scholarly journals The CXCL12 SNPs and their haplotypes are associated with serum lipid traits

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ling Qiu ◽  
Rui-Xing Yin ◽  
Rong-Jun Nie ◽  
Xi-Jiang Hu ◽  
Eksavang Khounphinith ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Serum Lipid ◽  
Direct Sequencing ◽  
Serum Triglyceride ◽  
Nucleotide Polymorphisms ◽  
Lipid Levels ◽  
Apo B ◽  
Cholesterol Levels ◽  
Serum Lipid Levels ◽  
Chemokine Ligand

AbstractThe relationship among the single nucleotide polymorphisms (SNPs) of the C-X-C motif chemokine ligand 12 gene (CXCL12) and the serum lipid profiles in the Chinese population has rarely been described, especially in somewhat old-fashioned and isolated Maonan minority. The goal of the current study was to elucidate the connection among the CXCL12 rs501120 and rs1746048 SNPs, haplotypes, several environmental factors and serum lipid traits in the Maonan as well as Han populations. Genotyping of the two SNPs, gel electrophoresis and direct sequencing were accomplished in 1,494 distinct subjects (Maonan, 750 and Han, 744) using polymerase chain reaction and restriction fragment length polymorphism. The frequencies of genotypes as well as alleles of the two SNPs were not similar between the two ethnic groups. The rs501120 SNP was related with serum total cholesterol levels, while the rs1746048 SNP was related with serum apolipoprotein (Apo) B levels. Four haplotypes were identified, of which the rs501120A-rs1746048C haplotype was the most common. The haplotypes of rs501120A-rs1746048T increased and rs501120G-rs1746048C decreased the risk of hyperlipidemia (P < 0.001 for each), showing consistent association with the levels of serum triglyceride, ApoA1 and ApoB. These outcomes specify that the CXCL12 SNPs as well as their haplotypes are related to serum lipid levels. Different serum lipid levels between both populations may partially be related to the CXCL12 SNPs, their haplotypes along with several environmental factors.

scholarly journals Frizzled-related proteins 4 (SFRP4) rs1802073G allele predicts the elevated serum lipid levels during acitretin treatment in psoriatic patients from Hunan, China

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4637 ◽  
Author(s):  
Xingchen Zhou ◽  
Wu Zhu ◽  
Minxue Shen ◽  
Yijing He ◽  
Cong Peng ◽  
...  
Keyword(s):  
Serum Level ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Serum Lipid Levels ◽  
Related Proteins

Background Acitretin is a second-generation synthetic retinoid, and is widely used for treating the severe psoriasis vulgaris. However, it should be chosen with caution for its cardiovascular risk, and it is reported that acitretin may increase the serum lipids. The purpose of this study is to investigate the relationship between the Frizzled-related proteins 4 (SFRP4) rs1802073 polymorphism and the changes of serum lipids in Chinese psoriatic patients during the treatment with acitretin. Methods In our study, 100 psoriatic patients were recruited systematically treated with acitretin (30 mg/day) for at least eight weeks. Data of the patients’ demographic and clinical characteristics and the results of serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were collected pre- and post-treatment. Results A total of 84 psoriatic patients were enrolled and divided into three groups by SFRP4 rs1802073 genotypes. The patients who carried with TT genotype had maintained levels of TG and LDL-C after acitretin treatment, while patients with GG/GT genotypes had significantly elevated levels of serum TG and LDL-C compared to the TT genotype (ΔTG%: 27.53 ± 59.13 vs −1.47 ± 37.79, p = 0.026, ΔLDL-C%: 10.62 ± 26.57 vs −1.29 ± 17.07, p = 0.042). The association of rs1802073 with TG and LDL-C profiles remained significant after adjusting for age, gender, and body mass index. Although without significance, the pre-post change in serum level of TC across rs1802073 GG/GT genotypes demonstrated a trend similar to TG and LDL, and the serum level of HDL-C demonstrated a trend opposite to TG, TC and LDL. Conclusions Our results demonstrated that SFRP4 rs1802073 polymorphism was found to be associated with elevated serum lipid levels after acitretin treatment, and it may serve as a genetic marker of safe and precise treatment for individual psoriatic patients.

scholarly journals Low cholesterol levels in children predict impulsivity in young adulthood

2019 ◽  
Vol 32 (4) ◽  
pp. 196-205
Author(s):  
Katrin Tomson-Johanson ◽  
Tanel Kaart ◽  
Raul-Allan Kiivet ◽  
Toomas Veidebaum ◽  
Jaanus Harro
Keyword(s):  
Young Adults ◽  
Birth Cohort ◽  
Young Adulthood ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Ldl Cholesterol ◽  
Lipid Levels ◽  
Cholesterol Levels ◽  
Serum Lipid Levels ◽  
Low Levels

