scholarly journals Structure of the type VI secretion system TssK–TssF–TssG baseplate subcomplex revealed by cryo-electron microscopy

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Young-Jun Park ◽  
Kaitlyn D. Lacourse ◽  
Christian Cambillau ◽  
Frank DiMaio ◽  
Joseph D. Mougous ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Secretion System ◽  
Type Vi Secretion System ◽  
Type Vi Secretion ◽  
Cryo Electron Microscopy

scholarly journals Clinical impact of the type VI secretion system on virulence of Campylobacter species during infection

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jessica Agnetti ◽  
Helena M. B. Seth-Smith ◽  
Sebastian Ursich ◽  
Josiane Reist ◽  
Marek Basler ◽  
...  
Keyword(s):  
Secretion System ◽  
Clinical Impact ◽  
Type Vi Secretion System ◽  
Type Vi Secretion ◽  
Campylobacter Species

scholarly journals VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion System

2016 ◽  
Vol 12 (6) ◽  
pp. e1005735 ◽  
Author(s):  
Francesca R. Cianfanelli ◽  
Juliana Alcoforado Diniz ◽  
Manman Guo ◽  
Virginia De Cesare ◽  
Matthias Trost ◽  
...  
Keyword(s):  
Secretion System ◽  
Functional Type ◽  
Type Vi Secretion System ◽  
Type Vi Secretion

scholarly journals Expression of the Type VI Secretion System 1 Component Hcp1 Is Indirectly Repressed by OpaR inVibrio parahaemolyticus

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Lizhi Ma ◽  
Yiquan Zhang ◽  
Xiaojuan Yan ◽  
Liping Guo ◽  
Li Wang ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Stress Responses ◽  
Structural Component ◽  
Vibrio Parahaemolyticus ◽  
Secretion System ◽  
Upstream Region ◽  
Bacterial Protein ◽  
Type Vi Secretion System ◽  
Type Vi Secretion ◽  
System 1

The type VI secretion system (T6SS) is bacterial protein injection machinery with roles in virulence, symbiosis, interbacterial interaction, antipathogenesis, and environmental stress responses. There are two T6SS loci, T6SS1 and T6SS2, in the two chromosomes ofVibrio parahaemolyticus, respectively. This work disclosed that the master quorum sensing (QS) regulator OpaR repressed the transcription ofhcp1encoding the structural component Hcp1 of T6SS1 inV. parahaemolyticus, indicating that QS had a negative regulatory action on T6SS1. A singleσ54-dependent promoter was transcribed forhcp1inV. parahaemolyticus, and its activity was repressed by the OpaR regulator. Since the OpaR protein could not bind to the upstream region ofhcp1, OpaR would repress the transcription ofhcp1in an indirect manner.

scholarly journals Bacterial symbionts use a type VI secretion system to eliminate competitors in their natural host

2018 ◽  
Vol 115 (36) ◽  
pp. E8528-E8537 ◽  
Author(s):  
Lauren Speare ◽  
Andrew G. Cecere ◽  
Kirsten R. Guckes ◽  
Stephanie Smith ◽  
Michael S. Wollenberg ◽  
...  
Keyword(s):  
Intraspecific Competition ◽  
Vibrio Fischeri ◽  
Secretion System ◽  
Dependent Manner ◽  
Light Organ ◽  
Type Vi Secretion System ◽  
Type Vi Secretion ◽  
Natural Isolates ◽  
Physical Mixing

Intraspecific competition describes the negative interaction that occurs when different populations of the same species attempt to fill the same niche. Such competition is predicted to occur among host-associated bacteria but has been challenging to study in natural biological systems. Although many bioluminescentVibrio fischeristrains exist in seawater, only a few strains are found in the light-organ crypts of an individual wild-caughtEuprymna scolopessquid, suggesting a possible role for intraspecific competition during early colonization. Using a culture-based assay to investigate the interactions of differentV. fischeristrains, we found “lethal” and “nonlethal” isolates that could kill or not kill the well-studied light-organ isolate ES114, respectively. The killing phenotype of these lethal strains required a type VI secretion system (T6SS) encoded in a 50-kb genomic island. Multiple lethal and nonlethal strains could be cultured from the light organs of individual wild-caught adult squid. Although lethal strains eliminate nonlethal strains in vitro, two lethal strains could coexist in interspersed microcolonies that formed in a T6SS-dependent manner. This coexistence was destabilized upon physical mixing, resulting in one lethal strain consistently eliminating the other. When juvenile squid were coinoculated with lethal and nonlethal strains, they occupied different crypts, yet they were observed to coexist within crypts when T6SS function was disrupted. These findings, using a combination of natural isolates and experimental approaches in vitro and in the animal host, reveal the importance of T6SS in spatially separating strains during the establishment of host colonization in a natural symbiosis.

scholarly journals Molecular weaponry: diverse effectors delivered by the Type VI secretion system

2015 ◽  
Vol 17 (12) ◽  
pp. 1742-1751 ◽  
Author(s):  
Juliana Alcoforado Diniz ◽  
Yi‐Chia Liu ◽  
Sarah J. Coulthurst
Keyword(s):  
Secretion System ◽  
Type Vi Secretion System ◽  
Type Vi Secretion
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