scholarly journals Effectiveness of human-origin Lactobacillus plantarum PL-02 in improving muscle mass, exercise performance and anti-fatigue

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mon-Chien Lee ◽  
Yi-Ju Hsu ◽  
Hsieh‐Hsun Ho ◽  
Yi‐Wei Kuo ◽  
Wen-Yang Lin ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Lactobacillus Plantarum ◽  
Muscle Mass ◽  
Exercise Performance ◽  
Endurance Performance ◽  
Glycogen Storage ◽  
Human Origin ◽  
Gold Medalist ◽  
Improve Exercise Performance

AbstractGut microbiota is very important for energy metabolism and regulation, which in turn affect the health and physiological functions of the host, and provide energy required for exercise. Supplementation with probiotics may be one of the ways to change the gut microbiota. In recent years, many studies have shown that probiotic supplementation can effectively improve sports performance. In this study, we screened Lactobacillus plantarum (PL-02), a probiotic of human-origin, from the intestines of 2008 Olympic women's 48 kg weightlifting gold medalist and explored the role of PL-02 in improved exercise endurance performance, reduced fatigue biochemical parameters, and changes in body composition. Male Institute of Cancer Research (ICR) mice were assigned to 0, 2.05 × 109, 4.10 × 109 and 1.03 × 1010 CFU/kg/day groups and were fed by oral gavage once daily for 4 weeks. The results showed that 4 weeks of PL-02 supplementation could significantly increase muscle mass, muscle strength and endurance performance, and hepatic and muscular glycogen storage. Furthermore, PL-02 could significantly decrease lactate, blood urea nitrogen (BUN), ammonia, and creatine kinase (CK) levels after exercise (p < 0.05). We believe that PL-02 can be used as a supplement to improve exercise performance and for its anti-fatigue effect.

scholarly journals Supplementation with Human-Origin Probiotic Lactobacillus plantarum PL-02 Could Effectively Improve Muscle Mass and Exercise Performance, and Have an Anti-Fatigue Effect

2021 ◽  
Author(s):  
Mon-Chien Lee ◽  
Yi-Ju Hsu ◽  
Hsieh‐Hsun Ho ◽  
Yi‐Wei Kuo ◽  
Wen-Yang Lin ◽  
...  
Keyword(s):  
Body Composition ◽  
Gut Microbiota ◽  
Lactobacillus Plantarum ◽  
Muscle Mass ◽  
Exercise Performance ◽  
Biochemical Parameters ◽  
Endurance Performance ◽  
Glycogen Storage ◽  
Human Origin ◽  
Fatigue Effect

Abstract Gut microbiota are very important for energy metabolism and regulation, which in turn affect the health and physiological functions of the host. The most direct way to change the gut microbiota is to supplement with probiotics. In this study, we screened Lactobacillus plantarum (PL-02), a probiotic of human-origin, from the intestines of Olympic gold medalists and explored the role of PL-02 in improved exercise endurance performance, reduced fatigue biochemical parameters, and changes in body composition. Male Institute of Cancer Research (ICR) mice were assigned to 0 CFU/kg (vehicle), 2.05 × 109 CFU/kg (PL-02-1X), 4.10 × 109 CFU/kg (PL-02-2X), and 1.03 × 1010 CFU/kg (PL-02-5X) groups and were fed by oral gavage once daily for 4 weeks to assess exercise performance, fatigue parameters, and body composition. The results showed that 4 weeks of PL-02 supplementation could significantly increase muscle mass, improve muscle strength and endurance performance, and increase hepatic and muscular glycogen storage. Furthermore, PL-02 could significantly decrease fatigue biochemical parameters, such as lactate, blood urea nitrogen (BUN), ammonia, and creatine kinase (CK) levels, after exercise. We believe that PL-02 can be used as a supplement to improve exercise performance and for its anti-fatigue effect.

scholarly journals Lactobacillus salivarius Subspecies salicinius SA-03 is a New Probiotic Capable of Enhancing Exercise Performance and Decreasing Fatigue

2020 ◽  
Vol 8 (4) ◽  
pp. 545 ◽  
Author(s):  
Mon-Chien Lee ◽  
Yi-Ju Hsu ◽  
Hsieh-Hsun Ho ◽  
Shih-Hung Hsieh ◽  
Yi-Wei Kuo ◽  
...  
Keyword(s):  
Exercise Performance ◽  
Endurance Performance ◽  
Nutritional Supplement ◽  
Glycogen Storage ◽  
Lactobacillus Salivarius ◽  
Post Exercise ◽  
Beneficial Effects ◽  
Natural Flora ◽  
Improve Exercise Performance ◽  
Exercise Fatigue

