scholarly journals Phosphate clearance in peritoneal dialysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Malgorzata Debowska ◽  
Rafael Gomez ◽  
Joyce Pinto ◽  
Jacek Waniewski ◽  
Bengt Lindholm
Keyword(s):  
Peritoneal Dialysis ◽  
Serum Level ◽  
Phosphorus Removal ◽  
Serum Levels ◽  
Phosphate Removal ◽  
Dialysis Therapy ◽  
Lower Serum ◽  
Factors Associated ◽  
Lower Serum Level ◽  
Phosphate Control

Abstract In renal failure, hyperphosphatemia is common and correlates with increased mortality making phosphate removal a key priority for dialysis therapy. We investigated phosphate clearance, removal and serum level, and factors associated with phosphate control in patients undergoing continuous ambulatory (CAPD), continuous cyclic (CCPD) and automated (APD) peritoneal dialysis (PD). In 154 prevalent PD patients (mean age 53.2 ± 17.6 year, 59% men, 47% anuric), 196 daily collections of urine and 368 collections of dialysate were evaluated in terms of renal, peritoneal and total (renal plus peritoneal) phosphorus removal (g/week), phosphate and creatinine clearances (L/week) and urea KT/V. Dialytic removal of phosphorus was lower in APD (1.34 ± 0.62 g/week) than in CAPD (1.89 ± 0.73 g/week) and CCPD (1.91 ± 0.63 g/week) patients; concomitantly, serum phosphorus was higher in APD than in CAPD (5.55 ± 1.61 vs. 4.84 ± 1.23 mg/dL; p < 0.05). Peritoneal and total phosphate clearances correlated with peritoneal (rho = 0.93) and total (rho = 0.85) creatinine clearances (p < 0.001) but less with peritoneal and total urea KT/V (rho = 0.60 and rho = 0.65, respectively, p < 0.001). Phosphate removal, clearance and serum levels differed between PD modalities. CAPD was associated with higher peritoneal removal and lower serum level of phosphate than APD.

Peritoneal phosphate removal varies by peritoneal dialysis regimen: an underestimated parameter of phosphate control

2012 ◽  
Vol 26 (1) ◽  
pp. 183-190 ◽  
Author(s):  
Carlos Botelho ◽  
Anabela Rodrigues ◽  
Jose Carlos Oliveira ◽  
António Cabrita
Keyword(s):  
Peritoneal Dialysis ◽  
Phosphate Removal ◽  
Phosphate Control

A lower serum level of middle-molecular-weight adiponectin is a risk factor for endometrial cancer

2013 ◽  
Vol 19 (4) ◽  
pp. 667-673 ◽  
Author(s):  
Yukari Ohbuchi ◽  
Yasunobu Suzuki ◽  
Ikuo Hatakeyama ◽  
Yoshifumi Nakao ◽  
Atsuya Fujito ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Endometrial Cancer ◽  
Risk Factor ◽  
Serum Level ◽  
Lower Serum ◽  
Lower Serum Level

scholarly journals Association of potato and other starchy vegetable consumption with cardiovascular diseases risk factors in Iranian elderly men

2020 ◽  
Author(s):  
Mursal Basiry ◽  
Elnaz Daneshzad ◽  
Hadis Mozaffari ◽  
Leila Azadbakht
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Serum Level ◽  
Vegetable Consumption ◽  
Cvd Risk Factors ◽  
Elderly Men ◽  
Cvd Risk ◽  
Lower Serum ◽  
Lower Serum Level ◽  
Potato Consumption

Abstract Objectives. Given the limited research on potato and other starchy vegetable consumption with cardiovascular diseases (CVD), we examined the association of potato and other starchy vegetable intakes in association with cardiovascular risk factors and inflammatory biomarkers among elderly men. Study Design. A cross-sectional study. Methods. In this study, 357 elderly men were participated. Dietary intake was assessed using food a valid and reliable frequency questionnaires. Two separated groups were considered. 1. Potato, 2. Other Starchy vegetables including corn, squash, green pea, and green lima beans. CVD risk factors including HDL, LDL, FBS, TG, TC, Alkaline phosphatase, Fibrinogen, Insulin, IL-6, TNF-α, SGOT and SGPT were measured. Results. Participants in the highest tertile of potato consumption had a 45% lower serum level of fasting blood sugar (OR: 0.55; 95%CI: 0.31, 1.97; P trend: 0.041). However, this significant association disappeared after controlling for confounders. The participants in the highest tertile of potato consumption had higher serum level of triglyceride (OR: 4.52 95%CI: 1.10, 18.56; P trend: 0.030). Moreover, participants in the highest tertiles of other starchy vegetable consumption had an 84% lower serum level of alanine aminotransferase (OR: 0.16 95%CI: 0.03, 0.90; P trend: 0.040). Conclusion. Overall, more consumption of potato may be related to developing CVD risk factors. Future research is needed to elucidate the association between potato and other starchy vegetable consumption with cardiovascular diseases risk factors in both genders.

