Serum vitamin E, C and A status of the drug addicts undergoing detoxification: influence of drug habit, sexual practice and lifestyle factors

Serum vitamin E levels are reduced in newborn infants. It has been reported that this deficiency is responsible, in part, for the development of anemia in premature infants during the first 6 weeks of life. The efficacy of vitamin E supplementation for the prevention of anemia in premature infants has been studied in a randomized, controlled, and blinded trial. Premature infants whose birth weights were less than 1,500 g were given, by gavage, 25 IU of dl-α-tocopherol or a similar volume of the drug vehicle. Treatment was continued for the first 6 weeks of life. A total of 178 infants were studied. Vitamin E levels were significantly higher in a supplemented group by day 3 and for the remainder of the 6-week period. At 6 weeks of age, there was no significant difference between the supplemented and unsupplemented groups in hemoglobin concentration, reticulocyte and platelet counts, or erythrocyte morphology. It is concluded that there is no evidence to support a policy of administering vitamin E to premature infants to prevent the anemia of prematurity.

Download Full-text

Lessons From the E-Ferol Tragedy

PEDIATRICS ◽

10.1542/peds.78.3.503 ◽

1986 ◽

Vol 78 (3) ◽

pp. 503-506

Author(s):

William F. Balistreri ◽

Michael K. Farrell ◽

Kevin E. Bove

Keyword(s):

Vitamin E ◽

Placental Transfer ◽

Serum Vitamin ◽

Maternal Blood ◽

Blood Levels ◽

Antioxidant Vitamin ◽

Low Birth Weight Infants ◽

Term Infants ◽

Naturally Occurring ◽

Supplemental Vitamin

"Those who cannot remember the past are condemned to repeat it."—G. Sabtatana Several factors combined to suggest that supplemental vitamin E should be administered to low birth weight infants. The persistent concern and controversy, the latter confounded by a paucity of data, have been discussed in recent editorials.1,2 At birh, tissue stores of the naturally occurring lipidsoluble antioxidant vitamin E (α-tocopherol) are low. The amount of total tocopherol in the tissue of premature infants is approximately one half that of full-term infants. 3 Maternal vitamin E supplementation seems to have minimal effect on serum vitamin E levels in the newborn because there is poor placental transfer; maternal blood levels are higher than cord levels.1-3

Download Full-text

Hematologic Studies in Undernourished Children with Low Serum Vitamin E Levels

American Journal of Clinical Nutrition ◽

10.1093/ajcn/17.3.158 ◽

1965 ◽

Vol 17 (3) ◽

pp. 158-163 ◽

Cited By ~ 9

Author(s):

R. V. ASFOUR ◽

S. FIRZLI

Keyword(s):

Vitamin E ◽

Serum Vitamin ◽

Low Serum

Download Full-text

Associations Between Potentially Modifiable and Nonmodifiable Risk Factors and Gait Speed in Middle- and Older-Aged Adults: Results From the Canadian Longitudinal Study on Aging

The Journals of Gerontology Series A ◽

10.1093/gerona/glab008 ◽

2021 ◽

Author(s):

Erica Figgins ◽

Yun-Hee Choi ◽

Mark Speechley ◽

Manuel Montero-Odasso

Keyword(s):

Risk Factors ◽

Longitudinal Study ◽

Gait Speed ◽

Chronic Conditions ◽

Serum Vitamin ◽

Lifestyle Factors ◽

Community Dwelling ◽

Life Course Perspective ◽

Factors Associated ◽

Modifiable Factors

Abstract Background Gait speed is a strong predictor of morbidity and mortality in older adults. Understanding the factors associated with gait speed and the associated adverse outcomes will inform mitigation strategies. We assessed the potentially modifiable and nonmodifiable factors associated with gait speed in a large national cohort of middle and older-aged Canadian adults. Methods We examined cross-sectional baseline data from the Canadian Longitudinal Study on Aging (CLSA) Comprehensive cohort. The study sample included 20 201 community-dwelling adults aged 45–85 years. The associations between sociodemographic and anthropometric factors, chronic conditions, and cognitive, clinical, and lifestyle factors and 4-m usual gait speed (m/s) were estimated using hierarchical multivariable linear regression. Results The coefficient of determination, R 2, of the final regression model was 19.7%, with 12.9% of gait speed variability explained by sociodemographic and anthropometric factors, and nonmodifiable chronic conditions and 6.8% explained by potentially modifiable chronic conditions, cognitive, clinical, and lifestyle factors. Potentially modifiable factors significantly associated with gait speed include cardiovascular conditions (unstandardized regression coefficient, B = −0.018; p < .001), stroke (B = −0.025; p = .003), hypertension (B = −0.007; p = .026), serum Vitamin D (B = 0.004; p < .001), C-reactive protein (B = −0.005; p = .005), depressive symptoms (B = −0.003; p < .001), physical activity (B = 0.0001; p < .001), grip strength (B = 0.003; p < .001), current smoking (B = −0.026; p < .001), severe obesity (B = −0.086; p < .001), and chronic pain (B = −0.008; p = .018). Conclusions The correlates of gait speed in adulthood are multifactorial, with many being potentially modifiable through interventions and education. Our results provide a life-course-perspective framework for future longitudinal assessments risk factors affecting gait speed.

Download Full-text