Probiotics are increasingly being used as a nutritional supplement by athletes to improve exercise performance and reduce post-exercise fatigue. Lactobacillus salivarius is a natural flora in the gastrointestinal tract of humans and animals. Lactobacillus salivarius subspecies salicinius (SA-03) is an isolate from the 2008 Olympic women’s 48 kg weightlifting gold medalist’s gut microbiota. In this study, we investigated its beneficial effects on physical fitness. Male ICR mice were divided into four groups (n = 10 per group) and orally administered with SA-03 for 4 weeks at 0, 2.05 × 109, 4.10 × 109, or 1.03 × 1010 CFU/kg/day. Results showed that 4 weeks of SA-03 supplementation significantly improved muscle strength and endurance performance, increased hepatic and muscular glycogen storage, and decreased lactate, blood urea nitrogen (BUN), ammonia, and creatine kinase (CK) levels after exercise. These observations suggest that SA-03 could be used as a nutritional supplement to enhance exercise performance and reduce.

Running longer, running stronger: a brief review of endurance exercise and oestrogen

2014 ◽  
Vol 10 (3) ◽  
pp. 147-157 ◽  
Author(s):  
S.A. Stone ◽  
M.E. Bibens ◽  
A.B. Jones ◽  
K.S. Curtis
Keyword(s):  
Endurance Exercise ◽  
Aerobic Capacity ◽  
Fluid Balance ◽  
Exercise Performance ◽  
Body Fluid ◽  
Endurance Performance ◽  
Physiological Factors ◽  
Hormonal Fluctuations ◽  
Body Fluid Balance

Athletic performance in endurance exercise is determined by an interplay among many physiological factors. Body fluid regulation, influenced by both hormonal and osmotic stimuli, is particularly important for maximising performance in endurance sports, as dehydration markedly decreases endurance. Oestrogen has a broad range of effects on the regulation of body fluid balance, as well as on aerobic capacity, metabolism, and other factors that impact endurance exercise performance, yet the role of oestrogen in endurance exercise performance has not been thoroughly examined. This review discusses the effects of oestrogen on compensatory hormonal and behavioural responses to dehydration, such as renin-angiotensin-aldosterone system activation and thirst, that restore body fluid balance and thereby affect exercise performance. Oestrogen-mediated effects and their potential consequences for endurance performance are also evaluated in the context of thermoregulation and aerobic capacity, as well as substrate utilisation during exercise. In addressing the role of oestrogen in endurance exercise, this review will examine human and animal models of endurance exercise and discuss similarities, differences, and limitations. Our aim is to integrate research from neuroscience, physiology, and exercise science to advance understanding of how oestrogen may impact exercise. Such understanding will have particularly important implications for female endurance athletes experiencing the hormonal fluctuations that occur during the reproductive cycle.

scholarly journals Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice

Nutrients ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 205 ◽  
Author(s):  
Yi-Ming Chen ◽  
Li Wei ◽  
Yen-Shuo Chiu ◽  
Yi-Ju Hsu ◽  
Tsung-Yu Tsai ◽  
...  
Keyword(s):  
Lactobacillus Plantarum ◽  
Muscle Mass ◽  
Exercise Performance

scholarly journals Lactobacillus plantarum PS128 Improves Physiological Adaptation and Performance in Triathletes through Gut Microbiota Modulation

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2315 ◽  
Author(s):  
Wen-Ching Huang ◽  
Chun-Hsu Pan ◽  
Chen-Chan Wei ◽  
Hui-Yu Huang
Keyword(s):  
Lactobacillus Plantarum ◽  
Exercise Performance ◽  
Maximal Oxygen Consumption ◽  
Endurance Performance ◽  
Short Chain Fatty Acids ◽  
Physiological Adaptation ◽  
Endurance Running ◽  
Supplement Group ◽  
Significant Difference ◽  
And Performance

A triathlon is an extremely high-intensity exercise and a challenge for physiological adaptation. A triathlete’s microbiome might be modulated by diet, age, medical treatments, lifestyle, and exercise, thereby maintaining aerobiosis and optimum health and performance. Probiotics, prebiotics, and synbiotics have been reported to have health-promoting activities (e.g., immunoregulation and cancer prevention). However, few studies have addressed how probiotics affect the microbiota of athletes and how this translates into functional activities. In our previous study, we found that Lactobacillus plantarum PS128 could ameliorate inflammation and oxidative stress, with improved exercise performance. Thus, here we investigate how the microbiota of triathletes are altered by L. plantarum PS128 supplementation, not only for exercise performance but also for possible physiological adaptation. The triathletes were assigned to two groups: an L. plantarum 128 supplement group (LG, 3 × 1010 colony-forming units (CFU)/day) and a placebo group (PG). Both groups continued with their regular exercise training for the next 4 weeks. The endurance performance, body composition, biochemistries, blood cells, microbiota, and associated metabolites were further investigated. PS128 significantly increased the athletes’ endurance, by about 130% as compared to the PG group, but there was no significant difference in maximal oxygen consumption (VO2max) and composition between groups. The PS128 supplementation (LG) modulated the athlete’s microbiota with both significant decreases (Anaerotruncus, Caproiciproducens, Coprobacillus, Desulfovibrio, Dielma, Family_XIII, Holdemania, and Oxalobacter) and increases (Akkermansia, Bifidobacterium, Butyricimonas, and Lactobacillus), and the LG showed lower diversity when compared to the PG. Also, the short-chain fatty acids (SCFAs; acetate, propionate, and butyrate) of the LG were significantly higher than the PG, which might be a result of a modulation of the associated microbiota. In conclusion, PS128 supplementation was associated with an improvement on endurance running performance through microbiota modulation and related metabolites, but not in maximal oxygen uptake.

