Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro
Keyword(s):
AbstractEffective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain an issue in the future making it important to have therapeutics to treat patients. There are few options for treating patients with COVID-19. We show probenecid potently blocks SARS-CoV-2 replication in mammalian cells and virus replication in a hamster model. Furthermore, we demonstrate that plasma concentrations up to 50-fold higher than the protein binding adjusted IC90 value are achievable for 24 h following a single oral dose. These data support the potential clinical utility of probenecid to control SARS-CoV-2 infection in humans.
Keyword(s):
Keyword(s):
Keyword(s):
Keyword(s):
2019 ◽
Vol 6
(Supplement_2)
◽
pp. S327-S327
Keyword(s):
Keyword(s):
1990 ◽
Vol 48
(3)
◽
pp. 168-169
Keyword(s):
1990 ◽
Vol 48
(3)
◽
pp. 290-291
1987 ◽
Vol 58
(03)
◽
pp. 921-926
◽