scholarly journals Body mass index, waist circumference and waist–hip ratio and serum levels of IGF-I and IGFBP-3 in European women

2006 ◽  
Vol 30 (11) ◽  
pp. 1623-1631 ◽  
Author(s):  
I T Gram ◽  
T Norat ◽  
S Rinaldi ◽  
L Dossus ◽  
A Lukanova ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
Serum Levels ◽  
Waist Hip Ratio ◽  
Igf I ◽  
European Women ◽  
Igfbp 3

scholarly journals A Sexually Dimorphic Pattern of Growth Hormone Secretion in the Elderly

1999 ◽  
Vol 84 (8) ◽  
pp. 2679-2685 ◽  
Author(s):  
P. C. Hindmarsh ◽  
E. Dennison ◽  
S. M. Pincus ◽  
C. Cooper ◽  
C. H. D. Fall ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
The Elderly ◽  
Major Determinant ◽  
Sexually Dimorphic ◽  
Gh Secretion ◽  
Waist Hip Ratio ◽  
Igf I ◽  
Serum Gh ◽  
Igfbp 3

In rodents, the sexually dimorphic pattern of pulsatile GH secretion is an important determinant of growth, liver enzyme function and insulin-like growth factor I (IGF-I) expression. Whether this difference is present in humans at different ages is unclear. We studied GH secretory patterns in the elderly by constructing 24-h serum GH profiles in 45 male and 38 female (age, 59.4–73.0 yr) volunteers and related patterns to IGF-I, IGF-binding protein-3 (IGFBP-3), and GH-binding protein levels; body mass index; and waist/hip ratio. Serum GH concentrations were measured in samples drawn at 20-min intervals and analyzed using a sensitive chemiluminescent assay (Nichols Institute Diagnostics: sensitivity, 0.036 mU/L). The 24-h serum GH profiles were analyzed using a concentration distribution method to determine GH peak and trough levels, spectral analysis, and assessment of serial irregularity by approximate entropy (ApEn). There was a highly significant difference in mean 24-h serum GH concentrations in females compared to males (males, 0.88 mU/L; females, 1.31 mU/L; P = 0.009) as a result of significantly higher trough GH levels (males, 0.04 mU/L; females, 0.16 mU/L; P < 0.001). Peak values were not significantly different. Serum IGF-I levels were significantly higher in males (males, 162.4 ng/mL; females, 87.8 ng/mL; P < 0.001). Peak GH values were related to serum IGF-I levels (males: r = 0.39; P = 0.009; females: r = 0.5; P = 0.002), whereas trough GH levels were not. IGFBP-3 levels were similar and related to GH peaks only in males (r = 0.32; P = 0.03). GH was secreted with a dominant periodicity of 200 min in males and 280 min in females (P < 0.025). The proportion of time taken up by regular oscillatory activity was less in females (females, 11.1%; males, 14.7%; P = 0.01). GH secretion assessed by ApEn was more disordered in females (males, 0.60; females, 0.81; P < 0.001), and increasing disorder was associated with lower IGF-I levels. Body mass index was negatively related to GH in both sexes. In males, trough values were the major determinant (r = −0.31; P = 0.04), whereas in females, the peak value was the major determinant (r = −0.35; P = 0.04). Trough GH levels were inversely related in both sexes to waist/hip ratio (males: r = −0.40; P = 0.006; females: r = −0.44; P = 0.006) and to increasing secretory disorder (ApEn; r = −0.46; P < 0.001). These data demonstrate a sexually dimorphic pattern of GH secretion in the elderly.

scholarly journals Waist Circumference as The Strongest Factor Related to Blood Glucose Level

2014 ◽  
Vol 2 (1) ◽  
pp. 48
Author(s):  
Nenni Septyaningrum ◽  
Santi Martini
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Body Mass ◽  
Glucose Level ◽  
Abdominal Obesity ◽  
Waist Hip Ratio ◽  
Sugar Levels