scholarly journals GSTP1 c.313A>G polymorphism in Russian and Polish athletes

2017 ◽  
Vol 49 (3) ◽  
pp. 127-131 ◽  
Author(s):  
Aleksandra Zarebska ◽  
Zbigniew Jastrzebski ◽  
Ildus I. Ahmetov ◽  
Piotr Zmijewski ◽  
Pawel Cieszczyk ◽  
...  
Keyword(s):  
Exercise Performance ◽  
Endurance Performance ◽  
Antioxidant Defense System ◽  
Replication Study ◽  
Glutathione S Transferase ◽  
Independent Population ◽  
Glutathione S Transferases ◽  
Gstp1 Gene ◽  
Improve Exercise Performance ◽  
Exercise Induced

The GSTP1 gene encodes glutathione S-transferase P1, which is a member of the glutathione S-transferases (GSTs), a family of enzymes playing an important role in detoxification and in the antioxidant defense system. There is some evidence indicating that GSTP1 c.313A>G polymorphism may be beneficial for exercise performance. Therefore, we decided to verify the association between the frequency of GSTP1 c.313A>G variants, physical performance, and athletes' status in two cohorts: in a group of Russian athletes ( n = 507) and in an independent population of Polish athletes ( n = 510) in a replication study. The initial association study conducted with the Russian athletes revealed that the frequency of the minor G allele was significantly higher in all athletes than in controls; that was confirmed in the replication study of Polish athletes. In the combined cohort, the differences between athletes ( n = 1017) and controls ( n = 1246) were even more pronounced (32.7 vs 25.0%, P < 0.0001). Our findings emphasize that the G allele of the GSTP1 gene c.313A>G single nucleotide polymorphism is associated with improved endurance performance. These observations could support the hypothesis that the GSTP1 G allele may improve exercise performance by better elimination of exercise-induced ROS.

The Role of Gut Microbiota in Shaping the Host Energy Metabolism and Exercise Performance

2014 ◽  
Vol 46 ◽  
pp. 630-631
Author(s):  
Chi-Chang Huang ◽  
Wen-Ching Huang ◽  
Yi-Ju Hsu ◽  
Chen-Chung Liao ◽  
Chien-Chao Chiu ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Gut Microbiota ◽  
Exercise Performance

MOLECULAR ASPECTS OF SARCOPENIA PATHOGENESIS IN CHRONOC KIDNEY DISEASE: INTEGRATED ROLE OF mTOR

2018 ◽  
Vol 22 (5) ◽  
pp. 9-16 ◽  
Author(s):  
M. Z. Gasanov
Keyword(s):  
Kidney Disease ◽  
Muscle Mass ◽  
Protein Metabolism ◽  
Mammalian Target Of Rapamycin ◽  
Healthy Person ◽  
Scientific Review ◽  
Cytoskeleton Organization ◽  
Molecular Aspects ◽  
End Stage

In recent decades, the main pathogenetic mechanisms for maintaining muscle mass and strength have been discovered. Most of the scientific papers on the molecular aspects of the  pathogenesis of sarcopenia were focused on the Akt-signaling  pathway. The subject of the study were people of elderly and senile  age, immobilized patients, patients with CKD 1-4 stages, animals. However, recently more attention has been paid to the role  of protein – the mammalian target of rapamycin mTOR. It seems to be a key link in the control of muscle mass and is a promising  marker in understanding the mechanisms of the pathogenesis of  sarcopenia. Its importance in protein metabolism in patients with  end stage kidney disease is not studied and requires further research. The presented scientific review contains  information on the role of mTOR and its components – mTORC1 and mTORC2 in maintaining muscle mass and strength in a healthy  person and in the formation of sarcopenia in patients with CKD. The  general aid of mTORC1 complex is regulation of protein production  which is necessary for cell growth and differentiation. mTORC2  complex functions are not enough studied. It is established that it  plays important role in such biological processes as cytoskeleton  organization, intracellular homeostasis maintaining, so it provides  cell resistance and cell survivability in negative external and internal  impulses. mTOR protein can be considered as promising molecular  marker in diagnostics of protein metabolism early disturbances in  patients with CKD and also as additory factor of sarcopenia severity assessment.

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