scholarly journals Specific gene expression in type 1 diabetic patients with and without cardiac autonomic neuropathy

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Joanna Gastol ◽  
Anna Polus ◽  
Maria Biela ◽  
Urszula Razny ◽  
Lukasz Pawlinski ◽  
...  
Keyword(s):  
Gene Expression ◽  
Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy ◽  
Specific Gene ◽  
Diabetic Patients ◽  
Specific Gene Expression ◽  
Type 1 Diabetic Patients

545-P: Posttranslation Control Mechanisms (miRNAs) in Type 1 Diabetic Patients with and without Cardiac Autonomic Neuropathy

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 545-P
Author(s):  
EWA TOBOR ◽  
ANNA POLUS ◽  
JOANNA GASTOL ◽  
BARTłOMIEJ MATEJKO ◽  
LUKASZ PAWLINSKI ◽  
...  
Keyword(s):  
Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy ◽  
Diabetic Patients ◽  
Control Mechanisms ◽  
Type 1 Diabetic Patients

scholarly journals ECG Body Surface Mapping Changes in Type 1 Diabetic Patients with and without Autonomic Neuropathy

2010 ◽  
pp. 203-209
Author(s):  
S Palová ◽  
K Szabo ◽  
J Charvát ◽  
J Slavíček ◽  
E Medová ◽  
...  
Keyword(s):  
Autonomic Neuropathy ◽  
Body Surface ◽  
Diagnostic System ◽  
Diabetes Mellitus Type 1 ◽  
Diabetic Patients ◽  
Body Surface Mapping ◽  
Surface Mapping ◽  
Patients With Diabetes ◽  
Type 1 Diabetic Patients

ECG body surface mapping (BSM) parameters in patients with diabetes mellitus Type 1 (DM1) are significantly different comparing to healthy non-diabetic subjects. Hypothesis that these changes are more pronounced in DM1 patients with autonomic neuropathy (AN) was tested. The parameters of BSM were registered by diagnostic system Cardiag 112.2 in 54 DM1 patients including 25 with AN and 30 control subjects. AN was diagnosed according to Ewing criteria when two or more Ewing tests were abnormal. In classic 12-lead ECG the heart rate was increased, QRS and QT shortened (p<0.01) and QTC prolonged in DM1 patients. The VCG measurement of QRS-STT angles and spatial QRS-STT angle showed non-significant differences. The absolute values of maximum and minimum in depolarization and repolarization isopotential, isointegral, isoarea maps were significantly different in DM1 patients in comparison with controls (p<0.01). The changes were more pronounced in DM1 patients with AN than in DM patients without AN (p<0.05). The QT duration measured in 82 leads of thorax was significantly shortened in 68 leads of both groups of DM 1 patients (p<0.01) when compared with controls. In 34 of them this shortening was more pronounced in DM1 patients with AN than in DM1 patients without AN (p<0.05). The results showed that the method of ECG BSM is capable to confirm the presence of autonomic neuropathy in diabetic patients.

scholarly journals Predictors of Cardiovascular Autonomic Neuropathy Onset and Progression in a Cohort of Type 1 Diabetic Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
M. Matta ◽  
A. Pavy-Le Traon ◽  
S. Perez-Lloret ◽  
C. Laporte ◽  
I. Berdugo ◽  
...  
Keyword(s):  
Autonomic Neuropathy ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Valsalva Maneuver ◽  
Cardiovascular Autonomic Neuropathy ◽  
Bivariate Analysis ◽  
Diabetic Patients ◽  
Laboratory Assessment ◽  
Low Bmi ◽  
Type 1 Diabetic Patients

Aim. The prevalence of cardiovascular autonomic neuropathy (CAN) in diabetes mellitus is well documented. However, the rate and predictors of both the development and progression of CAN have been less studied. Hereby, we assessed the rate and the major risk factors for CAN initiation and progression in a cohort of type 1 diabetic patients followed over a three-year period. Methods. 175 type 1 diabetic patients (mean age: 50 ± 11 years; female/male: 76/99) with positive bedside screening for CAN were included and underwent 2 standardized autonomic testings using 4 standardized tests (deep breathing, Valsalva maneuver, 30/15 ratio, and changes in blood pressure during standing), separated by 3 ± 1 years. CAN staging was achieved according to the Toronto Consensus Panel on Diabetic Autonomic Neuropathy into 4 categories: absent, possible, confirmed, or severe CAN. Results. Out of the 175 patients included, 31.4% were free of CAN, 34.2% had possible CAN, 24.6% had confirmed CAN, and 9.7% exhibited severe CAN at the first assessment. Among the 103 patients with nonsevere CAN at inclusion, forty-one (39.8%) had an increase of at least one category when reassessed and 62 (60.2%) remained stable. A bivariate analysis indicated that only BMI and exposure to selective serotonin reuptake inhibitors (SSRIs) were significantly different in both groups. A multivariate analysis indicated that lower BMI (OR: 0.15, CI 95%: 0.05–0.48, p=0.003) and SSRI exposure (OR: 4.18, CI 95%: 1.03–16.97, p=0.04) were the sole predictors of CAN deterioration. In the 55 patients negative for CAN at the first laboratory assessment, 12 became positive at the second assessment. Conclusion. No clear predictive factor for CAN onset was identified. However, once present, CAN progression was related to low BMI and SSRI exposure.

