AYURVEDIC DANTA DHAVANA - A NEED OF TIME: A REVIEW

Dhantadhavana is an important procedure for maintaining the oral hygiene. In Ayurveda there is detail explanation about Dantadhavana methods, procedure, action of drugs, benefits etc. due to civilization Ayurveda twigs and tooth powders got replaced by contemporary plastic made toothbrushes and chemical based toothpastes. Toothbrushes are made of plastic; hence it is an alarming sign for soil and air pollution. Contemporary science recommends usage of chemical-based toothpaste with added sweet flavouring agents. Action of toothpaste maybe bactericidal but data from W.H.O over Oro-dental disorders per year gives an idea that action of bactericidal is not up to mark. In Ayurveda rasa Siddhant-katu (pungent taste), tikta (bitter taste), Kashaya (astringent taste) is given much importance for Dantadhavana due to antibacterial, antiseptic action. Current world is shifting towards ayurvedic principles of daily regimens to maintain and promote the health. This paper will discuss over problems due to usage of contemporary toothbrushes and chemical based paste and ayurvedic view of Dantadhavana and solution by Ayurveda to come over the Oro-dental problems.

Involvement of the ACE2/Ang-(1–7)/MasR Axis in Pulmonary Fibrosis: Implications for COVID-19

Pulmonary fibrosis is a chronic, fibrotic lung disease affecting 3 million people worldwide. The ACE2/Ang-(1–7)/MasR axis is of interest in pulmonary fibrosis due to evidence of its anti-fibrotic action. Current scientific evidence supports that inhibition of ACE2 causes enhanced fibrosis. ACE2 is also the primary receptor that facilitates the entry of SARS-CoV-2, the virus responsible for the current COVID-19 pandemic. COVID-19 is associated with a myriad of symptoms ranging from asymptomatic to severe pneumonia and acute respiratory distress syndrome (ARDS) leading to respiratory failure, mechanical ventilation, and often death. One of the potential complications in people who recover from COVID-19 is pulmonary fibrosis. Cigarette smoking is a risk factor for fibrotic lung diseases, including the idiopathic form of this disease (idiopathic pulmonary fibrosis), which has a prevalence of 41% to 83%. Cigarette smoke increases the expression of pulmonary ACE2 and is thought to alter susceptibility to COVID-19. Cannabis is another popular combustible product that shares some similarities with cigarette smoke, however, cannabis contains cannabinoids that may reduce inflammation and/or ACE2 levels. The role of cannabis smoke in the pathogenesis of pulmonary fibrosis remains unknown. This review aimed to characterize the ACE2-Ang-(1–7)-MasR Axis in the context of pulmonary fibrosis with an emphasis on risk factors, including the SARS-CoV-2 virus and exposure to environmental toxicants. In the context of the pandemic, there is a dire need for an understanding of pulmonary fibrotic events. More research is needed to understand the interplay between ACE2, pulmonary fibrosis, and susceptibility to coronavirus infection.

ASSESSMENT OF TECHNICAL FACULTIES STUDENTS’ ACADEMIC ACHIEVEMENTS DURING THE STUDY OF ENGLISH

The article deals with the approaches of the organization of control of educational achievements of students of technical faculties during the study of English and presents their own experience in its implementation. It is established that for the effective organization of the educational process it is necessary to evaluate the work of students both during practical classes and their independent work systematically. During pedagogical activity it is established that during the current control it is expedient to organize preliminary and thematic control. When exercising control, it is necessary to take into account the correctness of the answers, the completeness of the disclosure of educational material and the independence of the task. Moreover, we note that there are different levels of knowledge acquisition, namely: the level of understanding; level of knowledge; level of reproductive action; level of productive action; level of creative action. Current control can take place in two ways: in the form of frontal control or individual control, orally or in writing, depending on the purpose of the inspection. It was found that no less important attention should be paid to the organization of control of independent work of students, which is aimed at testing the acquisition of both theoretical knowledge and work with oral topics. The final control in English includes both open (provided questions to which the student must provide a detailed answer) and closed (choose the correct answer) tests.

COVID-19 Vaccines: Current Conditions and Future Prospects

It has been over a year since SARS-CoV-2 was first reported in December of 2019 in Wuhan, China. To curb the spread of the virus, many therapies and cures have been tested and developed, most notably mRNA and DNA vaccines. Federal health agencies (CDC, FDA) have approved emergency usage of these S gene-based vaccines with the intention of minimizing any further loss of lives and infections. It is crucial to assess which vaccines are the most efficacious by examining their effects on the immune system, and by providing considerations for new technological vaccine strategies in the future. This paper provides an overview of the current SARS-CoV-2 vaccines with their mechanisms of action, current technologies utilized in manufacturing of the vaccines, and limitations in this new field with emerging data. Although the most popular COVID-19 vaccines have been proven effective, time will be the main factor in dictating which vaccine will be able to best address mutations and future infection.

