scholarly journals Characteristics and outcomes of 627 044 COVID-19 patients living with and without obesity in the United States, Spain, and the United Kingdom

2021 ◽  
Author(s):  
Martina Recalde ◽  
Elena Roel ◽  
Andrea Pistillo ◽  
Anthony G. Sena ◽  
Albert Prats-Uribe ◽  
...  
Keyword(s):  
The United States ◽  
Common Data Model ◽  
Medical Conditions ◽  
The United Kingdom ◽  
Hospitalization Rates ◽  
Respiratory Events ◽  
Obesity Status ◽  
Wide Range ◽  
Prevalence Of Obesity ◽  
The Uk

Abstract Background A detailed characterization of patients with COVID-19 living with obesity has not yet been undertaken. We aimed to describe and compare the demographics, medical conditions, and outcomes of COVID-19 patients living with obesity (PLWO) to those of patients living without obesity. Methods We conducted a cohort study based on outpatient/inpatient care and claims data from January to June 2020 from Spain, the UK, and the US. We used six databases standardized to the OMOP common data model. We defined two non-mutually exclusive cohorts of patients diagnosed and/or hospitalized with COVID-19; patients were followed from index date to 30 days or death. We report the frequency of demographics, prior medical conditions, and 30-days outcomes (hospitalization, events, and death) by obesity status. Results We included 627 044 (Spain: 122 058, UK: 2336, and US: 502 650) diagnosed and 160 013 (Spain: 18 197, US: 141 816) hospitalized patients with COVID-19. The prevalence of obesity was higher among patients hospitalized (39.9%, 95%CI: 39.8−40.0) than among those diagnosed with COVID-19 (33.1%; 95%CI: 33.0−33.2). In both cohorts, PLWO were more often female. Hospitalized PLWO were younger than patients without obesity. Overall, COVID-19 PLWO were more likely to have prior medical conditions, present with cardiovascular and respiratory events during hospitalization, or require intensive services compared to COVID-19 patients without obesity. Conclusion We show that PLWO differ from patients without obesity in a wide range of medical conditions and present with more severe forms of COVID-19, with higher hospitalization rates and intensive services requirements. These findings can help guiding preventive strategies of COVID-19 infection and complications and generating hypotheses for causal inference studies.

scholarly journals Characteristics and outcomes of 627 044 COVID-19 patients with and without obesity in the United States, Spain, and the United Kingdom

2020 ◽  
Author(s):  
Martina Recalde ◽  
Elena Roel ◽  
Andrea Pistillo ◽  
Anthony G Sena ◽  
Albert Prats-Uribe ◽  
...  
Keyword(s):  
Data Model ◽  
The United States ◽  
Common Data Model ◽  
Obese Patients ◽  
The United Kingdom ◽  
Respiratory Events ◽  
Obesity Status ◽  
The Us ◽  
Prevalence Of Obesity ◽  
The Uk

Background: COVID-19 may differentially impact people with obesity. We aimed to describe and compare the demographics, comorbidities, and outcomes of obese patients with COVID-19 to those of non-obese patients with COVID-19, or obese patients with seasonal influenza. Methods: We conducted a cohort study based on outpatient/inpatient care, and claims data from January to June 2020 from the US, Spain, and the UK. We used six databases standardized to the OMOP common data model. We defined two cohorts of patients diagnosed and/or hospitalized with COVID-19. We created corresponding cohorts for patients with influenza in 2017-2018. We followed patients from index date to 30 days or death. We report the frequency of socio-demographics, prior comorbidities, and 30-days outcomes (hospitalization, events, and death) by obesity status. Findings: We included 627 044 COVID-19 (US: 502 650, Spain: 122 058, UK: 2336) and 4 549 568 influenza (US: 4 431 801, Spain: 115 224, UK: 2543) patients. The prevalence of obesity was higher among hospitalized COVID-19 (range: 38% to 54%) than diagnosed COVID-19 (30% to 47%), or diagnosed/hospitalized influenza (15% to 48%) patients. Obese hospitalized COVID-19 patients were more often female and younger than non-obese COVID-19 patients or obese influenza patients. Obese COVID-19 patients were more likely to have prior comorbidities, present with cardiovascular and respiratory events during hospitalization, require intensive services, or die compared to non-obese COVID-19 patients. Obese COVID-19 patients were also more likely to require intensive services or die compared to obese influenza patients, despite presenting with fewer comorbidities. Interpretation: We show that obesity is more common among COVID-19 than influenza patients, and that obese patients present with more severe forms of COVID-19 with higher hospitalization, intensive services, and fatality than non-obese patients. These data are instrumental for guiding preventive strategies of COVID-19 infection and complications

