Association between chemotherapy and prognostic factors of survival in hepatocellular carcinoma: a SEER population-based cohort study

AbstractHepatectomy and transplantation are the main surgical therapies for HCC patients, and radiotherapy or chemotherapy is often used as adjuvant treatment. Researches have evaluated the independent predictors of HCC, but evidence for factors predicting the efficacy of chemotherapy is rare. Patients diagnosed with HCC between 2010 and 2015 from the SEER database were included and randomly divided into non-chemotherapy and chemotherapy groups. The predictors of CSS and OS were analyzed with the Cox proportional-hazards regression model and Fine and Gray’s competing risk model. Although there was no significant difference in survival analysis between the chemotherapy and non-chemotherapy groups, the cumulative cancer-specific mortality of most HCC patients was decreased in the chemotherapy group. AJCC stage, tumor size, grade, surgery and radiotherapy were predictors of OS and CSS in the non-chemotherapy group, while AJCC stage, tumor size, AFP, grade and surgery in the chemotherapy group. Surgery combined with chemotherapy was applicable to all AJCC stage patients. Surgery was the major treatment option for patients in AJCC I and AJCC II stage, and chemotherapy in AJCC III and AJCC IV stage. In conclusion, the study provided population-based estimates of the prognostic factors in HCC patients with or without chemotherapy.

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Association between chemotherapy and prognostic factors of survival in hepatocellular carcinoma: a SEER population‑based cohort study

10.21203/rs.3.rs-832887/v1 ◽

2021 ◽

Author(s):

Meiqi Liu ◽

Mengying Xu ◽

Tiantian Tang

Keyword(s):

Prognostic Factors ◽

Tumor Size ◽

Proportional Hazards ◽

Risk Model ◽

Population Based ◽

Cox Proportional Hazards ◽

Chemotherapy Group ◽

Ajcc Stage ◽

Significant Difference ◽

Size Grade

Abstract Background Hepatectomy and transplantation are the main surgical therapies for HCC patients, and radiotherapy or chemotherapy is often used as the adjuvant treatment. Researches have evaluated the independent predictors of HCC, but evidence for factors predicting the efficacy of chemotherapy is rare. Methods Patients diagnosed with HCC between 2010 and 2015 from the SEER database were included and randomly divided into non-chemotherapy and chemotherapy groups. The predictors of CSS and OS were analyzed with the Cox proportional-hazards regression model and Fine and Gray’s competing risk model. Results Although there was no significant difference in survival analysis between the chemotherapy and non-chemotherapy groups, the cumulative cancer-specific mortality of most HCC patients were decreased in chemotherapy group. AJCC stage, tumor size, grade, surgery and radiotherapy were predictors of OS and CSS in non-chemotherapy group, while AJCC stage, tumor size, AFP, grade and surgery in chemotherapy group. Surgery combined with chemotherapy was applicable to all AJCC stage patients. Surgery was the major treatment option for patients in AJCC Ⅰ and AJCC Ⅱ stage, and chemotherapy in AJCC Ⅲ and AJCC Ⅳ stage. Conclusions In conclusion, the study provided population-based estimates of the prognostic factors in HCC patients with or without chemotherapy.

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Characteristics and prognosis of pelvic Ewing sarcoma: a SEER population-based study

PeerJ ◽

10.7717/peerj.7710 ◽

2019 ◽

Vol 7 ◽

pp. e7710

Author(s):

Li Chen ◽

Cheng Long ◽

Jiaxin Liu ◽

Fei Xing ◽

Xin Duan

Keyword(s):

