Using low-cost sensor technologies and advanced computational methods to improve dose estimations in health panel studies: results of the AIRLESS project

Wearable devices offer a convenient means to monitor biosignals in real time at relatively low cost, and provide continuous monitoring without causing any discomfort. Among signals that contain critical information about human body status, electromyography (EMG) signal is particular useful in monitoring muscle functionality and activity during sport, fitness, or daily life. In particular surface electromyography (sEMG) has proven to be a suitable technique in several health monitoring applications, thanks to its non-invasiveness and ease to use. However, recording EMG signals from multiple channels yields a large amount of data that increases the power consumption of wireless transmission thus reducing the sensor lifetime. Compressed sensing (CS) is a promising data acquisition solution that takes advantage of the signal sparseness in a particular basis to significantly reduce the number of samples needed to reconstruct the signal. As a large variety of algorithms have been developed in recent years with this technique, it is of paramount importance to assess their performance in order to meet the stringent energy constraints imposed in the design of low-power wireless body area networks (WBANs) for sEMG monitoring. The aim of this paper is to present a comprehensive comparative study of computational methods for CS reconstruction of EMG signals, giving some useful guidelines in the design of efficient low-power WBANs. For this purpose, four of the most common reconstruction algorithms used in practical applications have been deeply analyzed and compared both in terms of accuracy and speed, and the sparseness of the signal has been estimated in three different bases. A wide range of experiments are performed on real-world EMG biosignals coming from two different datasets, giving rise to two different independent case studies.

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Computational methods for identifying the critical nodes in biological networks

Briefings in Bioinformatics ◽

10.1093/bib/bbz011 ◽

2019 ◽

Vol 21 (2) ◽

pp. 486-497 ◽

Cited By ~ 15

Author(s):

Xiangrong Liu ◽

Zengyan Hong ◽

Juan Liu ◽

Yuan Lin ◽

Alfonso Rodríguez-Patón ◽

...

Keyword(s):

Computational Methods ◽

Biological Networks ◽

Biological Network ◽

Low Cost ◽

Experimental Methods ◽

Computing Methods ◽

Critical Nodes

Abstract A biological network is complex. A group of critical nodes determines the quality and state of such a network. Increasing studies have shown that diseases and biological networks are closely and mutually related and that certain diseases are often caused by errors occurring in certain nodes in biological networks. Thus, studying biological networks and identifying critical nodes can help determine the key targets in treating diseases. The problem is how to find the critical nodes in a network efficiently and with low cost. Existing experimental methods in identifying critical nodes generally require much time, manpower and money. Accordingly, many scientists are attempting to solve this problem by researching efficient and low-cost computing methods. To facilitate calculations, biological networks are often modeled as several common networks. In this review, we classify biological networks according to the network types used by several kinds of common computational methods and introduce the computational methods used by each type of network.

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Hypothesis onSerenoa repens(Bartram) small extract inhibition of prostatic 5α-reductase through anin silicoapproach on 5β-reductase x-ray structure

PeerJ ◽

10.7717/peerj.2698 ◽

2016 ◽

Vol 4 ◽

pp. e2698 ◽

Cited By ~ 2

Author(s):

Paolo Governa ◽

Daniela Giachetti ◽

Marco Biagi ◽

Fabrizio Manetti ◽

Luca De Vico

Keyword(s):

Benign Prostatic Hyperplasia ◽

Computational Methods ◽

Low Cost ◽

Prostatic Hyperplasia ◽

Common Disease ◽

Serenoa Repens ◽

Herbal Products ◽

Docking Simulations ◽

Mechanism Of Inhibition ◽

The Right

Benign prostatic hyperplasia is a common disease in men aged over 50 years old, with an incidence increasing to more than 80% over the age of 70, that is increasingly going to attract pharmaceutical interest. Within conventional therapies, such asα-adrenoreceptor antagonists and 5α-reductase inhibitor, there is a large requirement for treatments with less adverse events on, e.g., blood pressure and sexual function: phytotherapy may be the right way to fill this need.Serenoa repensstandardized extract has been widely studied and its ability to reduce lower urinary tract symptoms related to benign prostatic hyperplasia is comprehensively described in literature. An innovative investigation on the mechanism of inhibition of 5α-reductase bySerenoa repensextract active principles is proposed in this work through computational methods, performing molecular docking simulations on the crystal structure of human liver 5β-reductase. The results confirm that both sterols and fatty acids can play a role in the inhibition of the enzyme, thus, suggesting a competitive mechanism of inhibition. This work proposes a further confirmation for the rational use of herbal products in the management of benign prostatic hyperplasia, and suggests computational methods as an innovative, low cost, and non-invasive process for the study of phytocomplex activity toward proteic targets.

