scholarly journals Toxoplasma gondii infection in domestic and wild felids as public health concerns: a systematic review and meta-analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kareem Hatam-Nahavandi ◽  
Rafael Calero-Bernal ◽  
Mohammad Taghi Rahimi ◽  
Abdol Sattar Pagheh ◽  
Mehdi Zarean ◽  
...  
Keyword(s):  
Public Health ◽  
Toxoplasma Gondii ◽  
Meta Analysis ◽  
Domestic Cats ◽  
Potential Threat ◽  
Pooled Prevalence ◽  
Wild Felids ◽  
Global Status ◽  
The One ◽  
Toxoplasma Gondii Infection

AbstractFelidae as definitive hosts for Toxoplasma gondii play a major role in transmission to all warm-blooded animals trough oocysts dissemination. Therefore the current comprehensive study was performed to determine the global status of T. gondii infection in domestic and wild felids aiming to provide comprehensive data of interest for further intervention approaching the One Health perspective. Different databases were searched by utilizing particular key words for publications related to T. gondii infecting domestic and wild feline host species, worldwide, from 1970 to 2020. The review of 337 reports showed that the seroprevalence of T. gondii in domestic cats and wild felids was estimated in 37.5% (95% CI 34.7–40.3) (I2 = 98.3%, P < 0.001) and 64% (95% CI 60–67.9) (I2 = 88%, P < 0.0001), respectively. The global pooled prevalence of oocysts in the fecal examined specimens from domestic cats was estimated in 2.6% (95% CI 1.9–3.3) (I2 = 96.1%, P < 0.0001), and that in fecal samples from wild felids was estimated in 2.4% (95% CI 1.1–4.2) (I2 = 86.4%, P < 0.0001). In addition, from 13,252 examined soil samples in 14 reviewed studies, the pooled occurrence of T. gondii oocysts was determined in 16.2% (95% CI 7.66–27.03%). The observed high rates of anti-T. gondii antibodies seroprevalence levels and oocyst excretion frequency in the felids, along with soil (environmental) contamination with oocysts may constitute a potential threat to animal and public health, and data will result of interest in further prophylaxis programs.

scholarly journals Toxoplasma gondii Infection and Clinical Characteristics of Patients With Schizophrenia: A Systematic Review and Meta-analysis

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Arjen L Sutterland ◽  
David A Mounir ◽  
Juul J Ribbens ◽  
Bouke Kuiper ◽  
Tom van Gool ◽  
...  
Keyword(s):  
Systematic Review ◽  
Toxoplasma Gondii ◽  
Publication Bias ◽  
Clinical Characteristics ◽  
Negative Symptoms ◽  
Age Of Onset ◽  
Meta Analysis ◽  
Random Effects Models ◽  
Duration Of Illness ◽  
Toxoplasma Gondii Infection

Abstract Schizophrenia is associated with an increased prevalence of IgG antibodies against Toxoplasma gondii (T. gondii seropositivity), whereby the infection seems to precede the disorder. However, it remains unclear whether a T. gondii infection affects clinical characteristics of schizophrenia. Therefore, a systematic review and meta-analysis was conducted following PRISMA guidelines examining the association between T. gondii seropositivity and severity of total, positive, or negative symptoms or age of onset in schizophrenia. PubMed, Embase, and PsycInfo were systematically searched up to June 23, 2019 (PROSPERO #CRD42018087766). Random-effects models were used for analysis. Furthermore, the influence of potential moderators was analyzed. Indications for publication bias were examined. From a total of 934 reports, 13 studies were included. No overall effect on severity of total, positive, or negative symptoms was found. However, in patients with a shorter duration of illness T. gondii seropositivity was associated with more severe positive symptoms (standardized mean difference [SMD] = 0.32; P &lt; .001). Similar but smaller effects were seen for total symptoms, while it was absent for negative symptoms. Additionally, a significantly higher age of onset was found in those with T. gondii seropositivity (1.8 y, P = .015), although this last finding was probably influenced by publication bias and study quality. Taken together, these findings indicate that T. gondii infection has a modest effect on the severity of positive and total symptoms in schizophrenia among those in the early stages of the disorder. This supports the hypothesis that T. gondii infection is causally related to schizophrenia, although more research remains necessary.