Prognostic Factors ◽

Ewing Sarcoma ◽

Tumor Size ◽

Proportional Hazards ◽

Multivariate Analyses ◽

Survival Rates ◽

Tumor Stage ◽

Population Based ◽

Cox Proportional Hazards ◽

Survival Prediction

Background The pelvis is one of the primary sites of Ewing sarcoma (ES) and is associated with poorer prognoses than the extremities. Due to the rarity of this disease and limited data available, the prognostic factors of pelvic ES remain controversial. Thus, this study aimed to identify independent prognostic factors, and develop a nomogram for predicting survival rates in patients with pelvic ES. Methods Using data provided by the Surveillance, Epidemiology, and End Results (SEER) database, variables including age, sex, race, tumor size, tumor stage, surgery, and radiotherapy were analyzed using the Kaplan–Meier method and Cox proportional hazards regression. Based on the results of multivariate analyses, a nomogram was built to predict the overall survival (OS) of patients with pelvic ES. The performance of the nomogram was evaluated by the concordance index (C-index). Results A total of 267 cases diagnosed between 2004 and 2016 were included in the study. Univariate and multivariate analyses showed that patients who were younger, white, had a localized tumor stage, or underwent surgery were associated with improved prognoses, while no significant differences were observed in OS based on sex, tumor size, or radiotherapy. A nomogram was developed and the C-index was 0.728, indicating adequate performance for survival prediction. Conclusions Age, race, tumor stage, and surgery were identified as independent prognostic factors for the OS of pelvic ES. The nomogram developed in this study can individually predict 3- and 5-year OS in patients with pelvic ES.

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Clinicopathological Features, Prognostic Factors, Survival Trends, and Treatment of Malignant Ovarian Germ Cell Tumors: A SEER Database Analysis

Oncology Research and Treatment ◽

10.1159/000509189 ◽

2021 ◽

Vol 44 (4) ◽

pp. 145-152

Author(s):

Hualei Guo ◽

Hao Chen ◽

Wenhui Wang ◽

Lingna Chen

Keyword(s):

Prognostic Factors ◽

Germ Cell ◽

Proportional Hazards ◽

Germ Cell Tumors ◽

Cox Proportional Hazards ◽

Low Grade ◽

Seer Database ◽

Survival Times ◽

Survival Curves ◽

Significant Difference

Objective: The aim of this study was to investigate the clinicopathological prognostic factors of malignant ovarian germ cell tumors (MOGCT) and evaluate the survival trends of MOGCT by histotype. Methods: We extracted data on 1,963 MOGCT cases diagnosed between 2000 and 2014 from the Surveillance, Epidemiology, and End Results (SEER) database and the histological classification of MOGCT, including 5 categories: dysgerminoma, embryonal carcinoma (EC), yolk sac tumor, malignant teratoma, and mixed germ cell tumor. We examined overall and disease-specific survival of the 5 histological types. Kaplan-Meier and Cox proportional hazards regression models were used to estimate survival curves and prognostic factors. We also estimated survival curves of MOGCT according to different treatments. Results: There was a significant difference in prognosis among different histological classifications. Age, histotype, grade, SEER stage, and surgery were independent prognostic factors for survival of patients with MOGCT. For all histotypes, 1-, 3-, and 5-year survival rate estimates were >85%, except for EC, which had the worst outcomes at 1 year (55.6%), 3 years (44.4%), and 5 years (33.3%). In the distant SEER stage, both chemotherapy and surgery were associated with improved survival outcomes compared with surgery- and chemotherapy-only groups. Conclusions: Dysgerminoma patients had the most favorable outcomes, whereas EC patients had the worst survival. A young age, low grade, and surgery were all significant predictors for improved survival. In contrast, a distant SEER stage was a risk factor for poor survival. Chemotherapy combined with surgery contributed to longer survival times of patients with MOGCT in the distant SEER stage.

