LIPG endothelial lipase and breast cancer risk by subtypes

AbstractExperimental data showed that endothelial lipase (LIPG) is a crucial player in breast cancer. However, very limited data exists on the role of LIPG on the risk of breast cancer in humans. We examined the LIPG-breast cancer association within our population-based case–control study from Galicia, Spain, BREOGAN (BREast Oncology GAlicia Network). Plasma LIPG and/or OxLDL were measured on 114 breast cancer cases and 82 controls from our case–control study, and were included in the present study. The risk of breast cancer increased with increasing levels of LIPG (multivariable OR for the highest category (95% CI) 2.52 (1.11–5.81), P-trend = 0.037). The LIPG-breast cancer association was restricted to Pre-menopausal breast cancer (Multivariable OR for the highest LIPG category (95% CI) 4.76 (0.94–28.77), P-trend = 0.06, and 1.79 (0.61–5.29), P-trend = 0.372, for Pre-menopausal and Post-menopausal breast cancer, respectively). The LIPG-breast cancer association was restricted to Luminal A breast cancers (Multivariable OR for the highest LIPG category (95% CI) 3.70 (1.42–10.16), P-trend = 0.015, and 2.05 (0.63–7.22), P-trend = 0.311, for Luminal A and non-Luminal A breast cancers, respectively). Subset analysis only based on HER2 receptor indicated that the LIPG-breast cancer relationship was restricted to HER2-negative breast cancers (Multivariable OR for the highest LIPG category (95% CI) 4.39 (1.70–12.03), P-trend = 0.012, and 1.10 (0.28–4.32), P-trend = 0.745, for HER2-negative and HER2-positive tumors, respectively). The LIPG-breast cancer association was restricted to women with high total cholesterol levels (Multivariable OR for the highest LIPG category (95% CI) 6.30 (2.13–20.05), P-trend = 0.018, and 0.65 (0.11–3.28), P-trend = 0.786, among women with high and low cholesterol levels, respectively). The LIPG-breast cancer association was also restricted to non-postpartum breast cancer (Multivariable OR for the highest LIPG category (95% CI) 3.83 (1.37–11.39), P-trend = 0.003, and 2.35 (0.16–63.65), P-trend = 0.396, for non-postpartum and postpartum breast cancer, respectively), although we lacked precision. The LIPG-breast cancer association was more pronounced among grades II and III than grade I breast cancers (Multivariable ORs for the highest category of LIPG (95% CI) 2.73 (1.02–7.69), P-trend = 0.057, and 1.90 (0.61–6.21), P-trend = 0.170, for grades II and III, and grade I breast cancers, respectively). No association was detected for OxLDL levels and breast cancer (Multivariable OR for the highest versus the lowest category (95% CI) 1.56 (0.56–4.32), P-trend = 0.457).

Download Full-text

Postoperative Radiotherapy in N– Breast Cancer. A Retrospective Case-Control Study

Tumori Journal ◽

10.1177/030089168106700509 ◽

1981 ◽

Vol 67 (5) ◽

pp. 443-445 ◽

Cited By ~ 1

Author(s):

Mario Cappellini ◽

Stefano Ciatto ◽

Raffaello Mungai

Keyword(s):

Breast Cancer ◽

Case Control Study ◽

Postoperative Radiotherapy ◽

Survival Rates ◽

Radical Mastectomy ◽

Case Control ◽

Breast Cancers ◽

Breast Cancer Patients ◽

Retrospective Case ◽

Control Study

The role of postoperative radiotherapy in N- breast cancer with centrally or medially located tumors is still controversial. The authors report the results of a retrospective non-randomized case-control study of T1–2 N- breast cancer patients with centrally or medially located tumors, treated or not with postoperative radiotherapy after radical mastectomy. Sixty-four patients were treated with postoperative radiotherapy (Co-60) to the internal mammary chain and supraclavicular nodes. Sixty-four control cases, matched by T size and site, N status, age and menstrual status and simply followed-up after radical mastectomy were selected. No significant differences in actuarial recurrence and NED survival rates were observed at 5 years in the 2 compared groups, thus indicating that postoperative radiotherapy for patients with N- centrally or medially located breast cancers is not worthwhile treatment policy.