AbstractObjective:Severe behavioural issues such as impulsive action and suicide have since long been associated with low levels of cholesterol. While it is known that cholesterol plays a role in neural development and hence low levels of serum lipids could have long-term effects on behaviour, no longitudinal studies showed the association of serum lipids levels with impulsivity. We aimed to examine the prognostic properties of serum lipid levels during childhood and adolescence on measures of impulsivity during early adulthood in a representative birth cohort sample.Methods:We have investigated whether serum lipid levels measured at 9, 15, 18 and 25 years of age have an association with impulsivity in 25 years old young adults. This analysis was based on data of the birth cohort representative samples of the Estonian Children Personality Behaviour and Health Study (original n = 1238). Impulsivity was self-reported with the Adaptive and Maladaptive Impulsivity Scale.Results:Total and low-density lipoprotein (LDL) cholesterol measured in boys aged 9, 15 and 18 years predicted disinhibition and thoughtlessness in 25-year-old young adults. High scores of disinhibition were associated with low total and LDL cholesterol levels in males but, while less consistently, with high total and LDL cholesterol levels in females. Cross-sectional analysis did not result in systematic outcomes.Conclusions:Serum lipid levels could have an impact on the development of Maladaptive Impulsivity starting from an early age. This effect of cholesterol continues throughout adolescence into young adulthood.

scholarly journals Association of MYLIP rs3757354 SNP and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations

2012 ◽  
Vol 11 (1) ◽  
pp. 141 ◽  
Author(s):  
Ting-Ting Yan ◽  
Rui-Xing Yin ◽  
Qing Li ◽  
Ping Huang ◽  
Xiao-Na Zeng ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Serum Lipid ◽  
Lipid Levels ◽  
Serum Lipid Levels

scholarly journals Association of the angiopoietin-like protein 8 rs2278426 polymorphism and several environmental factors with serum lipid levels

2015 ◽  
Vol 12 (3) ◽  
pp. 3285-3296 ◽  
Author(s):  
TAO GUO ◽  
RUI-XING YIN ◽  
JIAN WU ◽  
QUAN-ZHEN LIN ◽  
GUANG-YUAN SHI ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Serum Lipid ◽  
Lipid Levels ◽  
Serum Lipid Levels

scholarly journals A study of variation in serum lipid levels in patients with Plasmodium vivax malaria

2020 ◽  
Vol 7 (7) ◽  
pp. 1073
Author(s):  
Prashanth Kumar P. ◽  
Rashmi Amans Flora Nazareth
Keyword(s):  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Serum Lipid ◽  
Elevated Serum ◽  
Serum Triglyceride ◽  
Lipid Levels ◽  
College Hospital ◽  
Serum Triglycerides ◽  
Serum Lipid Levels ◽  
Plasmodium Vivax Malaria

Background: Malaria is a common protozoal infection. Plasmodium vivax malaria is the most common species distributed worldwide and in India. The vivax malarial infection is associated with various haematological and biochemical abnormalities, anaemia and thrombocytopenia among the frequently identified abnormal parameters. However vivax malaria is also associated with abnormal lipid levels including low cholesterol levels and normal to high serum triglyceride levels.Methods: This study is a cross-sectional observational study including 100 inpatients admitted to Medical College Hospital over a period of 18 months diagnosed with Plasmodium vivax malaria. The patients were selected based on inclusion and exclusion criteria. The relevant data was collected and analysed.Results: Vivax malaria infection was found to be more common among males (80%) and during third decade of life (51%). HDL Cholesterol was decreased in all cases, LDL Cholesterol and Total Cholesterol was also decreased in nearly all patients with only 1% cases having values above normal range. Serum Triglycerides was elevated more than 150 mg/dl in 69% cases with 25% cases having values above 200mg/dl. The hypocholestrolemia and hypertriglyceridemia were directly proportional to the thrombocytopenia, hyperbilirubinemia, elevated serum creatinine levels and parasite load.Conclusions: This study demonstrates the presence of altered serum lipid levels in the form of hypocholesterolemia and hypertriglyceridemia in cases of Plasmodium vivax malaria mono infection. This study also shows that the above lipid alterations were found to be deranged to greater extent in clinically, haematologically and biochemically severe form of infections.

scholarly journals Association of the rs7395662 SNP in the MADD-FOLH1 and Several Environmental Factors with Serum Lipid Levels in the Mulao and Han Populations

2013 ◽  
Vol 10 (11) ◽  
pp. 1537-1546 ◽  
Author(s):  
Ke-Ke Huang ◽  
Rui-Xing Yin ◽  
Xiao-Na Zeng ◽  
Ping Huang ◽  
Quan-Zhen Lin ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Serum Lipid ◽  
Lipid Levels ◽  
Serum Lipid Levels
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