scholarly journals Comparison between two devices in the detection of corneal thickness changes after cataract surgery

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maddalena De Bernardo ◽  
Livio Vitiello ◽  
Giulia Abbinante ◽  
Ilaria De Pascale ◽  
Luigi Capasso ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Corneal Thickness ◽  
Specular Microscopy ◽  
Slit Lamp ◽  
Thickness Increase ◽  
Pupil Center ◽  
Scheimpflug Camera ◽  
Corneal Apex

AbstractThis study compared corneal thickness (CT) changes obtained with specular microscopy (SM) and a rotating Scheimpflug camera (RSC) after conventional phacoemulsification surgery (PS). One hundred sixty six eyes of 83 patients were analyzed before and one month after PS. One eye underwent PS, while the fellow phakic one was used as control. CT was measured with SM at the center of the cornea and with RSC at the pupil center, at the corneal apex and at the thinnest point. In the operated eye, SM showed a larger CT mean increase than those one detected at the three different measurements’ points evaluated by RSC. Inversely, in the fellow phakic eye, SM showed a greater CT mean decrease than those one registered by RSC at its three measurement’s points. Thus, one month after surgery, even if cornea appears clear at the slit-lamp, a significant thickness increase is still present. This is even more evident if the slight decrease of the fellow phakic eye is considered. The differences between the two devices are probably related to the different measured areas.

scholarly journals Measurement of corneal thickness using Pentacam HR versus Nidek CEM-530 specular microscopy

2019 ◽  
Vol 48 (4) ◽  
pp. 030006051989238
Author(s):  
Maddalena De Bernardo ◽  
Palmiro Cornetta ◽  
Giuseppe Marotta ◽  
Giulio Salerno ◽  
Ilaria De Pascale ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Corneal Thickness ◽  
Random Order ◽  
Time Of Day ◽  
Specular Microscopy ◽  
Pupil Center ◽  
Ct Measurements ◽  
Significant Difference ◽  
Corneal Apex

Objective To compare corneal thickness (CT) measurements using the CEM-530 (Nidal, Gamagori, Japan) and Pentacam HR (Oculus, Wetzlar, Germany). Methods The CT of 209 healthy subjects (209 right eyes) aged 24 to 89 years (71.35 ± 10.72 years) was measured at the corneal apex (CA), pupil center (PC), and thinnest point (TP) with the Pentacam HR and at the corneal center with the CEM-530 in random order at the same time of day. Results A good correlation but statistically significant difference was found between the CEM-530 and Pentacam HR measurements at the CA (6.10 ± 8.12 µm, R2 = 0.8947), PC (7.46 ± 8.57 µm, R2 = 0.8826), and TP (12.44 ± 10.04 µm, R2 = 0.8392). Comparison of the two devices produced the following regression formulas: y = 0.8859x + 57.644 for the CA, y = 0.8852x +56.657 for the PC, and y = 0.8557x + 68.148 for the TP, where x is the CT obtained with the CEM-530 and y is that obtained with the Pentacam HR. Conclusions These findings indicate that the CEM-530 produces a thicker corneal measurement than the Pentacam HR. The herein-proposed correcting factors are needed to reliably compare these devices.

Comparison of Pentacam Scheimpflug Camera with Ultrasound Pachymetry and Noncontact Specular Microscopy in Measuring Central Corneal Thickness

2007 ◽  
Vol 32 (2) ◽  
pp. 89-94 ◽  
Author(s):  
Miyuki Fujioka ◽  
Makoto Nakamura ◽  
Yasuko Tatsumi ◽  
Azusa Kusuhara ◽  
Hidetaka Maeda ◽  
...  
Keyword(s):  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Specular Microscopy ◽  
Scheimpflug Camera ◽  
Ultrasound Pachymetry

scholarly journals Corneal thickness evaluation in healthy eyes: Comparison between two different Scheimpflug devices

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243370
Author(s):  
Nicola Rosa ◽  
Maddalena De Bernardo ◽  
Angela Pepe ◽  
Livio Vitiello ◽  
Giuseppe Marotta ◽  
...  
Keyword(s):  
Observational Study ◽  
Corneal Thickness ◽  
Pupil Center ◽  
Regression Formula ◽  
Ct Measurements ◽  
Corneal Apex ◽  
Thickness Evaluation ◽  
Healthy Eyes

Purpose To evaluate the correlation between corneal thickness (CT) measurements obtained with two Scheimpflug devices, Pentacam HR and Precisio, and to elaborate, if necessary, a regression formula which could make these results comparable. Design Retrospective, Comparative, Observational study. Setting Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana” University of Salerno, Italy Methods One hundred twenty four healthy eyes of 124 volunteers (65 males; range: 20–32 years; mean age of 24.8 ± 1.7) were included in this study. CT was measured using Pentacam HR and Precisio in three different points: the pupil center (PC), the corneal apex (CA) and the thinnest point (TP). Results CT obtained with both devices at the PC, at the CA and at the TP showed a good correlation (r = 0.97, r = 0.97, r = 0.97, respectively), but Pentacam HR measurements were significantly thicker than those provided by Precisio (p < 0.01). The differences between Pentacam HR and Precisio were 21.9 ± 8.8 μm at the PC, 21.9 ± 8.9 μm at the CA, 19.1 ± 9.0 μm at the TP. The calculated regression formulas were: y = 0.9558x + 2.3196 for the PC, y = 0.9519x + 4.5626 for the CA, y = 0.9364x + 15.436 for the TP, where x is the CT measured with Pentacam HR and y is the Precisio measurement. Conclusions The findings provided by this study highlight that Precisio measures thinner corneas compared to Pentacam HR. The identified regression formulas could be utilized to make interchangeable the results obtained with these two devices.