Seroprevalence of Toxoplasma gondii infection in cancer patients: A systematic review and meta-analysis

2019 ◽  
Vol 129 ◽  
pp. 30-42 ◽  
Author(s):  
Davood Anvari ◽  
Mehdi Sharif ◽  
Shahabeddin Sarvi ◽  
Sargis A. Aghayan ◽  
Shirzad Gholami ◽  
...  
Keyword(s):  
Systematic Review ◽  
Toxoplasma Gondii ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Toxoplasma Gondii Infection

Toxoplasma gondii Infection in Swine: Implications for Public Health

2021 ◽  
Author(s):  
Vasileios G. Papatsiros ◽  
Labrini V. Athanasiou ◽  
Polychronis Kostoulas ◽  
Alexios Giannakopoulos ◽  
Eleni Tzika ◽  
...  
Keyword(s):  
Public Health ◽  
Toxoplasma Gondii ◽  
Toxoplasma Gondii Infection

scholarly journals Is there any association between Toxoplasma gondii infection and depression? A systematic review and meta-analysis

PLoS ONE ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. e0218524 ◽  
Author(s):  
Tooran Nayeri Chegeni ◽  
Mehdi Sharif ◽  
Shahabeddin Sarvi ◽  
Mahmood Moosazadeh ◽  
Mahbobeh Montazeri ◽  
...  
Keyword(s):  
Systematic Review ◽  
Toxoplasma Gondii ◽  
Meta Analysis ◽  
Toxoplasma Gondii Infection

scholarly journals Prevalence of Gestational Diabetes Mellitus in Eastern and Southeastern Asia: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Cong Luat Nguyen ◽  
Ngoc Minh Pham ◽  
Colin W. Binns ◽  
Dat Van Duong ◽  
Andy H. Lee
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Screening Method ◽  
Middle Income ◽  
Random Effects Models ◽  
Pooled Prevalence ◽  
The One

Aim. To review the prevalence of gestational diabetes mellitus (GDM) in Eastern and Southeastern Asia. Methods. We systematically searched for observational studies on GDM prevalence from January 2000 to December 2016. Inclusion criteria were original English papers, with full texts published in peer-reviewed journals. The quality of included studies was evaluated using the guidelines of the National Health and Medical Research Council, Australia. Fixed effects and random effects models were used to estimate the summary prevalence of GDM and the corresponding 95% confidence intervals (CI). Results. A total of 4415 papers were screened, and 48 studies with 63 GDM prevalence observations were included in the final review. The pooled prevalence of GDM was 10.1% (95% CI: 6.5%–15.7%), despite substantial variations across nations. The prevalence of GDM in lower- or upper-middle income countries was about 64% higher than in their high-income counterparts. Moreover, the one-step screening method was twice more likely to be used in diagnosing GDM when compared to the two-step screening procedure. Conclusions. The prevalence of GDM in Eastern and Southeastern Asia was high and varied among and within countries. There is a need for international uniformity in screening strategies and diagnostic criteria for GDM.

scholarly journals Global, regional and national estimates ofToxoplasma gondiiseroprevalence in pregnant women: a protocol for a systematic review and modelling analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e030472 ◽  
Author(s):  
Jean Joel Bigna ◽  
Joel Noutakdie Tochie ◽  
Dahlia Noelle Tounouga ◽  
Anne Olive Bekolo ◽  
Nadia S Ymele ◽  
...  
Keyword(s):  
Public Health ◽  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Data Extraction ◽  
Meta Analysis ◽  
Empirical Studies ◽  
Published Data ◽  
Representative Study ◽  
Nationally Representative ◽  
Meta Analyses

