scholarly journals A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Carmine Vecchione ◽  
Francesco Villa ◽  
Albino Carrizzo ◽  
Chiara Carmela Spinelli ◽  
Antonio Damato ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
High Blood Pressure ◽  
Genetic Variant ◽  
Rare Genetic Variant ◽  
Nitric Oxide Signaling

scholarly journals Author Correction: A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Carmine Vecchione ◽  
Francesco Villa ◽  
Albino Carrizzo ◽  
Chiara Carmela Spinelli ◽  
Antonio Damato ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
High Blood Pressure ◽  
Genetic Variant ◽  
Rare Genetic Variant ◽  
Nitric Oxide Signaling

scholarly journals Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications

2019 ◽  
Vol 8 (12) ◽  
pp. 2051 ◽  
Author(s):  
Armita Mahdavi Gorabi ◽  
Nasim Kiaie ◽  
Saeideh Hajighasemi ◽  
Maciej Banach ◽  
Peter E. Penson ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Blood Pressure ◽  
Atherosclerotic Plaques ◽  
Therapeutic Effects ◽  
Therapeutic Implications ◽  
Nitric Oxide Signaling ◽  
Beneficial Effects ◽  
Signaling Mechanisms ◽  
Neurological Injuries

In addition to their cholesterol-lowering effects, statins are associated with pleiotropic effects including improvements in heart failure (HF), reduced blood pressure, prevention of the rupture of atherosclerotic plaques and improved angiogenesis. In addition to these cardiovascular benefits, statins have been implicated in the treatment of neurological injuries, cancer, sepsis, and cirrhosis. These cholesterol-independent beneficial effects of statins are predominantly mediated through signaling pathways leading to increased production and bioavailability of nitric oxide (NO). In this review, the mechanistic pathways and therapeutic effects of statin-mediated elevations of NO are described and discussed.

scholarly journals Rare genetic variant analysis on blood pressure in related samples

2014 ◽  
Vol 8 (S1) ◽  
Author(s):  
Han Chen ◽  
Seung Hoan Choi ◽  
Jaeyoung Hong ◽  
Chen Lu ◽  
Jacqueline N Milton ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Genetic Variant ◽  
Rare Genetic Variant ◽  
Variant Analysis

scholarly journals Endothelin-1, nitric oxide, serotonin and high blood pressure in male adolescents

2018 ◽  
Vol Volume 14 ◽  
pp. 213-223 ◽  
Author(s):  
Gulfiia Nagimovna Aflyatumova ◽  
Razina Nigmatullina ◽  
Dinara Ilgizarovna Sadykova ◽  
Mariia Dmitrievna Chibireva ◽  
Francesco Fugetto ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
High Blood Pressure ◽  
Male Adolescents ◽  
Endothelin 1

Dietary Zn Deficiency Does Not Influence Systemic Blood Pressure and Vascular Nitric Oxide Signaling in Normotensive Rats

2003 ◽  
Vol 91 (2) ◽  
pp. 157-172 ◽  
Author(s):  
Masamichi Sato ◽  
Nobutaka Kurihara ◽  
Kazuaki Moridaira ◽  
Hironosuke Sakamoto ◽  
Jun'ichi Tamura ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Systemic Blood Pressure ◽  
Zn Deficiency ◽  
Systemic Blood ◽  
Nitric Oxide Signaling

scholarly journals Paraventricular nucleus control of blood pressure in two-kidney, one-clip rats: effects of exercise training and resting blood pressure

2013 ◽  
Vol 305 (11) ◽  
pp. R1390-R1400 ◽  
Author(s):  
Noreen F. Rossi ◽  
Haiping Chen ◽  
Maria Maliszewska-Scislo
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Heart Rate ◽  
Exercise Training ◽  
Arterial Pressure ◽  
Paraventricular Nucleus ◽  
Sham Group ◽  
Wheel Running ◽  
Ang Ii ◽  
Nitric Oxide Signaling

Exercise-induced changes in γ-aminobutyric acid (GABA) or nitric oxide signaling within the paraventricular nucleus (PVN) have not been studied in renovascular hypertension. We tested whether exercise training decreases mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA) in two-kidney, one-clip (2K-1C) hypertensive rats due to enhanced nitric oxide or GABA signaling within PVN. Conscious, unrestrained male Sprague-Dawley rats with either sham (Sham) or right renal artery clipping (2K-1C) were assigned to sedentary (SED) or voluntary wheel running (ExT) for 6 or 12 wk. MAP and angiotensin II (ANG II) were elevated in 2K-1C SED rats. The 2K-1C ExT rats displayed lower MAP at 6 wk that did not decline further by 12 wk. Plasma ANG II was lower in 2K-1C ExT rats. Increases in MAP, heart rate, and RSNA to blockade of PVN nitric oxide in 2K-1C SED rats were attenuated compared with either Sham group. Exercise training restored the responses in 2K-1C ExT rats. The increase in MAP in response to bicuculline was inversely correlated with baseline MAP. The rise in MAP was lower in 2K-1C SED vs. either Sham group and was normalized in the 2K-1C ExT rats. Paradoxically, heart rate and RSNA responses were not diminished in 2K-1C SED rats but were significantly lower in the 2K-1C ExT rats. Thus the decrease in arterial pressure in 2K-1C hypertension associated with exercise training is likely due to diminished excitatory inputs to PVN because of lower ANG II and higher nitritergic tone rather than enhanced GABA inhibition of sympathetic output.

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