scholarly journals Association of white blood cell count with breast cancer burden varies according to menopausal status, body mass index, and hormone receptor status: a case-control study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Byoungjin Park ◽  
Hye Sun Lee ◽  
Ji Won Lee ◽  
Seho Park
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Blood Cell ◽  
Hormone Receptor ◽  
Case Control Study ◽  
Menopausal Status ◽  
Case Control ◽  
Hormone Receptor Status ◽  
Blood Cell Count ◽  
Control Study

scholarly journals Association between Polyphenol Intake and Breast Cancer Risk by Menopausal and Hormone Receptor Status

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 994
Author(s):  
Facundo Vitelli-Storelli ◽  
Raul Zamora-Ros ◽  
Antonio J. Molina ◽  
Tania Fernández-Villa ◽  
Adela Castelló ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Case Control Study ◽  
Menopausal Status ◽  
Population Based ◽  
Hormone Receptor Status ◽  
Receptor Status ◽  
Cancer Types ◽  
Polyphenol Intake ◽  
Control Study

There is limited evidence of phenolic compounds acting as protective agents on several cancer types, including breast cancer (BC). Nevertheless, some polyphenol classes have not been investigated and there is a lack of studies assessing the effect on menopausal status and hormone receptor status as influenced by these compounds. The objective of this study is to evaluate the association between the intake of all polyphenol classes in relation to the BC risk by menopausal and hormone receptor status. We used data from a population-based multi-case-control study (MCC-Spain) including 1472 BC cases and 1577 controls from 12 different regions of Spain. The odds ratios (ORs) with 95% CI were calculated using logistic regression of mixed effects by quartiles and log2 of polyphenol intakes (adjusted for the residual method) of overall BC, menopausal and receptor status. No associations were found between total intake of polyphenols and BC risk. However, inverse associations were found between stilbenes and all BC risk (ORQ4 vs. Q1: 0.70, 95%CI: 0.56–0.89, Ptrend = 0.001), the consumption of hydroxybenzaldehydes (ORQ4 vs. Q1: 0.75, 95%CI: 0.59–0.93, Ptrend = 0.012) and hydroxycoumarins (ORQ4 vs. Q1: 0.73, 95%CI: 0.57–0.93; Ptrend = 0.005) were also inversely associated. The intake of stilbenes, hydroxybenzaldehydes and hydroxycoumarins can contribute to BC reduction risk on all menopausal and receptor statuses.

scholarly journals Alcohol Consumption and Breast Cancer Risk According to Hormone Receptor Status in Japanese Women: A Case-Control Study

2018 ◽  
Vol 244 (1) ◽  
pp. 63-73 ◽  
Author(s):  
Yoko Takizawa ◽  
Masaaki Kawai ◽  
Yoichiro Kakugawa ◽  
Yoshikazu Nishino ◽  
Noriaki Ohuchi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Alcohol Consumption ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Hormone Receptor ◽  
Case Control Study ◽  
Case Control ◽  
Japanese Women ◽  
Hormone Receptor Status ◽  
Control Study

scholarly journals Dietary Inflammatory Index and Risk of Breast Cancer Based on Hormone Receptor Status: A Case-Control Study in Korea

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1949 ◽  
Author(s):  
Lee ◽  
Quiambao ◽  
Lee ◽  
Ro ◽  
Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Case Control Study ◽  
Case Control ◽  
Hormone Receptor Status ◽  
Korean Women ◽  
Dietary Inflammatory Index ◽  
Receptor Status ◽  
Inflammatory Index ◽  
Control Study

