scholarly journals A cartridge based Point-of-Care device for complete blood count

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Usama Abbasi ◽  
Prasanta Chowdhury ◽  
Sasikala Subramaniam ◽  
Prakhar Jain ◽  
Nitin Muthe ◽  
...  
Keyword(s):  
Credit Card ◽  
Blood Count ◽  
Complete Blood Count ◽  
Point Of Care ◽  
Rapid Diagnostics ◽  
Lab On Chip ◽  
Skilled Manpower ◽  
Chip Fabrication ◽  
On Chip ◽  
The Cost

AbstractWe demonstrate a proprietary lab-on-chip/μ TAS technology platform for a regulatory grade portable instrument for complete blood count (CBC) hematology tests including 3 part differential WBCs, RBCs, platelet and hemoglobin for rapid diagnostics at the point of care in resource-poor settings. Presently, diagnostics based on blood tests are confined to centralized laboratory settings, dependent on large footprint and expensive cytometers or on a microscope, requiring trained laboratory technicians. Consequently, such facilities are not present in rural and semi-urban settings, where there are opportunities and challenges in delivering efficient healthcare infrastructure at an affordable cost in resource-challenged environments. Our proposed design leverages advances in microfluidics and lab-on-chip fabrication techniques to miniaturize the conventional cytometer and bring down the cost significantly. The device can be operated autonomously, without skilled manpower, by primary healthcare professionals in the field and by patients (like glucose self-test devices). The instrument consists of a single-use chip, the size of a credit card, pre-loaded with reagents, in which the sample is loaded, and which is fluidically insulated from the environment. The controller, the size of a toaster, performs the necessary fluid handling and the impedance measurements to deliver the results in minutes.

INTEGRATED MICROFLUIDIC FLOW SENSOR FOR LAB-ON-CHIP AND POINT-OF-CARE APPLICATIONS

2020 ◽  
pp. 457-458
Author(s):  
V. Ryzhkov ◽  
M. Andronik ◽  
V. Echeistov ◽  
Z. Issabayeva ◽  
O. Sorokina ◽  
...  
Keyword(s):  
Microfluidic Chip ◽  
Point Of Care ◽  
Experimental Comparison ◽  
Fluid Flow Rate ◽  
Fabrication Technology ◽  
Flow Sensors ◽  
Lab On Chip ◽  
Microfluidic Flow ◽  
Chip Fabrication ◽  
On Chip

An integrated membrane-free sensor for precise measurements of fluid flow rate in microchannels of laboratories-on- chip has been developed. The sensor allows to measure flow on microfluidic chip in real time and is designed for liquid samples precise dilution control on the microfluidic chip. Fabrication technology of the microfluidic chip with built-in flow sensors as well as results of experimental comparison of developed sensor with a commercial flowmeter are presented.

scholarly journals 332: Can a point-of-care hemoglobin device replace complete blood count for fetal blood sampling during intrauterine transfusion?

2018 ◽  
Vol 218 (1) ◽  
pp. S207-S208
Author(s):  
Cathy Monteith ◽  
Jahan Jadauji ◽  
Hala Abu ◽  
Ann M. McHugh ◽  
Jennifer C. Donnelly ◽  
...  
Keyword(s):  
Blood Count ◽  
Complete Blood Count ◽  
Point Of Care ◽  
Blood Sampling ◽  
Fetal Blood ◽  
Fetal Blood Sampling ◽  
Intrauterine Transfusion

Coagulopathy in Cardiac Surgery: Etiology and Treatment Options

2020 ◽  
pp. 313-322
Author(s):  
Dana Teodorescu ◽  
Caroline Larkin
Keyword(s):  
Cardiac Surgery ◽  
Laboratory Testing ◽  
Blood Count ◽  
Complete Blood Count ◽  
Point Of Care ◽  
Treatment Options ◽  
Coagulation Factors ◽  
Bleeding Diathesis ◽  
Standard Laboratory ◽  
Post Cardiac Surgery