ABSTRACTThe increasing prevalence of overweight and obesity is associated with the increasing incident of type 2 diabetes mellitus. Obesity, especially abdominal obesity is an important risk factor for the onset of diabetes. The objective of this study was to determine the relationship between body mass index, waist circumference and waist hip ratio with blood glucose level. The study design was cross-sectional. The study population was elderly posyandu member aged 45 to 70 years in Menur clinic work area who were registered in elderly posyandu activities in May 2013. The numbers of sample were 60 respondents who drawn by simple random sampling method. The variabels of this study were the characteristics of respondent, body mass index, waist  circumference,  waist hip ratio and fasting blood glucose level. The study showed that respondents classified as overweight (38%), obesity (33, 3%), abdominal obesity based on waist circumference  (77.8%), abdominal obesity based on waist hip ratio (81,7 %) and blood glucose level more than 125 mg/dl (8.3%). Pearson correlation test showed that there was relationship between body mass index with blood sugar levels (p=0,007; r=0,345), between waist circumference with blood sugar levels (p=0,001; r=0,424) and  between waist hip ratio with blood sugar levels (p =0,002; r=0,392). Waist circumference as the strongest factor related to blood glucose level. Waist circumference measurement should be done in elderly posyandu activities to detect high-risk individuals with diabetes. Keywords: Diabetes, body mass index, waist circumference, waist hip ratio,                     blood glucose level

scholarly journals The Insulin-Like Growth Factor Axis and Plasma Lipid Levels in the Elderly1

1998 ◽  
Vol 83 (2) ◽  
pp. 499-502
Author(s):  
Gian Paolo Ceda ◽  
Elisabetta Dall’Aglio ◽  
Andrea Magnacavallo ◽  
Nicola Vargas ◽  
Vittorio Fontana ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Growth Factor ◽  
Body Mass ◽  
Elderly Population ◽  
Elderly Subjects ◽  
Insulin Like Growth Factor ◽  
Lipid Levels ◽  
Igf I ◽  
Igfbp 3

The activity of the hypothalamic-GH-insulin-like growth factor (IGF) network declines with age. It has recently been shown that increased cardiovascular mortality occurs in adults with GH deficiency. As hypercholesterolemia is common in GH-deficient adults, and because there is experimental evidence that GH may play a role in regulating plasma cholesterol, we decided to investigate the activity of the GH-IGF axis in an elderly population by measuring serum IGF-I, IGF-II, and IGF-binding protein-3 (IGFBP-3) levels and to study their relationship with blood lipid levels. One hundred and thirty-two elderly subjects, 52 men and 80 women, were studied (age range, 60–91 yr). Men had significantly lower levels of IGFBP-3, high density lipoprotein cholesterol (HDL-C) and apoprotein A1 (ApoA1) compared to the women, whereas IGF-I and IGF-II were only slightly lower. Using linear regression analysis, we observed an inverse relationship of age with IGF-I (r = −0.35; P < 0.001), IGF-II (r = 0.40; P < 0.001), IGFBP-3 (r = 0.52; P < 0.001), body mass index, and lipid levels. Univariate regression analysis showed a strong and positive correlation of both IGF-I and IGFBP-3 with HDL-C and ApoA1. Partial correlation analysis, after adjustment for age and body mass index, showed that IGFBP-3 and IGF-II were still significantly and positively related to HDL-C and ApoA1. Furthermore, a strong association was documented among IGF-I, IGF-II, and IGFBP-3. These data demonstrate that even in an elderly population, further aging is accompanied by a progressive decline in circulating IGF-I, IGF-II, and IGFBP-3, suggesting a continuing diminution of the GH-IGF axis throughout aging. Moreover, the strong correlation between HDL-C and an index of GH secretion, such as IGFBP-3, suggests that GH might play an important role in lipid metabolism in healthy elderly subjects.

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