scholarly journals Implications for Northern Europe of the emergence of West Nile virus in the USA

2003 ◽  
Vol 131 (1) ◽  
pp. 583-589 ◽  
Author(s):  
E. A. GOULD
Keyword(s):  
United Kingdom ◽  
West Nile Virus ◽  
The United States ◽  
Health Problems ◽  
West Nile ◽  
Potential Health ◽  
The United Kingdom ◽  
Wide Range ◽  
The Usa ◽  
The Uk

The unexpected appearance of fatal encephalitis in six elderly people living in New York in 1999, heralded the re-birth of arbovirology in the United States of America. The subsequent rapid spread through North America and impact of the disease on humans, birds, horses and a wide range of other species including alligators and frogs, has brought West Nile virus (WNV) to the attention of governments and the media, worldwide. The response of the public in the United Kingdom has not been hysterical, despite being fuelled by press reports that scientists have demonstrated the presence of WNV antibodies in birds in the UK. Nevertheless, concern has been expressed by government bodies either directly or indirectly connected with the potential health problems that could arise if WNV was introduced and caused the same degree of morbidity and mortality as that seen in the USA. Is the concern justified and are we likely to see significant health problems associated with WNV if this virus is confirmed to be present and circulating amongst birds in the UK? In this review I shall try to put the virus in its true context and assess the risks that WNV might pose both to animals and humans in the United Kingdom.

Science, Politics, and the Pandemic

2020 ◽  
Vol 119 (820) ◽  
pp. 303-309
Author(s):  
J. Nicholas Ziegler
Keyword(s):  
United States ◽  
Biomedical Research ◽  
Scale Up ◽  
Political Leadership ◽  
The United States ◽  
Scientific Advice ◽  
The United Kingdom ◽  
Effective Policy ◽  
Scientific Expertise ◽  
The Uk

Comparing the virus responses in Germany, the United Kingdom, and the United States shows that in order for scientific expertise to result in effective policy, rational political leadership is required. Each of these three countries is known for advanced biomedical research, yet their experiences in the COVID-19 pandemic diverged widely. Germany’s political leadership carefully followed scientific advice and organized public–private partnerships to scale up testing, resulting in relatively low infection levels. The UK and US political responses were far more erratic and less informed by scientific advice—and proved much less effective.

scholarly journals Social Sensing of Heatwaves

Sensors ◽  
2021 ◽  
Vol 21 (11) ◽  
pp. 3717
Author(s):  
James C. Young ◽  
Rudy Arthur ◽  
Michelle Spruce ◽  
Hywel T. P. Williams
Keyword(s):  
New York ◽  
The United States ◽  
Measured Temperature ◽  
Social Sensing ◽  
Public Response ◽  
Environmental Consequences ◽  
The United Kingdom ◽  
Social Reaction ◽  
Twitter Activity ◽  
The Uk

Heatwaves cause thousands of deaths every year, yet the social impacts of heat are poorly measured. Temperature alone is not sufficient to measure impacts and “heatwaves” are defined differently in different cities/countries. This study used data from the microblogging platform Twitter to detect different scales of response and varying attitudes to heatwaves within the United Kingdom (UK), the United States of America (US) and Australia. At the country scale, the volume of heat-related Twitter activity increased exponentially as temperature increased. The initial social reaction differed between countries, with a larger response to heatwaves elicited from the UK than from Australia, despite the comparatively milder conditions in the UK. Language analysis reveals that the UK user population typically responds with concern for individual wellbeing and discomfort, whereas Australian and US users typically focus on the environmental consequences. At the city scale, differing responses are seen in London, Sydney and New York on governmentally defined heatwave days; sentiment changes predictably in London and New York over a 24-h period, while sentiment is more constant in Sydney. This study shows that social media data can provide robust observations of public response to heat, suggesting that social sensing of heatwaves might be useful for preparedness and mitigation.