This chapter reviews the causes and outlines an approach to the management of coagulopathy following cardiac surgery. Bleeding after cardiac surgery is common and expected up to a rate of 2 mL/kg/h for the first 6 hours. A more significant hemorrhage needs to be investigated and treated. Causes are often multifactorial. It is imperative that surgical causes be excluded early concomitant to providing resuscitation, investigating other medical causes for bleeding, and treating coagulopathy empirically until laboratory testing becomes available. The most frequent causes for coagulopathy post–cardiac surgery are excess heparinization, prolonged cardiopulmonary bypass time, hypothermia, acidosis, and preexisting bleeding diathesis. The management of coagulopathy implies maintenance of the normal physiological conditions for coagulation, reversal of excess heparinization, treatment of hyperfibrinolysis, maintaining normal levels of coagulation factors, and transfusion of platelets if thrombocytopenia or platelet dysfunction occurs. The chapter reviews what is involved in standard laboratory testing (complete blood count, prothrombin time, activated partial thromboplastin time, fibrinogen level, etc.) for coagulopathy. Also discussed is point-of-care testing and how the results from these tests should be interpreted. The chapter details the various blood products that are required in this scenario and suggests doses and transfusion thresholds.

Point-of-Care Systems for Rapid DNA Quantification in Oncology

2008 ◽  
Vol 94 (2) ◽  
pp. 216-225 ◽  
Author(s):  
Marco Bianchessi ◽  
Sarah Burgarella ◽  
Marco Cereda
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Semiconductor Industry ◽  
Point Of Care Testing ◽  
Lab On Chip ◽  
Diagnostic Assays ◽  
Care Systems ◽  
Point Of Care Systems ◽  
The Common ◽  
On Chip

The development of new powerful applications and the improvement in fabrication techniques are promising an explosive growth in lab-on-chip use in the upcoming future. As the demand reaches significant levels, the semiconductor industry may enter in the field, bringing its capability to produce complex devices in large volumes, high quality and low cost. The lab-on-chip concept, when applied to medicine, leads to the point-of-care concept, where simple, compact and cheap instruments allow diagnostic assays to be performed quickly by untrained personnel directly at the patient's side. In this paper, some practical and economical considerations are made to support the advantages of point-of-care testing. A series of promising technologies developed by STMicroelectronics on lab-on-chips is also presented, mature enough to enter in the common medical practice. The possible use of these techniques for cancer research, diagnosis and treatment are illustrated together with the benefits offered by their implementation in point-of-care testing.

On-chip sample preparation for complete blood count from raw blood

Lab on a Chip ◽  
2015 ◽  
Vol 15 (6) ◽  
pp. 1533-1544 ◽  
Author(s):  
John Nguyen ◽  
Yuan Wei ◽  
Yi Zheng ◽  
Chen Wang ◽  
Yu Sun
Keyword(s):  
Sample Preparation ◽  
Microfluidic Device ◽  
Whole Blood ◽  
Blood Count ◽  
Complete Blood Count ◽  
Chip Sample ◽  
On Chip

We present a monolithic microfluidic device capable of on-chip sample preparation for both RBC and WBC measurements from whole blood.

scholarly journals Determination of Hemoglobin Level Among 9-Month-Old Infants Visiting Well Child Clinic

2021 ◽  
Vol 8 ◽  
pp. 2333794X2110366
Author(s):  
Pongtong Puranitee ◽  
Sajee Fuangfu ◽  
Oraporn Dumrongwongsiri
Keyword(s):  
Infant Formula ◽  
Associated Factors ◽  
Blood Count ◽  
Complete Blood Count ◽  
Point Of Care ◽  
Hemoglobin Level ◽  
Breastfed Infants ◽  
Confident Interval ◽  
Prevalence Of Anemia

Screening for anemia is recommended among infants aged 9 to 12 months. This study was conducted to determine the prevalence of anemia among 9-month-old infants at Well Child Clinic, and associated factors with anemia. Well Child record of all visits during January to December 2018 were reviewed. Hemoglobin (Hb) was determined by complete blood count (CBC) or point-of-care Hb (POC-Hb). Anemia was found in 99 from 145 infants (68.3%). The prevalence of anemia was 33.3% and 72.8% when tested by CBC and POC-Hb, respectively. Breastfed Infants had significantly lower mean Hb than formula-fed infants. The odd ratio [95% confident interval] of having anemia among infants who were fed with infant formula were 0.37 [0.14-0.94]; P = .038 when compared to breastfed infants. There was a high proportion of anemia among 9-month-old infants in Rama-WCC and breastfeeding was associated with anemia in infants. The use of POC-Hb may overestimate the prevalence of anemia.