Breast cancer is the most common cancer in women globally, and the risk of developing breast cancer is associated with inflammation. The present study aimed to examine the association between the Dietary Inflammatory Index (DII®) and breast cancer in Korean women and investigate whether the tumor’s hormone receptor status affects this association. In this case-control study, we enrolled 364 breast cancer patients and 364 age-matched controls. DII scores were calculated from dietary intake evaluated by a 106-item food frequency questionnaire. The DII score was significantly higher in cases than in controls. After adjusting for potential confounders, the odds ratio (OR) of breast cancer was higher in the highest DII tertile (OR = 3.68, 95% confidence interval (CI): 2.34–5.80, p for trend < 0.0001) than in the lowest tertile. We found that higher DII scores were related to an increased risk of breast cancer for estrogen receptor (ER)+/progesterone receptor (PR)+ tumors regardless of menopausal status (OR = 2.59, 95% CI: 1.37–4.88 in the highest DII category, p for trend = 0.01 for premenopausal women; OR = 11.00, 95% CI: 2.93–41.30 in the highest DII category, p for trend = 0.0004 for postmenopausal women), but not for ER−/PR− status. Our results suggested that the DII scores are positively associated with breast cancer risk in Korean women and that this relationship is more robust in ER+/PR+ tumors.

Risk of subsequent breast cancer after radiotherapy according to hormone-receptor status: A nested case-control study in the Childhood Cancer Survivor Study (CCSS).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 10520-10520
Author(s):  
Lindsay M. Morton ◽  
Lene Veiga ◽  
Rochelle E. Curtis ◽  
Diana Withrow ◽  
Peter Inskip ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Childhood Cancer ◽  
Hormone Receptor ◽  
Case Control Study ◽  
Case Control ◽  
Hormone Receptor Status ◽  
Receptor Status ◽  
Survivors Of Childhood Cancer ◽  
Nested Case Control ◽  
Control Study

10520 Background: Survivors of childhood cancer have a high absolute risk of subsequent breast cancer after chest-directed radiotherapy; however, it is not known if this risk differs by hormone-receptor status and radiation to the ovaries. Methods: We conducted a nested case-control study within the CCSS of 282 five-year survivors of childhood cancer with subsequent breast cancer and 1202 matched controls. Radiation dose to the location of the breast tumor (or corresponding location for controls) and mean dose to the ovaries were estimated from treatment records for each patient. Risk of radiation-related breast cancer was measured with the Excess Odds Ratio per Gray (EOR/Gy) and corresponding 95% confidence interval (CI), derived from conditional logistic regression. Results: The median age at subsequent breast cancer diagnosis was 39 years (range 21-58). Although 87% of cases and 70% of controls received radiotherapy, breast doses were higher in cases than controls (61% vs 24% breast dose > 10Gy), whereas ovarian doses were lower (7% vs 13% ovary dose > 5Gy). In the subset of cases (n = 159) with currently available estrogen receptor (ER) status (76% cases ER+, 24% cases ER-), there was a linear dose-response relation with radiation dose to the breast that was similar for ER+ (EOR/Gy = 0.51; 95%CI: 0.19-1.34) and ER- breast tumors (EOR/Gy = 0.41; 95%CI: 0.05-2.88). If the patient received an ovarian dose > 5Gy, this dose-response was significantly reduced for ER+ tumors but not for ER- tumors. Conclusions: Preliminary analyses demonstrate that radiation exposure to the breast to treat childhood cancer results in an increased risk of both ER+ and ER- breast cancers. The novel finding that only the risk of ER+ breast cancer is lowered if the ovaries are also exposed is consistent with known differences by hormone receptor status in the biological mechanisms of breast carcinogenesis.

Early adult body weight, body mass index, and premenopausal bilateral breast cancer: data from a case-control study

1995 ◽  
Vol 33 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Giske Ursin ◽  
Annlia Paganini-Hill ◽  
Jack Siemiatycki ◽  
W. Douglas Thompson ◽  
Robert W. Haile
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Case Control Study ◽  
Bilateral Breast Cancer ◽  
Case Control ◽  
Breast Cancer Data ◽  
Cancer Data ◽  
Adult Body ◽  
Adult Body Weight ◽  
Control Study

scholarly journals Sedentary Behavior and Alcohol Consumption Increase Breast Cancer Risk Regardless of Menopausal Status: A Case-Control Study

