◽  
Vol 11 (9) ◽  
Author(s):  
Xiangjie Huang ◽  
Sisi Xiao ◽  
Xinping Zhu ◽  
Yun Yu ◽  
Meng Cao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Nsclc Tissue ◽  
Cancer Cell Growth ◽  
Tissue Samples ◽  
Stat3 Signaling ◽  
Transcription 3

Abstract Our recent study demonstrated that the QKI-5 regulated miRNA, miR-196b-5p, and it functions as an onco-microRNA in non-small cell lung cancer (NSCLC) by directly targeting GATA6 and TSPAN12. However, the role of miR-196b-5p in NSCLC progression and metastasis still remains unclear. We found that miR-196b-5p promotes lung cancer cell proliferation and colony formation by directly targeting tumor suppressor, FAS. The expression of FAS was significantly downregulated in NSCLC tissue samples and was negatively correlated with the miR-196b-5p expression. Knocking down FAS activates NFkB signaling and subsequent IL6 secretion, resulting in phosphorylation of signal transducer and activator of transcription 3 (STAT3) to promote lung cancer cell growth. Our findings indicated that miR-196b-5p might exhibit novel oncogenic function by FAS-mediated STAT3 activation in NSCLC, and suggested that targeting the miR-196b-5p/FAS/NFkB/IL6/STAT3 pathway might be a promising therapeutic strategy in treating NSCLC.

scholarly journals Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299

2015 ◽  
Vol 14 (2) ◽  
pp. 4005-4014 ◽  
Author(s):  
G.M. Chen ◽  
R.F. Ding ◽  
Y.D. Tan ◽  
X.B. Pan ◽  
G.M. Jiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Human Lung ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Proliferation And Apoptosis

Proliferation of Human Non–Small-Cell Lung Cancer Cell Lines: Role of Interleukin-6

1998 ◽  
Vol 19 (4) ◽  
pp. 606-612 ◽  
Author(s):  
Michel Bihl ◽  
Michael Tamm ◽  
Markus Nauck ◽  
Heinrich Wieland ◽  
André P. Perruchoud ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cell Lung Cancer ◽  
Interleukin 6 ◽  
Small Cell ◽  
Lung Cancer Cell ◽  
Small Cell Lung

scholarly journals Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

2003 ◽  
Vol 10 (9) ◽  
pp. 837-846 ◽  
Author(s):  
Yichin Liu ◽  
Hilal A. Lashuel ◽  
Sungwoon Choi ◽  
Xuechao Xing ◽  
April Case ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Lung Cancer Cell

scholarly journals Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation

2016 ◽  
Vol 17 (11) ◽  
pp. 1860 ◽  
Author(s):  
Sophie Béraud-Dufour ◽  
Christelle Devader ◽  
Fabienne Massa ◽  
Morgane Roulot ◽  
Thierry Coppola ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cell ◽  
Focal Adhesion ◽  
Colorectal Cancer Cell ◽  
Soluble Form ◽  
Cell Dissociation ◽  
Neurotensin Receptor
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