Rapid and portable, lab-on-chip, point-of-care genotyping for evaluating clopidogrel metabolism

2015 ◽  
Vol 451 ◽  
pp. 240-246 ◽  
Author(s):  
Nicola Marziliano ◽  
Maria Francesca Notarangelo ◽  
Marco Cereda ◽  
Vittoria Caporale ◽  
Lucia Coppini ◽  
...  
Keyword(s):  
Point Of Care ◽  
Lab On Chip ◽  
On Chip

scholarly journals Fast, accurate, point-of-care COVID-19 pandemic diagnosis enabled through advanced lab-on-chip optical biosensors: Opportunities and challenges

2021 ◽  
Vol 8 (3) ◽  
pp. 031313
Author(s):  
Aref Asghari ◽  
Chao Wang ◽  
Kyoung Min Yoo ◽  
Ali Rostamian ◽  
Xiaochuan Xu ◽  
...  
Keyword(s):  
Point Of Care ◽  
Optical Biosensors ◽  
Lab On Chip ◽  
On Chip

scholarly journals Developments in Transduction, Connectivity and AI/Machine Learning for Point-of-Care Testing

Sensors ◽  
2019 ◽  
Vol 19 (8) ◽  
pp. 1917 ◽  
Author(s):  
Shane O’Sullivan ◽  
Zulfiqur Ali ◽  
Xiaoyi Jiang ◽  
Reza Abdolvand ◽  
M Selim Ünlü ◽  
...  
Keyword(s):  
Machine Learning ◽  
Data Analytics ◽  
Point Of Care ◽  
Developed Countries ◽  
Clinical Diagnostics ◽  
Least Developed Countries ◽  
Point Of Care Testing ◽  
Middle Income ◽  
Lab On Chip ◽  
On Chip

We review some emerging trends in transduction, connectivity and data analytics for Point-of-Care Testing (POCT) of infectious and non-communicable diseases. The patient need for POCT is described along with developments in portable diagnostics, specifically in respect of Lab-on-chip and microfluidic systems. We describe some novel electrochemical and photonic systems and the use of mobile phones in terms of hardware components and device connectivity for POCT. Developments in data analytics that are applicable for POCT are described with an overview of data structures and recent AI/Machine learning trends. The most important methodologies of machine learning, including deep learning methods, are summarised. The potential value of trends within POCT systems for clinical diagnostics within Lower Middle Income Countries (LMICs) and the Least Developed Countries (LDCs) are highlighted.

scholarly journals Printable graphene BioFETs for DNA quantification in Lab-on-PCB microsystems

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sotirios Papamatthaiou ◽  
Pedro Estrela ◽  
Despina Moschou
Keyword(s):  
Printed Circuit Board ◽  
Point Of Care ◽  
Dna Amplification ◽  
Electrochemical Sensing ◽  
Circuit Board ◽  
Label Free ◽  
Transistor Channel ◽  
Lab On Chip ◽  
Passive Electrode ◽  
On Chip

AbstractLab-on-Chip is a technology that aims to transform the Point-of-Care (PoC) diagnostics field; nonetheless a commercial production compatible technology is yet to be established. Lab-on-Printed Circuit Board (Lab-on-PCB) is currently considered as a promising candidate technology for cost-aware but simultaneously high specification applications, requiring multi-component microsystem implementations, due to its inherent compatibility with electronics and the long-standing industrial manufacturing basis. In this work, we demonstrate the first electrolyte gated field-effect transistor (FET) DNA biosensor implemented on commercially fabricated PCB in a planar layout. Graphene ink was drop-casted to form the transistor channel and PNA probes were immobilized on the graphene channel, enabling label-free DNA detection. It is shown that the sensor can selectively detect the complementary DNA sequence, following a fully inkjet-printing compatible manufacturing process. The results demonstrate the potential for the effortless integration of FET sensors into Lab-on-PCB diagnostic platforms, paving the way for even higher sensitivity quantification than the current Lab-on-PCB state-of-the-art of passive electrode electrochemical sensing. The substitution of such biosensors with our presented FET structures, promises further reduction of the time-to-result in microsystems combining sequential DNA amplification and detection modules to few minutes, since much fewer amplification cycles are required even for low-abundance nucleic acid targets.

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