scholarly journals Hedging in English texts written by lower secondary pupils attending Norwegian schools

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
James Jacob Thomson
Keyword(s):  
Language Learners ◽  
Second Language Learners ◽  
The United States ◽  
School Level ◽  
The Novel ◽  
Factors Affecting ◽  
9Th Grade ◽  
Written Texts ◽  
Wide Range ◽  
The Uk

This study analyses the use of hedges in English texts written by year nine[1] pupils attending Norwegian lower secondary schools. Hedges are quantified in a corpus of 82 pupil texts using a taxonomy consisting of five hedging categories: Adaptors, Rounders, Plausibility Shields, Explicit Markers of Author Involvement and Verbal Fillers (Prince et al., 1980; Salager-Meyer, 1994; Holmes, 1986). As the pupils are school-level second language learners of English, each device is also deemed to be either accurately or inaccurately used based on grammar, well-formedness and appropriateness (Fetzer, 2004). The analyses are compared across topic, holistic ratings and formality. Texts in the corpus are written about two topics: sports and literary analyses of the novel Holes (Sachar, 1998). Texts about sports contain significantly more hedges than texts about Holes. Comparing accurate and inaccurate categories across holistic ratings, different results were produced when considering topic. Informally written texts about sports contain higher frequencies of accurately used devices than formally written texts about sports. The results suggest that topic and formality are the most significant factors affecting hedging use in this corpus. While hedging frequency overall does not seem to correlate with holistic ratings, overuse and inaccurate use of hedges seems to affect quality. Based on the results, it is argued that pupils may benefit from exposure to a wide range of accurately used devices. [1] “Year 9” is a term usually used in the UK, synonymous with “9th grade” used in the United States, for pupils aged 13-14.

scholarly journals A Comparative Survey Of Capital Investment Decision Practices In The United States And The United Kingdom

2011 ◽  
Vol 1 (11) ◽  
Author(s):  
Thomas Klammer ◽  
Neil Wilner ◽  
Jan Smolarski
Keyword(s):  
United States ◽  
Risk Management ◽  
United Kingdom ◽  
The United States ◽  
Capital Expenditures ◽  
The United Kingdom ◽  
Management Techniques ◽  
Comparative Survey ◽  
The Uk

Capital expenditures can be crucial to firms long-term success, especially in a complex global environment. As companies increasingly compete in the global market place, it is important to study project evaluation processes from an international perspective. Capital investments involve substantial monetary commitments and risks that affect long-term firm profitability and influence capital allocation decisions in the future. Survey research in the area of capital expenditure analysis has been extensively done in both the United States [US] and the United Kingdom [UK]. This research is the first comparative survey of practices in both countries that we are aware of. A direct comparison of the use of project evaluation, management science, and risk management techniques in the two countries is made. The survey instrument used is an adaptation of the Klammer [1970] instrument that has been used repeatedly in surveys of American firms. This is the first time that it has been applied to British firms. The use of a common instrument allows for more meaningful comparisons. The samples consisted of 127 American and 59 British firms with sales of at least $100 million and capital expenditures of at least $10 million. Preliminary results indicate a continued extensive use of discounted cash flow techniques by US firms. Techniques such as payback or urgency continue to be used, but to a lesser degree than discounting. Firms in the UK also make extensive use of discounting but do so to a lesser degree than their American counterparts. Payback is widely used in the UK. Risk management techniques are widely used in both countries, with sensitivity analysis being the most popular technique in both countries. Extensive use of technical and administrative procedures, such as detailed budgets, standardized forms and post-audits, are evidenced in both countries. The paper offers reasons that have to do with organizational structure and form, as well as market differences, to explain our results.