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Major depressive disorder is associated with subsequent adult-onset asthma: a population-based cohort study

Epidemiology and Psychiatric Sciences ◽

10.1017/s2045796016000664 ◽

2016 ◽

Vol 26 (6) ◽

pp. 664-671 ◽

Cited By ~ 5

Author(s):

T-C. Shen ◽

C-L. Lin ◽

C.H. Liao ◽

C-C. Wei ◽

F-C. Sung ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Selective Serotonin Reuptake Inhibitors ◽

Proportional Hazards ◽

Population Based ◽

Cox Proportional Hazards ◽

Adult Patients ◽

Major Depressive ◽

Significant Difference ◽

Receptor Blockers

Aim.To examine the incidence of asthma in adult patients with major depressive disorder (MDD).Methods.From the National Health Insurance database of Taiwan, we identified 30 169 adult patients who were newly diagnosed with MDD between 2000 and 2010. Individuals without depression were randomly selected four times and frequency matched for sex, age and year of diagnosis. Both cohorts were followed-up for the occurrence of asthma up to the end of 2011. Adjusted hazard ratios (aHRs) of asthma were estimated using the Cox proportional hazards method.Results.The overall incidence of asthma was 1.91-fold higher in the MDD cohort than in the non-depression cohort (7.55 v. 3.96 per 1000 person-years), with an aHR of 1.66 (95% confidence interval (CI) 1.55–1.78). In both cohorts, the incidence of asthma was higher in patients and controls who were female, aged, with comorbidities and users of aspirin or beta-adrenergic receptor blockers. No significant difference was observed in the occurrence of asthma between patients with MDD treated with selective serotonin reuptake inhibitors (SSRIs) and those treated with non-SSRIs (SSRIs to non-SSRIs aHR = 1.03, 95% CI 0.91–1.17).Conclusion.Adult patients with MDD are at a higher risk of asthma than those without depression are.

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Predictors and survival of Primary clear cell carcinoma of liver: a population-based study of an uncommon primary liver tumor

10.21203/rs.3.rs-22841/v1 ◽

2020 ◽

Author(s):

Jie Wen ◽

Abudureyimujiang Aili ◽

xueyan yao ◽

Junjie Wang ◽

li xiang xue

Keyword(s):

Prognostic Factors ◽

Cell Carcinoma ◽

Proportional Hazards ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Cox Proportional Hazards ◽

Pathological Grade ◽

Primary Liver Tumor ◽

Risk Of Death ◽

Ajcc Stage

Abstract Background: The clinicopathological features and prognostic factors of primary clear cell carcinoma of the liver (PCCCL) remain unknown. Aims: We aimed to determine the clinical, pathological, demographic, and therapeutic characteristics of PCCCL and the effects of these factors on the prognosis. Methods: Patients were selected from the "Surveillance, Epidemiology and End Results" (SEER) database. Data were analyzed with the Kaplan-Meier, Cox proportional hazards regression, and multivariate ordinal regression analyses. Results: We included 248 PCCCL patients with an average age of 64.1 years. The majority (50.4%) had low pathological grade (grade I/II). The 3-, 5-, and 10-year overall survival (OS) probabilities and disease-specific survival (DSS) rates were 33.8%, 23.2%, 12.2%, and 39.8%, 28.3%, 19.1%, respectively. The widowed patients (OS, P=0.271; DSS, P=0.022) with tumor ≥ 1 cm (OS, P=0.001; DSS, P=0.002) had a higher risk of death. Uninsurance and medicaid were independently associated with a shorter survival (OS, P=0.029; DSS, P=0.017). Among surgical means, total proctectomy along with total colectomy, and wedge or segmental resection/partial proctosigmoidectomy were more beneficial to PCCCL. The black PCCCL patients had a poorer survival than the white group. Furthermore, pathological grade I PCCCL was more likely to present AJCC stage I (P=0.005, OR=-1.062). Conclusion: PCCCL patients had a poor outcome. PCCCL was inclined to be localized, male-prevalent and lower pathological grade. Insurance, tumor size, and marital status were independent prognostic factors for OS and DSS, whereas race affected only OS. Surgery could improve OS and DSS. Moreover, highly differentiated PCCCL was susceptible to early AJCC stage.

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Breast Angiosarcoma: a SEER Population- Based Study

10.21203/rs.3.rs-531109/v1 ◽

2021 ◽

Author(s):

Zhengshui Xu ◽

Xiaopeng Li ◽

Jing Guo ◽

Liyue Yuan ◽

Zilu Chen ◽

...