scholarly journals The Effect of Air Bubble on Corneal Endothelium after Phacoemulsification

2021 ◽  
Author(s):  
Ali Keles ◽  
Suleyman Korhan Karaman
Keyword(s):  
Visual Acuity ◽  
Cataract Surgery ◽  
Anterior Chamber ◽  
Corneal Endothelium ◽  
Corneal Thickness ◽  
Control Group ◽  
Specular Microscopy ◽  
Study Group ◽  
Air Bubble ◽  
Significant Difference

Abstract Purpose To investigate the effect of air bubble on the corneal endothelium at the end of the cataract surgery.Methods In this prospective study, patients who underwent cataract surgery with phacoemulsification were separated into two groups. The study group comprised 60 patients with air bubble injected into the anterior chamber at the end of the operation and the control group was formed of 46 patients without air bubble. Endothelial cell density (ECD), coefficient of variation (CV), hexagonality rate (6A), and central corneal thickness (CCT) measurements were taken using non-contact specular microscopy (Tomey EM-4000, Nagoya, Japan) preoperatively and at 1 day, 1 week and 1 month postoperatively. The phacoemulsification parameters during the operation were noted.Results No significant difference was determined between the groups preoperatively in respect of mean visual acuity, anterior chamber depth, ECD, CV, 6A, and CCT values ​​ (p > 0.05). The intraoperative average ultrasound power, effective phaco time, and ultrasound time values were similar (p > 0.05). The CCT value was lower in the study group than in the control group on postoperative day 1 (p = 0.021), but similar at 1 week and 1 month (p = 0.208, p = 0.394, respectively). No significant difference was determined between the groups in mean visual acuity, corneal edema, anterior chamber reaction, ECD, CV, and 6A values ​​at 1 day, 1 week and 1 month postoperatively (p > 0.05). Conclusion Although air bubble has no detrimental effect, there is also seen to be no protective effect on the corneal endothelium.

Evaluation of corneal endothelium using specular microscopy in patients with obstructive sleep apnea syndrome

2021 ◽  
pp. 112067212110065
Author(s):  
Murat Serkan Songur ◽  
Yavuz Selim İntepe ◽  
Seray Aslan Bayhan ◽  
Hasan Ali Bayhan ◽  
Ender Şahin ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Coefficient Of Variation ◽  
Corneal Endothelium ◽  
Corneal Thickness ◽  
Sleep Apnea Syndrome ◽  
Control Group ◽  
Specular Microscopy ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Purpose: In the present study we evaluate the corneal endothelium using specular microscopy in patients with obstructive sleep apnea syndrome (OSAS). Methods: The study included a total of 100 patients including 35 patients with mild OSAS, 34 patients with moderate OSAS and 31 patients with severe OSAS, and the right eyes of 30 patients as a control group. Patients were examined to exclude the possibility of ocular diseases. Cellular density in the cornea epithelium (cell/mm2), corneal thickness (µ), percentage of hexagonal cells (%) and the coefficient of variation were evaluated using a specular microscope. Results: Corneal thickness was significantly decreased in all OSAS groups when compared to the control group ( p = 0.002), while no significant difference was identified among the OSAS groups. The corneal endothelial cell density, percentage of hexagonal cells and coefficient of variation were significantly different between the OSAS groups and the control group ( p < 0.001). Conclusion: More significant impairments were noted in the corneal endothelium of the patients in the OSAS group than in the control group, and specular microscopy is in valuable in the follow-up and treatment of such patients.

scholarly journals A novel human donor cornea preservation cocktail incorporating a thermo-reversible gelation polymer (TGP), enhancing the corneal endothelial cell density maintenance and explant culture of corneal limbal cells

2021 ◽  
Author(s):  
Bhuvaneshwari Namitha ◽  
Munusamy Rajendran Chitra ◽  
Mathevan Bhavya ◽  
Periasamy Parikumar ◽  
Shojiro Katoh ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Density ◽  
Corneal Thickness ◽  
Explant Culture ◽  
Endothelial Cell Density ◽  
P Value ◽  
Specular Microscopy ◽  
Human Donor ◽  
Corneal Preservation

Abstract Purpose McCarey-Kaufman’s (MK) medium and Optisol-GS medium are the most commonly employed media for human donor corneal preservation. In this study, we evaluated the preservation efficacy of discarded human donor corneas using a Thermo-reversible gelation polymer (TGP) added to these two media. Methods Thirteen human corneal buttons collected from deceased donors, which were otherwise discarded due to low endothelial cell density (ECD) were used. They were stored in four groups: MK medium, MK medium with TGP, Optisol-GS and Optisol-GS with TGP at 4 °C for 96 h. Slit lamp examination and specular microscopy were performed. Corneal limbal tissues from these corneas were then cultured using explant methodology one with and the other without TGP scaffold, for 21 days. Results MK + TGP and Optisol-GS + TGP preserved corneas better than without TGP, which was observed by maintenance of ECD which was significantly higher in Optisol-GS + TGP than MK + TGP (p-value = 0.000478) and corneal thickness remaining the same for 96 h. Viable corneal epithelial cells could be grown from the corneas stored only in MK + TGP and Optisol-GS + TGP. During culture, the TGP scaffold helped maintain the native epithelial phenotype and progenitor/stem cell growth was confirmed by RT-PCR characterization. Conclusion TGP reconstituted with MK and Optisol—GS media yields better preservation of human corneal buttons in terms of relatively higher ECD maintenance and better in vitro culture outcome of corneal limbal tissue. This method has the potential to become a standard donor corneal transportation-preservation methodology and it can also be extended to other tissue or organ transportation upon further validation.

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