Download Full-text

Basal vs. luminal a breast cancer subtypes: a matched case-control study using estrogen receptor, progesterone receptor, and HER-2 as surrogate markers

Medical Oncology ◽

10.1007/s12032-008-9131-6 ◽

2008 ◽

Vol 26 (3) ◽

pp. 372-378 ◽

Cited By ~ 20

Author(s):

Ezzeldin Ibrahim ◽

Aboelkhair M. Al-Gahmi ◽

Ahmed A. Zeenelin ◽

Jamal M. Zekri ◽

Tawfik R. Elkhodary ◽

...

Keyword(s):

Breast Cancer ◽

Case Control Study ◽

Case Control ◽

Surrogate Markers ◽

Luminal A ◽

Cancer Subtypes ◽

Her 2 ◽

Matched Case ◽

Matched Case Control Study ◽

Control Study

Download Full-text

Inflammatory potential of diet in association with breast cancer risk: A matched case-control study

10.21203/rs.3.rs-57681/v1 ◽

2020 ◽

Author(s):

Zahra Hayati ◽

Vahid Montazeri ◽

Nitin Shivappa ◽

James R Hebert ◽

Saeed Pirouzpanah

Keyword(s):

Breast Cancer ◽

Case Control Study ◽

Molecular Subtypes ◽

Conditional Logistic Regression ◽

Large Population ◽

Case Control ◽

Luminal A ◽

Luminal B ◽

Anti Inflammatory ◽

Control Study

Abstract Background: The present study aimed to explore the association between the dietary inflammatory index (DII ® ) and the risk of different molecular subtypes of breast cancer (BrCa) for the first time in a large population-based case-control study conducted in Iran.Methods: The subjects consisted of 1007 women with histopathologically confirmed BrCa, and 1004 controls admitted to hospitals in Tabriz, Iran, for non-neoplastic conditions. The DII scores were computed based on dietary intake collected using a validated 136-item food frequency questionnaire. Energy-adjusted DII (E-DII TM ) also were calculated. Conditional logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs).Results: The pro-inflammatory diet [highest E-DII quartile (Q)] vs. the anti-inflammatory diet (lowest E-DII scores) showed significantly increased BrCa risk (OR Q4 vs. Q 1 : 1.87; 95% CI: 1.42‒2.47). This was aligned with the findings obtained in women at reproductive ages (premenopausal status) who diagnosed with luminal A [estrogen receptor-positive (ER + ) and/or progesterone receptor-positive (PR + ) and human epidermal growth factor receptor 2-negative (HER2 - )] (OR Q4 vs. Q 1 : 2.71; 95% CI: 1.74‒4.22) and luminal B (ER + and/or PR + , HER2 + ) (OR Q4 vs. Q 1 : 2.86; 95% CI: 1.39‒5.89). Women in the highest E-DII quartile were three times more likely to have triple-negative BrCa (ER - , PR - , HER2 - ) compared to luminal A (OR Q4 vs. Q1 : 3.00; 95% CI: 1.002‒8.96). Likewise, the risk of HER2-enriched BrCa (ER - , PR - and HER2 + ) vs. luminal B subtype was increased among those consumed the most pro-inflammatory E-DII (OR Q4 vs. Q1 : 2.44; 95% CI: 1.01‒5.88). A significant ascending trend was observed in mean E-DII scores, followed by rising tumor size (P=0.018).Conclusions: The pro-inflammatory diet, as indicated by increasing E-DII scores, was a risk factor of BrCa in Iranian women, providing updates to the invasive molecular subtypes of BrCa. Diets modulated for high anti-inflammatory and low pro-inflammatory dietary components are suggested to prevent the risk of more aggressive forms of BrCa.

Download Full-text

The influence of polymorphisms in genes related to oxidative stress on breast cancer survival in a German case-control study

Das Gesundheitswesen ◽

10.1055/s-0030-1266733 ◽

2010 ◽

Vol 72 (08/09) ◽

Author(s):

P Seibold ◽

R Hein ◽

O Popanda ◽

D Flesch-Janys ◽

P Schmezer ◽

...

