Ileal immune tonus is a prognosis marker of proximal colon cancer in mice and patients

AbstractIleal epithelial cell apoptosis and the local microbiota modulate the effects of oxaliplatin against proximal colon cancer by modulating tumor immunosurveillance. Here, we identified an ileal immune profile associated with the prognosis of colon cancer and responses to chemotherapy. The whole immune ileal transcriptome was upregulated in poor-prognosis patients with proximal colon cancer, while the colonic immunity of healthy and neoplastic areas was downregulated (except for the Th17 fingerprint) in such patients. Similar observations were made across experimental models of implanted and spontaneous murine colon cancer, showing a relationship between carcinogenesis and ileal inflammation. Conversely, oxaliplatin-based chemotherapy could restore a favorable, attenuated ileal immune fingerprint in responders. These results suggest that chemotherapy inversely shapes the immune profile of the ileum–tumor axis, influencing clinical outcome.

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Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer

British Journal of Cancer ◽

10.1038/bjc.2015.296 ◽

2015 ◽

Vol 113 (6) ◽

pp. 979-988 ◽

Cited By ~ 14

Author(s):

Robert N Jorissen ◽

Michael Christie ◽

Dmitri Mouradov ◽

Anuratha Sakthianandeswaren ◽

Shan Li ◽

...

Keyword(s):

Colon Cancer ◽

Poor Prognosis ◽

Proximal Colon ◽

Wild Type

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Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2016.07.001 ◽

2016 ◽

Vol 83 ◽

pp. 536-541 ◽

Cited By ~ 70

Author(s):

Yaser Gamallat ◽

Abdo Meyiah ◽

Eugene D. Kuugbee ◽

Ahmed Musa Hago ◽

Gift Chiwala ◽

...

Keyword(s):

Colon Cancer ◽

Animal Model ◽

Epithelial Cell ◽

Cell Apoptosis ◽

Lactobacillus Rhamnosus ◽

Cancer Development ◽

Epithelial Cell Apoptosis

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Suppression of the NF-κB cofactor Bcl3 inhibits mammary epithelial cell apoptosis and, in breast tumours, correlates with poor prognosis

Breast Cancer Research ◽

10.1186/bcr1884 ◽

2008 ◽

Vol 10 (S2) ◽

Cited By ~ 1

Author(s):

A Wakefield ◽

L Piggott ◽

D Croston ◽

WG Jiang ◽

R Clarkson

Keyword(s):

Epithelial Cell ◽

Cell Apoptosis ◽

Mammary Epithelial Cell ◽

Poor Prognosis ◽

Mammary Epithelial ◽

Breast Tumours ◽

Epithelial Cell Apoptosis

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A Tale of Two Colons and Two Cancers

Swiss Surgery ◽

10.1024/1023-9332.9.1.3 ◽

2003 ◽

Vol 9 (1) ◽

pp. 3-7 ◽

Cited By ~ 5

Author(s):

Gervaz ◽

Bühler ◽

Scheiwiller ◽

Morel

Keyword(s):

Colorectal Cancer ◽

Colon Cancer ◽

Adjuvant Chemotherapy ◽

Splenic Flexure ◽

Chromosomal Instability ◽

Proximal Colon ◽

Colorectal Carcinogenesis ◽

Physiological Data ◽

Central Hypothesis ◽

Group Stratification

The central hypothesis explored in this paper is that colorectal cancer (CRC) is a heterogeneous disease. The initial clue to this heterogeneity was provided by genetic findings; however, embryological and physiological data had previously been gathered, showing that proximal (in relation to the splenic flexure) and distal parts of the colon represent distinct entities. Molecular biologists have identified two distinct pathways, microsatellite instability (MSI) and chromosomal instability (CIN), which are involved in CRC progression. In summary, there may be not one, but two colons and two types of colorectal carcinogenesis, with distinct clinical outcome. The implications for the clinicians are two-folds; 1) tumors originating from the proximal colon have a better prognosis due to a high percentage of MSI-positive lesions; and 2) location of the neoplasm in reference to the splenic flexure should be documented before group stratification in future trials of adjuvant chemotherapy in patients with stage II and III colon cancer.

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