Functional logistic regression with PET imaging data: A voxel-level clinical diagnostic tool

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S635-S635 ◽  
Author(s):  
Philip T Reiss ◽  
R Todd Ogden ◽  
J John Mann ◽  
Ramin V Parsey
Keyword(s):  
Logistic Regression ◽  
Pet Imaging ◽  
Diagnostic Tool ◽  
Imaging Data ◽  
Clinical Diagnostic

scholarly journals P251 Small bowel capsule endoscopy is a valuable diagnostic tool in isolated terminal ileitis

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S275-S275
Author(s):  
M FREITAS ◽  
T Cúrdia Gonçalves ◽  
P Boal Carvalho ◽  
F Dias de Castro ◽  
B Rosa ◽  
...  
Keyword(s):  
Small Bowel ◽  
Capsule Endoscopy ◽  
Diagnostic Tool ◽  
Terminal Ileum ◽  
Diagnostic Yield ◽  
Common Finding ◽  
Imaging Data ◽  
Terminal Ileitis ◽  
Faecal Calprotectin ◽  
Valuable Diagnostic Tool

Abstract Background Terminal ileitis (TI), is a common condition in clinical practice and may be associated with a wide variety of diseases. Small bowel capsule endoscopy (SBCE) is a valuable diagnostic tool for small bowel diseases; however, data regarding its diagnostic impact on isolated TI are sparse. The aim of the study was to evaluate the diagnostic value of SBCE for isolated TI detected during ileocolonoscopy. Methods Retrospective study including consecutive patients undergoing SBCE after diagnosis of TI without colonic mucosal abnormalities on ileocolonoscopy between January 2016 and September 2019. Demographic, clinical, biochemical, endoscopic and imaging data were collected. Results One hundred and two patients with isolated ileitis on ileocolonoscopy were included. Positive findings on SBCE were found in 84 (82.4%) patients, being ulcers the most common finding (76.5%). Endoscopic abnormalities proximal to terminal ileum were found in 36.3% of patients. After SBCE, 63.7% of patients had a final diagnosis, Crohn’s disease (CD) was the most common (34.3%), followed by NSAIDs enteropathy (12.7%). Elevated faecal calprotectin (p = 0.001) was independently associated with positive SBCE findings. There was a tendency for high levels of erythrocyte sedimentation rate be associated with positive findings (p = 0.07). However, the presence of symptoms, imaging abnormalities and other laboratory findings such as leukocytosis, anaemia, and elevated C-reactive protein were not predictors of positive SBCE findings. At multivariate analysis, only elevated faecal calprotectin (OR 6.0, IC 95% 1.9–18.7; p = 0.002) was a significant predictive factor for positive SBCE findings. Conclusion SBCE revealed a high diagnostic yield in patients with isolated ileitis on ileocolonoscopy enabling a definite diagnosis in almost two-thirds of patients. Approximately one-third of patients had findings proximal to terminal ileum and a similar percentage was diagnosed with CD. In patients with isolated ileitis on ileocolonoscopy, SBCE should be considered to evaluate small bowel lesions, particularly when there is an elevated faecal calprotectin, even when other clinical, imagiological or laboratorial abnormalities are absent.

Risk, Cure and Complications in Advanced Hodgkin Disease

Hematology ◽  
2007 ◽  
Vol 2007 (1) ◽  
pp. 197-203 ◽  
Author(s):  
Sandra J. Horning
Keyword(s):  
Prognostic Factors ◽  
Pet Imaging ◽  
Diagnostic Tool ◽  
Predictive Accuracy ◽  
Controlled Trial ◽  
Response To Therapy ◽  
Hodgkin Disease ◽  
Current Therapy ◽  
Current Standard ◽  
Cure Rates

AbstractCurrent therapy for Hodgkin disease is aimed at high cure rates and optimal survivorship. Although intensified chemotherapy with the escalated BEACOPP regimen resulted in higher rates of cure and survival compared with COPP/ABVD in the high-profile HD9 randomized controlled trial (RCT), this regimen has not been universally adopted by patients and physicians due to the attendant increased risks of early and late complications. Appropriately, questions emerge as to whether the results of this trial should be interpreted as establishing the superiority of BEACOPP over the current standard ABVD therapy, and whether clinical or biologic prognostic factors can better select patients for more intensive treatment. The widespread availability and high predictive accuracy of functional imaging with PET scans has led to promising, preliminary studies assessing early response to therapy with this diagnostic tool. In this review, the characteristics and outcomes of patients treated with ABVD in RCT will be made and compared with COPP/ABVD in HD9; clinical and biologic prognostic factors will be discussed, including PET imaging; and newer strategies targeted at minimizing treatment complications while maximizing cure rates will be discussed. Although enthusiasm for PET imaging is great, the challenges for using this diagnostic tool for risk-adapted therapies are substantial. Importantly, physicians and patients should be aware of these challenges, support the RCT that seek to address them, and carefully weigh risks and benefits for individual patients.