scholarly journals ASSOCIATION OF HLA AND CYTOKINES OF BLOOD WITH ANTIINFLAMMATORY EFFECTS IN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS

2017 ◽  
pp. 13-19
Author(s):  
M. Kolesnyk ◽  
V. Driyanska ◽  
G. Drannik ◽  
O. Petrina ◽  
M. Velychko ◽  
...  
Keyword(s):  
Serum Level ◽  
Prognostic Markers ◽  
Hla Antigens ◽  
Serum Levels ◽  
High Serum ◽  
Chronic Glomerulonephritis ◽  
Healthy Donors ◽  
Lower Serum Level ◽  
Steroid Sensitive ◽  
Antiinflammatory Effects

Cytokines and HLA take important part in immunogenesis of many diseases, therefore the analysis of these indices and this associations in dependence of glomerulonephritis (GN) can define their value as the additional prognostic markers. Aim of the work is to determine the of associations the high serum levels of cytokines (IL-4, IL-17) and peculiarities of some HLA in phenotype to substantiate of chronic glomerulonephritis with nephrotic syndrome (CGN, NS) immunogen- esis and to ascertain the additional prognostic markers. Materials and methods. There was studied the HLA-antigens distribution in the 264 adult patients CGN, NS (the diagnosis was confirmed morphologically using the thin needle nephrobiopsy) and 350 healthy donors by typing the lymphocytes with the aid of standard microlymphocytotoxic test (Terasaki’s test). HLA antigens were defined using a standard microlymphocytotoxic test on the Terasaki's planchette with special panels ofanti-HLA serums (20 antigens of locus A, 31 - B and 9 - DR). The etiologic fraction (attributive risks ) was counted using the formula: ct = x - y/I - y, where x - frequency of antigen in patients and y - frequency in healthy. The ct reading was considered significant when it exceeded 0,1. Using ELISA, the level of the cytokines was studied in the blood serum - IL-4 in 76 and IL-17 – 79 patients. Results. HLA-A23, -24, -28, -B8, -38, -41, -44, DR1, -4, -w52 in adults patients have associations (RR>2) CGN, NS; the attributive risk (AR) (<j>0,1) to develop GN detected in patients have A24, A28, B8, DR 1, 4, w52. The CGN, NS patients has statistically higher serum level of the IL-4 and IL-17, with more high indices of this cytokines in patients with attributive risk antigens HLA-A24 and A-28. The highest levels of IL-17 detected also in adults case have B14 and B38, which associated with steroid sensitive NS. HLA-B8, which associated with steroid resistant NS, have more patients with CGN, NS with lower serum level of antiinflammatory IL-4. Conclusion. The patients with CGN, NS have associations of HLA and serum levels of pro- and antiinflammatory cytokines IL-4 and IL-17, which play role of additional prognostic predictors.

Comparison of Control of Serum Phosphate Levels during Continuous Ambulatory Peritoneal Dialysis and during Hemodialysis

1983 ◽  
Vol 3 (2) ◽  
pp. 97-98 ◽  
Author(s):  
Jorge B Cannata ◽  
James D Briggs ◽  
Gordon S Fell ◽  
Brian J.R. Junor
Keyword(s):  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Aluminium Hydroxide ◽  
Protein Intake ◽  
Serum Levels ◽  
Aluminium Toxicity ◽  
Hemodialysis Patients ◽  
Serum Phosphate ◽  
Serum Phosphate Level ◽  
Phosphate Control

Recent reports have suggested that oral aluminium hydroxide carries the risk of aluminium toxicity. We have compared the aluminium hydroxide dose and serum levels of phosphate and aluminium in 27 CAPD and 26 hemodialysis patients. Despite a more liberal protein intake and lower aluminium hydroxide dose, the CAPD patients achieved the same serum phosphate level as those on hemodialysis. While the reason for more efficient serum phosphate control with CAPD is uncertain, the better control gives CAPD an advantage in patients in whom it is particularly important to minimise exposure to aluminium.