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Cancer Survival ◽

Case Control Study ◽

Case Control ◽

Breast Cancer Survival ◽

Control Study

Download Full-text

Influence of body mass index on breast cancer risk related dietary patterns among women in Northern Tanzania: a case-control study

Das Gesundheitswesen ◽

10.1055/s-0031-1283501 ◽

2011 ◽

Vol 73 (08/09) ◽

Author(s):

I Jordan ◽

A Hebestreit ◽

B Swai ◽

M Krawinkel

Keyword(s):

Breast Cancer ◽

Body Mass Index ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Body Mass ◽

Dietary Patterns ◽

Case Control Study ◽

Case Control ◽

Northern Tanzania ◽

Control Study

Download Full-text

Reproductive Factors and Risk of Breast Cancer by Tumour Subtypes Among Ghanaian Women: A Population-Based Case-Control Study

SSRN Electronic Journal ◽

10.2139/ssrn.3426075 ◽

2019 ◽

Author(s):

Jonine Figueroa ◽

Brittny C. Davis Lynn ◽

Lawrence Edusei ◽

Nicholas Titiloye ◽

Ernest Adjei ◽

...

Keyword(s):

Breast Cancer ◽

Case Control Study ◽

Reproductive Factors ◽

Population Based ◽

Case Control ◽

Ghanaian Women ◽

Control Study

Download Full-text

The J-shaped Association Between Alcohol Consumption and Breast Cancer: A Case-Control Study

Current Nutrition & Food Science ◽

10.2174/1573401310666140306005334 ◽

2014 ◽

Vol 10 (2) ◽

pp. 120-127

Author(s):

Niki Mourouti ◽

Meropi Kontogianni ◽

Christos Papavagelis ◽

Theodora Psaltopoulou ◽

Petrini Plytzanopoulou ◽

...

Keyword(s):

Breast Cancer ◽

Alcohol Consumption ◽

Case Control Study ◽

Case Control ◽

Control Study

Download Full-text

A case–control study in France showing that a pro-inflammatory diet is associated with a higher risk of breast cancer

Scientific Reports ◽

10.1038/s41598-021-95955-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Mariem Hajji-Louati ◽

Emilie Cordina-Duverger ◽

Nasser Laouali ◽

Francesca-Romana Mancini ◽

Pascal Guénel

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Odds Ratio ◽

Hormone Receptors ◽

Case Control Study ◽

Breast Cancer Subtype ◽

Case Control ◽

Tumor Subtype ◽

Control Study

AbstractDietary regimens promoting inflammatory conditions have been implicated in breast cancer development, but studies on the association between pro-inflammatory diet and breast cancer risk have reported inconsistent results. We investigated the association between the inflammatory potential of diet and breast cancer risk in a case–control study in France including 872 breast cancer cases and 966 population controls. All women completed a food frequency questionnaire that was used to compute a Dietary Inflammatory Index (DII) based on the inflammatory weight of 33 dietary components. The DII ranged from a median of − 3.22 in the lowest quartile (anti-inflammatory) to + 2.96 in the highest quartile (pro-inflammatory). The odds ratio contrasting quartile 4 to quartile 1 was 1.31 (95% CI 1.00, 1.73; p-trend = 0.02). Slightly higher odds ratios were observed in post-menopausal women, particularly those with body mass index > 25 kg/m2 (odds ratio 1.62; 95% CI 0.92, 2.83; p-trend = 0.02), and among ever smokers (odds ratio 1.71; 95% CI 1.11, 2.65; p-trend 0.01). The analyses by breast cancer subtype showed that the DII was associated with breast tumors that expressed either the estrogen (ER) or progesterone (PR) hormone receptors or the Human Epidermal Growth Factor Receptor-2 (HER2), but no association was seen for the triple negative breast tumor subtype. Our results add further evidence that a pro-inflammatory diet is associated with breast cancer risk with possible effect variation according to tumor subtype.

Download Full-text