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An accurate cost effective DFT approach to study the sensing behaviour of polypyrrole towards nitrate ions in gas and aqueous phases

Physical Chemistry Chemical Physics ◽

10.1039/c6cp02271e ◽

2016 ◽

Vol 18 (28) ◽

pp. 19236-19247 ◽

Cited By ~ 30

Author(s):

Fatima Wasim ◽

Tariq Mahmood ◽

Khurshid Ayub

Keyword(s):

Interaction Energy ◽

Computational Methods ◽

Low Cost ◽

Cost Effective ◽

Nitrate Ions

A variety of low cost computational methods are evaluated to accurately calculate the interaction energy between polypyrrole and nitrate ions.

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Hypothesis on Serenoa repens (Bartram) small extract inhibition of prostatic 5α-reductase through an in silico approach on 5β-reductase x-ray structure

10.7287/peerj.preprints.2543v1 ◽

2016 ◽

Author(s):

Paolo Governa ◽

Daniela Giachetti ◽

Marco Biagi ◽

Fabrizio Manetti ◽

Luca De Vico

Keyword(s):

Benign Prostatic Hyperplasia ◽

Computational Methods ◽

Low Cost ◽

Prostatic Hyperplasia ◽

Common Disease ◽

Serenoa Repens ◽

Herbal Products ◽

Docking Simulations ◽

Mechanism Of Inhibition ◽

The Right

Benign prostatic hyperplasia is a common disease in men aged over 50 years old, with an incidence increasing to more than 80% over the age of 70, that is increasingly going to attract pharmaceutical interest. Within conventional therapies, such as α-adrenoreceptor antagonists and 5α-reductase inhibitor, there is a large requirement for treatments with less adverse events on, e.g., blood pressure and sexual function: phytotherapy may be the right way to fill this need. Serenoa repens standardized extract has been widely studied and its ability to reduce lower urinary tract symptoms related to benign prostatic hyperplasia is comprehensively described in literature. An innovative investigation on the mechanism of inhibition of 5α-reductase by Serenoa repens extract active principles is proposed in this work through computational methods, performing molecular docking simulations on the crystal structure of human liver 5β-reductase. The results confirm that both sterols and fatty acids can play a role in the inhibition of the enzyme, thus, suggesting a competitive mechanism of inhibition. This work proposes a further confirmation for the rational use of herbal products in the management of benign prostatic hyperplasia, and suggests computational methods as an innovative, low cost, and non-invasive process for the study of phytocomplex activity toward proteic targets.

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Hypothesis on Serenoa repens (Bartram) small extract inhibition of prostatic 5α-reductase through an in silico approach on 5β-reductase x-ray structure

10.7287/peerj.preprints.2543 ◽

2016 ◽

Author(s):

Paolo Governa ◽

Daniela Giachetti ◽

Marco Biagi ◽

Fabrizio Manetti ◽

Luca De Vico

Keyword(s):

Benign Prostatic Hyperplasia ◽

Computational Methods ◽

Low Cost ◽

Prostatic Hyperplasia ◽

Common Disease ◽

Serenoa Repens ◽

Herbal Products ◽

Docking Simulations ◽

Mechanism Of Inhibition ◽

The Right

Benign prostatic hyperplasia is a common disease in men aged over 50 years old, with an incidence increasing to more than 80% over the age of 70, that is increasingly going to attract pharmaceutical interest. Within conventional therapies, such as α-adrenoreceptor antagonists and 5α-reductase inhibitor, there is a large requirement for treatments with less adverse events on, e.g., blood pressure and sexual function: phytotherapy may be the right way to fill this need. Serenoa repens standardized extract has been widely studied and its ability to reduce lower urinary tract symptoms related to benign prostatic hyperplasia is comprehensively described in literature. An innovative investigation on the mechanism of inhibition of 5α-reductase by Serenoa repens extract active principles is proposed in this work through computational methods, performing molecular docking simulations on the crystal structure of human liver 5β-reductase. The results confirm that both sterols and fatty acids can play a role in the inhibition of the enzyme, thus, suggesting a competitive mechanism of inhibition. This work proposes a further confirmation for the rational use of herbal products in the management of benign prostatic hyperplasia, and suggests computational methods as an innovative, low cost, and non-invasive process for the study of phytocomplex activity toward proteic targets.