IntroductionTo set priorities for public health policy, funding for public health interventions, and healthcare planning which will ultimately contribute in bending the burden of toxoplasmosis towards maternal and neonatal health, it is necessary to have accurate data on the prevalence of toxoplasmosis in pregnancy. Therefore, we aimed to estimate the seroprevalence ofToxoplasma gondiiinfection in pregnant women by countries, WHO regions and globally.Methods and analysisWe will search multiple databases to identify studies that reported the prevalence (or enough data to compute this estimate) ofToxoplasma gondiiin the global population of pregnant women up till December 31, 2018 without any language restrictions. Study selection, data extraction and risk of bias assessment will be conducted independently by three pairs of investigators. For each country, we will estimate the prevalence based on empirical studies if there is either one nationally representative study, or two or more not nationally representative studies. Then, we will perform a country-specific random-effects meta-analyses. The heterogeneity will be evaluated using the χ² test on Cochrane’s Q statistic and quantified with H and I² statistics. For countries with one or no empirical studies or where the meta-analysis will result in a wide CI of 0%–100%, we will predict the country’s prevalence by using a Bayesian generalised non-linear multilevel model. The model will have a hierarchical structure in which estimates for each country will be informed by its own data, if available, or by data from other countries in the same WHO region.Ethics and disseminationSince this study will be based on published data, it does not require any ethical approval. Its findings will be published in a scientific peer-reviewed journal. They will also be presented at scientific conferences and to relevant public health sectors.PROSPERO registration numberCRD42019125572.

Is there any association between Toxoplasma gondii infection and bipolar disorder? A systematic review and meta-analysis

2017 ◽  
Vol 209 ◽  
pp. 59-65 ◽  
Author(s):  
João Luís Vieira Monteiro de Barros ◽  
Izabela Guimarães Barbosa ◽  
Haitham Salem ◽  
Natalia Pessoa Rocha ◽  
Arthur Kummer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Toxoplasma Gondii ◽  
Meta Analysis ◽  
Toxoplasma Gondii Infection

An updated meta-analysis of the association between Toxoplasma gondii infection and risk of epilepsy

2019 ◽  
Vol 113 (8) ◽  
pp. 453-462 ◽  
Author(s):  
Maryam Sadeghi ◽  
Seyed Mohammad Riahi ◽  
Mona Mohammadi ◽  
Vafa Saber ◽  
Somayeh Aghamolaie ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Positive Association ◽  
Final Analysis ◽  
Toxoplasma Infection ◽  
Significant Positive Association ◽  
Worldwide Distribution ◽  
Subgroup Analyses ◽  
Toxoplasma Gondii Infection

Abstract Toxoplasma gondii is a neurotropic pathogen with worldwide distribution. To evaluate the association between Toxoplasma infection and the risk of epilepsy by meta-analysis, observational peer-reviewed studies were retrieved from PubMed, Embase, Web of Science, Scopus and Google Scholar (up to 10 October 2018) and by reference review. Pooled risk estimates were calculated using a random effects model. Heterogeneity was assessed using Cochrane’s Q-test and I2. In total, 16 eligible studies involving 19 data sets were included for the final analysis. A total 7897 participants (3771 epileptic patients, 4026 healthy controls) were included. The pooled odds ratio (OR) for Toxoplasma infection was increased to 1.72 (95% confidence interval [CI] 1.37 to 2.16) among patients with epilepsy. There was moderate heterogeneity among the studies (χ2=39.8, I2=62.3%, p=0.001). The ORs from subgroup analyses showed that both cryptogenic epilepsy (OR 2.65 [95% CI 1.91 to 3.68]) and active convulsive epilepsy (OR 1.37 [95% CI 1.09 to 1.72]) were significantly associated with Toxoplasma infection. Another subgroup analyses according to age showed a significant positive association in children (OR 1.33), adults (OR 1.57) and in all ages (OR 1.89). Our findings support the association between Toxoplasma infection and epilepsy. More prospective studies with larger sample sizes and more experimental studies are recommended to elucidate a causative relationship.

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