Lower Serum Level of Adiponectin Is Associated with Increased Risk of Endoscopic Erosive Gastritis

2011 ◽  
Vol 56 (8) ◽  
pp. 2354-2360 ◽  
Author(s):  
Shunsuke Yamamoto ◽  
Kenji Watabe ◽  
Shusaku Tsutsui ◽  
Shinichi Kiso ◽  
Toshimitsu Hamasaki ◽  
...  
Keyword(s):  
Serum Level ◽  
Erosive Gastritis ◽  
Lower Serum ◽  
Increased Risk ◽  
Lower Serum Level

Dialytic Phosphate Removal: A Modifiable Measure of Dialysis Efficacy in Automated Peritoneal Dialysis

2009 ◽  
Vol 29 (4) ◽  
pp. 465-471 ◽  
Author(s):  
Claus P. Schmitt ◽  
Dagmara Borzych ◽  
Barbara Nau ◽  
Elke Wühl ◽  
Aleksandra Zurowska ◽  
...  
Keyword(s):  
Risk Factors ◽  
Peritoneal Dialysis ◽  
Cardiovascular Mortality ◽  
Dwell Time ◽  
Phosphate Removal ◽  
Automated Peritoneal Dialysis ◽  
Number Of Cycles ◽  
The Relationship ◽  
Phosphate Control ◽  
Total Fluid

Background Although hyperphosphatemia is one of the few established risk factors for cardiovascular mortality in patients on dialysis, the relationship between peritoneal dialysis (PD) prescription and dialytic phosphate removal is largely unexplored. Methods and Patients We analyzed 24-hour clearances ( n = 60) together with peritoneal equilibration tests (PETs) ( n = 52) performed in children and adolescents ( n = 35) on automated PD. Results Dialytic phosphate clearance was more closely correlated with 2-hour and 4-hour dialysate-to-plasma ratio (D/P) of phosphate in the PETs ( r = 0.44 and r = 0.52, both p < 0.0001) than with 2-hour and 4-hour D/P creatinine ( r = 0.26 and r = 0.27, both p < 0.05). Dialytic 24-hour phosphate clearance was independently predicted by total fluid turnover (partial R2 = 0.48, p < 0.001), the number of cycles ( r = 0.52, p < 0.001), 2-hour D/P phosphate (partial R2 = 0.07, p = 0.001), dwell time (partial R2 = 0.05, p = 0.01), and achieved ultrafiltration (partial R2 = 0.05, p = 0.005). 4-hour D/P phosphate and 24-hour phosphate clearance were significantly lower in hyperphosphatemic children (3.38 ± 1.17 vs 4.56 ± 1.99 L/1.73 m2/day, p < 0.05), whereas creatinine equilibration and clearance rates were not distinctive. Conclusion Dialytic phosphate removal is an important modifiable determinant of phosphate control in automated PD. It strongly depends on total dialysate turnover and the prescribed number of cycles and is more adequately predicted by phosphate than by creatinine equilibration characteristics. Due to the deleterious effects of hyperphosphatemia, dialytic phosphate removal should be monitored routinely.

scholarly journals Severe Fatigue and Memory Impairment Are Associated with Lower Serum Level of Anti-SARS-CoV-2 Antibodies in Patients with Post-COVID Symptoms

2021 ◽  
Vol 10 (19) ◽  
pp. 4337
Author(s):  
Tihamer Molnar ◽  
Reka Varnai ◽  
Daniel Schranz ◽  
Laszlo Zavori ◽  
Zoltan Peterfi ◽  
...  
Keyword(s):  
Serum Level ◽  
Memory Impairment ◽  
Disease Onset ◽  
Strongly Correlated ◽  
Lower Serum ◽  
Time Points ◽  
Persistent Symptoms ◽  
Severe Fatigue ◽  
Lower Serum Level

Background: Post-COVID manifestation is defined as persistent symptoms or long-term complications beyond 4 weeks from disease onset. Fatigue and memory impairment are common post-COVID symptoms. We aimed to explore associations between the timeline and severity of post-COVID fatigue and anti-SARS-CoV-2 antibodies. Methods: Fatigue and memory impairment were assessed in a total of 101 post-COVID subjects using the Chalder fatigue scale (CFQ-11) and a visual analogue scale. Using the bimodal scoring system generated from CFQ-11, a score ≥4 was defined as severe fatigue. Serum anti-SARS-CoV-2 spike (anti-S-Ig) and nucleocapsid (anti-NC-Ig) antibodies were examined at two time points: 4–12 weeks after onset of symptoms, and beyond 12 weeks. Results: The serum level of anti-S-Ig was significantly higher in patients with non-severe fatigue compared to those with severe fatigue at 4–12 weeks (p = 0.006) and beyond 12 weeks (p = 0.016). The serum level of anti-NC-Ig remained high in patients with non-severe fatigue at both time points. In contrast, anti-NC-Ig decreased significantly in severe fatigue cases regardless of the elapsed time (4–12 weeks: p = 0.024; beyond 12 weeks: p = 0.005). The incidence of memory impairment was significantly correlated with lower anti-S-Ig levels (−0.359, p < 0.001). Conclusion: The systemic immune response reflected by antibodies to SARS-CoV-2 is strongly correlated with the severity of post-COVID fatigue.

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