Contemporary Clinical Use of Aspirin: Mechanisms of Action, Current Concepts, Unresolved Questions, and Future Perspectives

The ability of aspirin to inhibit platelet aggregation has positioned this agent within the most frequently used drugs worldwide. The aim of this article is to review the contemporary clinical use of aspirin and also to discuss unresolved issues not yet translated into clinical practice. Results from several clinical trials have led to strong guideline recommendations for aspirin use in the acute management and secondary prevention of cardiovascular disease. On the contrary, guidelines regarding aspirin use as primary prevention of cardiovascular disease are almost conservative, supported by recent trials reporting that the bleeding risk outweighs the potential benefits in most patients. In pregnancy, aspirin has proved efficient in preventing preeclampsia and small-for-gestational-age births in women at high risk, and is hence widely recommended in clinical guidelines. Despite the vast amount of clinical data on aspirin, several unresolved questions remain. Randomized trials have reported that aspirin reduces the risk of recurrent venous thromboembolism, but the clinical relevance remains limited, because direct oral anticoagulants are more effective. Laboratory studies suggest that a twice-daily dosing regimen or evening intake may lead to more efficient platelet inhibition, and the potential clinical benefit of such strategies is currently being explored in ongoing clinical trials. Enteric-coated formulations of aspirin are frequently used, but it remains unclear if they are safer and as efficient as plain aspirin. In the future, aspirin use after percutaneous coronary interventions might not be mandatory in patients who also need anticoagulant therapy, as several trials support shorter aspirin duration strategies. On the other hand, new treatment indications for aspirin will likely arise, as there is growing evidence that aspirin may reduce the risk of colorectal cancer and other types of cancer.

Potential Drugs for COVID -19 Treatment Management With Their Contraindications and Drug- Drug Interaction

Novel Coronavirus (2019-nCOV) causes inflammatory response with worsening symptoms. Classification of potential anti-viral and anti-inflammatory drugs in managing the symptoms of the COVID-19 and reducing morbidity is important. The objective of this study is to identify a group of drugs, best suited for COVID-19 treatment based on recent developments in clinical trials, FDA drug evaluation, directions and developments and from drug therapies globally. Online literature search was done on Medline, PubMed and google scholar databases for studies on various treatments and drug therapies for COVID-19 and relevant studies were identified and the identified drugs are described in detail as per their Pharmacological, pharmaceutical properties of the drugs, mechanism of action, current COVID-19 drug therapy, contraindications and drug-drug interactions Certain drugs can inhibit action against viral infection and protect lungs from severe inflammatory response. This article summarizes several drugs like Hydroxychloroquine, Chloroquine, Remdesivir, Favipiravir, Lopinavir, Ritonavir, Dexamethasone, Ivermectin, Baricitinib, Casirivimab / imdevimab, Bamlanivimab along with auxiliary treatment like convalescent plasma transfusion. Remdesivir is first drug approved by FDA. Hydroxychloroquine, dexamethasone and remdesivir are showing results against COVID-19 but it is important to test the efficacy and safety of such drugs though some drugs have shown remarkable results.

Сomparative analysis of efficiency of use a screw drill on frozen soil

Introduction. Drilling of frozen and permafrost soils is one of the complex and energy-intensive processes of earthworks. Drilling tools used on frozen soils implement the process of drilling the soil by deformation of cutting or crushing action. Current drilling tools are not efficient enough to use because they implement energy-intensive drilling processes and are not always suitable for various types of soils. A screw drill is considered, which implements the process of soil destruction by shear and shear deformation, which is less energy intensive.Materials and methods. On the basis of theoretical studies of the interaction of 3 types of drilling tools with frozen soil, a comparative analysis was carried out to determine the efficiency of a screw drill use. The technical and economic indicators of the drilling process were compared. A method for determining the efficiency of the use a screw drill based on the analysis of special target functions is presented.Results. The results of a comparative analysis of drilling tools have been obtained. Depending on the nature of soil deformation, the effectiveness of one drilling tool over another is determined. As a result of a comparative analysis of the drilling speed and the energy intensity of the drilling process, the efficiency of the screw drill was established.Discussions and conclusion. In the course of the comparative analysis, the efficiency of the screw drill was determied, which implements shear deformation and soil separation, justifying the feasibility of further research.

Detection of loci exhibiting pleiotropic effects on body weight and egg number in female broilers

The objective of the present study was to discover the genetic variants, functional candidate genes, biological processes and molecular functions underlying the negative genetic correlation observed between body weight (BW) and egg number (EN) traits in female broilers. To this end, first a bivariate genome-wide association and second stepwise conditional-joint analyses were performed using 2586 female broilers and 240 k autosomal SNPs. The aforementioned analyses resulted in a total number of 49 independent cross-phenotype (CP) significant SNPs with 35 independent markers showing antagonistic action i.e., positive effects on one trait and negative effects on the other trait. A number of 33 independent CP SNPs were located within 26 and 14 protein coding and long non-coding RNA genes, respectively. Furthermore, 26 independent markers were situated within 44 reported QTLs, most of them related to growth traits. Investigation of the functional role of protein coding genes via pathway and gene ontology analyses highlighted four candidates (CPEB3, ACVR1, MAST2 and CACNA1H) as most plausible pleiotropic genes for the traits under study. Three candidates (CPEB3, MAST2 and CACNA1H) were associated with antagonistic pleiotropy, while ACVR1 with synergistic pleiotropic action. Current results provide a novel insight into the biological mechanism of the genetic trade-off between growth and reproduction, in broilers.