Shear wave elastography of the lateral abdominal muscles in C-shaped idiopathic scoliosis: a case–control study

AbstractConsidering that knowledge about lateral abdominal muscles (LAM) in idiopathic scoliosis (IS) is still very limited, the aims of this study were: (a) to compare LAM thickness and elasticity between C-shaped IS and non-scoliotic population; and (b) to compare LAM thickness and elasticity between C-shaped thoracic, thoracolumbar, and lumbar IS. A total of 259 adolescents were included in the final analysis; among these, 108 were IS and 151 were non-IS. LAM thickness and elasticity were measured at rest and during isometric contraction by an Aixplorer ultrasound scanner. Out of all LAM, only OE thickness was higher on the convex body side compared to the concave side in lumbar and thoracolumbar scoliosis. It may be related with muscle’s atrophy/hypertrophy or other tissues displacement rather than different force generated by the muscle on both body sides, because an asymmetry in the elasticity of the LAM between the convex and concave side was not presented. The only TrA was stiffer in lumbar scoliosis compared to thoracolumbar and thoracic scoliosis. LAM elasticity was similar in IS and non-IS adolescents.

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Erratum to: What is the Difference in Morphologic Features of the Thoracic Pedicle Between Patients With Adolescent Idiopathic Scoliosis and Healthy Subjects? A CT-based Case-control Study

Clinical Orthopaedics and Related Research ◽

10.1007/s11999-017-5484-5 ◽

2017 ◽

Vol 475 (11) ◽

pp. 2829-2830

Author(s):

Bo Gao ◽

Wenjie Gao ◽

Chong Chen ◽

Qinghua Wang ◽

Shaochun Lin ◽

...

Keyword(s):

Adolescent Idiopathic Scoliosis ◽

Idiopathic Scoliosis ◽

Healthy Subjects ◽

Case Control Study ◽

Case Control ◽

The Difference ◽

Control Study

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Shear Wave Elastography Combined with Molecular Subtype in Early Predicting Response to Neoadjuvant Chemotherapy for Breast Cancer: A Prospective Case-control Study

10.21203/rs.3.rs-600929/v1 ◽

2021 ◽

Author(s):

Jia-Xin Huang ◽

Shi-Yang Lin ◽

Yan Ou ◽

Cai-Gou Shi ◽

Yuan Zhong ◽

...

Keyword(s):

Breast Cancer ◽

Neoadjuvant Chemotherapy ◽

Case Control Study ◽

Molecular Subtype ◽

Shear Wave Elastography ◽

Predictive Performance ◽

Case Control ◽

Pathological Response ◽

Control Study ◽

Prospective Case Control Study

Abstract Background: This study was designed to investigate the performance of quantitative shear wave elastography (SWE) and the accuracy of SWE with the molecular subtype for early prediction of pathological response of breast cancer to neoadjuvant chemotherapy (NAC).Methods: In this prospective case-control study, 102 patients were screened from September 2016 to August 2020. Characteristics of conventional ultrasonography (US), SWE and contrast-enhanced magnetic resonance imaging (CE-MRI), were recorded, and the changes were compared to the pre-NAC baseline data. The pathological response was classified according to the Miller Payne grading system. Multivariate logistic regression was used to develop a predictive model for the response to NAC. Results: Significant differences related to changes in SWE characteristics of breast lesions between between pathological response groups were observed earlier than size on the conventional US and MRI images. According to the multivariate predictive model, the best parameter for predicting the pathological response after the first cycle of NAC was the molecular subtype of the tumor [area under the curve (AUC) = 0.83] with low sensitivity (66.04%). Better predictive performance was achieved when △AE/B and the molecular subtype were applied in combination after the second cycle of NAC (AUC = 0.92) with a higher sensitivity (86.79%). The predictive performance of molecular subtype combined with △AE/B and △SWVmean after the third and fourth cycles of NAC were improved (AUC = 0.94).Conclusion: The SWE can be an early predictor of the pathological response to NAC for breast cancer. The combination of SWE and the molecular subtype may be a preferred method for the clinical evaluation of NAC to facilitate the personalization of treatment regimens for breast cancer.

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Serum placental growth factor in late first trimester of pregnancy for prediction of preeclampsia in primigravida - a case control study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20164641 ◽

2016 ◽

Vol 6 (1) ◽

pp. 106

Author(s):

Rachna Agarwal ◽

Shweta Chaudhary ◽

Rajarshi Kar ◽

Gita Radhakrishnan ◽

Richa Sharma

Keyword(s):

Case Control Study ◽

Gestational Hypertension ◽

Final Analysis ◽

First Trimester ◽

Case Control ◽

Placental Growth Factor ◽

Serum Samples ◽

First Trimester Of Pregnancy ◽

Nested Case Control ◽

Control Study

Background: We studied the correlation of serum PLGF levels at 11-14 weeks in primigravida for prediction of future preeclampsia in a prospective nested case control study and estimated the critical levels of PLGF for possible use as screening test.Methods: Subjects with preeclampsia/gestational hypertension were taken as cases with an equal number of controls.Results: Out of 300 participants, final analysis was possible in 291 subjects. Thirty five were cases; two had early PE, 15 late PE and 18 had GH. PLGF level was lower in cases (20 pg/ml) compared to controls (79 pg/ml). PLGF was significantly lower in PE cases (15 pg/ml) compared to GH cases (34 pg/ml). PLGF had maximum area under the ROC curve (AUC) for PE with value of 0.867. Further, late PE had more AUC (0.853) as compared to GH (0.759). The cut off value for prediction of PE was found to be <30 pg/ml with 88.2% sensitivity and 71.4% specificity.Conclusions: PLGF levels were significantly lower in first trimester serum samples of subjects who later developed either preeclampsia or gestational hypertension. PLGF had better detection rate for PE and late PE as compared to GH.

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Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis

Analytical Cellular Pathology ◽

10.1155/2015/621893 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 4

Author(s):

Svetla Nikolova ◽

Milka Dikova ◽

Dobrin Dikov ◽

Assen Djerov ◽

Gyulnas Dzhebir ◽

...

Keyword(s):

Idiopathic Scoliosis ◽

Case Control Study ◽

Early Stage ◽

Promoter Polymorphism ◽

Case Control ◽

Chi Squared ◽

Bulgarian Population ◽

Deformity Progression ◽

Curve Severity ◽

Control Study

Scoliotic human nuclei pulposi can respond to exogenous proinflammatory stimuli by secreting increased amounts of interleukin-6 (IL-6). The G/C polymorphism of the promoter region ofIL-6gene influences levels and functional activity of the IL-6 protein. We conducted a case-control study of eighty patients with idiopathic scoliosis (IS) and one hundred sixty healthy unrelated gender-matched controls trying to investigate the association between IS and theIL-6promoter polymorphism at -174 position (rs1800795 G/C) in Bulgarian population. Molecular detection of theIL-6genotypes was performed by amplification followed by restriction technology. The statistical analysis was performed by Pearson’s chi-squared test. Our case-control study revealed a statistically significant association between theIL-6(-174 G/C) functional polymorphism and susceptibility to IS. In addition, a significant association between theIL-6(-174 G/C) polymorphism and curve severity was detected.IL-6gene could be considered as susceptibility and modifying factor of idiopathic scoliosis. The identification of molecular markers with diagnostic and prognostic value could be useful for early detection of children at risk for the development of scoliosis and for prognosis of the risk for a rapid deformity progression. That would facilitate the therapy decisions and early stage treatment of the patient with the least invasive procedures.

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