Keyword(s):

High Risk ◽

Tumor Size ◽

Proportional Hazards ◽

Population Based ◽

Therapeutic Strategies ◽

Cox Proportional Hazards ◽

Treatment Modalities ◽

Matched Data ◽

The Impact ◽

Extent Of Disease

Abstract Background Breast angiosarcoma is a rare malignancy with poor survival. Due to the paucity of data, the generation of high-quality evidence for its high-risk features and the impact of treatment modalities on survival have been hampered. Objective To examine high-risk features and the impact of treatment modalities on disease-specific survival (DSS) in breast angiosarcoma and differences between breast angiosarcoma cases with and without other prior cancers. Methods In this retrospective study, patients with breast angiosarcoma diagnosed from 1975 to 2016 were identified from the Surveillance, Epidemiology, and End Results database. Cox proportional hazards regression analysis adjusted for age, race, decade at diagnosis, location, pathologic grade, extent of disease, tumor size, and therapy to model DSS outcomes. Propensity score matching analyses were performed to adjust for the differences between breast angiosarcoma cases with and without other prior cancers to compare their DSS values. A Kaplan-Meier curve was used to visualize the cumulative survival probability. Results Of 648 patients with breast angiosarcoma, 55.4% had a prior cancer diagnosis. Older (age ≥ 70) patients were more likely to have breast angiosarcoma with prior cancer than younger patients (64.3% versus 21.8%). Via multivariate analysis, pathologic grade and extent of disease were identified to be significantly associated with DSS in breast angiosarcoma. In matched data, breast angiosarcoma patients with prior cancer had a better DSS than those without prior cancer (HR = 0.60, 95%CI 0.38–0.96, p = 0.0389). In breast angiosarcoma patients without prior cancer, patients with larger tumor size receiving surgery plus radiation or/and chemotherapy might have a better survival than those patients receiving surgery only (HR = 0.38, 95%CI 0.14–0.99, p = 0.0128). DSS is not impacted by the current therapeutic strategies in unselected breast angiosarcoma patients. Conclusions Breast angiosarcoma patients with prior cancer have a better DSS than those without prior cancer. Additionally, some breast angiosarcoma cases with prior cancer may be cutaneous angiosarcomas. Pathologic grade and extent disease are high-risk features. DSS is not impacted by the current therapeutic strategies in unselected breast angiosarcoma patients.

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Head & neck acinar cell carcinoma: a population-based study using the seer registry

10.21203/rs.3.rs-26412/v2 ◽

2020 ◽

Author(s):

Feiluore Yibulayin ◽

Lei Feng ◽

Meng Wang ◽

Meng-meng Lu ◽

Yuan Luo ◽

...

Keyword(s):

Prognostic Factors ◽

Cell Carcinoma ◽

Acinar Cell ◽

Acinar Cell Carcinoma ◽

Population Based ◽

Clinicopathologic Characteristics ◽

Population Based Study ◽

Ajcc Stage ◽

Significant Difference ◽

Grade Iii

Abstract Background: to explore the clinicopathologic characteristics, treatment and prognostic factors of head and neck acinar cell carcinoma (HNACC) comprehensively. Methods: A population-based study was conducted using data from the Surveillance, Epidemiology, and End Results database (1975- 2016). Overall survival (OS) and HNACC-specific survival of patients with different clinicopathologic variables were compared using the Kaplan-Meier method and Cox multivariate regression. Results: A total of 2624 primary HNACC cases (1052 males, 1572 females) were identified. There was a significant difference in gender distribution. Among the total cohort, 2416 cases originated from salivary glands, including 2325 parotid gland ACC cases. Regardless of confounding factors, the 10-year and 20-year disease-specific survival (DSS) was 93.6% and 90%, respectively. Surgery was favourably associated with better DSS and OS [HR = 0.13, P = 0.0092 and HR = 0.23, P = 0.0203]. Gender was the only demographic independent prognostic factor for both DSS and OS [male vs female, HR = 3.3, P = 0.0028 for DSS; HR = 2.44, P = 0.0376 for OS]. Higher pathological grade was adversely associated with DSS and OS [Grade II, HR= 4.03, P = 0.0444; Grade III + IV, HR = 35.64, P = 0.0000 for DSS; Grade III + IV, HR = 4.49, P = 0.0000 for OS, Grade I as reference]. In addition, TNM/AJCC stage was commonly associated with prognosis. Conclusion: Surgery was the only favourable prognostic indicator for both DSS and OS. Gender, age, pathological differentiation and TNM/AJCC stage were independent prognostic factors for survival.

