scholarly journals Quantitative Analysis of Salivary Oral Bacteria Associated with Severe Early Childhood Caries and Construction of Caries Assessment Model

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Lijuan Zhang ◽  
Tongzheng Sun ◽  
Pengfei Zhu ◽  
Zheng Sun ◽  
Shanshan Li ◽  
...  
Keyword(s):  
Early Childhood ◽  
Quantitative Analysis ◽  
Early Childhood Caries ◽  
Oral Bacteria ◽  
Assessment Model ◽  
Caries Assessment ◽  
Severe Early Childhood Caries ◽  
Childhood Caries

Magnetic Bead-Based Salivary Peptidome Profiling Analysis for Severe Early Childhood Caries

2014 ◽  
Vol 49 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Yan Si ◽  
Shuang Ao ◽  
Weijian Wang ◽  
Feng Chen ◽  
Shuguo Zheng
Keyword(s):  
Mass Spectrometry ◽  
Early Childhood ◽  
Early Childhood Caries ◽  
Expression Profiles ◽  
Salivary Protein ◽  
Preschool Age ◽  
Diagnostic Model ◽  
Peptide Mass ◽  
Severe Early Childhood Caries ◽  
Childhood Caries

Objective: To investigate the differential salivary protein expression profiles between children with severe early childhood caries (S-ECC) and caries-free (CF) children at the age of 3 years. Methods: We used matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) combined with weak cation exchange magnetic beads, and peptide mass fingerprints were created by scanning mass spectrometry signals. Salivary samples from 20 children were analyzed (10 for each group). Results: Eleven protein peaks were significantly different (p < 0.05) between the two groups. Eight of these peaks were higher in the S-ECC group and three were higher in the CF group. To establish a diagnostic model for discrimination between the two groups, we chose three peptides (3,186.2, 3,195.8 and 3,324.8 Da) that exhibited the best fitted curve, by which the two groups were better separated when compared with other combinations. Conclusions: The salivary biomarkers identified revealed significant differences between the CF and the S-ECC group. Our results provide novel insight into the salivary protein profile of preschool-age children with dental caries and may lead to the development of a new strategy for screening high-risk populations.

scholarly journals Dental Treatments under the General Anesthesia in a Child with Keratitis, Ichthyosis, and Deafness Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-6
Author(s):  
Sera Sımsek Derelioglu ◽  
Yücel Yılmaz ◽  
Sultan Keles
Keyword(s):  
Early Childhood ◽  
Case Report ◽  
General Anesthesia ◽  
Early Childhood Caries ◽  
Sensorineural Deafness ◽  
Oral Symptoms ◽  
Severe Early Childhood Caries ◽  
Childhood Caries

KID syndrome is a rare genodermatosis characterized by keratitis, ichthyosis, and sensorineural deafness. Although the dermatological, ophthalmologic, and sensorineural defects are emphasized in the literature, oral and dental evaluations are so superficial. In this case report, dental and oral symptoms of a three year and five months old boy with KID syndrome, suffering severe Early Childhood Caries (s-ECC) and dental treatments done under General Anesthesia (GA) were reported.

Streptococcus mutans isolated from children with severe-early childhood caries form higher levels of persisters

2020 ◽  
Vol 110 ◽  
pp. 104601 ◽  
Author(s):  
Aaron Bottner ◽  
Richard Y. He ◽  
Andrea Sarbu ◽  
S.M. Hashim Nainar ◽  
Delphine Dufour ◽  
...  
Keyword(s):  
Early Childhood ◽  
Streptococcus Mutans ◽  
Early Childhood Caries ◽  
Severe Early Childhood Caries ◽  
Childhood Caries

scholarly journals Candida biome of severe early childhood caries (S-ECC) and its cariogenic virulence traits

