scholarly journals Tracking human genes along the translational continuum

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Kyubum Lee ◽  
Mindy Clyne ◽  
Wei Yu ◽  
Zhiyong Lu ◽  
Muin J. Khoury

Abstract Understanding the drivers of research on human genes is a critical component to success of translation efforts of genomics into medicine and public health. Using publicly available curated online databases we sought to identify specific genes that are featured in translational genetic research in comparison to all genomics research publications. Articles in the CDC’s Public Health Genomics and Precision Health Knowledge Base were stratified into studies that have moved beyond basic research to population and clinical epidemiologic studies (T1: clinical and population human genome epidemiology research), and studies that evaluate, implement, and assess impact of genes in clinical and public health areas (T2+: beyond bench to bedside). We examined gene counts and numbers of publications within these phases of translation in comparison to all genes from Medline. We are able to highlight those genes that are moving from basic research to clinical and public health translational research, namely in cancer and a few genetic diseases with high penetrance and clinical actionability. Identifying human genes of translational value is an important step towards determining an evidence-based trajectory of the human genome in clinical and public health practice over time.

2005 ◽  
Vol 32 (5) ◽  
pp. 583-588 ◽  
Author(s):  
Sharon L. R. Kardia ◽  
Catharine Wang

This article highlights the important role of health behavior and health education (HBHE) research in public health genetics. Broadly defined, public health genetics is the integration of genetic advancements and technologies in the study and practice of public health. The potential role of HBHE within this area is presented across two intersecting continua—namely, the continuum between research and practice and the continuum between individual/personalized medicine and population health. The authors begin this article with an overview of current issues arising from the use of genetic information to improve the public’s health and provide a framework for understanding the multidimensional role of HBHE research in translating genetic research into medical and public health practice. An introduction to the nine articles and two practice notes included in this special issue is also provided to draw attention to the crosscutting themes and issues presented.


2021 ◽  
pp. 152483992110293
Author(s):  
Tramaine Paul McMullen ◽  
Jennifer Mandelbaum ◽  
Kristian Myers ◽  
Courtney Brightharp ◽  
Kelly Kavanaugh ◽  
...  

Government health departments at all levels make meaningful contributions to advancing the public health of communities, yet state health departments lack the time and infrastructure to share their findings with the broader scientific community. To address this gap in data dissemination, the South Carolina Department of Health and Environmental Control developed a “collaborative writing team” (CWT) pilot. As part of this pilot program, teams of staff members leveraged existing data to advance the public health knowledge base, with an emphasis on public health practice. The six steps of the CWT included (1) identify team members’ skills/strengths, (2) discuss available data, (3) determine opportunities to share data, (4) divide responsibilities based on team members’ strengths, (5) write and submit product, and (6) debrief. Between December 2019 and November 2020, the team had six abstracts accepted to two national conferences, one abstract accepted to a state public health conference, and one editorial published in a peer-reviewed journal. Feedback from participants indicated that self-efficacy in areas including writing, project facilitation, and analysis had increased among team. CWTs are a framework for people working within public health practice settings to disseminate findings.


Author(s):  
Maureen Dobbins ◽  
Alejandra Dubois ◽  
Donna Atkinson ◽  
Olivier Bellefleur ◽  
Claire Betker ◽  
...  

Abstract Since December 2019, there has been a global explosion of research on COVID-19. In Canada, the six National Collaborating Centres (NCCs) for Public Health form one of the central pillars supporting evidence-informed decision making by gathering, synthesizing and translating emerging findings. Funded by the Public Health Agency of Canada and located across Canada, the six NCCs promote and support the use of scientific research and other knowledges to strengthen public health practice, programs and policies. This paper offers an overview of the NCCs as an example of public health knowledge mobilization in Canada and showcases the NCCs’ contribution to the COVID-19 response while reflecting on the numerous challenges encountered.


2021 ◽  
pp. 237337992110071
Author(s):  
R. Tyler Derreth ◽  
Vanya C. Jones ◽  
Mindi B. Levin

The 2020 summer of protests for racial justice amid continued police violence coupled with the widening health disparities due to COVID-19 have made the need for social change and community-informed public health practice abundantly clear. Public health professionals need to combine public health knowledge with collaboration, communication, and reflection to address these health disparities and social injustices. Likewise, as public health educators, we need to develop curricula that train students in these complex skills in order to be effective practitioners. To do this, public health schools and programs should adopt critical service-learning as a central pedagogy in curricula because it is specifically designed to address our current crises with its combination of practice, research, and reflection that together aims for social change. As a means of institutionalizing the pedagogy, faculty can practice and advocate for resources as faculty champions of service-learning.


Author(s):  
A M Viens ◽  
Caroline Vass

Abstract This article reports and reflects on an element of a recent survey of UK public health professionals, specifically in relation to the Public Health Knowledge and Skills Framework (PHSKF) and the ethical requirements that underpin public health practice. Only 38.4% of respondents reported accessing the PHKSF and a mere 13.7% reported accessing the accompanying background paper on ethical public health practice. Given that ethical practice underpins the PHSKF, it is concerning that so few respondents are familiar with the PHSKF and one of the source documents. While issuing frameworks and guidance is one way to support public health practice, there is a further need for greater integration of skills and knowledge around ethical public health practice within education and training initiatives.


Author(s):  
David A Savitz

Abstract Interpreting the results of epidemiologic studies calls for objectivity and rigorous scrutiny, acknowledging the limitations that temper the applicability of the findings to public health action. Current trends have posed new challenges to balancing goal of scientific objectivity and validity with public health applications. The ongoing tension between epidemiology’s aspirations and capability has several sources: the need to overpromise in research proposals, compromising methodologic rigor because of public health importance, defending findings in the face of hostile critics, and appealing to core constituencies who have specific expectations from the research.


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