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Comparing the Characteristics and Predicting the Survival of Head and Neck Melanoma versus Body Melanoma: A Population-based Study

10.21203/rs.3.rs-154802/v1 ◽

2021 ◽

Author(s):

Yuxin Ding ◽

Runyi Jiang ◽

Yuhong Chen ◽

Jing Jing ◽

Xiaoshuang Yang ◽

...

Keyword(s):

Prognostic Factors ◽

Head And Neck ◽

Proportional Hazards ◽

Population Based ◽

Cox Proportional Hazards ◽

Kaplan Meier ◽

Cox Proportional Hazards Models ◽

Great Consistency ◽

Lentigo Maligna Melanoma ◽

Head And Neck Melanoma

Abstract Background Previous studies have reported poorer survival in head and neck melanoma (HNM) than in body melanoma (BM). Individualized tools to predict the prognosis for patients with HNM or BM remain insufficient. Objectives To compare the characteristics of HNM and BM, and to establish and validate the nomograms for predicting the 3-, 5- and 10-year survival of patients with HNM or BM. Methods We studied patients with HNM or BM from 2004 to 2015 in the Surveillance, Epidemiology, and End Results (SEER) database. The HNM group and BM group were randomly divided into training and validation cohorts. We performed the Kaplan-Meier method for survival analysis, and used multivariate Cox proportional hazards models to identify independent prognostic factors. Nomograms for HNM patients or BM patients were developed via the rms package, and were measured by the concordance index (C-index), the area under the receiver operator characteristic (ROC) curve (AUC) and calibration plots. Results Of 70605 patients acquired, 21% (n = 15071) had HNM and 79% (n = 55534) had BM. The HNM group contained more older patients, male patients, and lentigo maligna melanoma, and more frequently had thicker tumors and metastases than the BM group. The 5-year CSS and OS rates were 88.1 ± 0.3% and 74.4 ± 0.4% in the HNM group and 92.5 ± 0.1% and 85.8 ± 0.2% in the BM group, respectively. Eight independent prognostic factors (age, sex, histology, thickness, ulceration, stage, metastases, and surgery) were identified to construct nomograms for HNM patients or BM patients. The performance of the nomograms were excellent: the C-index of the CSS prediction for HNM patients and BM patients in the training cohort were 0.839 and 0.895, respectively; in the validation cohort, they were 0.848 and 0.888, respectively; the AUCs for the 3-, 5- and 10-year CSS rates of HNM were 0.871, 0.865 and 0.854 (training), and 0.881, 0.879 and 0.861 (validation), respectively; of BM, the AUCs were 0.924, 0.918 and 0.901 (training) and 0.916, 0.908 and 0.893 (validation), respectively; and the calibration plots showed great consistency. Conclusions The characteristics of HNM and BM are heterogeneous, and we constructed and validated specific nomograms as practical prognostic tools for patients with HNM or BM.

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Head & Neck Acinar Cell Carcinoma: A Population-Based Study Using the Seer Registry

10.21203/rs.3.rs-26412/v1 ◽

2020 ◽

Author(s):

Feiluore Yibulayin ◽

Meng Wang ◽

Meng-meng Lu ◽

Yuan Luo ◽

Hui Liu ◽

...