scholarly journals The potential of backscattering interferometry as an in vitro clinical diagnostic tool for the serological diagnosis of infectious disease

The Analyst ◽  
2010 ◽  
Vol 135 (7) ◽  
pp. 1535 ◽  
Author(s):  
Amanda Kussrow ◽  
Carolyn S. Enders ◽  
Arnold R. Castro ◽  
David L. Cox ◽  
Ronald C. Ballard ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Diagnostic Tool ◽  
Serological Diagnosis ◽  
Backscattering Interferometry ◽  
Clinical Diagnostic

Positron emission tomography/computed tomography as a clinical diagnostic tool for anterior mediastinal tumors

Surgery Today ◽  
2018 ◽  
Vol 49 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Tatsuaki Watanabe ◽  
Hideo Shimomura ◽  
Tatsushi Mutoh ◽  
Ryoko Saito ◽  
Ryoi Goto ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Positron Emission Tomography ◽  
Diagnostic Tool ◽  
Emission Tomography ◽  
Mediastinal Tumors ◽  
Clinical Diagnostic ◽  
Positron Emission

scholarly journals Parametric Estimation of Reference Signal Intensity for Semi-Quantification of Tau Deposition: A Flortaucipir and [18F]-APN-1607 Study

2021 ◽  
Vol 15 ◽  
Author(s):  
Huiwei Zhang ◽  
Min Wang ◽  
Jiaying Lu ◽  
Weiqi Bao ◽  
Ling Li ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Pet Imaging ◽  
Roc Curve ◽  
Signal Intensity ◽  
Reference Signal ◽  
Parametric Estimation ◽  
Amyloid Pet ◽  
Reference Region ◽  
Imaging Data ◽  
Pet Scanning

BackgroundTau positron emission tomography (PET) imaging can reveal the pathophysiology and neurodegeneration that occurs in Alzheimer’s disease (AD) in vivo. The standardized uptake value ratio (SUVR) is widely used for semi-quantification of tau deposition but is susceptible to disturbance from the reference region and the partial volume effect (PVE). To overcome this problem, we applied the parametric estimation of reference signal intensity (PERSI) method—which was previously evaluated for flortaucipir imaging—to two tau tracers, flortaucipir and [18F]-APN-1607.MethodsTwo cohorts underwent tau PET scanning. Flortaucipir PET imaging data for cohort I (65 healthy controls [HCs], 60 patients with mild cognitive impairment [MCI], and 12 AD patients) were from the AD Neuroimaging Initiative database. [18F]-APN-1607 ([18F]-PM-PBB3) PET imaging data were for Cohort II, which included 21 patients with a clinical diagnosis of amyloid PET-positive AD and 15 HCs recruited at Huashan Hospital. We used white matter (WM) postprocessed by PERSI (PERSI-WM) as the reference region and compared this with the traditional semi-quantification method that uses the whole cerebellum as the reference. SUVRs were calculated for regions of interest including the frontal, parietal, temporal, and occipital lobes; anterior and posterior cingulate; precuneus; and Braak I/II (entorhinal cortex and hippocampus). Receiver operating characteristic (ROC) curve analysis and effect sizes were used to compare the two methods in terms of ability to discriminate between different clinical groups.ResultsIn both cohorts, regional SUVR determined using the PERSI-WM method was superior to using the cerebellum as reference region for measuring tau retention in AD patients (e.g., SUVR of the temporal lobe: flortaucipir, 1.08 ± 0.17 and [18F]-APN-1607, 1.57 ± 0.34); and estimates of the effect size and areas under the ROC curve (AUC) indicated that it also increased between-group differences (e.g., AUC of the temporal lobe for HC vs AD: flortaucipir, 0.893 and [18F]-APN-1607: 0.949).ConclusionThe PERSI-WM method significantly improves diagnostic discrimination compared to conventional approach of using the cerebellum as a reference region and can mitigate the PVE; it can thus enhance the efficacy of semi-quantification of multiple tau tracers in PET scanning, making it suitable for large-scale clinical application.

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