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Decomposition of the metastable beta titanium alloy Ti-15-3

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100075117 ◽

1983 ◽

Vol 41 ◽

pp. 264-265

Author(s):

Y. L. Chen ◽

S. Fujlshiro

Keyword(s):

Low Cost ◽

High Strength ◽

Alpha Phase ◽

Thick Sheet ◽

Omega Phase ◽

Beta Titanium Alloy ◽

Beta Titanium ◽

Beta Matrix ◽

Metastable Beta ◽

Very High

Metastable beta titanium alloys have been known to have numerous advantages such as cold formability, high strength, good fracture resistance, deep hardenability, and cost effectiveness. Very high strength is obtainable by precipitation of the hexagonal alpha phase in a bcc beta matrix in these alloys. Precipitation hardening in the metastable beta alloys may also result from the formation of transition phases such as omega phase. Ti-15-3 (Ti-15V- 3Cr-3Al-3Sn) has been developed recently by TIMET and USAF for low cost sheet metal applications. The purpose of the present study was to examine the aging characteristics in this alloy.The composition of the as-received material is: 14.7 V, 3.14 Cr, 3.05 Al, 2.26 Sn, and 0.145 Fe. The beta transus temperature as determined by optical metallographic method was about 770°C. Specimen coupons were prepared from a mill-annealed 1.2 mm thick sheet, and solution treated at 827°C for 2 hr in argon, then water quenched. Aging was also done in argon at temperatures ranging from 316 to 616°C for various times.

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Chromic Acid Etching of Polyethylene

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100070801 ◽

1973 ◽

Vol 31 ◽

pp. 72-73

Author(s):

J. D. Muzzy ◽

R. D. Hester ◽

J. L. Hubbard

Keyword(s):

Chromic Acid ◽

Low Cost ◽

Acid Etching ◽

Crystalline Morphology ◽

Bulk Specimen ◽

Morphological Studies ◽

Perfect Form ◽

Molecular Length ◽

Lamellar Texture ◽

Cost Studies

Polyethylene is one of the most important plastics produced today because of its good physical properties, ease of fabrication and low cost. Studies to improve the properties of polyethylene are leading to an understanding of its crystalline morphology. Polyethylene crystallized by evaporation from dilute solutions consists of thin crystals called lamellae. The polyethylene molecules are parallel to the thickness of the lamellae and are folded since the thickness of the lamellae is much less than the molecular length. This lamellar texture persists in less perfect form in polyethylene crystallized from the melt.Morphological studies of melt crystallized polyethylene have been limited due to the difficulty of isolating the microstructure from the bulk specimen without destroying or deforming it.

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Glass Knife Geometry as Seen by the SEM

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100066322 ◽

1971 ◽

Vol 29 ◽

pp. 454-455

Author(s):

J. Temple Black

Keyword(s):

Low Cost ◽

Amorphous Material ◽

Stress Concentrations ◽

Basic Tool ◽

Tool Materials ◽

Optical Inspection ◽

Surface Flaws ◽

Slip Planes ◽

Glass Knife ◽

Diamond Knife

In ultramicrotomy, the two basic tool materials are glass and diamond. Glass because of its low cost and ease of manufacture of the knife itself is still widely used despite the superiority of diamond knives in many applications. Both kinds of knives produce plastic deformation in the microtomed section due to the nature of the cutting process and microscopic chips in the edge of the knife. Because glass has no well defined slip planes in its structure (it's an amorphous material), it is very strong and essentially never fails in compression. However, surface flaws produce stress concentrations which reduce the strength of glass to 10,000 to 20,000 psi from its theoretical or flaw free values of 1 to 2 million psi. While the microchips in the edge of the glass or diamond knife are generally too small to be observed in the SEM, the second common type of defect can be identified. This is the striations (also termed the check marks or feathers) which are always present over the entire edge of a glass knife regardless of whether or not they are visable under optical inspection. These steps in the cutting edge can be observed in the SEM by proper preparation of carefully broken knives and orientation of the knife, with respect to the scanning beam.

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Spectraplot: A PC-based spectrum translation and display program

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010010665x ◽

1988 ◽

Vol 46 ◽

pp. 918-919

Author(s):

H. O. Colijn

Keyword(s):

Low Cost ◽

Transfer Program ◽

File Transfer ◽

Transfer Data ◽

Error Checking ◽

Data Files ◽

The University

Many labs today wish to transfer data between their EDS systems and their existing PCs and minicomputers. Our lab has implemented SpectraPlot, a low- cost PC-based system to allow offline examination and plotting of spectra. We adopted this system in order to make more efficient use of our microscopes and EDS consoles, to provide hardcopy output for an older EDS system, and to allow students to access their data after leaving the university.As shown in Fig. 1, we have three EDS systems (one of which is located in another building) which can store data on 8 inch RT-11 floppy disks. We transfer data from these systems to a DEC MINC computer using “SneakerNet”, which consists of putting on a pair of sneakers and running down the hall. We then use the Hermit file transfer program to download the data files with error checking from the MINC to the PC.

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