Association between Somatic Cell Count progeny tests in the United States of America (USA), The Netherlands and the United Kingdom (UK)

1997 ◽  
Vol 1997 ◽  
pp. 25-25
Author(s):  
R A Mrode ◽  
G J T Swanson
Keyword(s):  
Somatic Cell ◽  
Cell Count ◽  
The United States ◽  
Clinical Mastitis ◽  
Management Control ◽  
The United Kingdom ◽  
Cell Counts ◽  
Animal Data ◽  
Control Programmes ◽  
The Uk

Mastitis remains a costly health problem to dairy farmers despite a significant reduction in both clinical and sub-clinical mastitis over the last 25 years. This reduction has been due predominantly to the success of management control programmes. The continuing losses have raised the interest in breeding as a means to reduce mastitis incidence. Somatic Cell Counts (SCC) have been used since 1977 as an indirect means of monitoring mastitis within dairy herds. Since 1991 an optional individual cell count service has been offered by Milk Recording Organisations in the UK. The result is that 0.80 of recorded cows have SCC records. The Animal Data Centre has analysed the SCC data to establish genetic parameters and produced preliminary evaluations on bulls and cows (Mrode et al, 1996). As a forerunner to launching SCC evaluations it is important to determine whether SCC evaluations in the UK agree with similar evaluations overseas.

Antitrust Regulation of IT Giants` Activities: Main Trends of Foreign and Russian Legislation

2021 ◽  
Author(s):  
D.V. Shram ◽  
Keyword(s):  
House Of Representatives ◽  
Network Effects ◽  
The United States ◽  
The European Union ◽  
The United Kingdom ◽  
The Us ◽  
The Usa ◽  
Economic Concentration ◽  
The Uk ◽  
Antitrust Regulation

The article is devoted to the antimonopoly regulation of IT giants` activities. The author presents an overview of the main trends in foreign and Russian legislation in this area. The problems the antimonopoly regulation of digital markets faces are the following: the complexity of determining the criteria for the dominant position of economic entities in the digital economy and the criteria for assessing the economic concentration in the commodity digital markets; the identification and suppression of cartels; the relationship between competition law and intellectual property rights in the digital age. Some aspects of these problems are considered through the prism of the main trends in the antimonopoly policy in the United States, the European Union, the United Kingdom and Russia. The investigation findings of the USA House of Representatives Antitrust Subcommittee against Apple, Google, Amazon and Facebook are presented. The author justifies the need to separate them, which requires the adoption of appropriate amendments to the antimonopoly legislation. The article analyzes the draft law of the European Commission on the regulation of digital markets – Digital Markets Act, reveals the criteria for classifying IT companies as «gatekeepers», and notes the specific approaches to antimonopoly regulation in the UK and the US. The article describes the concepts «digital platform» and «network effects», presented in the «fifth antimonopoly package of amendments», developed in 2018 by the Federal Antimonopoly Service of the Russian Federation, and gives an overview of the comments of the Ministry of Economic Development regarding these concepts wording in the text of the draft law, which formed the basis for the negative conclusion of the regulator. It is concluded that in the context of the digital markets’ globalization, there is a need for the international legal nature antitrust norms formation, since regional legislation obviously cannot cope with the monopolistic activities of IT giants.

Diabetes mellitus and the kidney

2010 ◽  
pp. 4021-4032
Author(s):  
Rudolf Bilous
Keyword(s):  
Renal Disease ◽  
United States Of America ◽  
The United States ◽  
Endstage Renal Disease ◽  
The United Kingdom ◽  
The Uk ◽  
Developed World ◽  
Incident Rates

Diabetic nephropathy is the commonest cause of endstage renal disease in the developed world, causing 44% of prevalent cases requiring renal replacement therapy in the United States of America in 2012 and 25% in the United Kingdom in 2013. Incident rates have increased slightly in the UK at 25% of all new patients accepted onto RRT in 2013. Most patients have type 2 diabetes, and in most countries the proportion with endstage renal disease who have type 1 diabetes is falling....

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