scholarly journals Cardiovascular Autonomic Neuropathy and Early Atherosclerosis in Adolescent Type 1 Diabetic Patient

2015 ◽  
Vol 3 (4) ◽  
pp. 681-688 ◽  
Author(s):  
Soha M. Abd El Dayem ◽  
Ahmed A. Battah ◽  
Abo El Magd El Bohy
Keyword(s):  
Coronary Artery ◽  
Autonomic Neuropathy ◽  
Clinical Laboratory ◽  
Cardiovascular Autonomic Neuropathy ◽  
Stepwise Multiple Regression ◽  
Cardiac Autonomic Neuropathy ◽  
Diabetic Patients ◽  
Laboratory Assessment ◽  
Early Atherosclerosis

AIM: To evaluate cardiovascular autonomic neuropathy (CAN) in type 1 Diabetics and to detect its relation to coronary artery calcification.PATIENTS AND METHODS: It is a cross sectional study included 62 diabetics and 30 controls. Clinical, laboratory assessment and 24 Hr holter were done for all patients and controls and coronary artery calcium (CAC) scoring by multisclice CT was done for all patients only. T-test, Mann Whitney U test, and stepwise multiple regression were used for statistical analyses.RESULTS: CAC score was positive in 8.1 % of patients. Heart rate variability (HRV) was significantly lower in diabetics. All parameters of HRV were insignificantly lower in diabetics with positive CAC score. Patients with microalbuminuria had a significantly lower HRV. HRV had a significant correlation with age of patients, duration of disease, HbA1, and Qtc in diabetics.CONCLUSION: Percentage of arrhythmia and early atherosclerosis is high in adolescent type 1 diabetic patients. CAN is associated with early atherosclerosis. Cardiac autonomic neuropathy is associated with older age, longer duration, and poor glycemic control and microalbuminuria.

scholarly journals The influence of cardiovascular autonomic neuropathy on mortality in type 1 diabetic patients; 10-year follow-up

2016 ◽  
Vol 160 (1) ◽  
pp. 111-117 ◽  
Author(s):  
Silvie Lacigova ◽  
Jitka Brozova ◽  
Daniela Cechurova ◽  
Jitka Tomesova ◽  
Michal Krcma ◽  
...  
Keyword(s):  
Autonomic Neuropathy ◽  
Cardiovascular Autonomic Neuropathy ◽  
Diabetic Patients ◽  
Type 1 Diabetic Patients

scholarly journals Diabetic Cardiovascular Autonomic Neuropathy

2021 ◽  
Author(s):  
Amira Siddig ◽  
Abbasher Hussien Mohamed Ahmed ◽  
Khabab Abbasher Hussien Mohamed Ahmed ◽  
Mohammed Eltahier Abdalla Omer
Keyword(s):  
Autonomic Neuropathy ◽  
Diabetic Neuropathies ◽  
Cardiovascular Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
Study Population

Abstract Introduction: Diabetic neuropathies are thought to result from diabetic microvascular injury involving small blood vessels that supply nerves. Cardiac autonomic neuropathy (CAN) represents a serious complication associated with Diabetic neuropathies. Objectives: The aim of the study is to investigate the presence of cardiovascular diabetic autonomic neuropathy in a group of adult diabetic Sudanese patients with ischemic heart disease. Methodology: This is a descriptive prospective cross sectional hospital based study. The study population included type 1 and type 2 diabetic patients admitted to the cardiac care unit in ELshaab Teaching Hospital with acute coronary syndrome over a period of two years, from April 2017to April 2019. Results: A total of 49 males (65.33%) and 26 females (34.67%) were included in the study. CAN was detected in 94.67% of the studied group Conclusion: An incidence of 94.67% cardiovascular autonomic neuropathy in our sample indicates a high occurrence of this syndrome among our diabetic patients. Poor glycemic control is a common feature among our studied group. Sub-clinical autonomic neuropathy can be detected early using autonomic function tests.

Sign in / Sign up

Export Citation Format

Share Document