2020 ◽  
Vol 12 (1) ◽  
pp. 1724484 ◽  
Author(s):  
Kausar Sadia Fakhruddin ◽  
Lakshman Perera Samaranayake ◽  
Hiroshi Egusa ◽  
Hien Chi Ngo ◽  
Chamila Panduwawala ◽  
...  
Keyword(s):  
Early Childhood ◽  
Early Childhood Caries ◽  
Virulence Traits ◽  
Severe Early Childhood Caries ◽  
Childhood Caries

scholarly journals Prevalence and associated Risk Factors of Severe Early Childhood Caries in 12- to 36-month-old Children of Sirmaur District, Himachal Pradesh, India

2017 ◽  
Vol 10 (2) ◽  
pp. 183-187 ◽  
Author(s):  
Ritu G Mangla ◽  
Raman Kapur ◽  
Abhishek Dhindsa
Keyword(s):  
Risk Factors ◽  
Early Childhood ◽  
Oral Health ◽  
Day Care ◽  
Early Childhood Caries ◽  
Himachal Pradesh ◽  
Day Care Centers ◽  
Associated Risk Factors ◽  
Severe Early Childhood Caries ◽  
Childhood Caries

ABSTRACT Aim To assess the prevalence, distribution, and associated risk factors of severe early childhood caries (S-ECC) among 12- to 36-month-old children of district Sirmaur, Himachal Pradesh, India. Materials and methods The present study was conducted on a random sample of 510 children, both boys and girls, between 12 and 36 months of age randomly selected from various government-sponsored day-care centers, private day-care centers, and vaccination centers. Caries was recorded using World Health Organization criteria. Statistical analysis was done by using chi-square test and Mann–Whitney test. A two-sided p value was calculated for each statistical test. Multiple logistic regressions were done to calculate the risk of S-ECC from independent variables. Results In the present study, S-ECC was found in 21% of 510, 12 to 36 months old children of Sirmaur district, Himachal Pradesh. The S-ECC was found to be significantly higher in 25 to 36 months old children's age group and was 27.8% in them as compared with 8% in 12 to 24 months old children. Conclusion Providing anticipatory guidance and education to parents is essential for the promotion of optimal oral health of their children. There is a need for moving upstream to propose and implement policies and programs to improve the oral health of the very young, especially in a developing country like India, which lacks much data on S-ECC. How to cite this article Mangla RG, Kapur R, Dhindsa A, Madan M. Prevalence and associated Risk Factors of Severe Early Childhood Caries in 12- to 36-month-old Children of Sirmaur District, Himachal Pradesh, India. Int J Clin Pediatr Dent 2017;10(2):183-187.

scholarly journals Bacterial diversity and functional analysis of severe early childhood caries and recurrence in India

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Balakrishnan Kalpana ◽  
Puniethaa Prabhu ◽  
Ashaq Hussain Bhat ◽  
Arunsaikiran Senthilkumar ◽  
Raj Pranap Arun ◽  
...  
Keyword(s):  
Early Childhood ◽  
Bacterial Diversity ◽  
Biofilm Formation ◽  
Early Childhood Caries ◽  
Oral Microbiome ◽  
Oral Disease ◽  
Indian Children ◽  
Severe Early Childhood Caries ◽  
Childhood Caries

AbstractDental caries is the most prevalent oral disease affecting nearly 70% of children in India and elsewhere. Micro-ecological niche based acidification due to dysbiosis in oral microbiome are crucial for caries onset and progression. Here we report the tooth bacteriome diversity compared in Indian children with caries free (CF), severe early childhood caries (SC) and recurrent caries (RC). High quality V3–V4 amplicon sequencing revealed that SC exhibited high bacterial diversity with unique combination and interrelationship. Gracillibacteria_GN02 and TM7 were unique in CF and SC respectively, while Bacteroidetes, Fusobacteria were significantly high in RC. Interestingly, we found Streptococcus oralis subsp. tigurinus clade 071 in all groups with significant abundance in SC and RC. Positive correlation between low and high abundant bacteria as well as with TCS, PTS and ABC transporters were seen from co-occurrence network analysis. This could lead to persistence of SC niche resulting in RC. Comparative in vitro assessment of biofilm formation showed that the standard culture of S. oralis and its phylogenetically similar clinical isolates showed profound biofilm formation and augmented the growth and enhanced biofilm formation in S. mutans in both dual and multispecies cultures.

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