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1871 ◽  
Author(s):  
Jordana Carolina Marques Godinho-Mota ◽  
Larissa Vaz Gonçalves ◽  
Joao Felipe Mota ◽  
Leonardo Ribeiro Soares ◽  
Raquel Machado Schincaglia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Alcohol Consumption ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Sedentary Behavior ◽  
Case Control Study ◽  
Menopausal Status ◽  
Case Control ◽  
Alcoholic Beverages ◽  
Control Study

Identification of modifiable risk factors for breast cancer is critical for primary prevention of the disease. The aim of this study was to evaluate how certain lifestyle variables modify the chances of developing breast cancer based on menopausal status. A case-control study was performed in a group of 542 women, 197 who were diagnosed with breast cancer and 344 control individuals. The groups were matched by age, body mass index, and menopausal status. Participants were evaluated for level of physical activity, alcohol consumption, smoking habit, weight, height, and waist circumference (WC). A multivariate logistic regression model was used to estimate odds ratios and 95% confidence intervals (95% CI). Regular consumption of alcoholic beverages (2.91, 95% CI 1.58–5.38 and 1.86, 95% CI 1.15–3.03) and sedentary behavior (2.08; 95% CI 1.12–3.85 and 1.81; 95% CI 1.12–2.94) were associated with breast cancer risk in pre- and postmenopausal women, respectively. High WC (3.31, 95% CI 1.45–7.55) was associated with an increased risk of developing breast cancer in premenopausal women. While in postmenopausal women, current smoking (2.43, 95% CI 1.01–5.83) or previous history of smoking (1.90; 95% CI 1.14–3.14) increased the chances of developing breast cancer. Sedentary behavior and current consumption of alcoholic beverages were more likely to increase the risk of developing breast cancer regardless of menopausal status.

Case control study of hormone replacement therapy (HRT) and breast cancer in Japanese women

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 10012-10012
Author(s):  
M. Takeuchi ◽  
T. Saeki ◽  
M. Sano ◽  
H. Sonoo ◽  
H. Honjo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Menopausal Status ◽  
Previous History ◽  
Case Control ◽  
Japanese Women ◽  
Sensitivity Analyses ◽  
Control Group ◽  
History Of ◽  
Control Study

10012 Background: Some prospective studies in US and UK (represented by Women’s Health Initiative and Million Women Study) show that HRT use may increase the risk of breast cancer. However, it is unclear whether or not this perspective is applicable to Japanese women, due to several factors such as the difference in incidence of breast cancer, difference in HRT prevalence, which are to be concerned in this study. To investigate the relationship between HRT use and breast cancer, a case-control study was conducted in Japan. Methods: We sent self-administered questionnaire to 4,500 cases who have a previous history of confirmed histological breast cancer and 4,500 controls who were selected according to the inclusion criteria. All the subjects were between age 45 and 69 at the time of enrollment. Among these subjects, 3,434 in case group and 2,427 in control group sent back their questionnaire (total 5,861). The datacenter was run in Kitasato Univ. and the statistical analysis was performed using SAS (version 9.1). Control was selected by considering the screening record for GI disease and respiratory disorders, with no previous history of breast cancer, gynecological and hormonal disease at the time of screening. We asked about past history of exposure to the factors supposed to be breast cancer-causing; previous or current use of HRT, age at diagnosis, academic background, BMI, lifestyle habits, age of menarche, birth history, history of breast feeding, family history, use of contraceptive agents and menopausal status. Results: As the main analysis result, 164 (5.0%) out of 3,316 cases and 253 (7.4%) out of 2355 controls had used HRT (Odds ratio 0.432 [95% CI 0.352–0.530]. Conclusions: The result of this study shows that HRT users were less likely to develop breast cancer than never users. However, in this study, there was a difference in the observation period for the past use of HRT between cases and controls. Considering the transition of HRT prevalence in Japan, there may be a possibility that this difference can be a cause of a serious bias for the main analysis result. Further sensitivity analyses are needed to evaluate the robustness of the findings and this point is under consideration. No significant financial relationships to disclose.

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