Keyword(s):

Prognostic Factors ◽

Cell Carcinoma ◽

Acinar Cell ◽

Acinar Cell Carcinoma ◽

Population Based ◽

Clinicopathologic Characteristics ◽

Population Based Study ◽

Ajcc Stage ◽

Significant Difference ◽

Grade Iii

Abstract Background:to explorethe clinicopathologic characteristics, treatment and prognostic factors of head and neck acinar cell carcinoma (HNACC) comprehensively.Methods:A population-based study was conductedusing data from the Surveillance, Epidemiology, and End Results database (1975- 2016). Overall survival (OS) and HNACC-specific survival of patients with different clinicopathologic variables were compared using the Kaplan-Meier method and Cox multivariate regression.Results:A total of 2624 primary HNACC cases (1052 males, 1572 females) were identified. There was a significant difference in gender distribution. Among the total cohort, 2416 cases originated from salivary glands, including 2325 parotid gland ACC cases. Regardless of confounding factors, the 10-year and 20-year disease-specific survival (DSS) was 93.6% and 90%, respectively. Surgery was favourably associated with better DSS and OS [HR= 0.13, P = 0.0092 andHR = 0.23, P = 0.0203]. Gender was the only demographic independent prognostic factor for both DSS and OS [male vs female, HR = 3.3, P = 0.0028 for DSS; HR = 2.44, P = 0.0376 for OS]. Higher pathological grade was adversely associated with DSS and OS [Grade II, HR= 4.03, P = 0.0444; Grade III + IV, HR = 35.64, P = 0.0000 for DSS; Grade III + IV, HR = 4.49, P = 0.0000 for OS, Grade I as reference]. In addition, TNM/AJCC stage was commonly associated with prognosis.Conclusion:Surgerywasthe only favourable prognostic indicator for both DSS and OS. Gender, age, pathological differentiation and TNM/AJCC stage were independent prognostic factors for survival.

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Endoscopic and Surgical Treatment of T1N0M0 Colorectal Neuroendocrine Tumors: A Population-Based Comparative Study

10.21203/rs.3.rs-34558/v1 ◽

2020 ◽

Author(s):

Hanlong Zhu ◽

Si Zhao ◽

Kun Ji ◽

Wei Wu ◽

Jian Zhou ◽

...

Keyword(s):

Neuroendocrine Tumors ◽

Tumor Size ◽

Proportional Hazards ◽

Population Based ◽

Cox Proportional Hazards ◽

Treatment Modalities ◽

Cancer Specific Survival ◽

Term Survival ◽

Population Based Study

Abstract Background: With the rapid advances in endoscopic technology, endoscopic therapy (ET) is increasingly applied to the treatment of small (≤20 mm) colorectal neuroendocrine tumors (NETs). However, long-term data comparing ET and surgery for management of T1N0M0 colorectal NETs are lacking. The purpose of this work was to compare overall survival (OS) and cancer-specific survival (CSS) of such patients with ET or surgery.Methods: Patients with T1N0M0 colorectal NETs were identified within the Surveillance Epidemiology and End Results (SEER) database (2004-2016). Demographics, tumor characteristics, therapeutic methods, and survival were compared. Propensity score matching (PSM) was used 1:3 and among this cohort, Cox proportional hazards regression models were performed to evaluate correlation between treatment and outcomes.Results: Of 4487 patients with T1N0M0 colorectal NETs, 1125 were identified in the matched cohort, among whom 819 (72.8%) underwent ET and 306 (27.2%) underwent surgery. There was no difference in the 5-year and 10-year OS and CSS rates between the 2 treatment modalities. Likewise, analyses stratified by tumor size and site showed that patients did not benefit more from surgery compared with ET. Moreover, multivariate analyses found no significant differences in OS [Hazard Ratio (HR) = 0.857, 95% Confidence Interval (CI): 0.513–1.431, P = 0.555] and CSS (HR = 0.925, 95% CI: 0.282–3.040, P = 0.898) between the 2 groups. Similar results were observed when comparisons were limited to patients with different tumor size and site.Conclusions: In this population-based study, patients treated endoscopically had comparable long-term survival compared with those treated surgically, which demonstrates ET as an alternative to surgery in T1N0M0 colorectal NETs.

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